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Prostate Biopsy Volume Indices do not Predict for Significant Gleason Upgrading

Prostate Biopsy Volume Indices do not Predict for Significant Gleason Upgrading ORIGINAL ARTICLE Prostate Biopsy Volume Indices do not Predict for Significant Gleason Upgrading Christopher R. King, PhD, MD,* Deep A. Patel, MD,* and Martha K. Terris, MD†‡ Key Words: prostate biopsy, Gleason grade, biopsy volume Abstract: Significant discordance exists between biopsy and indices matched prostatectomy grades. This study tests the hypothesis that surrogate tumor volume indices available from biopsies could yield (Am J Clin Oncol 2005;28: 125–129) an improved prediction of the underlying pathologic Gleason grade. Records of 124 patients who underwent radical prostatectomy were reviewed. Biopsies were characterized by primary and secondary Gleason grade, number of positive cores, and linear tumor length. he discordance between the biopsy Gleason grade and the Surgical specimens were characterized by primary and secondary Tunderlying pathologic Gleason grade is well documented. Gleason grade, organ-confined disease, seminal vesicle invasion, Several large series examining this issue have shown that for and margins. Biochemical failure (BF) was defined by a postoper- sextant biopsies, the rate of an exact match is approximately ative prostate-specific antigen 0.05 ng/mL. There were 28 patients (24%) who experienced biochemical failure. On multivariate anal- 42%, differences of 2 or more Gleason sum points occur in ysis, only the pathologic Gleason sum (P http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Clinical Oncology Wolters Kluwer Health

Prostate Biopsy Volume Indices do not Predict for Significant Gleason Upgrading

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References (14)

ISSN
0277-3732
eISSN
1537-453X
DOI
10.1097/01.coc.0000143848.24158.c3
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Prostate Biopsy Volume Indices do not Predict for Significant Gleason Upgrading Christopher R. King, PhD, MD,* Deep A. Patel, MD,* and Martha K. Terris, MD†‡ Key Words: prostate biopsy, Gleason grade, biopsy volume Abstract: Significant discordance exists between biopsy and indices matched prostatectomy grades. This study tests the hypothesis that surrogate tumor volume indices available from biopsies could yield (Am J Clin Oncol 2005;28: 125–129) an improved prediction of the underlying pathologic Gleason grade. Records of 124 patients who underwent radical prostatectomy were reviewed. Biopsies were characterized by primary and secondary Gleason grade, number of positive cores, and linear tumor length. he discordance between the biopsy Gleason grade and the Surgical specimens were characterized by primary and secondary Tunderlying pathologic Gleason grade is well documented. Gleason grade, organ-confined disease, seminal vesicle invasion, Several large series examining this issue have shown that for and margins. Biochemical failure (BF) was defined by a postoper- sextant biopsies, the rate of an exact match is approximately ative prostate-specific antigen 0.05 ng/mL. There were 28 patients (24%) who experienced biochemical failure. On multivariate anal- 42%, differences of 2 or more Gleason sum points occur in ysis, only the pathologic Gleason sum (P

Journal

American Journal of Clinical Oncology – Wolters Kluwer Health

Published: Apr 1, 2005

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