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The versatile interactions of p53 with DNA: when flexibility serves specificity

The versatile interactions of p53 with DNA: when flexibility serves specificity Cell Death and Differentiation (2006) 13, 885–889 & 2006 Nature Publishing Group All rights reserved 1350-9047/06 $30.00 www.nature.com/cdd News and Commentary The versatile interactions of p53 with DNA: when flexibility serves specificity 1,2 ,2 E Kim and W Deppert* specific DNA binding, p53-SSDB) or by specific structural determinants presented by DNA in non-B DNA conformations Neuro-Oncology Research Group, Department of Neurosurgery, University of (DNA structure-selective binding, p53-DSSB). Regardless of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, D-23538 whether the p53 target site is determined by the presence of a Luebeck, Germany specific sequence motif or by the three-dimensional structure Heinrich-Pette-Institute, Martinistrasse 52, D-20251 Hamburg, Germany of the DNA, either mode of DNA recognition ensures the * Corresponding author: W Deppert, Heinrich-Pette-Institute, Martinistrasse 52, specificity of the interaction. Last but not least, in addition to D-20251 Hamburg, Germany. Tel: þ 49 40 48051261; the different modes of recognition that underlie the site- Fax: þ 49 40 48051117; E-mail: [email protected] specific targeting of p53 to DNA, as in p53-SSDB or p53- DSSB, high-affinity binding of wild-type p53 to unspecific Cell Death and Differentiation (2006) 13, 885–889. linear double-stranded DNA represents yet another mode of doi:10.1038/sj.cdd.4401909; published online 17 March 2006 interaction that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cell Death & Differentiation Springer Journals

The versatile interactions of p53 with DNA: when flexibility serves specificity

Kim, E; Deppert, W
Cell Death & Differentiation , Volume 13 (6) – Mar 17, 2006
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References (13)

Publisher
Springer Journals
Copyright
Copyright © 2006 by Nature Publishing Group
Subject
Life Sciences; Life Sciences, general; Biochemistry, general; Cell Biology; Stem Cells; Apoptosis; Cell Cycle Analysis
ISSN
1350-9047
eISSN
1476-5403
DOI
10.1038/sj.cdd.4401909
Publisher site
See Article on Publisher Site

Abstract

Cell Death and Differentiation (2006) 13, 885–889 & 2006 Nature Publishing Group All rights reserved 1350-9047/06 $30.00 www.nature.com/cdd News and Commentary The versatile interactions of p53 with DNA: when flexibility serves specificity 1,2 ,2 E Kim and W Deppert* specific DNA binding, p53-SSDB) or by specific structural determinants presented by DNA in non-B DNA conformations Neuro-Oncology Research Group, Department of Neurosurgery, University of (DNA structure-selective binding, p53-DSSB). Regardless of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, D-23538 whether the p53 target site is determined by the presence of a Luebeck, Germany specific sequence motif or by the three-dimensional structure Heinrich-Pette-Institute, Martinistrasse 52, D-20251 Hamburg, Germany of the DNA, either mode of DNA recognition ensures the * Corresponding author: W Deppert, Heinrich-Pette-Institute, Martinistrasse 52, specificity of the interaction. Last but not least, in addition to D-20251 Hamburg, Germany. Tel: þ 49 40 48051261; the different modes of recognition that underlie the site- Fax: þ 49 40 48051117; E-mail: [email protected] specific targeting of p53 to DNA, as in p53-SSDB or p53- DSSB, high-affinity binding of wild-type p53 to unspecific Cell Death and Differentiation (2006) 13, 885–889. linear double-stranded DNA represents yet another mode of doi:10.1038/sj.cdd.4401909; published online 17 March 2006 interaction that

Journal

Cell Death & Differentiation – Springer Journals

Published: Mar 17, 2006

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