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Ganglionic Transmission

Ganglionic Transmission By ROBERT L. VOLLE Department of Pharmacology, School of Medicine, University of Connecticut, McCook Hospital, Hartford, Connecticut SYNAPTIC POTENTIALS Stimulation of sympathetic ganglia in the presence of curare-like drugs gives rise to a slowly occurring surface potential consisting in sequence of an initial negative potential (N wave), a positive potential (P wave) and a late negative potential (LN wave). The triphasic waveform has been iden­ tified in ganglia of the turtle (1), rabbit (2-4), frog (5-10), rat (11), and cat (12). In each species, pharmacological analysis of the several potentials has indicated that although transmission of the three potentials was me­ diated by cholinergic processes, functionally distinctive cholinoceptive sites were present in the ganglia. Whereas the N wave was depressed by the fur­ ther addition of curare-like drugs, the P and LN waves were depressed by drugs related to atropine. In addition, some evidence has been presented to indicate that the P wave resulted from a two-step process involving cholin­ ergic and adrenergic transmission (3, 7). It is clear from the foregoing that ganglionic transmission must be regarded now in terms of an intricate in­ teraction among diverse systems. The questions remaining, however, are centered primarily around the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Ganglionic Transmission

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Publisher
Annual Reviews
Copyright
Copyright 1969 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.09.040169.001031
pmid
4389242
Publisher site
See Article on Publisher Site

Abstract

By ROBERT L. VOLLE Department of Pharmacology, School of Medicine, University of Connecticut, McCook Hospital, Hartford, Connecticut SYNAPTIC POTENTIALS Stimulation of sympathetic ganglia in the presence of curare-like drugs gives rise to a slowly occurring surface potential consisting in sequence of an initial negative potential (N wave), a positive potential (P wave) and a late negative potential (LN wave). The triphasic waveform has been iden­ tified in ganglia of the turtle (1), rabbit (2-4), frog (5-10), rat (11), and cat (12). In each species, pharmacological analysis of the several potentials has indicated that although transmission of the three potentials was me­ diated by cholinergic processes, functionally distinctive cholinoceptive sites were present in the ganglia. Whereas the N wave was depressed by the fur­ ther addition of curare-like drugs, the P and LN waves were depressed by drugs related to atropine. In addition, some evidence has been presented to indicate that the P wave resulted from a two-step process involving cholin­ ergic and adrenergic transmission (3, 7). It is clear from the foregoing that ganglionic transmission must be regarded now in terms of an intricate in­ teraction among diverse systems. The questions remaining, however, are centered primarily around the

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1969

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