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Contents Introduction The murine NK cell: Assay, surface features and physiology Effector-target cell interaction: Selectivity and mechanism of killing Genetic control of in vitro NK reactivity A comparison of the genetics of in vivo tumor resistance and in vitro NK reactivity VI. Role of NK cells in non-T-dependent tumor resistance v n . Concluding remarks. I. INTRODUCTION The immune system in higher animals has as a major distinguishing feature a high degree of complexity. The diversified machinery in this system can be considered to represent the gradual accumulation of preserved experiences during phylogeny where primitive as well as sophisticated reactions occur in parallel during the immune response. Interactions of complicated nature are known to occur within the system and the actual effector part (s) in causing the actual rejection of, e.g. an invading organism, is frequently difficult to dissect free from other contributing factors. The cellular part of the immune system can be divided in many ways. One approach is to talk about specific cells (most people would then mean lymphocytes of B and T type that effectuate their functions via their own, antigen-specific receptors) in contrast to nonspecific cells (here often granulocytes and monocytes-macrophages are linked together).
Immunological Reviews – Wiley
Published: Apr 1, 1979
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