Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/structural-biology-of-sars-cov-2-and-implications-for-therapeutic-kl3OWRnHEI
References (160)
-
(2017)
a randomised, doubleblind, placebocontrolled, phase 2 trial -
K. Saikrishnan, Benjamin Powell, N. Cook, M. Webb, D. Wigley (2009)
Mechanistic Basis of 5′-3′ Translocation in SF1B HelicasesCell, 137
-
J. Ziebuhr (2005)
The Coronavirus ReplicaseCoronavirus Replication and Reverse Genetics, 287
-
Xiaopan Gao, B. Qin, Pu Chen, K. Zhu, P. Hou, J. Wojdyla, Meitian Wang, S. Cui (2020)
Crystal structure of SARS-CoV-2 papain-like proteaseActa Pharmaceutica Sinica. B, 11
-
W. Kamitani, Cheng Huang, Krishna Narayanan, K. Lokugamage, S. Makino (2009)
A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 proteinNature Structural & Molecular Biology, 16
-
Yao Zhao, Xiaoyu Du, Yinkai Duan, Xiaoyan Pan, Yifang Sun, Tian You, Lin Han, Zhenming Jin, W. Shang, Jing Yu, Hang Guo, Qianying Liu, Yan Wu, Chao Peng, Jun Wang, Chen Zhu, Xiuna Yang, Kailin Yang, Ying Lei, L. Guddat, Wenqing Xu, Gengfu Xiao, Lei Sun, Lei-ke Zhang, Z. Rao, Haitao Yang (2021)
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitorsProtein & Cell, 12
-
D. Pinto, Young-Jun Park, M. Beltramello, A. Walls, M. Tortorici, S. Bianchi, S. Jaconi, K. Culap, F. Zatta, A. Marco, A. Peter, B. Guarino, R. Spreafico, E. Cameroni, J. Case, Rita Chen, C. Havenar-Daughton, G. Snell, A. Telenti, Herbert Virgin, A. Lanzavecchia, Michael Diamond, K. Fink, D. Veesler, D. Corti (2020)
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibodyNature, 583
-
G. Song, Wan-ting He, Sean Callaghan, F. Anzanello, Deli Huang, James Ricketts, J. Torres, N. Beutler, Linghang Peng, Sirena Vargas, Jon Cassell, M. Parren, Linlin Yang, C. Ignacio, Davey Smith, J. Voss, D. Nemazee, A. Ward, T. Rogers, D. Burton, R. Andrabi (2020)
Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infectionbioRxiv
-
James Chen, B. Malone, E. Llewellyn, M. Grasso, Patrick Shelton, P. Olinares, K. Maruthi, E. Eng, Hasan Vatandaslar, B. Chait, T. Kapoor, S. Darst, E. Campbell (2020)
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription ComplexCell, 182
-
Yunlong Cao, B. Su, Xianghua Guo, Wenjie Sun, Yongqiang Deng, L. Bao, Qinyu Zhu, Xu Zhang, Yinghui Zheng, Chenyan Geng, Xiaoran Chai, Runsheng He, Xiaofeng Li, Qi Lv, Hua Zhu, Wei Deng, Yanfeng Xu, Yanjun Wang, Luxin Qiao, Ya-fang Tan, Liyang Song, Guopeng Wang, Xiaoxia Du, Ning Gao, Jiangning Liu, Junyu Xiao, X. Su, Z. Du, Yingmei Feng, Chuan Qin, C. Qin, R. Jin, X. Xie, CH Vlclvh (2020)
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B CellsCell, 182
-
P. Gong, O. Peersen (2010)
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymeraseProceedings of the National Academy of Sciences, 107
-
Leonid Yurkovetskiy, Xue Wang, Kristen Pascal, C. Tomkins-Tinch, T. Nyalile, Yetao Wang, A. Baum, W. Diehl, Ann Dauphin, C. Carbone, Kristen Veinotte, S. Egri, S. Schaffner, J. Lemieux, J. Munro, A. Rafique, Abhi Barve, Pardis Sabeti, C. Kyratsous, N. Dudkina, K. Shen, J. Luban (2020)
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein VariantbioRxiv
-
G. Kokic, H. Hillen, D. Tegunov, C. Dienemann, F. Seitz, J. Schmitzová, L. Farnung, A. Siewert, C. Höbartner, P. Cramer (2021)
Mechanism of SARS-CoV-2 polymerase stalling by remdesivirNature Communications, 12
-
M. Thoms, R. Buschauer, M. Ameismeier, L. Koepke, T. Denk, M. Hirschenberger, H. Kratzat, Manuel Hayn, T. Mackens-Kiani, Jingdong Cheng, J. Straub, C. Stürzel, T. Fröhlich, O. Berninghausen, T. Becker, F. Kirchhoff, K. Sparrer, R. Beckmann (2020)
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2Science (New York, N.y.), 369
-
Lihong Liu, Pengfei Wang, M. Nair, Jian Yu, M. Rapp, Qian Wang, Yang Luo, J. Chan, V. Sahi, A. Figueroa, Xinzheng Guo, G. Cerutti, Jude Bimela, J. Gorman, T. Zhou, Zhiwei Chen, K. Yuen, P. Kwong, J. Sodroski, M. Yin, Zizhang Sheng, Yaoxing Huang, L. Shapiro, D. Ho (2020)
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spikeNature, 584
-
Yu Chen, H. Cai, Ji’an Pan, N. Xiang, P. Tien, T. Ahola, D. Guo (2009)
Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferaseProceedings of the National Academy of Sciences, 106
-
Yongfei Cai, Jun Zhang, T. Xiao, Hanqin Peng, Sarah Sterling, R. Walsh, S. Rawson, Sophia Rits-Volloch, Bing Chen (2020)
Distinct conformational states of SARS-CoV-2 spike proteinScience (New York, N.y.)
-
C. Barnes, A. West, Kathryn Huey-Tubman, Magnus Hoffmann, N. Sharaf, Pauline Hoffman, Nicholas Koranda, H. Gristick, C. Gaebler, F. Muecksch, J. Lorenzi, Shlomo Finkin, Thomas Hägglöf, A. Hurley, Katrina Millard, Y. Weisblum, F. Schmidt, T. Hatziioannou, P. Bieniasz, M. Caskey, D. Robbiani, M. Nussenzweig, P. Bjorkman (2020)
Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of AntibodiesCell, 182
-
Nan Wang, Yao Sun, Rui Feng, Yuxi Wang, Yan Guo, Li Zhang, Yongqiang Deng, Lei Wang, Zhen Cui, Lei Cao, Yanjing Zhang, Weimin Li, F. Zhu, C. Qin, Xiangxi Wang (2020)
Structure-based development of human antibody cocktails against SARS-CoV-2Cell Research, 31
-
T. Fung, D. Liu (2019)
Human Coronavirus: Host-Pathogen Interaction.Annual review of microbiology
-
R. Sanjuán, Miguel Nebot, N. Chirico, L. Mansky, R. Belshaw (2010)
Viral Mutation RatesJournal of Virology, 84
-
S. Günther, P. Reinke, Y. Fernández-García, J. Lieske, T. Lane, H. Ginn, F. Koua, C. Ehrt, W. Ewert, D. Oberthuer, O. Yefanov, S. Meier, K. Lorenzen, Boris Krichel, Janine-Denise Kopicki, L. Gelisio, W. Brehm, I. Dunkel, B. Seychell, H. Gieseler, B. Norton-Baker, B. Escudero-Pérez, M. Domaracky, S. Saouane, A. Tolstikova, T. White, Anna Hänle, M. Groessler, H. Fleckenstein, F. Trost, M. Galchenkova, Y. Gevorkov, Chufeng Li, S. Awel, A. Peck, M. Barthelmess, F. Schlünzen, P. Xavier, N. Werner, H. Andaleeb, N. Ullah, S. Falke, V. Srinivasan, B. França, M. Schwinzer, H. Brognaro, C. Rogers, D. Melo, Joanna Zaitseva-Doyle, J. Knoška, Gisel Peña-Murillo, A. Mashhour, V. Hennicke, P. Fischer, J. Hakanpää, J. Meyer, P. Gribbon, B. Ellinger, M. Kuzikov, M. Wolf, A. Beccari, G. Bourenkov, D. Stetten, G. Pompidor, I. Bento, S. Panneerselvam, I. Karpičs, T. Schneider, M. Garcia-Alai, S. Niebling, Christian Günther, C. Schmidt, R. Schubert, Huijong Han, J. Boger, Diana Monteiro, Linlin Zhang, Xinyuanyuan Sun, J. Pletzer-Zelgert, J. Wollenhaupt, C. Feiler, M. Weiss, E. Schulz, P. Mehrabi, Katarina Karničar, Aleksandra Usenik, J. Loboda, H. Tidow, A. Chari, R. Hilgenfeld, C. Uetrecht, R. Cox, A. Zaliani, T. Beck, M. Rarey, S. Günther, D. Turk, W. Hinrichs, H. Chapman, A. Pearson, C. Betzel, A. Meents (2021)
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main proteaseScience (New York, N.y.), 372
-
D. Kneller, S. Galanie, G. Phillips, Hugh O’Neill, L. Coates, A. Kovalevsky (2020)
Malleability of the SARS-CoV-2 3CL Mpro Active-Site Cavity Facilitates Binding of Clinical AntiviralsStructure (London, England : 1993), 28
-
H Yang (2005)
10.1371/journal.pbio.0030324PLoS Biol., 3
-
M. Yuan, Hejun Liu, N. Wu, Chang-Chun Lee, Xueyong Zhu, Fangzhu Zhao, Deli Huang, Wenli Yu, Yuanzi Hua, H. Tien, T. Rogers, E. Landais, D. Sok, J. Jardine, D. Burton, I. Wilson (2020)
Structural basis of a shared antibody response to SARS-CoV-2Science (New York, N.y.), 369
-
Damon Deming, Rachel Graham, M. Denison, R. Baric (2007)
Processing of Open Reading Frame 1a Replicase Proteins nsp7 to nsp10 in Murine Hepatitis Virus Strain A59 ReplicationJournal of Virology, 81
-
J. Qiao, Yue-Shan Li, R. Zeng, Feng-Liang Liu, Rong-Hua Luo, Chong Huang, Yi-Fei Wang, Jie Zhang, B. Quan, Chenjian Shen, X. Mao, Xinlei Liu, Weining Sun, Wei Yang, X. Ni, Kai Wang, Ling Xu, Zilei Duan, Qing-Cui Zou, Hai-Lin Zhang, Wang Qu, Yang-Hao-Peng Long, Ming-hua Li, Rui Yang, Xiaolong Liu, Jing You, Yangli Zhou, R. Yao, Wen-Pei Li, Jingming Liu, Pei Chen, Yang Liu, Guifeng Lin, Xin Yang, Jun Zou, Linli Li, Yiguo Hu, G. Lu, Weiming Li, Yuquan Wei, Yong-tang Zheng, Jiankun Lei, Sheng-yong Yang (2021)
SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse modelScience (New York, N.y.), 371
-
V. Mandala, M. McKay, A. Shcherbakov, A. Dregni, A. Kolocouris, M. Hong (2020)
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayersNature structural & molecular biology, 27
-
Donghyuk Shin, Rukmini Mukherjee, D. Grewe, D. Bojkova, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, M. Widera, A. Mehdipour, G. Tascher, P. Geurink, A. Wilhelm, Gerbrand Noort, H. Ovaa, S. Müller, K. Knobeloch, K. Rajalingam, B. Schulman, J. Cinatl, G. Hummer, S. Ciesek, I. Dikič (2020)
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunityNature, 587
-
Ziliang Zhou, Chunliu Huang, Zhechong Zhou, Zhaoxia Huang, LiLi Su, Sisi Kang, Xiaoxue Chen, Qiuyue Chen, Suhua He, X. Rong, Fei Xiao, Jun Chen, Shoudeng Chen (2021)
Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14+ monocytesiScience, 24
-
Tyler Starr, Allison Greaney, Allison Greaney, Sarah Hilton, Sarah Hilton, Daniel Ellis, K. Crawford, K. Crawford, A. Dingens, M. Navarro, John Bowen, M. Tortorici, A. Walls, N. King, D. Veesler, Jesse Bloom, Jesse Bloom, Jesse Bloom (2020)
Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 BindingCell, 182
-
Andrew Harrison, Tao Lin, Penghua Wang (2020)
Mechanisms of SARS-CoV-2 Transmission and PathogenesisTrends in Immunology, 41
-
D. Wrapp, Nianshuang Wang, Kizzmekia Corbett, J. Goldsmith, C. Hsieh, O. Abiona, B. Graham, J. McLellan (2020)
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformationScience (New York, N.y.), 367
-
A. Douangamath, D. Fearon, P. Gehrtz, T. Krojer, P. Lukacik, C. Owen, E. Resnick, C. Strain-Damerell, A. Aimon, Péter Ábrányi‐Balogh, J. Brandão-Neto, A. Carbery, Gemma Davison, A. Dias, Thomas Downes, L. Dunnett, M. Fairhead, James Firth, S. Jones, Aaron Keeley, G. Keserü, Hanna Klein, Mathew Martin, Martin Noble, P. O’Brien, A. Powell, R. Reddi, R. Skyner, M. Snee, Michael Waring, C. Wild, N. London, F. Delft, M. Walsh (2020)
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main proteaseNature Communications, 11
-
J. Lan, J. Ge, Jinfang Yu, S. Shan, Huan Zhou, S. Fan, Qi Zhang, Xuanling Shi, Qisheng Wang, Linqi Zhang, Xinquan Wang (2020)
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptorNature, 581
-
C. Barnes, A. West, Kathryn Huey-Tubman, Magnus Hoffmann, N. Sharaf, Pauline Hoffman, Nicholas Koranda, H. Gristick, C. Gaebler, F. Muecksch, J. Lorenzi, Shlomo Finkin, Thomas Hagglof, A. Hurley, Katrina Millard, Y. Weisblum, F. Schmidt, T. Hatziioannou, P. Bieniasz, M. Caskey, D. Robbiani, M. Nussenzweig, P. Bjorkman (2020)
Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodiesbioRxiv
-
A. Dementiev, A. Joachimiak, Ha-Giang Nguyen, A. Gorelik, K. Illes, S. Shabani, M. Gelsomino, E. Ahn, B. Nagar, N. Doan (2018)
Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.Journal of medicinal chemistry, 62 2
-
Shuai Xia, Meiqin Liu, Chao Wang, W. Xu, Qiaoshuai Lan, Siliang Feng, F. Qi, L. Bao, L. Du, Shuwen Liu, C. Qin, Fei Sun, Z. Shí, Yun Zhu, Shibo Jiang, Lu Lu (2020)
Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusionCell Research, 30
-
Cheng Huang, K. Lokugamage, Janet Rozovics, Krishna Narayanan, B. Semler, S. Makino (2011)
SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA CleavagePLoS Pathogens, 7
-
Mickaël Bouvet, C. Debarnot, I. Imbert, B. Selisko, E. Snijder, B. Canard, E. Decroly (2010)
In Vitro Reconstitution of SARS-Coronavirus mRNA Cap MethylationPLoS Pathogens, 6
-
M. Rosas-Lemus, G. Minasov, L. Shuvalova, Nicole Inniss, O. Kiryukhina, J. Brunzelle, Karla Satchell (2020)
High-resolution structures of the SARS-CoV-2 2’-O-methyltransferase reveal strategies for structure-based inhibitor designScience signaling, 13
-
X. Xue, Hongwei Yu, Haitao Yang, F. Xue, Zhixin Wu, Weiran Shen, Jun Li, Zhengkang Zhou, Yi Ding, Qi Zhao, Xuejun Zhang, M. Liao, M. Bartlam, Z. Rao (2007)
Structures of Two Coronavirus Main Proteases: Implications for Substrate Binding and Antiviral Drug DesignJournal of Virology, 82
-
Y. Weisblum, F. Schmidt, Fengwen Zhang, Justin DaSilva, D. Poston, Julio Lorenzi, F. Muecksch, Magda Rutkowska, Hans-Heinrich Hoffmann, E. Michailidis, C. Gaebler, M. Agudelo, A. Cho, Zijun Wang, A. Gazumyan, M. Cipolla, Larry Luchsinger, C. Hillyer, M. Caskey, D. Robbiani, C. Rice, M. Nussenzweig, T. Hatziioannou, P. Bieniasz (2020)
Author response: Escape from neutralizing antibodies by SARS-CoV-2 spike protein variantseLife
-
Zhenming Jin, Yao Zhao, Yuanyuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, T. Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, L. Guddat, Gengfu Xiao, Lei-ke Zhang, Haitao Yang, Z. Rao (2020)
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofurNature Structural & Molecular Biology, 27
-
Ya Peng, Ning Du, Y. Lei, Sonam Dorje, J. Qi, T. Luo, G. Gao, Hao Song (2020)
Structures of the SARS‐CoV‐2 nucleocapsid and their perspectives for drug designThe EMBO Journal, 39
-
D. Zhou, Helen Duyvesteyn, Cheng-Pin Chen, Chung-Guei Huang, Ting-Hua Chen, S. Shih, Yi-Chun Lin, Chien-Yu Cheng, S. Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Che Ma, J. Huo, L. Carrique, T. Malinauskas, R. Ruza, P. Shah, T. Tan, P. Rijal, R. Donát, K. Godwin, K. Buttigieg, J. Tree, Julika Radecke, N. Paterson, P. Supasa, J. Mongkolsapaya, G. Screaton, M. Carroll, J. Jaramillo, Michael Knight, W. James, R. Owens, J. Naismith, A. Townsend, E. Fry, Yuguang Zhao, Jingshan Ren, D. Stuart, Kuan-Ying Huang (2020)
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patientNature Structural & Molecular Biology, 27
-
Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, U. Curth, C. Drosten, Lucie Sauerhering, S. Becker, K. Rox, R. Hilgenfeld (2020)
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitorsScience (New York, N.y.), 368
-
Y Weisblum (2020)
10.7554/eLife.61312eLife, 9
-
Brandi Williamson, F. Feldmann, Benjamin Schwarz, K. Meade-White, D. Porter, Jonathan Schulz, N. Doremalen, I. Leighton, C. Yinda, L. Pérez-Pérez, A. Okumura, J. Lovaglio, P. Hanley, G. Saturday, C. Bosio, S. Anzick, Kent Barbian, T. Cihlar, C. Martens, D. Scott, V. Munster, E. Wit (2020)
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2Nature, 585
-
E. Wit, N. Doremalen, D. Falzarano, V. Munster (2016)
SARS and MERS: recent insights into emerging coronavirusesNature Reviews. Microbiology, 14
-
Shuang Li, Qi Zhao, Yinjie Zhang, Yang Zhang, M. Bartlam, Xuemei Li, Z. Rao (2010)
New nsp8 isoform suggests mechanism for tuning viral RNA synthesisProtein & Cell, 1
-
Haitao Yang, Maojun Yang, Yi Ding, Yiwei Liu, Z. Lou, Zhe Zhou, Lei Sun, L. Mo, S. Ye, H. Pang, G. Gao, K. Anand, M. Bartlam, R. Hilgenfeld, Z. Rao (2003)
The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitorProceedings of the National Academy of Sciences of the United States of America, 100
-
M. McCallum, A. Marco, Florian Lempp, M. Tortorici, D. Pinto, A. Walls, M. Beltramello, Alex Chen, Zhuoming Liu, F. Zatta, Samantha Zepeda, J. Iulio, John Bowen, Martin Montiel-Ruiz, Jiayi Zhou, Laura Rosen, S. Bianchi, B. Guarino, C. Fregni, R. Abdelnabi, S. Foo, Paul Rothlauf, L. Bloyet, F. Benigni, E. Cameroni, J. Neyts, A. Riva, G. Snell, A. Telenti, S. Whelan, H. Virgin, D. Corti, M. Pizzuto, D. Veesler (2021)
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2Cell, 184
-
J. Shang, G. Ye, K. Shi, Yushun Wan, C. Luo, H. Aihara, Q. Geng, Ashley Auerbach, Fang Li (2020)
Structural basis of receptor recognition by SARS-CoV-2Nature, 581
-
Zhe Lv, Yongqiang Deng, Qing Ye, Lei Cao, Chun-Yun Sun, Changfa Fan, Wei-jin Huang, Shihui Sun, Yao Sun, Ling Zhu, Qi Chen, Nan Wang, J. Nie, Zhen Cui, Dandan Zhu, N. Shaw, Xiao-Feng Li, Qian-qian Li, Liangzhi Xie, Youchun Wang, Z. Rao, C. Qin, Xiangxi Wang (2020)
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibodyScience (New York, N.y.)
-
Fan Wu, Su Zhao, Bin Yu, Yan-Mei Chen, Wen Wang, Zhigang Song, Y. Hu, Zhaowu Tao, Jun-hua Tian, Yuan-Yuan Pei, Mingli Yuan, Yuling Zhang, Fahui Dai, Yi Liu, Qimin Wang, Jiao-Jiao Zheng, Lin Xu, E. Holmes, Yong‐Zhen Zhang (2020)
A new coronavirus associated with human respiratory disease in ChinaNature, 579
-
J. Reina, N. Reina (2015)
The Middle East respiratory syndrome coronavirus☆Medicina Clinica (English Ed.), 145
-
Haitao Yang, M. Bartlam, Z. Rao (2006)
Drug design targeting the main protease, the Achilles' heel of coronaviruses.Current pharmaceutical design, 12 35
-
S. Daffis, Kristy Szretter, Jill Schriewer, Jianqing Li, Soonjeon Youn, J. Errett, Tsai-Yu Lin, S. Schneller, Roland Züst, Hongping Dong, V. Thiel, V. Thiel, G. Sen, Volker Fensterl, W. Klimstra, T. Pierson, R. Buller, M. Gale, P. Shi, M. Diamond (2010)
2′-O methylation of the viral mRNA cap evades host restriction by IFIT family membersNature, 468
-
Krishna Narayanan, Cheng Huang, K. Lokugamage, W. Kamitani, T. Ikegami, C. Tseng, S. Makino (2008)
Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected CellsJournal of Virology, 82
-
B. Harcourt, D. Jukneliene, A. Kanjanahaluethai, John Bechill, Kari Severson, Catherine Smith, P. Rota, S. Baker (2004)
Identification of Severe Acute Respiratory Syndrome Coronavirus Replicase Products and Characterization of Papain-Like Protease ActivityJournal of Virology, 78
-
Yu Guo, Lisu Huang, Guangshun Zhang, Yanfeng Yao, He Zhou, S. Shěn, Bingqing Shen, Bo Li, Xin Li, Qian Zhang, Mingjie Chen, Da Chen, Jia Wu, D. Fu, Xin-Xin Zeng, Ming-Ming Feng, C. Pi, Yuanbo Wang, Xingdong Zhou, Min-Giang Lu, Yarong Li, Yaohui Fang, Yun-Yueh Lu, Xue Hu, Shanshan Wang, Wanju Zhang, G. Gao, F. Adrián, Qisheng Wang, F. Yu, Yun Peng, A. Gabibov, J. Min, Yuhui Wang, Heyu Huang, A. Stepanov, Wei Zhang, Yan Cai, Jun-wei Liu, Zhiming Yuan, Chen Zhang, Z. Lou, F. Dèng, Hongkai Zhang, Chao Shan, L. Schweizer, K. Sun, Z. Rao (2021)
A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomesNature Communications, 12
-
Anna Wec, D. Wrapp, A. Herbert, Daniel Maurer, Denise Haslwanter, M. Sakharkar, R. Jangra, M. Dieterle, A. Lilov, Deli Huang, Longping Tse, N. Johnson, C. Hsieh, Nianshuang Wang, J. Nett, E. Champney, Irina Burnina, Michael Brown, Shu Lin, M. Sinclair, Carl Johnson, Sarat Pudi, R. Bortz, A. Wirchnianski, Ethan Laudermilch, Catalina Florez, J. Fels, Cecilia O’Brien, B. Graham, D. Nemazee, D. Burton, R. Baric, J. Voss, K. Chandran, J. Dye, J. McLellan, L. Walker (2020)
Broad neutralization of SARS-related viruses by human monoclonal antibodiesScience (New York, N.y.), 369
-
Jingfang Mu, Jiuyue Xu, Lei-ke Zhang, T. Shu, Di Wu, Muhan Huang, Yujie Ren, Xu-fang Li, Q. Geng, Yi Xu, Y. Qiu, Xi Zhou (2020)
SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cellsScience China. Life Sciences, 63
-
Q. Peng, R. Peng, Bin Yuan, Min Wang, Jingru Zhao, L. Fu, J. Qi, Yi Shi (2020)
Structural Basis of SARS-CoV-2 Polymerase Inhibition by FavipiravirThe Innovation, 2
-
T. Flower, C. Buffalo, R. Hooy, M. Allaire, X. Ren, J. Hurley (2020)
Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion proteinProceedings of the National Academy of Sciences of the United States of America, 118
-
Xiaomo Jiang, Zhijian Chen (2011)
The role of ubiquitylation in immune defence and pathogen evasionNature Reviews Immunology, 12
-
Anand Ramanathan, G. Robb, S. Chan (2016)
mRNA capping: biological functions and applicationsNucleic Acids Research, 44
-
B. Ju, Qi Zhang, J. Ge, Ruoke Wang, Jing Sun, Xiangyang Ge, Jiazhen Yu, S. Shan, Bingjie Zhou, Shuo Song, Xian-Chun Tang, Jinfang Yu, J. Lan, Jing Yuan, Haiyan Wang, Juanjuan Zhao, Shuye Zhang, Youchun Wang, Xuanling Shi, Lei Liu, Jincun Zhao, Xinquan Wang, Zheng Zhang, Linqi Zhang (2020)
Human neutralizing antibodies elicited by SARS-CoV-2 infectionNature, 584
-
Konstantin Ivanov, J. Ziebuhr (2004)
Human Coronavirus 229E Nonstructural Protein 13: Characterization of Duplex-Unwinding, Nucleoside Triphosphatase, and RNA 5′-Triphosphatase ActivitiesJournal of Virology, 78
-
Liming Yan, Ji Ge, Litao Zheng, Ying Zhang, Yan Gao, Tao Wang, Yucen Huang, Yunxiang Yang, Shan Gao, Mingyu Li, Zhenyu Liu, Haofeng Wang, Yingjian Li, Yu Chen, L. Guddat, Quan Wang, Z. Rao, Z. Lou (2020)
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap SynthesisCell, 184
-
Yousef Alhammad, M. Kashipathy, Anuradha Roy, J. Gagné, Peter McDonald, P. Gao, Louis Nonfoux, K. Battaile, David Johnson, Erik Holmstrom, G. Poirier, S. Lovell, Anthony Fehr (2020)
The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-RibosylhydrolaseJournal of Virology, 95
-
L. Fu, F. Ye, Yong Feng, Feng Yu, Qisheng Wang, Yan Wu, Cheng Zhao, Huan Sun, Baoying Huang, P. Niu, Hao Song, Yi Shi, Xuebing Li, W. Tan, Jianxun Qi, George Gao (2020)
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main proteaseNature Communications, 11
-
Jian Lei, Y. Kusov, R. Hilgenfeld (2017)
Nsp3 of coronaviruses: Structures and functions of a large multi-domain proteinAntiviral Research, 149
-
S. Hattori, Nobuyo Higashi-Kuwata, H. Hayashi, Srinivasarao Allu, Jakka Raghavaiah, H. Bulut, D. Das, B. Anson, E. Lendy, Y. Takamatsu, N. Takamune, N. Kishimoto, K. Murayama, Kazuya Hasegawa, Mi Li, D. Davis, E. Kodama, R. Yarchoan, A. Wlodawer, S. Misumi, A. Mesecar, Arun Ghosh, H. Mitsuya (2021)
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replicationNature Communications, 12
-
D. Wrapp, D. Vlieger, Kizzmekia Corbett, G. Torres, W. Breedam, K. Roose, Loes Schie, M. Hoffmann, S. Pöhlmann, B. Graham, N. Callewaert, B. Schepens, X. Saelens, J. McLellan (2020)
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid AntibodiesCell, 181
-
B. Malone, James Chen, Qi Wang, E. Llewellyn, Y. Choi, P. Olinares, Xinyun Cao, C. Hernández, E. Eng, B. Chait, D. Shaw, R. Landick, S. Darst, E. Campbell (2021)
Structural basis for backtracking by the SARS-CoV-2 replication–transcription complexProceedings of the National Academy of Sciences of the United States of America, 118
-
Kam-Leung Siu, Kit-San Yuen, carlos Castaño-Rodríguez, Z. Ye, M. Yeung, S. Fung, Shuofeng Yuan, Chi-Ping Chan, K. Yuen, L. Enjuanes, D. Jin (2019)
Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3‐dependent ubiquitination of ASCThe FASEB Journal, 33
-
Jose Nieto-Torres, C. Verdiá-Báguena, Jose Jimenez-Guardeño, J. Regla-Nava, carlos Castaño-Rodríguez, R. Fernández-Delgado, J. Torres, V. Aguilella, L. Enjuanes (2015)
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasomeVirology, 485
-
Yuanyuan Ma, Lijie Wu, N. Shaw, Yan Gao, Jin Wang, Yuna Sun, Z. Lou, Liming Yan, Rong-guang Zhang, Z. Rao (2015)
Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complexProceedings of the National Academy of Sciences, 112
-
S. Belouzard, J. Millet, Beth Licitra, G. Whittaker (2012)
Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike ProteinViruses, 4
-
K. Anand, G. Palm, J. Mesters, S. Siddell, J. Ziebuhr, R. Hilgenfeld (2002)
Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domainThe EMBO Journal, 21
-
D. Fu, Guangshun Zhang, Yuhui Wang, Zheng Zhang, Hengrui Hu, S. Shěn, Jun Wu, Bo Li, Xin Li, Yaohui Fang, Jia Liu, Qiao Wang, Yunjiao Zhou, W. Wang, Yufeng Li, Zhonghua Lu, Xiaoxiao Wang, Cui Nie, Yujie Tian, Da Chen, Yuan Wang, Xingdong Zhou, Qisheng Wang, F. Yu, Chen Zhang, C. Deng, Liang Zhou, G. Guan, Na Shao, Z. Lou, F. Dèng, Hongkai Zhang, Xinwen Chen, Manli Wang, Louis Liu, Z. Rao, Yu Guo (2021)
Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopesPLoS Biology, 19
-
K. McCarthy, L. Rennick, Sham Nambulli, Lindsey Robinson-McCarthy, W. Bain, G. Haidar, W. Duprex (2021)
Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escapeScience (New York, N.y.), 371
-
R. Shi, Chao Shan, Xiaomin Duan, Zhihai Chen, Peipei Liu, Jinwen Song, Tao Song, Xiaoshan Bi, Chao Han, Lian-ao Wu, G. Gao, Xue Hu, Yanan Zhang, Z. Tong, Wei-jin Huang, William Liu, Guizhen Wu, Bo Zhang, Lan Wang, J. Qi, H. Feng, Fu-Sheng Wang, Qihui Wang, G. Gao, Zhiming Yuan, Jinghua Yan (2020)
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2Nature
-
Y. Kusov, Jin-zhi Tan, E. Álvarez, L. Enjuanes, R. Hilgenfeld (2015)
A G-quadruplex-binding macrodomain within the “SARS-unique domain” is essential for the activity of the SARS-coronavirus replication–transcription complexVirology, 484
-
Xiaofen Zhong, Zu-feng Guo, Huanghao Yang, Lisheng Peng, Yong Xie, Tin-yau Wong, S. Lai, Zhihong Guo (2006)
Amino terminus of the SARS coronavirus protein 3a elicits strong, potentially protective humoral responses in infected patients.The Journal of general virology, 87 Pt 2
-
Jie Cui, Fang Li, Z. Shí (2018)
Origin and evolution of pathogenic coronavirusesNature Reviews. Microbiology, 17
-
P. Masters (2006)
The Molecular Biology of CoronavirusesAdvances in Virus Research, 66
-
Faheem, B. Kumar, K. Sekhar, Selvaraj Kunjiappan, J. Jamalis, R. Balaña-Fouce, B. Tekwani, Murugesan Sankaranarayanan (2020)
Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19Bioorganic Chemistry, 104
-
Naina Barretto, D. Jukneliene, K. Ratia, Zhongbin Chen, A. Mesecar, S. Baker (2005)
The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating ActivityJournal of Virology, 79
-
Wioletta Rut, Z. Lv, Mikołaj Żmudziński, Stephanie Patchett, D. Nayak, S. Snipas, Farid Oualid, Tony Huang, M. Békés, M. Drąg, S. Olsen (2020)
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug designScience Advances, 6
-
Y. Zhai, F. Sun, Xuemei Li, H. Pang, Xiaoling Xu, M. Bartlam, Z. Rao (2005)
Insights into SARS-CoV transcription and replication from the structure of the nsp7–nsp8 hexadecamerNature Structural & Molecular Biology, 12
-
A. Rathnayake, Jian Zheng, Yunjeong Kim, K. Perera, Samantha Mackin, D. Meyerholz, M. Kashipathy, K. Battaile, S. Lovell, S. Perlman, W. Groutas, Kyeong-Ok Chang (2020)
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected miceScience Translational Medicine, 12
-
Jonathan Kil, E. Lobarinas, C. Spankovich, S. Griffiths, P. Antonelli, E. Lynch, C. Prell (2017)
Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trialThe Lancet, 390
-
G. Sutton, E. Fry, Lester Carter, S. Sainsbury, T. Walter, J. Nettleship, N. Berrow, R. Owens, R. Gilbert, A. Davidson, S. Siddell, L. Poon, J. Diprose, D. Alderton, M. Walsh, J. Grimes, D. Stuart (2004)
The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional InsightsStructure (London, England : 1993), 12
-
H. Hillen, G. Kokic, L. Farnung, C. Dienemann, D. Tegunov, P. Cramer (2020)
Structure of replicating SARS-CoV-2 polymeraseNature, 584
-
D. Collier, A. Marco, I. Ferreira, B. Meng, R. Datir, A. Walls, Steven S, J. Bassi, D. Pinto, C. Fregni, S. Bianchi, M. Tortorici, John Bowen, K. Culap, S. Jaconi, E. Cameroni, G. Snell, M. Pizzuto, A. Pellanda, C. Garzoni, A. Riva, A. Elmer, N. Kingston, B. Graves, L. McCoy, Kenneth Smith, J. Bradley, Nigel Temperton, L. Ceron-Gutierrez, G. Barcenas-Morales, William Harvey, H. Virgin, A. Lanzavecchia, L. Piccoli, R. Doffinger, M. Wills, D. Veesler, D. Corti, Ravindra Gupta (2021)
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodiesNature, 608
-
Xiangyang Chi, R. Yan, Jun Zhang, Guanying Zhang, Yuanyuan Zhang, Meng Hao, Zhe Zhang, Pengfei Fan, Yunzhu Dong, Yilong Yang, Zhengshan Chen, Yingying Guo, Jinlong Zhang, Yaning Li, Xiaohong Song, Yi Chen, L. Xia, L. Fu, L. Hou, Junjie Xu, Changming Yu, Jianmin Li, Qiang Zhou, Wei Chen (2020)
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2Science (New York, N.y.), 369
-
Liming Yan, Ying Zhang, Ji Ge, Litao Zheng, Yan Gao, Tao Wang, Zhihui Jia, Haofeng Wang, Yucen Huang, Mingyu Li, Quan Wang, Z. Rao, Z. Lou (2020)
Architecture of a SARS-CoV-2 mini replication and transcription complexNature Communications, 11
-
Ziyang Fu, Bing Huang, Jinle Tang, Shuyan Liu, Ming Liu, Yuxin Ye, Zhihong Liu, Yuxian Xiong, Wenjie Zhu, D. Cao, Ji‐Heng Li, Xiaogang Niu, Huan Zhou, Y. Zhao, Guoliang Zhang, Hao Huang (2021)
The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discoveryNature Communications, 12
-
A. Walls, Young-Jun Park, M. Tortorici, A. Wall, Andrew McGuire, D. Veesler (2020)
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike GlycoproteinCell, 181
-
Yan Gao, Liming Yan, Yucen Huang, Fengjiang Liu, Yao Zhao, Lin Cao, Tao Wang, Qianqian Sun, Z. Ming, Lianqi Zhang, Ji Ge, Litao Zheng, Ying Zhang, Haofeng Wang, Yan Zhu, Chen Zhu, T. Hu, T. Hua, Bing Zhang, Xiuna Yang, Jun Li, Haitao Yang, Zhijie Liu, Wenqing Xu, L. Guddat, Quan Wang, Z. Lou, Z. Rao (2020)
Structure of the RNA-dependent RNA polymerase from COVID-19 virusScience (New York, N.y.), 368
-
Ayushi Chaudhary, Harjeet Singh, K. Bhatia, Megha Sirohi, U. Singh (2020)
Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome, 1
-
L. Michelle, Houston Simon, P. Helena, V. LithgowKaren, Hof Rebecca, Wetherell Charmaine, Kao Wei-Chien, Yi-Pin Lin, J. Tara, Ebady Rhodaba, E. CameronCaroline, J. BoulangerMartin (2016)
Data collection and refinement statistics.PLOS Pathogens
-
Chunlong Ma, M. Sacco, B. Hurst, J. Townsend, Yanmei Hu, Tommy Szeto, Xiujun Zhang, Bart Tarbet, M. Marty, Yu Chen, Jun Wang (2020)
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main proteasebioRxiv
-
Jian Li, Xuelan Zhou, Y. Zhang, F. Zhong, Cheng Lin, P. McCormick, F. Jiang, Jun Luo, Huan Zhou, Qisheng Wang, Yang Fu, J. Duan, Jin Zhang (2020)
Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding modeScience Bulletin, 66
-
Zhihui Jia, Liming Yan, Zhilin Ren, Lijie Wu, Jin Wang, Jing Guo, Litao Zheng, Z. Ming, Lianqi Zhang, Z. Lou, Z. Rao (2019)
Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysisNucleic Acids Research, 47
-
T. Rogers, Fangzhu Zhao, Deli Huang, N. Beutler, Alison Burns, Wan-ting He, Oliver Limbo, C. Smith, G. Song, J. Woehl, Linlin Yang, R. Abbott, Sean Callaghan, Elijah Garcia, Jonathan Hurtado, M. Parren, Linghang Peng, S. Ramirez, James Ricketts, M. Ricciardi, Stephen Rawlings, N. Wu, M. Yuan, Davey Smith, D. Nemazee, J. Teijaro, J. Voss, I. Wilson, R. Andrabi, Bryan Briney, E. Landais, D. Sok, J. Jardine, D. Burton (2020)
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal modelScience (New York, N.y.), 369
-
L. Subissi, C. Posthuma, A. Collet, Jessika Zevenhoven-Dobbe, A. Gorbalenya, E. Decroly, E. Snijder, B. Canard, I. Imbert (2014)
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activitiesProceedings of the National Academy of Sciences, 111
-
D. Cavanagh (2005)
Coronaviruses in poultry and other birdsAvian Pathology, 34
-
D. Hamre, J. Procknow (1966)
A New Virus Isolated from the Human Respiratory Tract.∗Proceedings of the Society for Experimental Biology and Medicine, 121
-
L. Hanke, L. Perez, D. Sheward, H. Das, T. Schulte, Ainhoa Morro, M. Corcoran, A. Achour, G. Hedestam, B. Hällberg, B. Murrell, G. McInerney (2020)
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interactionNature Communications, 11
-
M. Yuan, N. Wu, Xueyong Zhu, Chang-Chun Lee, R. So, Huibin Lv, C. Mok, I. Wilson (2020)
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoVScience (New York, N.y.), 368
-
Kai Yang, Xinyu Ma, Yuying Ma, Yugendar Alugubelli, D. Scott, E. Vatansever, Aleksandra Drelich, B. Sankaran, Zhi-Zhong Geng, Lauren Blankenship, Hannah Ward, Yan-jing Sheng, Jason Hsu, K. Kratch, Baoyu Zhao, Hamed Hayatshahi, Jin Liu, Pingwei Li, C. Fierke, C. Tseng, Shiqing Xu, W. Liu (2020)
A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors **ChemMedChem, 16
-
H. Su, Sheng Yao, Wen Zhao, Minjun Li, Jia Liu, W. Shang, Hang Xie, Chang-qiang Ke, Hang-chen Hu, Mei-na Gao, Kunqian Yu, Hong Liu, Jingshan Shen, Wei Tang, Lei-ke Zhang, Geng-Fu Xiao, Li Ni, Daowen Wang, Jian-Ping Zuo, Hualiang Jiang, Fang Bai, Yan Wu, Y. Ye, Ye-chun Xu (2020)
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredientsActa Pharmacologica Sinica, 41
-
H. Yao, Yao Sun, Yongqiang Deng, Nan Wang, Yongcong Tan, Na-Na Zhang, Xiao-Feng Li, Chao Kong, Yan-Peng Xu, Qi Chen, Tianshu Cao, Hui Zhao, Xintian Yan, Lei Cao, Zhe Lv, Dandan Zhu, Rui Feng, N. Wu, Wenhai Zhang, Yuhao Hu, Keda Chen, Rong-Rong Zhang, Qingyu Lv, Shihui Sun, Yunhua Zhou, R. Yan, Guan Yang, Xing Sun, Chanjuan Liu, Xiangyun Lu, Lin-fang Cheng, H. Qiu, Xingyao Huang, Tianhao Weng, Danrong Shi, Weidong Jiang, Junbin Shao, Lei Wang, Jie Zhang, T. Jiang, Guojun Lang, C. Qin, Lanjuan Li, Xiangxi Wang (2020)
Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protectionCell Research, 31
-
Leonid Yurkovetskiy, Xue Wang, Kristen Pascal, C. Tomkins-Tinch, T. Nyalile, Yetao Wang, A. Baum, W. Diehl, Ann Dauphin, C. Carbone, Kristen Veinotte, S. Egri, S. Schaffner, J. Lemieux, J. Munro, A. Rafique, Abhi Barve, Pardis Sabeti, C. Kyratsous, N. Dudkina, K. Shen, J. Luban (2020)
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein VariantCell, 183
-
William Harvey, A. Carabelli, B. Jackson, Ravindra Gupta, E. Thomson, E. Harrison, C. Ludden, R. Reeve, A. Rambaut, S. Peacock, D. Robertson (2021)
SARS-CoV-2 variants, spike mutations and immune escapeNature Reviews. Microbiology, 19
-
Jonathan Kil, C. Pierce, Huy Tran, R. Gu, E. Lynch (2007)
Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidaseHearing Research, 226
-
M. Vries, Adil Mohamed, Rachel Prescott, Ana Valero-Jimenez, L. Desvignes, Rebecca O'connor, C. Steppan, J. Devlin, E. Ivanova, A. Herrera, Austin Schinlever, Paige Loose, Kelly Ruggles, Sergei Koralov, A. Anderson, Joseph Binder, Meike Dittmann (2021)
A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CLpro Inhibitor PF-00835231 as a Potential New Treatment for COVID-19Journal of Virology, 95
-
T. Klemm, G. Ebert, D. Calleja, C. Allison, L. Richardson, Jonathan Bernardini, Bernadine Lu, Nathan Kuchel, Christoph Grohmann, Yuri Shibata, Z. Gan, James Cooney, M. Doerflinger, A. Au, T. Blackmore, Gerbrand Noort, P. Geurink, H. Ovaa, J. Newman, A. Riboldi-Tunnicliffe, P. Czabotar, Jeffrey Mitchell, R. Feltham, B. Lechtenberg, K. Lowes, G. Dewson, M. Pellegrini, G. Lessene, D. Komander (2020)
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2The EMBO Journal, 39
-
R. Hoffman, R. Kania, M. Brothers, J. Davies, R. Ferre, K. Gajiwala, Mingying He, R. Hogan, K. Kozminski, Lilian Li, Jonathan Lockner, J. Lou, M. Marra, L. Mitchell, B. Murray, J. Nieman, Stephen Noell, Simon Planken, T. Rowe, K. Ryan, George Smith, J. Solowiej, C. Steppan, Barbara Taggart (2020)
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19Journal of Medicinal Chemistry
-
Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Lei-ke Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Ren-di Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, L. Guddat, Wenqing Xu, Gengfu Xiao, C. Qin, Z. Shí, Hualiang Jiang, Z. Rao, Haitao Yang (2020)
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitorsNature, 582
-
Konstantin Ivanov, V. Thiel, J. Dobbe, Y. Meer, E. Snijder, J. Ziebuhr (2004)
Multiple Enzymatic Activities Associated with Severe Acute Respiratory Syndrome Coronavirus HelicaseJournal of Virology, 78
-
W. Yin, X. Luan, Zhihai Li, Ziwei Zhou, Qingxing Wang, M. Gao, Xiao-xi Wang, F. Zhou, Jingjing Shi, E. You, Mingliang Liu, Qingxia Wang, Yi Jiang, Hualiang Jiang, Gengfu Xiao, Lei-ke Zhang, Xuekui Yu, Shuyang Zhang, H. Xu (2021)
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suraminNature Structural & Molecular Biology, 28
-
L. Lei, S. Ying, Bao-jun Luo, Y. Yi, H. Xiang, Su Wenli, Zounan Sun, Guo Deyin, Qingyu Zhu, Jingmei Liu, Guo-hui Chang (2013)
Attenuation of Mouse Hepatitis Virus by Deletion of the LLRKxGxKG Region of Nsp1PLoS ONE, 8
-
K. Choi (2012)
Viral polymerases.Advances in experimental medicine and biology, 726
-
Ziliang Zhou, Chunliu Huang, Zhechong Zhou, Zhaoxia Huang, LiLi Su, Sisi Kang, Xiaoxue Chen, Qiuyue Chen, Suhua He, X. Rong, Fei Xiao, Jun Chen, Shoudeng Chen (2020)
Structural Insight Reveals SARS-CoV-2 Orf7a as an Immunomodulating Factor for Human CD14+ Monocytes -
E. Smith, Nicole Sexton, M. Denison (2014)
Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses.Annual review of virology, 1 1
-
G. Song, Wan-ting He, Sean Callaghan, F. Anzanello, Deli Huang, James Ricketts, J. Torres, N. Beutler, Linghang Peng, Sirena Vargas, Jon Cassell, M. Parren, Linlin Yang, C. Ignacio, Davey Smith, J. Voss, D. Nemazee, A. Ward, T. Rogers, D. Burton, R. Andrabi (2021)
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infectionNature Communications, 12
-
Mei-Yue Wang, Rong Zhao, Li-Juan Gao, Xue Gao, De-Ping Wang, Ji-min Cao (2020)
SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics DevelopmentFrontiers in Cellular and Infection Microbiology, 10
-
Yu Chen, Qianyun Liu, D. Guo (2020)
Emerging coronaviruses: Genome structure, replication, and pathogenesisJournal of Medical Virology, 92
-
D. Kern, B. Sorum, Sonali Mali, C. Hoel, Savitha Sridharan, J. Remis, D. Toso, A. Kotecha, D. Bautista, S. Brohawn (2021)
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscsNature Structural & Molecular Biology, 28
-
Zhiqiang Zheng, V. Monteil, Sebastian Maurer-Stroh, Chow Yew, Carol Leong, N. Mohd-Ismail, Suganya Arularasu, Vincent Chow, R. Lin, A. Mirazimi, Wanjin Hong, Yee-Joo Tan (2020)
Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2Eurosurveillance, 25
-
C. Gordon, E. Tchesnokov, E. Woolner, Jason Perry, Joy Feng, D. Porter, M. Götte (2020)
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potencyThe Journal of Biological Chemistry, 295
-
N. Hurlburt, Emilie Seydoux, Yu-Hsin Wan, V. Edara, A. Stuart, Junli Feng, M. Suthar, A. McGuire, L. Stamatatos, M. Pancera (2020)
Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturationNature Communications, 11
-
(2021)
Coronavirus Resource Center. COVID-19 dashboard -
L. Menéndez-Arias, R. Andino (2017)
Viral polymerasesVirus Research, 234
-
J. Osipiuk, S. Azizi, Steve Dvorkin, M. Endres, R. Jedrzejczak, Krysten Jones, Soowon Kang, R. Kathayat, Youngchang Kim, V. Lisnyak, S. Maki, V. Nicolaescu, Cooper Taylor, C. Tesar, Yu-an Zhang, Zhiyao Zhou, G. Randall, K. Michalska, S. Snyder, B. Dickinson, A. Joachimiak (2020)
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitorsNature Communications, 12
-
(2020)
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies -
I. Imbert, J. Guillemot, J. Bourhis, C. Bussetta, B. Coutard, M. Egloff, F. Ferron, A. Gorbalenya, B. Canard (2006)
A second, non-canonical RNA-dependent RNA polymerase in SARS CoronavirusThe EMBO Journal, 25
-
Xiaolu Lu, Ji’an Pan, Jiali Tao, D. Guo (2010)
SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonismVirus Genes, 42
-
Jian Lei, Yue Ma-Lauer, Yinze Han, M. Thoms, R. Buschauer, J. Jores, V. Thiel, R. Beckmann, Wen Deng, H. Leonhardt, R. Hilgenfeld, A. Brunn (2021)
The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translationThe EMBO Journal, 40
-
D. Matthews, Ward Smith, R. Ferre, B. Condon, G. Budahazi, Wes Slsson, J. Villafranca, C. Janson, H. McElroy, C. Gribskov, S. Worland (1994)
Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyproteinCell, 77
-
Chung-ke Chang, M. Hou, Chi-Fon Chang, C. Hsiao, Tai-Huang Huang (2014)
The SARS coronavirus nucleocapsid protein – Forms and functionsAntiviral Research, 103
-
A. Velthuis, S. Worm, E. Snijder (2011)
The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extensionNucleic Acids Research, 40
-
N. Hurlburt, Yu-Hsin Wan, A. Stuart, Junli Feng, A. McGuire, L. Stamatatos, M. Pancera (2020)
Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturationbioRxiv
-
Quan Wang, Jiqin Wu, Haofeng Wang, Yan Gao, Qiaojie Liu, A. Mu, W. Ji, Liming Yan, Yan Zhu, Chen Zhu, X. Fang, Xiaobao Yang, Yucen Huang, Hai-long Gao, Fengjiang Liu, Ji Ge, Qianqian Sun, Xiuna Yang, Wenqing Xu, Zhijie Liu, Haitao Yang, Z. Lou, B. Jiang, L. Guddat, P. Gong, Z. Rao (2020)
Structural Basis for RNA Replication by the SARS-CoV-2 PolymeraseCell, 182
-
Yan Wu, Feiran Wang, Chenguang Shen, Weiyu Peng, Delin Li, Cheng Zhao, Z. Li, Shihua Li, Y. Bi, Yang Yang, Y. Gong, Haixia Xiao, Z. Fan, Shuguang Tan, Guizhen Wu, W. Tan, Xuancheng Lu, Changfa Fan, Qihui Wang, Yingxia Liu, Chen Zhang, J. Qi, G. Gao, F. Gao, Lei Liu (2020)
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2Science (New York, N.y.), 368
-
(2020)
a framework for antiCOVID-19 drug design -
S. Weiss, S. Navas-Martín (2005)
Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome CoronavirusMicrobiology and Molecular Biology Reviews, 69
-
J. Hansen, A. Baum, Kristen Pascal, Vincenzo Russo, Stephanie Giordano, Elzbieta Wloga, Benjamin Fulton, Ying Yan, Katrina Koon, Krunal Patel, K. Chung, Aynur Hermann, Erica Ullman, Jonathan Cruz, A. Rafique, Tammy Huang, J. Fairhurst, Christen Libertiny, M. Malbec, Wen-yi Lee, R. Welsh, Glen Farr, Seth Pennington, D. Deshpande, Jemmie Cheng, A. Watty, P. Bouffard, R. Babb, N. Levenkova, Calvin Chen, Bojie Zhang, A. Hernandez, K. Saotome, Yi Zhou, M. Franklin, S. Sivapalasingam, D. Lye, S. Weston, James Logue, Robert Haupt, M. Frieman, Gang Chen, W. Olson, A. Murphy, N. Stahl, G. Yancopoulos, C. Kyratsous (2020)
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktailScience (New York, N.y.), 369
-
J. Huo, Audrey Bas, R. Ruza, Helen Duyvesteyn, H. Mikolajek, T. Malinauskas, T. Tan, P. Rijal, M. Dumoux, P. Ward, Jingshan Ren, D. Zhou, P. Harrison, M. Weckener, D. Clare, V. Vogirala, Julika Radecke, L. Moynié, Yuguang Zhao, Javier Gilbert-Jaramillo, Michael Knight, J. Tree, K. Buttigieg, N. Coombes, M. Elmore, M. Carroll, L. Carrique, P. Shah, W. James, A. Townsend, D. Stuart, R. Owens, J. Naismith (2020)
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2Nature Structural & Molecular Biology, 27
-
R. Yan, Yuanyuan Zhang, Yaning Li, L. Xia, Yingying Guo, Qiang Zhou (2020)
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2Science (New York, N.y.), 367
-
Wenhao Dai, Bing Zhang, Xiaming Jiang, H. Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, X. Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Z. Rao, Lei-ke Zhang, Yechun Xu, Haitao Yang, Hong Liu (2020)
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main proteaseScience (New York, N.y.)
-
Qihui Wang, Yanfang Zhang, Lili Wu, S. Niu, Chunli Song, Zengyuan Zhang, G. Lu, C. Qiao, Yu Hu, K. Yuen, Qisheng Wang, Huan Zhou, Jinghua Yan, J. Qi (2020)
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2Cell, 181
-
D. Gordon, J. Hiatt, M. Bouhaddou, V. Rezelj, Svenja Ulferts, Hannes Braberg, Alexander Jureka, K. Obernier, Jeffrey Guo, J. Batra, Robyn Kaake, A. Weckstein, T. Owens, Meghna Gupta, S. Pourmal, E. Titus, Merve Cakir, Margaret Soucheray, Michael McGregor, Z. Çakır, Gwendolyn Jang, Matthew O’Meara, Tia Tummino, Ziyang Zhang, Helene Foussard, Ajda Rojc, Yuan Zhou, Dmitry Kuchenov, Ruth Hüttenhain, Jiewei Xu, Manon Eckhardt, D. Swaney, Jacqueline Fabius, Manisha Ummadi, B. Tutuncuoglu, U. Rathore, Mayank Modak, Paige Haas, Kelsey Haas, Zun Naing, Ernst Pulido, Ying Shi, Inigo Barrio-Hernandez, D. Memon, Eirini Petsalaki, Alistair Dunham, Miguel Marrero, David Burke, C. Koh, T. Vallet, J. Silvas, C. Azumaya, Christian Billesbølle, A. Brilot, M. Campbell, Amy Diallo, M. Dickinson, D. Diwanji, N. Herrera, N. Hoppe, H. Kratochvil, Yanxin Liu, G. Merz, M. Moritz, Henry Nguyen, C. Nowotny, C. Puchades, A. Rizo, U. Schulze-Gahmen, A. Smith, Ming Sun, I. Young, Jianhua Zhao, D. Asarnow, J. Biel, Alisa Bowen, Julian Braxton, Jen Chen, C. Chio, U. Chio, I. Deshpande, Loan Doan, B. Faust, S. Flores, M. Jin, Kate Kim, V. Lam, Fei Li, Junrui Li, Yen-Li Li, Yang Li, Xi Liu, Megan Lo, Kyle Lopez, A. Melo, F. Moss, P. Nguyen, J. Paulino, K. Pawar, J. Peters, T. Pospiech, M. Safari, S. Sangwan, K. Schaefer, Paul Thomas, A. Thwin, R. Trenker, E. Tse, T. Tsui, Feng Wang, Natalie Whitis, Zanlin Yu, Kaihua Zhang, Yang Zhang, Fengbo Zhou, Daniel Saltzberg, Anthony Hodder, A. Shun-Shion, Daniel Williams, K. White, R. Rosales, Thomas Kehrer, Lisa Miorin, Elena Moreno, A. Patel, Suzannah Rihn, M. Khalid, Albert Vallejo-Gracia, P. Fozouni, C. Simoneau, Theodore Roth, David Wu, M. Karim, M. Ghoussaini, I. Dunham, F. Berardi, Sebastian Weigang, Maxime Chazal, Jisoo Park, James Logue, M. McGrath, S. Weston, Robert Haupt, C. Hastie, M. Elliott, Fiona Brown, Kerry Burness, Elaine Reid, Mark Dorward, Clare Johnson, S. Wilkinson, Anna Geyer, D. Giesel, Carla Baillie, S. Raggett, Hannah Leech, R. Toth, Nicola Goodman, Kathleen Keough, Abigail Lind, Reyna Klesh, K. Hemphill, Jared Carlson-Stevermer, Jennifer Oki, K. Holden, T. Maures, K. Pollard, A. Sali, D. Agard, Yifan Cheng, J. Fraser, A. Frost, N. Jura, T. Kortemme, A. Manglik, D. Southworth, R. Stroud, D. Alessi, Paul Davies, M. Frieman, T. Ideker, C. Abate, N. Jouvenet, G. Kochs, B. Shoichet, M. Ott, M. Palmarini, K. Shokat, A. García-Sastre, J. Rassen, R. Grosse, O. Rosenberg, K. Verba, C. Basler, M. Vignuzzi, A. Peden, P. Beltrão, N. Krogan (2020)
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanismsScience (New York, N.y.), 370
-
B. Malone, James Chen, Qi Wang, E. Llewellyn, Y. Choi, P. Olinares, Xinyun Cao, C. Hernández, E. Eng, B. Chait, D. Shaw, R. Landick, S. Darst, E. Campbell (2021)
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complexbioRxiv
-
T. Appleby, Jason Perry, E. Murakami, O. Barauskas, Joy Feng, A. Cho, D. Fox, D. Wetmore, M. Mcgrath, A. Ray, M. Sofia, S. Swaminathan, T. Edwards (2015)
Structural basis for RNA replication by the hepatitis C virus polymeraseScience, 347
- Publisher
- Springer Journals
- Copyright
- Copyright © Springer Nature Limited 2021
- ISSN
- 1740-1526
- eISSN
- 1740-1534
- DOI
- 10.1038/s41579-021-00630-8
- Publisher site
- See Article on Publisher Site
Abstract
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited. The development of drugs that target vital proteins in the viral life cycle is a feasible approach for treating COVID-19. Belonging to the subfamily Orthocoronavirinae with the largest RNA genome, SARS-CoV-2 encodes a total of 29 proteins. These non-structural, structural and accessory proteins participate in entry into host cells, genome replication and transcription, and viral assembly and release. SARS-CoV-2 proteins can individually perform essential physiological roles, be components of the viral replication machinery or interact with numerous host cellular factors. In this Review, we delineate the structural features of SARS-CoV-2 from the whole viral particle to the individual viral proteins and discuss their functions as well as their potential as targets for therapeutic interventions.
Journal
Nature Reviews Microbiology – Springer Journals
Published: Nov 1, 2021