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- Publisher
- Karger
- Copyright
- © 1961 S. Karger AG, Basel
- ISSN
- 0001-5792
- eISSN
- 1421-9662
- DOI
- 10.1159/000206656
- Publisher site
- See Article on Publisher Site
Abstract
Acta hacmat. 26: 224-232 (1961). From the Department of Pharmacology, University of Tennessee Medical Units Memphis, Tennessee T h e P r o d u c tio n o f a n E ry th ro p o ie tic F a c to r by th e In S itu P e rfu s e d K idney By J a m e s W. F i s h e r * a n d B. J . B i r d w e l l T he role of the kidney as an organ which either produces or activates erythropoietin is still controversial. Conflicting results have been reported after bilateral nephrectomy in rabbits and rats (1-5). U nder these circumstances it seemed advisable to investigate ery thropoietin production in the perfused kidney, isolated in situ. Cobalt was chosen as a stim ulant; it not only stimulates erythro- poiesis (6), b ut animals injected with cobalt develop a high titer of erythropoietin in their plasma (7). W ith this technique, it should be possible to establish the significance of the kidney in erythro poietin production. In the studies reported here erythropoietin titers were measured in plasma following perfusion
Journal
Acta Haematologica – Karger
Published: Jan 1, 2009