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The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in <i>Drosophila</i>

The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene... Downloaded from genesdev.cshlp.org on November 4, 2021 - Published by Cold Spring Harbor Laboratory Press The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila 1,4 1,4 1 1 1,3 Georg Halder, Patricia Polaczyk, Mary Ellen Kraus, Angela Hudson, Jaeseob Kim, 2 1,5 Allen Laughon, and Sean Carroll 1 2 Howard Hughes Medical Institute and Laboratory of Molecular Biology, and Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706 USA; Institute for Molecular Biology and Genetics, Seoul National University, Kwanak-Ku, Seoul, 151-742, Korea A small number of major regulatory (selector) genes have been identified in animals that control the development of particular organs or complex structures. In Drosophila, the vestigial gene is required for wing formation and is able to induce wing-like outgrowths on other structures. However, the molecular function of the nuclear Vestigial protein, which bears no informative similarities to other proteins, was unknown. Here, we show that Vestigial requires the function of the Scalloped protein, a member of the TEA family of transcriptional regulators, to directly activate the expression of genes involved in wing morphogenesis. Genetic and molecular analyses reveal that Vestigial regulates wing identity by forming a complex with the Scalloped http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in <i>Drosophila</i>

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.12.24.3900
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Abstract

Downloaded from genesdev.cshlp.org on November 4, 2021 - Published by Cold Spring Harbor Laboratory Press The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila 1,4 1,4 1 1 1,3 Georg Halder, Patricia Polaczyk, Mary Ellen Kraus, Angela Hudson, Jaeseob Kim, 2 1,5 Allen Laughon, and Sean Carroll 1 2 Howard Hughes Medical Institute and Laboratory of Molecular Biology, and Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706 USA; Institute for Molecular Biology and Genetics, Seoul National University, Kwanak-Ku, Seoul, 151-742, Korea A small number of major regulatory (selector) genes have been identified in animals that control the development of particular organs or complex structures. In Drosophila, the vestigial gene is required for wing formation and is able to induce wing-like outgrowths on other structures. However, the molecular function of the nuclear Vestigial protein, which bears no informative similarities to other proteins, was unknown. Here, we show that Vestigial requires the function of the Scalloped protein, a member of the TEA family of transcriptional regulators, to directly activate the expression of genes involved in wing morphogenesis. Genetic and molecular analyses reveal that Vestigial regulates wing identity by forming a complex with the Scalloped

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Genes & Development – Unpaywall

Published: Dec 15, 1998

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