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In vivo and in vitro Suppression of Humoral and Cellular Immunological Response by Rifampicin

In vivo and in vitro Suppression of Humoral and Cellular Immunological Response by Rifampicin RIFAMPICIN—3 - (4 - methyl - l -piperazyl - iminomethyl) -rifamycin SV—a semi-synthetic derivative of rifamycin which was isolated from Streptomyces mediterraneus 1, is a clinically useful, orally active antibiotic. Even at low concentrations (0.5–5 µg/ml.), it is known to inhibit microbial growth by blocking cellular DNA-directed RNA polymerase (EC 2.7.7.6)2,3. Although similar inhibition of RNA synthesis does not occur in mammalian cell-free systems unless large amounts of rifampicin (200 µg/ml.) are used4, concentrations exceeding 10 µg of rifampicin/ml. medium cause detectable damage in the case of monolayer cultures of BHK21 C 13 cells5. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

In vivo and in vitro Suppression of Humoral and Cellular Immunological Response by Rifampicin

PǍUNESCU, E.
Nature , Volume 228 (5277) – Dec 19, 1970
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References (6)

Publisher
Springer Journals
Copyright
Copyright © 1970 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/2281188a0
Publisher site
See Article on Publisher Site

Abstract

RIFAMPICIN—3 - (4 - methyl - l -piperazyl - iminomethyl) -rifamycin SV—a semi-synthetic derivative of rifamycin which was isolated from Streptomyces mediterraneus 1, is a clinically useful, orally active antibiotic. Even at low concentrations (0.5–5 µg/ml.), it is known to inhibit microbial growth by blocking cellular DNA-directed RNA polymerase (EC 2.7.7.6)2,3. Although similar inhibition of RNA synthesis does not occur in mammalian cell-free systems unless large amounts of rifampicin (200 µg/ml.) are used4, concentrations exceeding 10 µg of rifampicin/ml. medium cause detectable damage in the case of monolayer cultures of BHK21 C 13 cells5.

Journal

Nature – Springer Journals

Published: Dec 19, 1970

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