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Rate and Extent of Early Axonal Degeneration of the Human Facial Nerve

Rate and Extent of Early Axonal Degeneration of the Human Facial Nerve Electrophysiologic and histologic studies on a severed human facial nerve have shown that 1) response to stimulation by electroneuronography was lost on the sixth day following injury, 2) wallerian degeneration progressed in a nonuniform “front,” leaving some of the distal stump axons still viable and responsive to intraoperative stimulation 2 days following injury, and 3) the extent of proximal retrograde degeneration was far greater than to the next node of Ranvier. These findings are discussed in light of the current knowledge regarding peripheral nerve degeneration, and explanations are suggested. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png "Annals of Otology, Rhinology, and Laryngology" SAGE

Rate and Extent of Early Axonal Degeneration of the Human Facial Nerve

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References (11)

Publisher
SAGE
Copyright
© 1998 SAGE Publications
ISSN
0003-4894
eISSN
1943-572X
DOI
10.1177/000348949810700101
pmid
9439380
Publisher site
See Article on Publisher Site

Abstract

Electrophysiologic and histologic studies on a severed human facial nerve have shown that 1) response to stimulation by electroneuronography was lost on the sixth day following injury, 2) wallerian degeneration progressed in a nonuniform “front,” leaving some of the distal stump axons still viable and responsive to intraoperative stimulation 2 days following injury, and 3) the extent of proximal retrograde degeneration was far greater than to the next node of Ranvier. These findings are discussed in light of the current knowledge regarding peripheral nerve degeneration, and explanations are suggested.

Journal

"Annals of Otology, Rhinology, and Laryngology"SAGE

Published: Jan 1, 1998

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