Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Clinical disease activity is a major determinant of plasma D-dimer elevation in outpatients with rheumatoid arthritis: A hospital-based cross-sectional study

Clinical disease activity is a major determinant of plasma D-dimer elevation in outpatients with... ABSTRACTObjectivesTo identify factors associated with plasma D-dimer levels in outpatients with rheumatoid arthritis (RA).MethodsWe consecutively recruited 460 RA patients who visited our hospital for routine follow-ups between June and October 2021. Plasma D-dimer, RA-related characteristics, comorbidities, and cardiovascular and venous thromboembolism (VTE) risk factors were examined at enrolment. Patients with elevated D-dimer levels underwent whole-leg venous ultrasonography to diagnose deep vein thrombosis (DVT).ResultsParticipants had no DVT signs or symptoms. Among them, 252 (54.8%) were positive for plasma D-dimer (≥0.5 μg/ml) and 40 (8.7%) had high D-dimer levels (≥3 μg/ml). The mean was 1.07 μg/ml. After adjustments, age [odds ratio (OR) 1.88 per additional 10 years, P = .003], high and moderate clinical disease activity index (OR 8.79, P < .001), and the presence of comorbidities or cardiovascular/VTE risk factors (OR 2.94, P = .017) were identified as the factors independently associated with high D-dimer levels. Among patients with D-dimer levels ≥3 μg/ml, 10 (25%) had DVT in their lower limbs, and D-dimer levels were significantly higher in patients with DVT compared with those without it (mean 6.0  vs. 4.1 μg/ml, P < .001).ConclusionsClinical disease activity is a major contributor to plasma D-dimer elevation in RA outpatients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Modern Rheumatology Oxford University Press

Clinical disease activity is a major determinant of plasma D-dimer elevation in outpatients with rheumatoid arthritis: A hospital-based cross-sectional study

Download PDF
9 pages

Loading next page...
 
/lp/oxford-university-press/clinical-disease-activity-is-a-major-determinant-of-plasma-d-dimer-jq1QxEQ4ho

References (40)

Publisher
Oxford University Press
Copyright
© Japan College of Rheumatology 2023. Published by Oxford University Press.
ISSN
1439-7595
eISSN
1439-7609
DOI
10.1093/mr/road018
Publisher site
See Article on Publisher Site

Abstract

ABSTRACTObjectivesTo identify factors associated with plasma D-dimer levels in outpatients with rheumatoid arthritis (RA).MethodsWe consecutively recruited 460 RA patients who visited our hospital for routine follow-ups between June and October 2021. Plasma D-dimer, RA-related characteristics, comorbidities, and cardiovascular and venous thromboembolism (VTE) risk factors were examined at enrolment. Patients with elevated D-dimer levels underwent whole-leg venous ultrasonography to diagnose deep vein thrombosis (DVT).ResultsParticipants had no DVT signs or symptoms. Among them, 252 (54.8%) were positive for plasma D-dimer (≥0.5 μg/ml) and 40 (8.7%) had high D-dimer levels (≥3 μg/ml). The mean was 1.07 μg/ml. After adjustments, age [odds ratio (OR) 1.88 per additional 10 years, P = .003], high and moderate clinical disease activity index (OR 8.79, P < .001), and the presence of comorbidities or cardiovascular/VTE risk factors (OR 2.94, P = .017) were identified as the factors independently associated with high D-dimer levels. Among patients with D-dimer levels ≥3 μg/ml, 10 (25%) had DVT in their lower limbs, and D-dimer levels were significantly higher in patients with DVT compared with those without it (mean 6.0  vs. 4.1 μg/ml, P < .001).ConclusionsClinical disease activity is a major contributor to plasma D-dimer elevation in RA outpatients.

Journal

Modern Rheumatology – Oxford University Press

Published: Feb 2, 2023

Keywords: Blood coagulation; D-dimer; deep vein thrombosis; rheumatoid arthritis; venous thromboembolism

There are no references for this article.