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Suppression of Glomerulonephritis in Lupus‐Prone NZB × NZW Mice by RN486, a Selective Inhibitor of Bruton's Tyrosine Kinase

Suppression of Glomerulonephritis in Lupus‐Prone NZB × NZW Mice by RN486, a Selective Inhibitor... ARTHRITIS & RHEUMATISM Vol. 65, No. 9, September 2013, pp 2380–2391 DOI 10.1002/art.38047 © 2013, American College of Rheumatology Suppression of Glomerulonephritis in Lupus-Prone NZB  NZW Mice by RN486, a Selective Inhibitor of Bruton’s Tyrosine Kinase Paola Mina-Osorio, Jacob LaStant, Natalie Keirstead, Toni Whittard, Julia Ayala, Stella Stefanova, Rosario Garrido, Nena Dimaano, Holly Hilton, Mario Giron, Kai-Yeung Lau, Julie Hang, Jennifer Postelnek, Yong Kim, Soo Min, Alka Patel, John Woods, Meera Ramanujam, Julie DeMartino, Satwant Narula, and Daigen Xu high low Objective. Bruton’s tyrosine kinase (BTK) plays a lysis demonstrated depletion of CD138 B220 critical role in B cell development and function. We plasma cells in the spleen. RN486 inhibited secretion of recently described a selective BTK inhibitor, RN486, IgG anti-dsDNA but not IgM anti-dsDNA, suggesting that blocks B cell receptor (BCR) and Fc receptor that pharmacologic blockade of BTK resembles the signaling and is efficacious in animal models of arthri- reported transgenic expression of low levels of endoge- tis. The aim of this study was to examine the potential nous BTK in B cells. In addition, RN486 may also efficacy of BTK in systemic lupus erythematosus (SLE), impact the effector function of autoantibodies, as evi- using an http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arthritis & Rheumatology Wiley

Suppression of Glomerulonephritis in Lupus‐Prone NZB × NZW Mice by RN486, a Selective Inhibitor of Bruton's Tyrosine Kinase

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References (48)

Publisher
Wiley
Copyright
Copyright © 2013 by the American College of Rheumatology
ISSN
2326-5191
eISSN
2326-5205
DOI
10.1002/art.38047
pmid
23754328
Publisher site
See Article on Publisher Site

Abstract

ARTHRITIS & RHEUMATISM Vol. 65, No. 9, September 2013, pp 2380–2391 DOI 10.1002/art.38047 © 2013, American College of Rheumatology Suppression of Glomerulonephritis in Lupus-Prone NZB  NZW Mice by RN486, a Selective Inhibitor of Bruton’s Tyrosine Kinase Paola Mina-Osorio, Jacob LaStant, Natalie Keirstead, Toni Whittard, Julia Ayala, Stella Stefanova, Rosario Garrido, Nena Dimaano, Holly Hilton, Mario Giron, Kai-Yeung Lau, Julie Hang, Jennifer Postelnek, Yong Kim, Soo Min, Alka Patel, John Woods, Meera Ramanujam, Julie DeMartino, Satwant Narula, and Daigen Xu high low Objective. Bruton’s tyrosine kinase (BTK) plays a lysis demonstrated depletion of CD138 B220 critical role in B cell development and function. We plasma cells in the spleen. RN486 inhibited secretion of recently described a selective BTK inhibitor, RN486, IgG anti-dsDNA but not IgM anti-dsDNA, suggesting that blocks B cell receptor (BCR) and Fc receptor that pharmacologic blockade of BTK resembles the signaling and is efficacious in animal models of arthri- reported transgenic expression of low levels of endoge- tis. The aim of this study was to examine the potential nous BTK in B cells. In addition, RN486 may also efficacy of BTK in systemic lupus erythematosus (SLE), impact the effector function of autoantibodies, as evi- using an

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Arthritis & Rheumatology – Wiley

Published: Sep 1, 2013

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