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Interictal to Ictal Transition in Human Temporal Lobe Epilepsy: Insights From a Computational Model of Intracerebral EEG

Interictal to Ictal Transition in Human Temporal Lobe Epilepsy: Insights From a... ORIGINAL ARTICLES Interictal to Ictal Transition in Human Temporal Lobe Epilepsy: Insights From a Computational Model of Intracerebral EEG Fabrice Wendling,* Alfredo Hernandez,* Jean-Jacques Bellanger,* Patrick Chauvel,† and Fabrice Bartolomei† ing dendritic GABAergic inhibition compensates a gradually in- Summary: In human partial epilepsies and in experimental models creasing excitation up to a brutal drop at seizure onset when faster of chronic and/or acute epilepsy, the role of inhibition and the oscillations (beta and low gamma band, 15 to 40 Hz) are observed. relationship between the inhibition and excitation and epileptogen- These faster oscillations are then explained by the model feedback esis has long been questioned. Besides experimental methods carried loop between pyramidal cells and interneurons targeting their peri- out either in vitro (human or animal tissue) or in vivo (animals), somatic region. These findings obtained from model identification in pathophysiologic mechanisms can be approached by direct record- human temporal lobe epilepsy are in agreement with some results ing of brain electrical activity in human epilepsy. Indeed, in some obtained experimentally, either on animal models of epilepsy or on clinical presurgical investigation methods like stereoelectroencepha- the human epileptic tissue. lography, intracerebral electrodes are used in patients suffering from drug resistant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Neurophysiology Wolters Kluwer Health

Interictal to Ictal Transition in Human Temporal Lobe Epilepsy: Insights From a Computational Model of Intracerebral EEG

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ISSN
0736-0258
eISSN
1537-1603
DOI
110.1097/01.wnp.0000184051.37267.f0

Abstract

ORIGINAL ARTICLES Interictal to Ictal Transition in Human Temporal Lobe Epilepsy: Insights From a Computational Model of Intracerebral EEG Fabrice Wendling,* Alfredo Hernandez,* Jean-Jacques Bellanger,* Patrick Chauvel,† and Fabrice Bartolomei† ing dendritic GABAergic inhibition compensates a gradually in- Summary: In human partial epilepsies and in experimental models creasing excitation up to a brutal drop at seizure onset when faster of chronic and/or acute epilepsy, the role of inhibition and the oscillations (beta and low gamma band, 15 to 40 Hz) are observed. relationship between the inhibition and excitation and epileptogen- These faster oscillations are then explained by the model feedback esis has long been questioned. Besides experimental methods carried loop between pyramidal cells and interneurons targeting their peri- out either in vitro (human or animal tissue) or in vivo (animals), somatic region. These findings obtained from model identification in pathophysiologic mechanisms can be approached by direct record- human temporal lobe epilepsy are in agreement with some results ing of brain electrical activity in human epilepsy. Indeed, in some obtained experimentally, either on animal models of epilepsy or on clinical presurgical investigation methods like stereoelectroencepha- the human epileptic tissue. lography, intracerebral electrodes are used in patients suffering from drug resistant

Journal

Journal of Clinical Neurophysiology – Wolters Kluwer Health

Published: Oct 1, 2005

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