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Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy Metazoan organisms may discriminate between self and non-self not only by the presence of foreign antigens but also by the absence of normal self markers1. Mammalian adaptive immune responses use the first strategy, with the additional requirement that foreign antigens are recognized in the context of self-major histocompatibility complex (MHC) products at the cell surface2. Aberrant cells which fail to express MHC products adequately can therefore avoid detection2–4. A more primitive but complementary defence system, eliminating such cells on the basis of absent self-markers, is suggested by a re-interpretation5,6 of phenomena associated with metastasis and natural resistance. We now show that murine lymphoma cells selected for loss of H–2 expression are less malignant after low-dose inoculation in syngeneic hosts than are wild-type cells, and that the rejection of such cells is non-adaptive. On the basis of our data, we suggest that natural killer cells are effector cells in a defence system geared to detect the deleted or reduced expression of self-MHC. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

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References (50)

Publisher
Springer Journals
Copyright
Copyright © Springer Nature Limited 1986
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/319675a0
Publisher site
See Article on Publisher Site

Abstract

Metazoan organisms may discriminate between self and non-self not only by the presence of foreign antigens but also by the absence of normal self markers1. Mammalian adaptive immune responses use the first strategy, with the additional requirement that foreign antigens are recognized in the context of self-major histocompatibility complex (MHC) products at the cell surface2. Aberrant cells which fail to express MHC products adequately can therefore avoid detection2–4. A more primitive but complementary defence system, eliminating such cells on the basis of absent self-markers, is suggested by a re-interpretation5,6 of phenomena associated with metastasis and natural resistance. We now show that murine lymphoma cells selected for loss of H–2 expression are less malignant after low-dose inoculation in syngeneic hosts than are wild-type cells, and that the rejection of such cells is non-adaptive. On the basis of our data, we suggest that natural killer cells are effector cells in a defence system geared to detect the deleted or reduced expression of self-MHC.

Journal

Nature – Springer Journals

Published: Feb 20, 1986

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