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New genetic loci link adipose and insulin biology to body fat distribution

New genetic loci link adipose and insulin biology to body fat distribution Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

New genetic loci link adipose and insulin biology to body fat distribution

Shungin, Dmitry; Winkler, Thomas W.; Croteau-Chonka, Damien C.; Ferreira, Teresa; Locke, Adam E.; Mägi, Reedik; Strawbridge, Rona J.; Pers, Tune H.; Fischer, Krista; Justice, Anne E.; Workalemahu, Tsegaselassie; Wu, Joseph M. W.; Buchkovich, Martin L.; Heard-Costa, Nancy L.; Roman, Tamara S.; Drong, Alexander W.; Song, Ci; Gustafsson, Stefan; Day, Felix R.; Esko, Tonu; Fall, Tove; Kutalik, Zoltán; Luan, Jian’an; Randall, Joshua C.; Scherag, André; Vedantam, Sailaja; Wood, Andrew R.; Chen, Jin; Fehrmann, Rudolf; Karjalainen, Juha; Kahali, Bratati; Liu, Ching-Ti; Schmidt, Ellen M.; Absher, Devin; Amin, Najaf; Anderson, Denise; Beekman, Marian; Bragg-Gresham, Jennifer L.; Buyske, Steven; Demirkan, Ayse; Ehret, Georg B.; Feitosa, Mary F.; Goel, Anuj; Jackson, Anne U.; Johnson, Toby; Kleber, Marcus E.; Kristiansson, Kati; Mangino, Massimo; Mateo Leach, Irene; Medina-Gomez, Carolina; Palmer, Cameron D.; Pasko, Dorota; Pechlivanis, Sonali; Peters, Marjolein J.; Prokopenko, Inga; Stančáková, Alena; Ju Sung, Yun; Tanaka, Toshiko; Teumer, Alexander; Van Vliet-Ostaptchouk, Jana V.; Yengo, Loïc; Zhang, Weihua; Albrecht, Eva; Ärnlöv, Johan; Arscott, Gillian M.; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J.; Berne, Christian; Blüher, Matthias; Böhringer, Stefan; Bonnet, Fabrice; Böttcher, Yvonne; Bruinenberg, Marcel; Carba, Delia B.; Caspersen, Ida H.; Clarke, Robert; Warwick Daw, E.; Deelen, Joris; Deelman, Ewa; Delgado, Graciela; Doney, Alex S. F.; Eklund, Niina; Erdos, Michael R.; Estrada, Karol; Eury, Elodie; Friedrich, Nele; Garcia, Melissa E.; Giedraitis, Vilmantas; Gigante, Bruna; Go, Alan S.; Golay, Alain; Grallert, Harald; Grammer, Tanja B.; Gräßler, Jürgen; Grewal, Jagvir; Groves, Christopher J.; Haller, Toomas; Hallmans, Goran; Hartman, Catharina A.; Hassinen, Maija; Hayward, Caroline; Heikkilä, Kauko; Herzig, Karl-Heinz; Helmer, Quinta; Hillege, Hans L.; Holmen, Oddgeir; Hunt, Steven C.; Isaacs, Aaron; Ittermann, Till; James, Alan L.; Johansson, Ingegerd; Juliusdottir, Thorhildur; Kalafati, Ioanna-Panagiota; Kinnunen, Leena; Koenig, Wolfgang; Kooner, Ishminder K.; Kratzer, Wolfgang; Lamina, Claudia; Leander, Karin; Lee, Nanette R.; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; Lorentzon, Mattias; Mach, François; Magnusson, Patrik K. E.; Mahajan, Anubha; McArdle, Wendy L.; Menni, Cristina; Merger, Sigrun; Mihailov, Evelin; Milani, Lili; Mills, Rebecca; Moayyeri, Alireza; Monda, Keri L.; Mooijaart, Simon P.; Mühleisen, Thomas W.; Mulas, Antonella; Müller, Gabriele; Müller-Nurasyid, Martina; Nagaraja, Ramaiah; Nalls, Michael A.; Narisu, Narisu; Glorioso, Nicola; Nolte, Ilja M.; Olden, Matthias; Rayner, Nigel W.; Renstrom, Frida; Ried, Janina S.; Robertson, Neil R.; Rose, Lynda M.; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Sennblad, Bengt; Seufferlein, Thomas; Sitlani, Colleen M.; Vernon Smith, Albert; Stirrups, Kathleen; Stringham, Heather M.; Sundström, Johan; Swertz, Morris A.; Swift, Amy J.; Syvänen, Ann-Christine; Tayo, Bamidele O.; Thorand, Barbara; Thorleifsson, Gudmar; Tomaschitz, Andreas; Troffa, Chiara; van Oort, Floor V. A.; Verweij, Niek; Vonk, Judith M.; Waite, Lindsay L.; Wennauer, Roman; Wilsgaard, Tom; Wojczynski, Mary K.; Wong, Andrew; Zhang, Qunyuan; Hua Zhao, Jing; Brennan, Eoin P.; Choi, Murim; Eriksson, Per; Folkersen, Lasse; Franco-Cereceda, Anders; Gharavi, Ali G.; Hedman, Åsa K.; Hivert, Marie-France; Huang, Jinyan; Kanoni, Stavroula; Karpe, Fredrik; Keildson, Sarah; Kiryluk, Krzysztof; Liang, Liming; Lifton, Richard P.; Ma, Baoshan; McKnight, Amy J.; McPherson, Ruth; Metspalu, Andres; Min, Josine L.; Moffatt, Miriam F.; Montgomery, Grant W.; Murabito, Joanne M.; Nicholson, George; Nyholt, Dale R.; Olsson, Christian; Perry, John R. B.; Reinmaa, Eva; Salem, Rany M.; Sandholm, Niina; Schadt, Eric E.; Scott, Robert A.; Stolk, Lisette; Vallejo, Edgar E.; Westra, Harm-Jan; Zondervan, Krina T.; Amouyel, Philippe; Arveiler, Dominique; Bakker, Stephan J. L.; Beilby, John; Bergman, Richard N.; Blangero, John; Brown, Morris J.; Burnier, Michel; Campbell, Harry; Chakravarti, Aravinda; Chines, Peter S.; Claudi-Boehm, Simone; Collins, Francis S.; Crawford, Dana C.; Danesh, John; de Faire, Ulf; de Geus, Eco J. C.; Dörr, Marcus; Erbel, Raimund; Eriksson, Johan G.; Farrall, Martin; Ferrannini, Ele; Ferrières, Jean; Forouhi, Nita G.; Forrester, Terrence; Franco, Oscar H.; Gansevoort, Ron T.; Gieger, Christian; Gudnason, Vilmundur; Haiman, Christopher A.; Harris, Tamara B.; Hattersley, Andrew T.; Heliövaara, Markku; Hicks, Andrew A.; Hingorani, Aroon D.; Hoffmann, Wolfgang; Hofman, Albert; Homuth, Georg; Humphries, Steve E.; Hyppönen, Elina; Illig, Thomas; Jarvelin, Marjo-Riitta; Johansen, Berit; Jousilahti, Pekka; Jula, Antti M.; Kaprio, Jaakko; Kee, Frank; Keinanen-Kiukaanniemi, Sirkka M.; Kooner, Jaspal S.; Kooperberg, Charles; Kovacs, Peter; Kraja, Aldi T.; Kumari, Meena; Kuulasmaa, Kari; Kuusisto, Johanna; Lakka, Timo A.; Langenberg, Claudia; Le Marchand, Loic; Lehtimäki, Terho; Lyssenko, Valeriya; Männistö, Satu; Marette, André; Matise, Tara C.; McKenzie, Colin A.; McKnight, Barbara; Musk, Arthur W.; Möhlenkamp, Stefan; Morris, Andrew D.; Nelis, Mari; Ohlsson, Claes; Oldehinkel, Albertine J.; Ong, Ken K.; Palmer, Lyle J.; Penninx, Brenda W.; Peters, Annette; Pramstaller, Peter P.; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rice, Treva K.; Ridker, Paul M.; Ritchie, Marylyn D.; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J.; Saramies, Jouko; Sarzynski, Mark A.; Schwarz, Peter E. H.; Shuldiner, Alan R.; Staessen, Jan A.; Steinthorsdottir, Valgerdur; Stolk, Ronald P.; Strauch, Konstantin; Tönjes, Anke; Tremblay, Angelo; Tremoli, Elena; Vohl, Marie-Claude; Völker, Uwe; Vollenweider, Peter; Wilson, James F.; Witteman, Jacqueline C.; Adair, Linda S.; Bochud, Murielle; Boehm, Bernhard O.; Bornstein, Stefan R.; Bouchard, Claude; Cauchi, Stéphane; Caulfield, Mark J.; Chambers, John C.; Chasman, Daniel I.; Cooper, Richard S.; Dedoussis, George; Ferrucci, Luigi; Froguel, Philippe; Grabe, Hans-Jörgen; Hamsten, Anders; Hui, Jennie; Hveem, Kristian; Jöckel, Karl-Heinz; Kivimaki, Mika; Kuh, Diana; Laakso, Markku; Liu, Yongmei; März, Winfried; Munroe, Patricia B.; Njølstad, Inger; Oostra, Ben A.; Palmer, Colin N. A.; Pedersen, Nancy L.; Perola, Markus; Pérusse, Louis; Peters, Ulrike; Power, Chris; Quertermous, Thomas; Rauramaa, Rainer; Rivadeneira, Fernando; Saaristo, Timo E.; Saleheen, Danish; Sinisalo, Juha; Eline Slagboom, P.; Snieder, Harold; Spector, Tim D.; Thorsteinsdottir, Unnur; Stumvoll, Michael; Tuomilehto, Jaakko; Uitterlinden, André G.; Uusitupa, Matti; van der Harst, Pim; Veronesi, Giovanni; Walker, Mark; Wareham, Nicholas J.; Watkins, Hugh; Wichmann, H-Erich; Abecasis, Goncalo R.; Assimes, Themistocles L.; Berndt, Sonja I.; Boehnke, Michael; Borecki, Ingrid B.; Deloukas, Panos; Franke, Lude; Frayling, Timothy M.; Groop, Leif C.; Hunter, David J.; Kaplan, Robert C.; O’Connell, Jeffrey R.; Qi, Lu; Schlessinger, David; Strachan, David P.; Stefansson, Kari; van Duijn, Cornelia M.; Willer, Cristen J.; Visscher, Peter M.; Yang, Jian; Hirschhorn, Joel N.; Carola Zillikens, M.; McCarthy, Mark I.; Speliotes, Elizabeth K.; North, Kari E.; Fox, Caroline S.; Barroso, Inês; Franks, Paul W.; Ingelsson, Erik; Heid, Iris M.; Loos, Ruth J. F.; Cupples, L. Adrienne; Morris, Andrew P.; Lindgren, Cecilia M.; Mohlke, Karen L
Nature , Volume 518 (7538) – Feb 11, 2015
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References (117)

  • Ivet Elias, S. Franckhauser, F. Bosch (2013)

    New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance

    Adipocyte, 2

  • David Croft, Gavin O'Kelly, Guanming Wu, R. Haw, M. Gillespie, L. Matthews, M. Caudy, P. Garapati, Gopal Gopinath, B. Jassal, S. Jupe, Irina Kalatskaya, S. Mahajan, Bruce May, N. Ndegwa, E. Schmidt, V. Shamovsky, C. Yung, E. Birney, H. Hermjakob, P. D’Eustachio, L. Stein (2010)

    Reactome: a database of reactions, pathways and biological processes

    Nucleic Acids Research, 39

  • S. Sanna, A. Jackson, R. Nagaraja, C. Willer, Wei-min Chen, L. Bonnycastle, Haiqing Shen, N. Timpson, G. Lettre, G. Usala, P. Chines, H. Stringham, L. Scott, Mariano Dei, Sandra Lai, Giuseppe Albai, L. Crisponi, S. Naitza, K. Doheny, E. Pugh, Y. Ben-Shlomo, S. Ebrahim, D. Lawlor, R. Bergman, R. Watanabe, M. Uda, J. Tuomilehto, J. Coresh, J. Hirschhorn, A. Shuldiner, D. Schlessinger, F. Collins, G. Smith, E. Boerwinkle, A. Cao, M. Boehnke, G. Abecasis, K. Mohlke (2008)

    Common variants in the GDF5-UQCC region are associated with variation in human height

    Nature Genetics, 40

  • Kesheng Wang, Xuefeng Liu, Nagesh Aragam (2010)

    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder

    Schizophrenia Research, 124

  • S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M. Ferreira, David Bender, J. Maller, P. Sklar, P. Bakker, M. Daly, P. Sham (2007)

    PLINK: a tool set for whole-genome association and population-based linkage analyses.

    American journal of human genetics, 81 3

  • R. Scott, V. Lagou, R. Welch, E. Wheeler, May Montasser, J. Luan, R. Mägi, R. Strawbridge, E. Rehnberg, S. Gustafsson, S. Kanoni, L. Rasmussen-Torvik, L. Yengo, C. Lecoeur, D. Shungin, S. Sanna, C. Sidore, Paul Johnson, J. Jukema, T. Johnson, A. Mahajan, N. Verweij, G. Thorleifsson, J. Hottenga, Sonia Shah, A. Smith, B. Sennblad, C. Gieger, P. Salo, M. Perola, N. Timpson, David Evans, B. Pourcain, Ying Wu, Jeanette Andrews, J. Hui, L. Bielak, Wei Zhao, M. Horikoshi, P. Navarro, A. Isaacs, J. O’Connell, K. Stirrups, V. Vitart, C. Hayward, T. Esko, E. Mihailov, Ross Fraser, T. Fall, B. Voight, S. Raychaudhuri, Han Chen, C. Lindgren, Andrew Morris, N. Rayner, N. Robertson, Denis Rybin, Ching‐Ti Liu, J. Beckmann, Sara Willems, P. Chines, A. Jackson, H. Kang, H. Stringham, Kijoung Song, Toshiko Tanaka, J. Peden, A. Goel, A. Hicks, P. An, M. Müller-Nurasyid, A. Franco-Cereceda, L. Folkersen, L. Marullo, H. Jansen, A. Oldehinkel, M. Bruinenberg, J. Pankow, K. North, N. Forouhi, R. Loos, S. Edkins, T. Varga, G. Hallmans, H. Oksa, Mulas Antonella, R. Nagaraja, S. Trompet, I. Ford, S. Bakker, A. Kong, M. Kumari, B. Gigante, C. Herder, P. Munroe, M. Caulfield, J. Antti, M. Mangino, K. Small, I. Miljkovic, Yongmei Liu, M. Atalay, W. Kiess, A. James, F. Rivadeneira, A. Uitterlinden, C. Palmer, A. Doney, G. Willemsen, J. Smit, Susan Campbell, O. Polašek, L. Bonnycastle, S. Hercberg, M. Dimitriou, J. Bolton, G. Fowkes, P. Kovacs, J. Lindström, T. Zemunik, S. Bandinelli, S. Wild, H. Basart, W. Rathmann, H. Grallert, W. Maerz, W. Maerz, M. Kleber, B. Boehm, A. Peters, P. Pramstaller, M. Province, I. Borecki, N. Hastie, I. Rudan, H. Campbell, H. Watkins, M. Farrall, M. Stumvoll, L. Ferrucci, D. Waterworth, R. Bergman, F. Collins, J. Tuomilehto, R. Watanabe, E. Geus, B. Penninx, A. Hofman, B. Oostra, B. Psaty, P. Vollenweider, James Wilson, A. Wright, G. Hovingh, A. Metspalu, M. Uusitupa, P. Magnusson, K. Kyvik, J. Kaprio, J. Price, G. Dedoussis, P. Deloukas, P. Meneton, L. Lind, M. Boehnke, A. Shuldiner, C. Duijn, Andrew Morris, A. Toenjes, P. Peyser, J. Beilby, J. Beilby, A. Körner, J. Kuusisto, M. Laakso, S. Bornstein, P. Schwarz, T. Lakka, R. Rauramaa, L. Adair, G. Smith, T. Spector, T. Illig, U. Faire, A. Hamsten, V. Gudnason, M. Kivimäki, A. Hingorani, S. Keinänen-Kiukaanniemi, T. Saaristo, D. Boomsma, K. Stefánsson, P. Harst, J. Dupuis, N. Pedersen, N. Sattar, T. Harris, F. Cucca, S. Ripatti, V. Salomaa, K. Mohlke, B. Balkau, P. Froguel, P. Froguel, P. Froguel, A. Pouta, M. Järvelin, N. Wareham, N. Bouatia-Naji, M. McCarthy, P. Franks, J. Meigs, Tanya Teslovich, J. Florez, C. Langenberg, E. Ingelsson, I. Prokopenko, I. Barroso (2012)

    Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

    Nature genetics, 44

  • B. Voight, B. Voight, Hyun Kang, Jun Ding, Cameron Palmer, Cameron Palmer, C. Sidore, C. Sidore, P. Chines, N. Burtt, C. Fuchsberger, Yatong Li, J. Erdmann, T. Frayling, I. Heid, A. Jackson, T. Johnson, Tuomas Kilpeläinen, Cecilia Lindgren, Andrew Morris, I. Prokopenko, I. Prokopenko, J. Randall, Richa Saxena, Richa Saxena, N. Soranzo, Elizabeth Speliotes, Elizabeth Speliotes, Tanya Teslovich, E. Wheeler, J. Maguire, Melissa Parkin, Simon Potter, N. Rayner, N. Rayner, N. Rayner, N. Robertson, N. Robertson, K. Stirrups, W. Winckler, S. Sanna, A. Mulas, R. Nagaraja, F. Cucca, Inês Barroso, I. Barroso, P. Deloukas, Ruth Loos, S. Kathiresan, P. Munroe, C. Newton‐Cheh, A. Pfeufer, N. Samani, Nilesh Samani, H. Schunkert, J. Hirschhorn, J. Hirschhorn, J. Hirschhorn, D. Altshuler, M. McCarthy, Mark McCarthy, Mark McCarthy, G. Abecasis, M. Boehnke (2012)

    The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

    PLoS Genetics, 8

  • C. Willer, Yun Li, G. Abecasis (2010)

    METAL: fast and efficient meta-analysis of genomewide association scans

    Bioinformatics, 26

  • ENCODEConsortium, Martin Min (2012)

    An Integrated Encyclopedia of DNA Elements in the Human Genome

    Nature, 489

  • S. Raychaudhuri, R. Plenge, E. Rossin, Aylwin Ng, S. Purcell, P. Sklar, E. Scolnick, R. Xavier, D. Altshuler, M. Daly (2009)

    Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions

    PLoS Genetics, 5

  • Tomasz Zygmunt, C. Gay, J. Blondelle, Manvendra Singh, K. Flaherty, Paula Means, L. Herwig, A. Krudewig, H. Belting, M. Affolter, J. Epstein, Jesús Torres-Vázquez (2011)

    Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1.

    Developmental cell, 21 2

  • E. Cirulli, Dalia Kasperavičiūtė, D. Attix, A. Need, D. Ge, G. Gibson, D. Goldstein (2010)

    Common genetic variation and performance on standardized cognitive tests

    European Journal of Human Genetics, 18

  • C. Böger, Ming-Huei Chen, A. Tin, M. Olden, A. Köttgen, I. Boer, C. Fuchsberger, C. O’Seaghdha, C. Pattaro, A. Teumer, Ching‐Ti Liu, N. Glazer, Man Li, J. O’Connell, Toshiko Tanaka, C. Peralta, Z. Kutalik, J. Luan, J. Zhao, Shih-Jen Hwang, E. Akylbekova, H. Kramer, P. Harst, A. Smith, K. Lohman, M. Andrade, C. Hayward, B. Kollerits, A. Tönjes, T. Aspelund, E. Ingelsson, G. Eiriksdottir, L. Launer, T. Harris, A. Shuldiner, B. Mitchell, D. Arking, N. Franceschini, E. Boerwinkle, Josephine Egan, D. Hernandez, M. Reilly, R. Townsend, T. Lumley, D. Siscovick, B. Psaty, B. Kestenbaum, T. Haritunians, S. Bergmann, P. Vollenweider, G. Waeber, V. Mooser, D. Waterworth, Andrew Johnson, J. Florez, J. Meigs, Xiaoning Lu, S. Turner, E. Atkinson, Tennille Leak, K. Aasarød, F. Skorpen, A. Syvänen, T. Illig, J. Baumert, W. Koenig, B. Krämer, O. Devuyst, J. Mychaleckyj, C. Minelli, S. Bakker, Lyudmyla Kedenko, B. Paulweber, S. Coassin, K. Endlich, H. Kroemer, R. Biffar, S. Stracke, H. Völzke, M. Stumvoll, R. Mägi, H. Campbell, V. Vitart, N. Hastie, V. Gudnason, S. Kardia, Yongmei Liu, O. Polašek, G. Curhan, F. Kronenberg, I. Prokopenko, I. Rudan, J. Árnlöv, S. Hallan, G. Navis, A. Parsa, L. Ferrucci, J. Coresh, M. Shlipak, S. Bull, N. Paterson, H. Wichmann, N. Wareham, R. Loos, J. Rotter, P. Pramstaller, L. Cupples, J. Beckmann, Qiong Yang, I. Heid, R. Rettig, A. Dreisbach, M. Bochud, C. Fox, W. Kao (2011)

    CUBN is a gene locus for albuminuria.

    Journal of the American Society of Nephrology : JASN, 22 3

  • (2012)

    Browser’s Notes

    Skeletal Radiology, 42

  • Rintaro Saito, M. Smoot, K. Ono, Johannes Ruscheinski, Peng-Liang Wang, Samad Lotia, Alexander Pico, Gary Bader, T. Ideker (2012)

    A travel guide to Cytoscape plugins

    Nature Methods, 9

  • Uimc Helq (2012)

    Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

  • C. Pattaro, A. Köttgen, A. Teumer, Maija Garnaas, Carsten Böger, C. Fuchsberger, M. Olden, Ming-Huei Chen, Adrienne Tin, D. Taliun, Man Li, Xiaoyi Gao, Mathias Gorski, Qiong Yang, C. Hundertmark, Meredith Foster, C. O’Seaghdha, N. Glazer, Aaron Isaacs, Ching-Ti Liu, Albert Smith, Jeffrey O’Connell, M. Struchalin, Toshiko Tanaka, Guo Li, Andrew Johnson, H. Gierman, M. Feitosa, Shih-Jen Hwang, Elizabeth Atkinson, K. Lohman, Marilyn Cornelis, Åsa Johansson, A. Tönjes, Abbas Dehghan, V. Chouraki, Elizabeth Holliday, R. Sorice, Z. Kutalik, T. Lehtimäki, T. Esko, Harshal Deshmukh, Sheila Ulivi, Audrey Chu, F. Murgia, S. Trompet, M. Imboden, B. Kollerits, G. Pistis, T. Harris, L. Launer, T. Aspelund, G. Eiriksdottir, Braxton Mitchell, Eric Boerwinkle, H. Schmidt, M. Cavalieri, Madhumathi Rao, Frank Hu, A. Demirkan, B. Oostra, M. Andrade, Stephen Turner, Jingzhong Ding, Jeanette Andrews, Barry Freedman, Wolfgang Koenig, Thomas Illig, A. Döring, H. Wichmann, I. Kolčić, T. Zemunik, M. Boban, C. Minelli, H. Wheeler, W. Igl, Ghazal Zaboli, Sarah Wild, Alan Wright, Harry Campbell, D. Ellinghaus, Ute Nöthlings, G. Jacobs, R. Biffar, K. Endlich, F. Ernst, G. Homuth, Heyo Kroemer, Matthias Nauck, Sylvia Stracke, U. Völker, H. Völzke, Peter Kovacs, M. Stumvoll, Reedik Mägi, A. Hofman, A. Uitterlinden, F. Rivadeneira, Y. Aulchenko, O. Polašek, Nick Hastie, V. Vitart, Catherine Helmer, J. Wang, D. Ruggiero, Sven Bergmann, M. Kähönen, J. Viikari, T. Nikopensius, Michael Province, Shamika Ketkar, H. Colhoun, Alex Doney, A. Robino, Franco Giulianini, Bernhard Krämer, L. Portas, I. Ford, B. Buckley, M. Adam, G. Thun, Bernhard Paulweber, M. Haun, C. Sala, Marie Metzger, Paul Mitchell, M. Ciullo, Stuart Kim, P. Vollenweider, Olli Raitakari, A. Metspalu, Colin Palmer, Paolo Gasparini, Mario Pirastu, J. Jukema, Nicole Probst-Hensch, Florian Kronenberg, D. Toniolo, V. Gudnason, A. Shuldiner, Josef Coresh, R. Schmidt, L. Ferrucci, D. Siscovick, C. Duijn, I. Borecki, S. Kardia, Yongmei Liu, G. Curhan, I. Rudan, U. Gyllensten, James Wilson, A. Franke, P. Pramstaller, Rainer Rettig, I. Prokopenko, J. Witteman, C. Hayward, P. Ridker, A. Parsa, M. Bochud, I. Heid, W. Goessling, D. Chasman, W. Kao, Caroline Fox (2012)

    Genome-wide association and functional follow-up reveals new loci for kidney function

  • R. Freathy, D. Mook-Kanamori, U. Sovio, I. Prokopenko, N. Timpson, D. Berry, N. Warrington, E. Widén, J. Hottenga, M. Kaakinen, L. Lange, J. Bradfield, M. Kerkhof, J. Marsh, R. Mägi, Chih-Mei Chen, H. Lyon, M. Kirin, L. Adair, Y. Aulchenko, A. Bennett, J. Borja, N. Bouatia-Naji, P. Charoen, L. Coin, D. Cousminer, E. Geus, P. Deloukas, P. Elliott, David Evans, P. Froguel, B. Glaser, C. Groves, A. Hartikainen, N. Hassanali, J. Hirschhorn, A. Hofman, J. Holly, E. Hyppönen, S. Kanoni, B. Knight, J. Laitinen, C. Lindgren, W. McArdle, P. O’Reilly, C. Pennell, D. Postma, A. Pouta, A. Ramasamy, N. Rayner, S. Ring, F. Rivadeneira, B. Shields, D. Strachan, I. Surakka, A. Taanila, Carla Tiesler, A. Uitterlinden, C. Duijn, A. Wijga, G. Willemsen, Haitao Zhang, Jianhua Zhao, James Wilson, E. Steegers, A. Hattersley, J. Eriksson, L. Peltonen, K. Mohlke, S. Grant, H. Hakonarson, G. Koppelman, G. Dedoussis, J. Heinrich, M. Gillman, L. Palmer, T. Frayling, D. Boomsma, G. Smith, C. Power, V. Jaddoe, M. Jarvelin, M. McCarthy (2010)

    Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

    Nature genetics, 42

  • H. Mi, P. Thomas (2009)

    PANTHER pathway: an ontology-based pathway database coupled with data analysis tools.

    Methods in molecular biology, 563

  • Youfa Wang, E. Rimm, M. Stampfer, W. Willett, F. Hu (2005)

    Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men.

    The American journal of clinical nutrition, 81 3

  • T. Pers, J. Karjalainen, Yingleong Chan, H. Westra, A. Wood, Jian Yang, J. Lui, S. Vedantam, S. Gustafsson, T. Esko, T. Frayling, Elizabeth Speliotes, M. Boehnke, S. Raychaudhuri, R. Fehrmann, J. Hirschhorn, L. Franke (2015)

    Biological interpretation of genome-wide association studies using predicted gene functions

    Nature Communications, 6

  • C. Gieger, A. Radhakrishnan, A. Cvejic, Weihong Tang, E. Porcu, G. Pistis, J. Serbanovic-Canic, Ulrich Elling, A. Goodall, Y. Labrune, Lorna Lopez, R. Mägi, Stuart Meacham, Y. Okada, N. Pirastu, R. Sorice, A. Teumer, K. Voss, Weihua Zhang, R. Ramírez‐Solís, J. Bis, D. Ellinghaus, Martin Gögele, J. Hottenga, C. Langenberg, P. Kovacs, P. O’Reilly, So-Youn Shin, T. Esko, J. Hartiala, S. Kanoni, F. Murgia, A. Parsa, J. Stephens, P. Harst, C. Schoot, H. Allayee, A. Attwood, B. Balkau, F. Bastardot, S. Basu, S. Baumeister, G. Biino, L. Bomba, A. Bonnefond, F. Cambien, J. Chambers, F. Cucca, P. D'Adamo, G. Davies, R. Boer, E. Geus, A. Döring, P. Elliott, J. Erdmann, David Evans, M. Falchi, Wei Feng, A. Folsom, I. Frazer, Q. Gibson, N. Glazer, Chris Hammond, A. Hartikainen, S. Heckbert, C. Hengstenberg, M. Hersch, T. Illig, R. Loos, J. Jolley, K. Khaw, Brigitte Kühnel, M. Kyrtsonis, V. Lagou, Heather Lloyd-Jones, T. Lumley, M. Mangino, A. Maschio, I. Leach, B. McKnight, Y. Memari, B. Mitchell, G. Montgomery, Yusuke Nakamura, M. Nauck, G. Navis, U. Nöthlings, I. Nolte, D. Porteous, A. Pouta, P. Pramstaller, J. Pullat, S. Ring, J. Rotter, D. Ruggiero, A. Ruokonen, C. Sala, N. Samani, J. Sambrook, D. Schlessinger, S. Schreiber, H. Schunkert, J. Scott, N. Smith, H. Snieder, J. Starr, M. Stumvoll, A. Takahashi, W. Tang, K. Taylor, A. Tenesa, S. Thein, A. Tönjes, M. Uda, Sheila Ulivi, D. Veldhuisen, P. Visscher, U. Völker, H. Wichmann, K. Wiggins, G. Willemsen, Tsun-Po Yang, J. Zhao, P. Zitting, J. Bradley, G. Dedoussis, P. Gasparini, S. Hazen, A. Metspalu, M. Pirastu, A. Shuldiner, L. Pelt, J. Zwaginga, D. Boomsma, I. Deary, A. Franke, P. Froguel, S. Ganesh, M. Jarvelin, N. Martin, C. Meisinger, B. Psaty, T. Spector, N. Wareham, J. Akkerman, M. Ciullo, P. Deloukas, A. Greinacher, S. Jupe, N. Kamatani, J. Khadake, J. Kooner, J. Penninger, I. Prokopenko, D. Stemple, D. Toniolo, L. Wernisch, S. Sanna, A. Hicks, A. Rendon, M. Ferreira, W. Ouwehand, N. Soranzo (2011)

    New gene functions in megakaryopoiesis and platelet formation

    Nature, 480

  • J. Randall, T. Winkler, Z. Kutalik, S. Berndt, A. Jackson, K. Monda, Tuomas Kilpeläinen, T. Esko, Reedik Mägi, Shengxu Li, T. Workalemahu, M. Feitosa, Damien Croteau-Chonka, F. Day, T. Fall, T. Ferreira, S. Gustafsson, A. Locke, I. Mathieson, A. Scherag, S. Vedantam, A. Wood, L. Liang, V. Steinthorsdottir, G. Thorleifsson, Emmanouil Dermitzakis, A. Dimas, F. Karpe, Josine Min, G. Nicholson, Deborah Clegg, T. Person, J. Krohn, Sabrina Bauer, C. Buechler, Kristina Eisinger, A. Bonnefond, P. Froguel, J. Hottenga, I. Prokopenko, L. Waite, T. Harris, Albert Smith, A. Shuldiner, W. McArdle, M. Caulfield, P. Munroe, H. Grönberg, Y. Chen, Guo Li, Jacques Beckmann, T. Johnson, U. Thorsteinsdóttir, M. Teder-Laving, K. Khaw, N. Wareham, J. Zhao, N. Amin, B. Oostra, A. Kraja, Michael Province, L. Cupples, N. Heard-Costa, J. Kaprio, S. Ripatti, I. Surakka, F. Collins, J. Saramies, J. Tuomilehto, A. Jula, V. Salomaa, J. Erdmann, C. Hengstenberg, C. Loley, H. Schunkert, C. Lamina, H. Wichmann, E. Albrecht, C. Gieger, Andrew Hicks, Å. Johansson, P. Pramstaller, S. Kathiresan, Elizabeth Speliotes, B. Penninx, A. Hartikainen, M. Jarvelin, U. Gyllensten, D. Boomsma, H. Campbell, James Wilson, S. Chanock, M. Farrall, A. Goel, C. Medina-Gomez, F. Rivadeneira, K. Estrada, A. Uitterlinden, A. Hofman, M. Zillikens, M. Heijer, Lambertus Kiemeney, A. Maschio, P. Hall, J. Tyrer, A. Teumer, H. Völzke, P. Kovacs, A. Tönjes, M. Mangino, Timothy Spector, C. Hayward, I. Rudan, Alistair Hall, Nilesh Samani, A. Attwood, J. Sambrook, Joseph Hung, L. Palmer, M. Lokki, J. Sinisalo, G. Boucher, H. Huikuri, M. Lorentzon, C. Ohlsson, N. Eklund, J. Eriksson, C. Barlassina, C. Rivolta, I. Nolte, H. Snieder, M. Klauw, Jana Vliet-Ostaptchouk, P. Gejman, Jianxin Shi, K. Jacobs, Z. Wang, S. Bakker, Irene Leach, G. Navis, P. Harst, Nicholas Martin, S. Medland, Grant Montgomery, Jian Yang, D. Chasman, P. Ridker, L. Rose, T. Lehtimäki, O. Raitakari, D. Absher, C. Iribarren, H. Basart, K. Hovingh, E. Hyppönen, C. Power, Denise Anderson, J. Beilby, Jennie Hui, J. Jolley, H. Sager, S. Bornstein, Peter Schwarz, K. Kristiansson, M. Perola, J. Lindström, A. Swift, M. Uusitupa, M. Atalay, Timo Lakka, R. Rauramaa, J. Bolton, G. Fowkes, Ross Fraser, Jackie Price, K. Fischer, Kaarel KrjutÅ¡kov, A. Metspalu, E. Mihailov, C. Langenberg, J. Luan, Ken Ong, P. Chines, S. Keinanen-Kiukaanniemi, T. Saaristo, S. Edkins, Paul Franks, G. Hallmans, D. Shungin, Andrew Morris, Colin Palmer, R. Erbel, S. Moebus, M. Nöthen, S. Pechlivanis, K. Hveem, Narisu Narisu, A. Hamsten, S. Humphries, R. Strawbridge, E. Tremoli, H. Grallert, B. Thorand, T. Illig, W. Koenig, M. Müller-Nurasyid, A. Peters, Bernhard Boehm, M. Kleber, Winfried März, B. Winkelmann, J. Kuusisto, M. Laakso, D. Arveiler, G. Cesana, K. Kuulasmaa, J. Virtamo, JOHN WILLIAM GORDON Yarnell, D. Kuh, A. Wong, L. Lind, U. Faire, B. Gigante, Patrik Magnusson, Nancy Pedersen, G. Dedoussis, M. Dimitriou, G. Kolovou, S. Kanoni, K. Stirrups, L. Bonnycastle, I. Njølstad, T. Wilsgaard, A. Ganna, E. Rehnberg, A. Hingorani, M. Kivimaki, M. Kumari, T. Assimes, Inês Barroso, M. Boehnke, I. Borecki, P. Deloukas, Caroline Fox, T. Frayling, L. Groop, T. Haritunians, D. Hunter, E. Ingelsson, R. Kaplan, K. Mohlke, J. O’Connell, D. Schlessinger, David Strachan, Kári Stefánsson, Cornelia Duijn, G. Abecasis, M. McCarthy, J. Hirschhorn, L. Qi, Ruth Loos, Cecilia Lindgren, Kari North, I. Heid (2013)

    Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.

    PLoS genetics, 9 6

  • B. Bernstein, J. Stamatoyannopoulos, J. Costello, B. Ren, A. Milosavljevic, A. Meissner, Manolis Kellis, M. Marra, A. Beaudet, J. Ecker, P. Farnham, M. Hirst, E. Lander, T. Mikkelsen, J. Thomson (2010)

    The NIH Roadmap Epigenomics Mapping Consortium

    Nature Biotechnology, 28

  • Jianxing Feng, T. Liu, Bo Qin, Yong Zhang, Xiaole Liu (2012)

    Identifying ChIP-seq enrichment using MACS

    Nature Protocols, 7

  • Ryota Suzuki, Hidetoshi Shimodaira (2006)

    Pvclust: an R package for assessing the uncertainty in hierarchical clustering

    Bioinformatics, 22 12

  • (1997)

    MX: Statistical Modeling

  • Á. Jiménez-Marín, Melania Collado-Romero, M. Ramírez-Boo, C. Arce, J. Garrido (2009)

    Biological pathway analysis by ArrayUnlock and Ingenuity Pathway Analysis

    BMC Proceedings, 3

  • (1992)

    Scientific Affairs Division

    Methodology for genetic studies of twins and families

  • S. Buyske, Ying Wu, C. Carty, I. Cheng, T. Assimes, L. Dumitrescu, L. Hindorff, S. Mitchell, J. Ambite, E. Boerwinkle, P. Bůžková, C. Carlson, Barbara Cochran, D. Duggan, C. Eaton, M. Fesinmeyer, N. Franceschini, J. Haessler, N. Jenny, H. Kang, C. Kooperberg, Yi Lin, L. Marchand, T. Matise, Jennifer Robinson, Carlos Rodriguez, F. Schumacher, B. Voight, A. Young, T. Manolio, K. Mohlke, C. Haiman, U. Peters, D. Crawford, K. North (2012)

    Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study

    PLoS ONE, 7

  • Jian Yang, T. Ferreira, Andrew Morris, S. Medland, P. Madden, Andrew Heath, Nicholas Martin, G. Montgomery, M. Weedon, Ruth Loos, T. Frayling, M. McCarthy, J. Hirschhorn, Michael Goddard, P. Visscher (2012)

    Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

    Nature Genetics, 44

  • Bernie Devlin, K. Roeder (1999)

    Genomic Control for Association Studies

    Biometrics, 55

  • K. Lage, E. Karlberg, Zenia Størling, Pall Olason, A. Pedersen, O. Rigina, A. Hinsby, Z. Tümer, F. Pociot, F. Pociot, N. Tommerup, Y. Moreau, S. Brunak (2007)

    A human phenome-interactome network of protein complexes implicated in genetic disorders

    Nature Biotechnology, 25

  • D. Foti, E. Chiefari, M. Fedele, R. Iuliano, L. Brunetti, F. Paonessa, G. Manfioletti, F. Barbetti, A. Brunetti, C. Croce, A. Fusco, A. Brunetti (2005)

    Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

    Nature Medicine, 11

  • A. Franke, D. McGovern, J. Barrett, Kai Wang, L. Graham, Radford-Smith, T. Ahmad, C. Lees, T. Balschun, James Lee, Rebecca, D Roberts, C. Anderson, J. Bis, S. Bumpstead, D. Ellinghaus, Eleonora Festen, M. Georges, T. Haritunians, L. Jostins, Anna, Latiano, C. Mathew, G. Montgomery, N. Prescott, Jérôme, I. Rotter, P. Schumm, Y. Sharma, L. Simms, K. Taylor, David, Whiteman, C. Wijmenga, R. Baldassano, M. Barclay, M. Theodore, Bayless, S. Brand, Carsten Buning, A. Cohen, Jean-Frederick, Colombel, M. Cottone, L. Stronati, T. Denson, M. Vos, Renata, D’Inca, M. Dubinsky, C. Edwards, T. Florin, D. Franchimont, R. Gearry, J. Glas, A. Gossum, S. Guthery, Jonas, Halfvarson, Daan Hommes, J. Hugot, D. Laukens, I. Lawrance, M. Lémann, A. Levine, C. Libioulle, E. Louis, C. Mowat, William, Newman, J. Panés, A. Phillips, D. Proctor, M. Regueiro, Paul, Rutgeerts, J. Sanderson, M. Sans, F. Seibold, A. Steinhart, P. Stokkers, L. Torkvist, Gerd Ublick, S. Raychaudhuri, Todd Green, T. Walters, S. Targan, S. Brant, J. Rioux, M. D’Amato, R. Weersma, S. Kugathasan, A. Griffiths, C. John, Mansfield, S. Vermeire, R. Duerr, M. Silverberg, Jack, Satsangi, S. Schreiber, Judy Cho, V. Annese, H. Hakonarson, M. Daly, M. Parkes (2010)

    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

    Nature Genetics, 42

  • (1990)

    Introduction to Quantitative Genetics 3rd edn

  • Hana Allen, K. Estrada, G. Lettre, S. Berndt, M. Weedon, F. Rivadeneira, C. Willer, A. Jackson, S. Vedantam, S. Raychaudhuri, T. Ferreira, A. Wood, R. Weyant, A. Segrè, Elizabeth Speliotes, E. Wheeler, N. Soranzo, Ju-Hyun Park, Jian Yang, D. Gudbjartsson, N. Heard-Costa, J. Randall, L. Qi, A. Smith, R. Mägi, T. Pastinen, L. Liang, I. Heid, J. Luan, G. Thorleifsson, T. Winkler, M. Goddard, K. Lo, Cameron Palmer, T. Workalemahu, Y. Aulchenko, Å. Johansson, M. Zillikens, M. Feitosa, T. Esko, T. Johnson, Shamika Ketkar, P. Kraft, M. Mangino, I. Prokopenko, D. Absher, E. Albrecht, F. Ernst, N. Glazer, C. Hayward, J. Hottenga, K. Jacobs, J. Knowles, Z. Kutalik, K. Monda, O. Polašek, Michael Preuss, N. Rayner, N. Robertson, V. Steinthorsdottir, J. Tyrer, B. Voight, F. Wiklund, Jianfeng Xu, J. Zhao, D. Nyholt, Niina Pellikka, M. Perola, J. Perry, I. Surakka, Mari-Liis Tammesoo, E. Altmaier, N. Amin, T. Aspelund, T. Bhangale, G. Boucher, D. Chasman, Constance Chen, L. Coin, M. Cooper, A. Dixon, Q. Gibson, E. Grundberg, K. Hao, M. Junttila, L. Kaplan, J. Kettunen, I. König, T. Kwan, R. Lawrence, D. Levinson, M. Lorentzon, B. McKnight, A. Morris, Martina Müller, J. Ngwa, S. Purcell, S. Rafelt, R. Salem, E. Salvi, S. Sanna, Jianxin Shi, U. Sovio, J. Thompson, M. Turchin, L. Vandenput, D. Verlaan, V. Vitart, Charles White, A. Ziegler, P. Almgren, A. Balmforth, H. Campbell, L. Citterio, A. Grandi, A. Dominiczak, J. Duan, P. Elliott, R. Elosúa, J. Eriksson, N. Freimer, E. Geus, N. Glorioso, Shen Haiqing, A. Hartikainen, A. Havulinna, A. Hicks, J. Hui, W. Igl, T. Illig, A. Jula, E. Kajantie, T. Kilpeläinen, M. Koiranen, I. Kolčić, S. Koskinen, P. Kovacs, J. Laitinen, Jianjun Liu, M. Lokki, A. Marušić, A. Maschio, T. Meitinger, A. Mulas, G. Paré, A. Parker, J. Peden, A. Petersmann, I. Pichler, K. Pietiläinen, A. Pouta, M. Ridderstråle, J. Rotter, J. Sambrook, A. Sanders, C. Schmidt, J. Sinisalo, J. Smit, H. Stringham, G. Walters, E. Widén, S. Wild, G. Willemsen, L. Zagato, L. Zgaga, P. Zitting, Helene Alavere, M. Farrall, W. McArdle, M. Nelis, M. Peters, S. Ripatti, J. Meurs, K. Aben, K. Ardlie, J. Beckmann, J. Beilby, R. Bergman, S. Bergmann, F. Collins, D. Cusi, M. Heijer, G. Eiriksdottir, P. Gejman, A. Hall, A. Hamsten, H. Huikuri, C. Iribarren, M. Kähönen, J. Kaprio, S. Kathiresan, L. Kiemeney, T. Kocher, L. Launer, T. Lehtimäki, O. Melander, T. Mosley, A. Musk, M. Nieminen, C. O’Donnell, C. Ohlsson, B. Oostra, L. Palmer, O. Raitakari, P. Ridker, J. Rioux, A. Rissanen, C. Rivolta, H. Schunkert, A. Shuldiner, D. Siscovick, M. Stumvoll, A. Tönjes, J. Tuomilehto, G. Ommen, J. Viikari, A. Heath, N. Martin, G. Montgomery, M. Province, M. Kayser, A. Arnold, L. Atwood, E. Boerwinkle, S. Chanock, P. Deloukas, C. Gieger, H. Grönberg, P. Hall, A. Hattersley, C. Hengstenberg, Wolfgang Hoffman, G. Lathrop, V. Salomaa, S. Schreiber, M. Uda, D. Waterworth, A. Wright, T. Assimes, I. Barroso, A. Hofman, K. Mohlke, D. Boomsma, M. Caulfield, L. Cupples, J. Erdmann, C. Fox, V. Gudnason, U. Gyllensten, T. Harris, R. Hayes, M. Jarvelin, V. Mooser, P. Munroe, W. Ouwehand, B. Penninx, P. Pramstaller, T. Quertermous, I. Rudan, N. Samani, T. Spector, H. Völzke, H. Watkins, James Wilson, L. Groop, T. Haritunians, F. Hu, R. Kaplan, A. Metspalu, K. North, D. Schlessinger, N. Wareham, D. Hunter, J. O’Connell, D. Strachan, H. Wichmann, I. Borecki, C. Duijn, E. Schadt, U. Thorsteinsdóttir, L. Peltonen, A. Uitterlinden, P. Visscher, N. Chatterjee, R. Loos, M. Boehnke, M. McCarthy, E. Ingelsson, C. Lindgren, G. Abecasis, K. Stefánsson, T. Frayling, J. Hirschhorn (2010)

    Hundreds of variants clustered in genomic loci and biological pathways affect human height

    Nature, 467

  • M. Snijder, J. Dekker, M. Visser, L. Bouter, C. Stehouwer, P. Kostense, J. Yudkin, R. Heine, G. Nijpels, J. Seidell (2003)

    Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study.

    The American journal of clinical nutrition, 77 5

  • A Catalog of Published Genome-Wide Association Studies

  • J. Painter, C. Anderson, D. Nyholt, S. Macgregor, Jianghai Lin, S. Lee, A. Lambert, Z. Zhao, F. Roseman, Qun Guo, S. Gordon, L. Wallace, A. Henders, P. Visscher, P. Kraft, N. Martin, A. Morris, S. Treloar, S. Kennedy, S. Missmer, G. Montgomery, K. Zondervan (2010)

    Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis

    Nature genetics, 43

  • R. Fehrmann, J. Karjalainen, M. Krajewska, H. Westra, D. Maloney, A. Simeonov, T. Pers, J. Hirschhorn, R. Jansen, E. Schultes, Herman Haagen, E. Vries, G. Meerman, C. Wijmenga, M. Vugt, L. Franke (2015)

    Gene expression analysis identifies global gene dosage sensitivity in cancer

    Nature Genetics, 47

  • C. Elks, J. Perry, P. Sulem, D. Chasman, N. Franceschini, Chunyan He, K. Lunetta, Jenny Visser, Enda Byrne, D. Cousminer, D. Gudbjartsson, T. Esko, B. Feenstra, J. Hottenga, Daniel Koller, Z. Kutalik, Peng Lin, M. Mangino, M. Marongiu, P. McArdle, A. Smith, L. Stolk, S. Wingerden, Jinghua Zhao, E. Albrecht, T. Corre, E. Ingelsson, C. Hayward, P. Magnusson, E. Smith, Shelia Ulivi, N. Warrington, L. Zgaga, Helene Alavere, N. Amin, T. Aspelund, S. Bandinelli, I. Barroso, Gerald Berenson, S. Bergmann, H. Blackburn, E. Boerwinkle, Julie Buring, F. Busonero, Harry Campbell, S. Chanock, Wei Chen, Marilyn Cornelis, D. Couper, Andrea Coviello, P. D'Adamo, U. Faire, E. Geus, P. Deloukas, A. Döring, G. Smith, D. Easton, G. Eiriksdottir, V. Emilsson, Johan Eriksson, Luigi Ferrucci, Aaron Folsom, T. Foroud, Melissa Garcia, Paolo Gasparini, F. Geller, C. Gieger, The Consortium, V. Gudnason, Per Hall, S. Hankinson, Liana Ferreli, Andrew Heath, Dena Hernandez, A. Hofman, Frank Hu, T. Illig, M. Järvelin, Andrew Johnson, D. Karasik, K. Khaw, Douglas Kiel, Tuomas Kilpeläinen, I. Kolčić, Peter Kraft, L. Launer, J. Laven, Shengxu Li, J. Liu, Daniel Levy, N. Martin, W. McArdle, Mads Melbye, Vincent Mooser, Jeffrey Murray, S. Murray, Michael Nalls, P. Navarro, M. Nelis, A. Ness, K. Northstone, B. Oostra, M. Peacock, L. Palmer, A. Palotie, G. Paré, A. Parker, Nancy Pedersen, L. Peltonen, C. Pennell, Paul Pharoah, O. Polašek, Andrew Plump, A. Pouta, Eleonora Porcu, T. Rafnar, John Rice, Susan Ring, F. Rivadeneira, I. Rudan, C. Sala, V. Salomaa, S. Sanna, D. Schlessinger, N. Schork, A. Scuteri, A. Segrè, A. Shuldiner, N. Soranzo, U. Sovio, S. Srinivasan, David Strachan, Mari-Liis Tammesoo, E. Tikkanen, D. Toniolo, Kim Tsui, L. Tryggvadottir, J. Tyrer, M. Uda, R. Dam, J. Meurs, P. Vollenweider, G. Waeber, N. Wareham, D. Waterworth, M. Weedon, H. Wichmann, G. Willemsen, James Wilson, Alan Wright, Lauren Young, G. Zhai, Z. Wei, L. Bierut, D. Boomsma, H. Boyd, L. Crisponi, E. Demerath, C. Duijn, Michael Econs, T. Harris, David Hunter, Ruth Loos, A. Metspalu, G. Montgomery, P. Ridker, Timothy Spector, E. Streeten, K. Stefánsson, U. Thorsteinsdóttir, A. Uitterlinden, E. Widén, J. Murabito, Ken Ong, A. Murray (2010)

    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

    Nature Genetics, 42

  • (1990)

    Introduction to Quantitative Genetics

  • C. Hagberg, Annelie Falkevall, Xun Wang, E. Larsson, J. Huusko, I. Nilsson, L. Meeteren, Erik Samén, Li Lu, Maarten Vanwildemeersch, J. Klar, G. Genové, K. Pietras, S. Stone-Elander, L. Claesson-Welsh, S. Ylä-Herttuala, P. Lindahl, U. Eriksson (2010)

    Vascular endothelial growth factor B controls endothelial fatty acid uptake

    Nature, 464

  • Hongling Li, Tangping Li, Shihua Wang, Jian-feng Wei, Junfen Fan, Jing Li, Q. Han, L. Liao, C. Shao, R. Zhao (2013)

    miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells.

    Stem cell research, 10 3

  • Author manuscript; available in PMC

  • Author Manuscripts Europe PMC Funders Author Manuscripts 16

  • A. Cvejic, L. Haer-Wigman, J. Stephens, Myrto Kostadima, P. Smethurst, M. Frontini, E. Akker, Paul Bertone, Ewa Bielczyk-Maczynska, Samantha Farrow, R. Fehrmann, Alan Gray, M. Haas, Vincent Haver, Gregory Jordan, J. Karjalainen, H. Kerstens, G. Kiddle, Heather Lloyd-Jones, M. Needs, J. Poole, A. Soussan, A. Rendon, K. Rieneck, J. Sambrook, H. Schepers, H. Silljé, Botond Sipos, D. Swinkels, Asif Tamuri, N. Verweij, N. Watkins, H. Westra, D. Stemple, L. Franke, N. Soranzo, H. Stunnenberg, N. Goldman, P. Harst, C. Schoot, W. Ouwehand, C. Albers (2013)

    SMIM1 underlies the Vel blood group and influences red blood cell traits

    Nature Genetics, 45

  • A. Meissner, Manolis Kellis, M. Marra, A. Beaudet, J. Ecker, P. Farnham, M. Hirst, E. Lander, T. Mikkelsen, J. Thomson (2010)

    The NIH Roadmap Epigenomics Mapping

  • Y. Benjamini, Y. Hochberg (1995)

    Controlling the false discovery rate: a practical and powerful approach to multiple testing

    Journal of the royal statistical society series b-methodological, 57

  • (1997)

    MX: Statistical Modeling. 4th edn Department of Psychiatry

  • (2014)

    Ridker 136,240 , Marylyn D. Ritchie 241 , Igor Rudan 185,242 , Veikko Salomaa 51

  • Andrew Steinthorsd, Andrew Morris, B. Voight, Tanya Teslovich, T. Ferreira, A. Segrè, V. Steinthorsdottir, R. Strawbridge, H. Khan, H. Grallert, A. Mahajan, I. Prokopenko, H. Kang, C. Dina, T. Esko, Ross Fraser, S. Kanoni, Ashish Kumar, V. Lagou, C. Langenberg, J. Luan, C. Lindgren, M. Müller-Nurasyid, S. Pechlivanis, N. Rayner, L. Scott, S. Wiltshire, L. Yengo, L. Kinnunen, E. Rossin, S. Raychaudhuri, Andrew Johnson, A. Dimas, R. Loos, S. Vedantam, Han Chen, J. Florez, C. Fox, Ching‐Ti Liu, Denis Rybin, D. Couper, W. Kao, Man Li, M. Cornelis, P. Kraft, Qi Sun, R. Dam, H. Stringham, P. Chines, K. Fischer, P. Fontanillas, O. Holmen, S. Hunt, A. Jackson, A. Kong, R. Lawrence, Julia Meyer, J. Perry, Carl Platou, Simon Potter, E. Rehnberg, N. Robertson, S. Sivapalaratnam, A. Stančáková, K. Stirrups, G. Thorleifsson, E. Tikkanen, A. Wood, P. Almgren, M. Atalay, R. Benediktsson, L. Bonnycastle, N. Burtt, Jason Carey, G. Charpentier, A. Crenshaw, A. Doney, M. Dorkhan, S. Edkins, V. Emilsson, Elodie Eury, T. Forsén, K. Gertow, B. Gigante, George Grant, C. Groves, C. Guiducci, C. Herder, Á. Hreidarsson, J. Hui, A. James, A. Jonsson, W. Rathmann, N. Klopp, J. Kravic, K. Krjutškov, C. Langford, K. Leander, E. Lindholm, S. Lobbens, S. Männistö, G. Mirza, Thomas Mühleisen, B. Musk, Melissa Parkin, L. Rallidis, J. Saramies, B. Sennblad, Sonia Shah, G. Sigurðsson, A. Silveira, G. Steinbach, B. Thorand, J. Trakalo, F. Veglia, R. Wennauer, W. Winckler, D. Zabaneh, H. Campbell, C. Duijn, A. Uitterlinden, A. Hofman, E. Sijbrands, G. Abecasis, K. Owen, E. Zeggini, M. Trip, N. Forouhi, A. Syvänen, J. Eriksson, L. Peltonen, M. Nöthen, B. Balkau, C. Palmer, V. Lyssenko, T. Tuomi, B. Isomaa, D. Hunter, L. Qi, A. Shuldiner, M. Roden, I. Barroso, T. Wilsgaard, J. Beilby, K. Hovingh, J. Price, James Wilson, R. Rauramaa, T. Lakka, L. Lind, G. Dedoussis, I. Njølstad, N. Pedersen, K. Khaw, N. Wareham, S. Keinanen-Kiukaanniemi, T. Saaristo, E. Korpi-Hyövälti, J. Saltevo, M. Laakso, J. Kuusisto, A. Metspalu, F. Collins, K. Mohlke, R. Bergman, J. Tuomilehto, B. Boehm, C. Gieger, K. Hveem, S. Cauchi, P. Froguel, D. Baldassarre, E. Tremoli, S. Humphries, D. Saleheen, J. Danesh, E. Ingelsson, S. Ripatti, V. Salomaa, R. Erbel, K. Jöckel, S. Moebus, A. Peters, T. Illig, U. Faire, A. Hamsten, Andrew Morris, P. Donnelly, T. Frayling, A. Hattersley, E. Boerwinkle, O. Melander, S. Kathiresan, P. Nilsson, P. Deloukas, U. Thorsteinsdóttir, L. Groop, K. Stefánsson, F. Hu, J. Pankow, J. Dupuis, J. Meigs, D. Altshuler, M. Boehnke, M. McCarthy (2012)

    Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

    Nature genetics, 44

  • (2012)

    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women

    PLoS Genet, 8

  • J. Lovejoy, C. Champagne, L. Jonge, Hui Xie, Steven Smith (2008)

    Increased visceral fat and decreased energy expenditure during the menopausal transition

    International Journal of Obesity, 32

  • Y. Kamatani, K. Matsuda, Y. Okada, M. Kubo, N. Hosono, Y. Daigo, Yusuke Nakamura, N. Kamatani (2010)

    Genome-wide association study of hematological and biochemical traits in a Japanese population

    Nature Genetics, 42

  • D. Canoy (2008)

    Distribution of body fat and risk of coronary heart disease in men and women

    Current Opinion in Cardiology, 23

  • Alisa Manning, Alisa Manning, Alisa Manning, Robert Scott, Jonna Grimsby, N. Bouatia-Naji, N. Bouatia-Naji, Han Chen, Denis Rybin, Ching-Ti Liu, L. Bielak, I. Prokopenko, N. Amin, Daniel Barnes, G. Cadby, G. Cadby, J. Hottenga, Erik Ingelsson, A. Jackson, T. Johnson, S. Kanoni, C. Ladenvall, V. Lagou, J. Lahti, C. Lecoeur, C. Lecoeur, Yongmei Liu, M. Martínez-Larrad, May Montasser, P. Navarro, John Perry, John Perry, John Perry, L. Rasmussen-Torvik, P. Salo, Naveed Sattar, D. Shungin, D. Shungin, R. Strawbridge, Tosh Tanaka, C. Duijn, Ping An, M. Andrade, Jeanette Andrews, T. Aspelund, Mustafa Atalay, Y. Aulchenko, B. Balkau, S. Bandinelli, Jacques Beckmann, J. Beilby, C. Bellis, R. Bergman, J. Blangero, M. Boban, M. Boehnke, E. Boerwinkle, L. Bonnycastle, D. Boomsma, I. Borecki, Y. Böttcher, Claude Bouchard, Eric Brunner, Danijela Budimir, Harry Campbell, O. Carlson, P. Chines, R. Clarke, F. Collins, Arturo Corbató-Anchuelo, David Couper, U. Faire, G. Dedoussis, P. Deloukas, M. Dimitriou, Josephine Egan, G. Eiriksdottir, M. Erdos, J. Eriksson, Elodie Eury, Elodie Eury, L. Ferrucci, I. Ford, N. Forouhi, Caroline Fox, Caroline Fox, M. Franzosi, Paul Franks, T. Frayling, P. Froguel, Pilar Galan, E. Geus, Bruna Gigante, N. Glazer, A. Goel, L. Groop, V. Gudnason, Göran Hallmans, Anders Hamsten, Ola Hansson, T. Harris, C. Hayward, Simon Heath, S. Hercberg, Andrew Hicks, A. Hingorani, A. Hofman, Jennie Hui, Joseph Hung, M. Järvelin, M. Järvelin, Min Jhun, Paul Johnson, J. Jukema, A. Jula, W. Kao, J. Kaprio, J. Kaprio, S. Kardia, Sirkka Keinänen-Kiukaanniemi, M. Kivimäki, I. Kolčić, Peter Kovacs, M. Kumari, J. Kuusisto, KIRSTEN Kyvik, Markku Laakso, Timo Lakka, Lars Lannfelt, G. Lathrop, L. Launer, K. Leander, Guo Li, Lars Lind, J. Lindström, S. Lobbens, S. Lobbens, R. Loos, J. Luan, V. Lyssenko, Reedik Mägi, Reedik Mägi, Patrik Magnusson, M. Marmot, Pierre Meneton, K. Mohlke, Vincent Mooser, M. Morken, Iva Miljkovic, Narisu Narisu, Jeffrey O'Connell, Ken Ong, B. Oostra, L. Palmer, L. Palmer, A. Palotie, J. Pankow, J. Peden, Nancy Pedersen, Marina Pehlić, Leena Peltonen, B. Penninx, B. Penninx, B. Penninx, M. Peričić, M. Perola, L. Pérusse, P. Peyser, O. Polašek, P. Pramstaller, Michael Province, K. Räikkönen, R. Rauramaa, E. Rehnberg, Kenneth Rice, Jerome Rotter, I. Rudan, I. Rudan, A. Ruokonen, T. Saaristo, M. Sabater-Lleal, V. Salomaa, David Savage, Richa Saxena, Richa Saxena, Peter Schwarz, Udo Seedorf, B. Sennblad, M. Serrano-Ríos, A. Shuldiner, Eric Sijbrands, D. Siscovick, Johannes Smit, K. Small, Nicholas Smith, Nicholas Smith, Albert Smith, A. Stančáková, K. Stirrups, Michael Stumvoll, Yan Sun, A. Swift, A. Tönjes, J. Tuomilehto, S. Trompet, A. Uitterlinden, Matti Uusitupa, M. Vikström, V. Vitart, M. Vohl, B. Voight, P. Vollenweider, G. Waeber, Dawn Waterworth, Hugh Watkins, Hugh Watkins, Eleanor Wheeler, E. Widén, Sarah Wild, Sara Willems, G. Willemsen, James Wilson, J. Witteman, Alan Wright, H. Yaghootkar, D. Zélénika, T. Zemunik, L. Zgaga, L. Zgaga, N. Wareham, M. McCarthy, M. McCarthy, Inês Barroso, Inês Barroso, R. Watanabe, Jose Florez, Jose Florez, José Dupuis, José Dupuis, James Meigs, C. Langenberg (2012)

    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

    Nature Genetics, 44

  • Hitoshi Suzuki (2011)

    The North Atlantic Treaty Organization

  • Traits associated at P<5 × 10 −8 in GWAS or the GWAS catalog using the index SNP or a proxy, and the genes(s) named. FI, fasting insulin adjusted for BMI

  • Cristen G, C. Willer, Ellen Schmidt, Sebanti Sengupta, G. Peloso, S. Gustafsson, S. Kanoni, A. Ganna, Jin Chen, Martin Buchkovich, S. Mora, J. Beckmann, J. Bragg-Gresham, Hsing-Yi Chang, A. Demirkan, H. Hertog, R. Do, L. Donnelly, G. Ehret, T. Esko, M. Feitosa, T. Ferreira, K. Fischer, P. Fontanillas, Ross Fraser, Daniel Freitag, D. Gurdasani, K. Heikkilä, E. Hyppönen, A. Isaacs, A. Jackson, Å. Johansson, T. Johnson, M. Kaakinen, J. Kettunen, M. Kleber, Xiaohui Li, J. Luan, L. Lyytikäinen, P. Magnusson, M. Mangino, E. Mihailov, May Montasser, M. Müller-Nurasyid, I. Nolte, J. O’Connell, Cameron Palmer, M. Perola, A. Petersen, S. Sanna, R. Saxena, S. Service, Sonia Shah, D. Shungin, C. Sidore, Ci Song, R. Strawbridge, I. Surakka, Toshiko Tanaka, Tanya Teslovich, G. Thorleifsson, E. Herik, B. Voight, K. Volcik, L. Waite, A. Wong, Ying Wu, Weihua Zhang, D. Absher, G. Asiki, I. Barroso, L. Been, J. Bolton, L. Bonnycastle, P. Brambilla, M. Burnett, G. Cesana, M. Dimitriou, A. Doney, A. Döring, P. Elliott, S. Epstein, G. Eyjolfsson, B. Gigante, M. Goodarzi, H. Grallert, Martha Gravito, C. Groves, G. Hallmans, A. Hartikainen, C. Hayward, D. Hernandez, A. Hicks, H. Hólm, Y. Hung, T. Illig, Michelle Jones, P. Kaleebu, J. Kastelein, K. Khaw, Eric Kim, N. Klopp, P. Komulainen, M. Kumari, C. Langenberg, T. Lehtimäki, Shih-Yi Lin, J. Lindström, R. Loos, F. Mach, W. McArdle, C. Meisinger, B. Mitchell, Gabrielle Müller, R. Nagaraja, Narisu Narisu, T. Nieminen, R. Nsubuga, I. Olafsson, K. Ong, A. Palotie, T. Papamarkou, C. Pomilla, A. Pouta, D. Rader, M. Reilly, P. Ridker, F. Rivadeneira, I. Rudan, A. Ruokonen, N. Samani, H. Scharnagl, J. Seeley, K. Silander, A. Stančáková, K. Stirrups, A. Swift, L. Tiret, A. Uitterlinden, L. Pelt, S. Vedantam, N. Wainwright, C. Wijmenga, S. Wild, G. Willemsen, T. Wilsgaard, James Wilson, E. Young, J. Zhao, L. Adair, D. Arveiler, T. Assimes, S. Bandinelli, F. Bennett, M. Bochud, B. Boehm, D. Boomsma, I. Borecki, S. Bornstein, P. Bovet, M. Burnier, H. Campbell, A. Chakravarti, J. Chambers, Y. Chen, F. Collins, Richard Cooper, J. Danesh, G. Dedoussis, U. Faire, A. Feranil, J. Ferrières, L. Ferrucci, N. Freimer, C. Gieger, L. Groop, V. Gudnason, U. Gyllensten, A. Hamsten, T. Harris, A. Hingorani, J. Hirschhorn, A. Hofman, G. Hovingh, C. Hsiung, S. Humphries, S. Hunt, K. Hveem, C. Iribarren, M. Järvelin, A. Jula, M. Kähönen, J. Kaprio, Antero Kesäniemi, M. Kivimaki, J. Kooner, P. Koudstaal, R. Krauss, D. Kuh, J. Kuusisto, K. Kyvik, M. Laakso, T. Lakka, L. Lind, C. Lindgren, N. Martin, W. März, M. McCarthy, C. McKenzie, P. Meneton, A. Metspalu, L. Moilanen, A. Morris, P. Munroe, I. Njølstad, N. Pedersen, C. Power, P. Pramstaller, J. Price, B. Psaty, T. Quertermous, R. Rauramaa, D. Saleheen, V. Salomaa, D. Sanghera, J. Saramies, P. Schwarz, W. Sheu, A. Shuldiner, A. Siegbahn, T. Spector, K. Stefánsson, D. Strachan, B. Tayo, E. Tremoli, J. Tuomilehto, M. Uusitupa, C. Duijn, P. Vollenweider, L. Wallentin, N. Wareham, J. Whitfield, B. Wolffenbuttel, J. Ordovás, E. Boerwinkle, Colin Palmer, U. Thorsteinsdóttir, D. Chasman, J. Rotter, P. Franks, S. Ripatti, L. Cupples, M. Sandhu, S. Rich, M. Boehnke, P. Deloukas, S. Kathiresan, K. Mohlke, E. Ingelsson, G. Abecasis (2013)

    Discovery and refinement of loci associated with lipid levels

    Nature Genetics, 45

  • (2003)

    The International HapMap Project

    Nature, 426

  • R. Hanada, H. Teranishi, J. Pearson, M. Kurokawa, H. Hosoda, N. Fukushima, Yoshihiko Fukue, R. Serino, H. Fujihara, Y. Ueta, M. Ikawa, M. Okabe, N. Murakami, M. Shirai, H. Yoshimatsu, K. Kangawa, M. Kojima (2004)

    Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway

    Nature Medicine, 10

  • Supplemental Information 2: Kyoto Encyclopedia of genes and genomes.

  • Jian Yang, S. Lee, M. Goddard, P. Visscher (2011)

    GCTA: a tool for genome-wide complex trait analysis.

    American journal of human genetics, 88 1

  • (2012)

    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

    Nat. Genet, 44

  • A. Need, D. Attix, Jill McEvoy, E. Cirulli, Kristen Linney, Priscilla Hunt, D. Ge, E. Heinzen, J. Maia, K. Shianna, M. Weale, L. Cherkas, Gail Clement, T. Spector, G. Gibson, D. Goldstein (2009)

    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.

    Human molecular genetics, 18 23

  • (2014)

    Biological interpretation of genome-wide association studies using predicted gene functions

  • K. Frazer, D. Ballinger, D. Cox, D. Hinds, L. Stuve, R. Gibbs, J. Belmont, A. Boudreau, P. Hardenbol, S. Leal, S. Pasternak, D. Wheeler, T. Willis, F. Yu, Huanming Yang, Changqing Zeng, Yang Gao, Haoran Hu, Weitao Hu, Chaohua Li, Wei Lin, Siqi Liu, Hao Pan, Xiaoli Tang, Jian Wang, Wei Wang, Jun Yu, Bo Zhang, Qingrun Zhang, Hongbin Zhao, Hui-Ping Zhao, Jun Zhou, S. Gabriel, Rachel Barry, B. Blumenstiel, Amy Camargo, M. Defelice, M. Faggart, Marie-Anne Goyette, Supriya Gupta, Jamie Moore, Huy Nguyen, R. Onofrio, Melissa Parkin, J. Roy, E. Stahl, E. Winchester, L. Ziaugra, D. Altshuler, Yan Shen, Zhijian Yao, Wei Huang, X. Chu, Yungang He, Li Jin, Yangfan Liu, Yayun Shen, Weiwei Sun, Haifeng Wang, Yi Wang, Ying Wang, Xiao-yan Xiong, Liang Xu, M. Waye, S. Tsui, H. Xue, J. Wong, L. Galver, Jian-Bing Fan, K. Gunderson, S. Murray, A. Oliphant, M. Chee, A. Montpetit, F. Chagnon, Vincent Ferretti, M. Leboeuf, J. Olivier, M. Phillips, Stéphanie Roumy, C. Sallée, A. Verner, T. Hudson, P. Kwok, Dongmei Cai, D. Koboldt, Raymond Miller, L. Pawlikowska, P. Taillon-Miller, M. Xiao, L. Tsui, W. Mak, You-Qiang Song, P. Tam, Yusuke Nakamura, T. Kawaguchi, T. Kitamoto, Takashi Morizono, A. Nagashima, Y. Ohnishi, A. Sekine, Toshihiro Tanaka, T. Tsunoda, P. Deloukas, C. Bird, Marcos Delgado, E. Dermitzakis, R. Gwilliam, S. Hunt, J. Morrison, Don Powell, B. Stranger, P. Whittaker, D. Bentley, M. Daly, P. Bakker, J. Barrett, Y. Chretien, J. Maller, S. Mccarroll, N. Patterson, I. Pe’er, A. Price, S. Purcell, D. Richter, Pardis Sabeti, R. Saxena, S. Schaffner, P. Sham, P. Varilly, Lincoln Stein, Lalitha Krishnan, A. Smith, M. Tello-Ruiz, Gudmundur Thorisson, A. Chakravarti, Peter Chen, D. Cutler, C. Kashuk, Shin Lin, G. Abecasis, W. Guan, Yun Li, Heather Munro, Zhaohui Qin, D. Thomas, G. McVean, A. Auton, L. Bottolo, Niall Cardin, S. Eyheramendy, C. Freeman, J. Marchini, S. Myers, C. Spencer, M. Stephens, P. Donnelly, L. Cardon, G. Clarke, David Evans, A. Morris, B. Weir, J. Mullikin, S. Sherry, M. Feolo, Andrew Skol, Houcan Zhang, I. Matsuda, Y. Fukushima, D. Macer, Eiko Suda, C. Rotimi, C. Adebamowo, I. Ajayi, Toyin Aniagwu, P. Marshall, C. Nkwodimmah, C. Royal, M. Leppert, M. Dixon, A. Peiffer, Renzong Qiu, A. Kent, Kazuto Kato, N. Niikawa, I. Adewole, B. Knoppers, Morris Foster, E. Clayton, Jessica Watkin, D. Muzny, L. Nazareth, E. Sodergren, G. Weinstock, I. Yakub, B. Birren, R. Wilson, L. Fulton, J. Rogers, J. Burton, N. Carter, C. Clee, M. Griffiths, Matthew Jones, K. McLay, R. Plumb, M. Ross, S. Sims, D. Willey, Zhu Chen, Hua Han, L. Kang, M. Godbout, J. Wallenburg, P. L'Archevêque, G. Bellemare, Koji Saeki, Hongguang Wang, Daochang An, Hongbo Fu, Qing Li, Zhen Wang, Ren-hao Wang, A. Holden, L. Brooks, J. Mcewen, M. Guyer, V. Wang, Jane Peterson, Michael Shi, J. Spiegel, L. Sung, Lynn Zacharia, F. Collins, Karen Kennedy, Ruth Jamieson, J. Stewart (2007)

    A second generation human haplotype map of over 3.1 million SNPs

    Nature, 449

  • Yihai Cao (2013)

    Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity.

    Cell metabolism, 18 4

  • Richa Saxena, M. Hivert, C. Langenberg, Toshiko Tanaka, J. Pankow, P. Vollenweider, V. Lyssenko, N. Bouatia-Naji, José Dupuis, A. Jackson, W. Kao, Man Li, N. Glazer, Alisa Manning, J. Luan, H. Stringham, I. Prokopenko, T. Johnson, N. Grarup, Trine Boesgaard, C. Lecoeur, Peter Shrader, Jeffrey O'Connell, E. Ingelsson, David Couper, Kenneth Rice, Kijoung Song, Camilla Andreasen, Christian Dina, A. Köttgen, O. Bacquer, F. Pattou, Jalal Taneera, V. Steinthorsdottir, Denis Rybin, Kristin Ardlie, Michael Sampson, Lu Qi, M. Hoek, M. Weedon, Y. Aulchenko, B. Voight, H. Grallert, B. Balkau, R. Bergman, S. Bielinski, A. Bonnefond, L. Bonnycastle, K. Borch-Johnsen, Y. Böttcher, Eric Brunner, Thomas Buchanan, S. Bumpstead, Christine Cavalcanti-Proença, Guillaume Charpentier, Y. Chen, P. Chines, Francis Collins, Marilyn Cornelis, Gabriel Crawford, J.-P. Delplanque, Alex Doney, Josephine Egan, M. Erdos, M. Firmann, N. Forouhi, Caroline Fox, M. Goodarzi, J. Graessler, A. Hingorani, B. Isomaa, Torben Jørgensen, M. Kivimaki, Peter Kovacs, Knut Krohn, M. Kumari, Torsten Lauritzen, C. Lévy‐Marchal, V. Mayor, J. Mcateer, D. Meyre, Braxton Mitchell, K. Mohlke, M. Morken, Narisu Narisu, Colin Palmer, R. Pakyz, L. Pascoe, F. Payne, Daniel Pearson, Wolfgang Rathmann, A. Sandbaek, A. Sayer, Laura Scott, Stephen Sharp, Eric Sijbrands, Andrew Singleton, D. Siscovick, Nicholas Smith, T. Sparsø, A. Swift, H. Syddall, G. Thorleifsson, A. Tönjes, T. Tuomi, J. Tuomilehto, T. Valle, G. Waeber, Andrew Walley, Dawn Waterworth, E. Zeggini, Jinghua Zhao (2010)

    Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

    Nature Genetics, 42

  • H. Nakagami (2013)

    The Mechanism of White and Brown Adipocyte Differentiation

    Diabetes & Metabolism Journal, 37

  • M. Kanehisa, S. Goto, Yoko Sato, Miho Furumichi, M. Tanabe (2011)

    KEGG for integration and interpretation of large-scale molecular data sets

    Nucleic Acids Research, 40

  • C. Fox, Charles White, K. Lohman, N. Heard-Costa, Paul Cohen, Yingying Zhang, Andrew Johnson, V. Emilsson, Ching‐Ti Liu, Y. Chen, K. Taylor, M. Allison, M. Budoff, The Consortium, J. Rotter, J. Carr, U. Hoffmann, Jingzhong Ding, L. Cupples, Yongmei Liu (2012)

    Genome-Wide Association of Pericardial Fat Identifies a Unique Locus for Ectopic Fat

    PLoS Genetics, 8

  • A. Gharavi, K. Kiryluk, Murim Choi, Yifu Li, P. Hou, Jingyuan Xie, S. Sanna-Cherchi, C. Men, B. Julian, R. Wyatt, J. Novak, J. He, Hai-yan Wang, J. Lv, Li Zhu, Weiming Wang, Zhaohui Wang, K. Yasuno, M. Gunel, S. Mane, S. Umlauf, Irina Tikhonova, Isabel Beerman, S. Savoldi, R. Magistroni, G. Ghiggeri, M. Bodria, Francesca Lugani, P. Ravani, C. Ponticelli, L. Allegri, G. Boscutti, G. Frascà, A. Amore, L. Peruzzi, R. Coppo, C. Izzi, B. Viola, E. Prati, M. Salvadori, R. Mignani, L. Gesualdo, F. Bertinetto, P. Mesiano, A. Amoroso, F. Scolari, N. Chen, Hong Zhang, R. Lifton (2011)

    Genome-wide association study identifies susceptibility loci for IgA nephropathy

    Nature Genetics, 43

  • M. Mori, H. Nakagami, Gerardo Rodriguez-Araujo, Keisuke Nimura, Y. Kaneda (2012)

    Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells

    PLoS Biology, 10

  • George Ehret, P. Munroe, Andrew Johnson, D. Chasman, Albert Smith, MartinD. Tobin, G. Verwoert, Vasyl Pihur, N. Amin, J. Bragg-Gresham, A. Teumer, Pankaj, Arora, G. Lucas, Andrew Hicks, A. Jackson, D. Arking, Inga Prokopenko, Paavo, Zitting, Jackie Cooper, S. Humphries, A. Rasheed, S. Bakker, WiekH. van, Gilst, C. Janipalli, K. Mani, B. Oostra, A. Demirkan, Aaron Isaacs, F. Rivadeneira, E. Lakatta, M. Orrù, M. Mangino, T. Spector, G. Zhai, Michael Nalls, Pankaj Sharma, J. Terzić, M. Kranthi, Kumar, M. Denniff, E. Lynne, Wagenknecht, F. Fowkes, Fadi Charchar, Peter Schwarz, C. Hayward, Charles Rotimi, P. Talmud, Fredrik, Nyberg, D. Kuh, M. Laan, K. Hveem, L. Palmer, Y. Schouw, J. Casas, K. Mohlke, Olli Raitakari, E. Tai, Richard Cooper, Markku Laakso, D. Rao, T. Harris, RichardW. Morris, M. Kivimaki, Tetsuro Miki, Xiaofeng Zhu, Olle Melander, P. Ridker, S. Bandinelli, David Altshuler, Ruth Loos, A. Shuldiner, Pierre Meneton, A. Uitterlinden, N. Wareham, David Strachan, Jacqueline, C. Witteman, Anna-Liisa Hartikainen, Jacques Beckmann, Eric, Boerwinkle, Ramachandran Vasan, M. Boehnke, G. Martin, Larson, B. Psaty, Aravinda Chakravarti, Paul Elliott, C. Duijn, C. Newton‐Cheh, Daniel Levy (2011)

    Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk

    Nature, 478

  • HDL, high-density lipoprotein cholesterol; tg, triglycerides

  • L. Almasy, J. Blangero (1998)

    Multipoint quantitative-trait linkage analysis in general pedigrees.

    American journal of human genetics, 62 5

  • A. Pal, T. Barber, M. Bunt, S. Rudge, Qifeng Zhang, K. Lachlan, N. Cooper, Helen Linden, J. Levy, M. Wakelam, L. Walker, F. Karpe, A. Gloyn (2012)

    PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

    The New England journal of medicine, 367 11

  • A. Segrè, L. Groop, V. Mootha, M. Daly, D. Altshuler (2010)

    Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits

    PLoS Genetics, 6

  • IEEE International Symposium on Bio-Informatics and Biomedical Engineering

  • C. Bult, J. Richardson, J. Blake, J. Kadin, M. Ringwald, J. Eppig (2000)

    Mouse genome informatics in a new age of biological inquiry

    Proceedings IEEE International Symposium on Bio-Informatics and Biomedical Engineering

  • George Leahy (1994)

    Methodology for Genetic Studies of Twins and Families

    Journal of Epidemiology and Community Health, 48

  • Z. Dastani, M. Hivert, N. Timpson, J. Perry, Xin Yuan, R. Scott, P. Henneman, I. Heid, J. Kizer, L. Lyytikäinen, C. Fuchsberger, Toshiko Tanaka, Andrew Morris, K. Small, A. Isaacs, M. Beekman, S. Coassin, K. Lohman, L. Qi, S. Kanoni, J. Pankow, H. Uh, Ying Wu, A. Bidulescu, L. Rasmussen-Torvik, C. Greenwood, M. Ladouceur, J. Grimsby, A. Manning, Ching‐Ti Liu, J. Kooner, V. Mooser, P. Vollenweider, K. Kapur, J. Chambers, N. Wareham, C. Langenberg, R. Frants, Ko Willems-vanDijk, B. Oostra, Sara Willems, C. Lamina, T. Winkler, B. Psaty, R. Tracy, Jennifer Brody, I. Chen, J. Viikari, M. Kähönen, P. Pramstaller, David Evans, Beate Pourcain, N. Sattar, A. Wood, S. Bandinelli, O. Carlson, J. Egan, S. Böhringer, D. Heemst, Lyudmyla Kedenko, K. Kristiansson, Marja-Liisa Nuotio, B. Loo, T. Harris, M. Garcia, A. Kanaya, M. Haun, N. Klopp, H. Wichmann, P. Deloukas, E. Katsareli, D. Couper, B. Duncan, M. Kloppenburg, L. Adair, J. Borja, James Wilson, S. Musani, Xiuqing Guo, T. Johnson, R. Semple, Tanya Teslovich, M. Allison, S. Redline, Sarah Buxbaum, K. Mohlke, I. Meulenbelt, C. Ballantyne, G. Dedoussis, F. Hu, Yongmei Liu, B. Paulweber, T. Spector, P. Slagboom, L. Ferrucci, A. Jula, M. Perola, O. Raitakari, J. Florez, V. Salomaa, J. Eriksson, T. Frayling, A. Hicks, T. Lehtimäki, G. Smith, D. Siscovick, F. Kronenberg, C. Duijn, R. Loos, D. Waterworth, J. Meigs, J. Dupuis, J. Richards, B. Voight, L. Scott, V. Steinthorsdottir, C. Dina, R. Welch, E. Zeggini, C. Huth, Y. Aulchenko, G. Thorleifsson, L. McCulloch, T. Ferreira, H. Grallert, N. Amin, Guanming Wu, C. Willer, S. Raychaudhuri, S. Mccarroll, Oliver Hofmann, A. Segrè, M. Hoek, P. Navarro, K. Ardlie, B. Balkau, R. Benediktsson, A. Bennett, R. Blagieva, E. Boerwinkle, L. Bonnycastle, K. Boström, B. Bravenboer, S. Bumpstead, N. Burtt, G. Charpentier, P. Chines, M. Cornelis, Gabriel Crawford, A. Doney, K. Elliott, A. Elliott, M. Erdos, C. Fox, C. Franklin, Martha Ganser, C. Gieger, N. Grarup, Todd Green, S. Griffin, C. Groves, C. Guiducci, S. Hadjadj, N. Hassanali, C. Herder, B. Isomaa, A. Jackson, P. Johnson, T. Jørgensen, W. Kao, A. Kong, P. Kraft, J. Kuusisto, T. Lauritzen, Man Li, A. Lieverse, C. Lindgren, V. Lyssenko, M. Marre, T. Meitinger, K. Midthjell, M. Morken, Narisu Narisu, Peter Nilsson, K. Owen, F. Payne, A. Petersen, Carl Platou, Christine Proença, I. Prokopenko, Wolfgang Rathmann, N. Rayner, N. Robertson, G. Rocheleau, M. Roden, Michael Sampson, R. Saxena, B. Shields, P. Shrader, Gunnar Sigurdsson, T. Sparsø, K. Strassburger, H. Stringham, Qi Sun, A. Swift, B. Thorand, J. Tichet, T. Tuomi, R. Dam, T. Haeften, T. Herpt, Jana Vliet-Ostaptchouk, G. Walters, M. Weedon, C. Wijmenga, J. Witteman, R. Bergman, S. Cauchi, F. Collins, A. Gloyn, U. Gyllensten, T. Hansen, Winston Hide, G. Hitman, A. Hofman, D. Hunter, K. Hveem, M. Laakso, Andrew Morris, C. Palmer, I. Rudan, E. Sijbrands, Lincoln Stein, J. Tuomilehto, A. Uitterlinden, Mark Walker, R. Watanabe, G. Abecasis, B. Boehm, Harry Campbell, M. Daly, A. Hattersley, O. Pedersen, I. Barroso, L. Groop, R. Sladek, U. Thorsteinsdóttir, James Wilson, T. Illig, P. Froguel, C. Duijn, K. Stefánsson, D. Altshuler, M. Boehnke, M. McCarthy, N. Soranzo, E. Wheeler, N. Glazer, N. Bouatia-Naji, R. Mägi, J. Randall, P. Elliott, Denis Rybin, A. Dehghan, J. Hottenga, Kijoung Song, A. Goel, T. Lajunen, A. Doney, Christine Cavalcanti-Proença, M. Kumari, N. Timpson, C. Zabena, E. Ingelsson, P. An, J. O’Connell, J. Luan, A. Elliott, S. Mccarroll, R. Roccasecca, F. Pattou, P. Sethupathy, Y. Ariyurek, P. Barter, J. Beilby, Y. Ben-Shlomo, S. Bergmann, M. Bochud, A. Bonnefond, K. Borch-Johnsen, Y. Böttcher, E. Brunner, S. Bumpstead, Y. Chen, P. Chines, R. Clarke, L. Coin, M. Cooper, L. Crisponi, I. Day, E. Geus, J. Delplanque, A. Fedson, A. Fischer-Rosinský, N. Forouhi, M. Franzosi, P. Galan, M. Goodarzi, J. Graessler, S. Grundy, R. Gwilliam, G. Hallmans, Naomi Hammond, Xijing Han, A. Hartikainen, C. Hayward, S. Heath, S. Hercberg, D. Hillman, A. Hingorani, J. Hui, Joseph Hung, M. Kaakinen, J. Kaprio, Y. Kesaniemi, M. Kivimaki, B. Knight, S. Koskinen, Peter Kovacs, K. Kyvik, G. Lathrop, D. Lawlor, O. Bacquer, C. Lecoeur, Yun Li, R. Mahley, M. Mangino, M. Martínez-Larrad, J. Mcateer, R. McPherson, C. Meisinger, D. Melzer, D. Meyre, B. Mitchell, S. Mukherjee, S. Naitza, M. Neville, M. Orrù, R. Pakyz, G. Paolisso, C. Pattaro, D. Pearson, J. Peden, N. Pedersen, A. Pfeiffer, I. Pichler, O. Polašek, D. Posthuma, Simon Potter, A. Pouta, M. Province, N. Rayner, K. Rice, S. Ripatti, F. Rivadeneira, O. Rolandsson, A. Sandbaek, M. Sandhu, S. Sanna, A. Sayer, P. Scheet, U. Seedorf, S. Sharp, B. Shields, G. Sigurðsson, E. Sijbrands, A. Silveira, Laila Simpson, A. Singleton, N. Smith, U. Sovio, A. Swift, H. Syddall, A. Syvänen, A. Tönjes, A. Uitterlinden, K. Dijk, Dhiraj Varma, S. Visvikis-Siest, V. Vitart, N. Vogelzangs, G. Waeber, Peter Wagner, A. Walley, K. Ward, H. Watkins, S. Wild, G. Willemsen, J. Witteman, J. Yarnell, D. Zélénika, B. Zethelius, G. Zhai, Jinghua Zhao, M. Zillikens, I. Borecki, P. Meneton, P. Magnusson, D. Nathan, Gordon Williams, K. Silander, Stefan Bornstein, Peter Schwarz, J. Spranger, F. Karpe, A. Shuldiner, Chris Cooper, M. Serrano-Ríos, L. Lind, L. Palmer, F. Hu, P. Franks, S. Ebrahim, M. Marmot, W. Kao, P. Pramstaller, A. Wright, M. Stumvoll, A. Hamsten, T. Buchanan, T. Valle, J. Rotter, B. Penninx, D. Boomsma, A. Cao, A. Scuteri, D. Schlessinger, M. Uda, A. Ruokonen, M. Jarvelin, L. Peltonen, V. Mooser, R. Sladek, K. Musunuru, A. Smith, Andrew Edmondson, I. Stylianou, M. Koseki, J. Pirruccello, D. Chasman, C. Johansen, S. Fouchier, G. Peloso, M. Barbalić, S. Ricketts, J. Bis, M. Feitosa, M. Orho-Melander, O. Melander, Xiaohui Li, Mingyao Li, Y. Cho, M. Go, Y. Kim, Jong-Young Lee, T. Park, Kyungeun Kim, X. Sim, R. Ong, Damien Croteau-Chonka, L. Lange, Joshua Smith, Andreas Ziegler, Weihua Zhang, R. Zee, J. Whitfield, J. Thompson, I. Surakka, T. Spector, J. Smit, J. Sinisalo, J. Scott, J. Saharinen, C. Sabatti, L. Rose, Robert Roberts, M. Rieder, A. Parker, G. Paré, Christopher O'Donnell, M. Nieminen, D. Nickerson, G. Montgomery, W. McArdle, D. Masson, N. Martin, F. Marroni, G. Lucas, R. Luben, M. Lokki (2012)

    Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

    PLoS Genetics, 8

  • L. Maynard, W. Wisemandle, A. Roche, W. Chumlea, S. Guo, R. Siervogel (2001)

    Childhood body composition in relation to body mass index.

    Pediatrics, 107 2

  • (2013)

    Accessed 31 Jan 2013];A Catalog of Published Genome-Wide Association Studies. Available at http://www.genome.gov/gwastudies

  • Edinburgh Research Explorer Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women

  • A. Wood, T. Esko, Jian Yang, S. Vedantam, T. Pers, S. Gustafsson, Audrey Chu, K. Estrada, J. Luan, Z. Kutalik, N. Amin, Martin Buchkovich, Damien Croteau-Chonka, F. Day, Y. Duan, T. Fall, R. Fehrmann, T. Ferreira, A. Jackson, J. Karjalainen, K. Lo, A. Locke, R. Mägi, E. Mihailov, E. Porcu, J. Randall, A. Scherag, Anna Vinkhuyzen, H. Westra, T. Winkler, T. Workalemahu, J. Zhao, D. Absher, E. Albrecht, Denise Anderson, J. Baron, M. Beekman, A. Demirkan, G. Ehret, B. Feenstra, M. Feitosa, K. Fischer, Ross Fraser, A. Goel, Jian Gong, A. Justice, S. Kanoni, M. Kleber, K. Kristiansson, U. Lim, Vaneet Lotay, J. Lui, M. Mangino, I. Leach, C. Medina-Gomez, M. Nalls, D. Nyholt, Cameron Palmer, D. Pasko, S. Pechlivanis, I. Prokopenko, J. Ried, S. Ripke, D. Shungin, A. Stančáková, R. Strawbridge, Y. Sung, Toshiko Tanaka, A. Teumer, S. Trompet, S. Laan, J. Setten, Jana Vliet-Ostaptchouk, Zhaoming Wang, L. Yengo, Weihua Zhang, U. Afzal, J. Ärnlöv, Gillian Arscott, S. Bandinelli, Amy Barrett, C. Bellis, A. Bennett, C. Berne, M. Blüher, J. Bolton, Y. Böttcher, H. Boyd, M. Bruinenberg, B. Buckley, S. Buyske, I. Caspersen, P. Chines, R. Clarke, S. Claudi‐boehm, M. Cooper, E. Daw, P. Jong, J. Deelen, G. Delgado, J. Denny, R. Dhonukshe-Rutten, M. Dimitriou, A. Doney, M. Dörr, N. Eklund, Elodie Eury, L. Folkersen, M. Garcia, F. Geller, V. Giedraitis, A. Go, H. Grallert, T. Grammer, J. Grässler, H. Grönberg, L. Groot, C. Groves, J. Haessler, P. Hall, T. Haller, G. Hallmans, A. Hannemann, C. Hartman, M. Hassinen, C. Hayward, N. Heard-Costa, Q. Helmer, G. Hemani, A. Henders, H. Hillege, M. Hlatky, W. Hoffmann, P. Hoffmann, O. Holmen, J. Houwing-Duistermaat, T. Illig, A. Isaacs, A. James, J. Jeff, B. Johansen, Å. Johansson, J. Jolley, Thorhildur Juliusdottir, J. Junttila, A. Kho, L. Kinnunen, N. Klopp, T. Kocher, W. Kratzer, P. Lichtner, L. Lind, J. Lindström, S. Lobbens, M. Lorentzon, Yingchang Lu, V. Lyssenko, P. Magnusson, A. Mahajan, M. Maillard, W. McArdle, C. McKenzie, S. McLachlan, P. McLaren, C. Menni, S. Merger, L. Milani, A. Moayyeri, K. Monda, M. Morken, G. Müller, M. Müller-Nurasyid, A. Musk, Narisu Narisu, M. Nauck, I. Nolte, M. Nöthen, Laticia Oozageer, S. Pilz, N. Rayner, Frida Renstrom, N. Robertson, L. Rose, R. Roussel, S. Sanna, H. Scharnagl, S. Scholtens, F. Schumacher, H. Schunkert, R. Scott, J. Sehmi, T. Seufferlein, Jianxin Shi, K. Silventoinen, J. Smit, A. Smith, Joanna Smolonska, A. Stanton, K. Stirrups, D. Stott, H. Stringham, J. Sundström, M. Swertz, A. Syvänen, B. Tayo, G. Thorleifsson, J. Tyrer, S. Dijk, N. Schoor, N. Velde, D. Heemst, F. Oort, S. Vermeulen, N. Verweij, J. Vonk, L. Waite, M. Waldenberger, R. Wennauer, L. Wilkens, C. Willenborg, T. Wilsgaard, M. Wojczynski, A. Wong, A. Wright, Qunyuan Zhang, D. Arveiler, S. Bakker, J. Beilby, R. Bergman, S. Bergmann, R. Biffar, J. Blangero, D. Boomsma, S. Bornstein, P. Bovet, P. Brambilla, Morris Brown, H. Campbell, M. Caulfield, A. Chakravarti, R. Collins, F. Collins, D. Crawford, L. Cupples, J. Danesh, U. Faire, H. Ruijter, R. Erbel, J. Erdmann, J. Eriksson, M. Farrall, E. Ferrannini, J. Ferrières, I. Ford, N. Forouhi, T. Forrester, R. Gansevoort, P. Gejman, C. Gieger, A. Golay, O. Gottesman, V. Gudnason, U. Gyllensten, D. Haas, A. Hall, T. Harris, A. Hattersley, A. Heath, C. Hengstenberg, A. Hicks, L. Hindorff, A. Hingorani, A. Hofman, G. Hovingh, S. Humphries, S. Hunt, E. Hypponen, K. Jacobs, M. Jarvelin, P. Jousilahti, A. Jula, J. Kaprio, J. Kastelein, M. Kayser, F. Kee, S. Keinanen-Kiukaanniemi, L. Kiemeney, J. Kooner, C. Kooperberg, S. Koskinen, P. Kovacs, A. Kraja, M. Kumari, J. Kuusisto, T. Lakka, C. Langenberg, L. Marchand, T. Lehtimäki, Sara Lupoli, P. Madden, S. Männistö, P. Manunta, A. Marette, T. Matise, B. McKnight, T. Meitinger, F. Moll, G. Montgomery, A. Morris, A. Morris, J. Murray, M. Nelis, C. Ohlsson, A. Oldehinkel, K. Ong, W. Ouwehand, G. Pasterkamp, A. Peters, P. Pramstaller, J. Price, L. Qi, O. Raitakari, T. Rankinen, D. Rao, T. Rice, M. Ritchie, I. Rudan, V. Salomaa, N. Samani, J. Saramies, M. Sarzynski, P. Schwarz, S. Sebert, P. Sever, A. Shuldiner, J. Sinisalo, V. Steinthorsdottir, R. Stolk, J. Tardif, A. Tönjes, A. Tremblay, E. Tremoli, J. Virtamo, M. Vohl, P. Amouyel, F. Asselbergs, T. Assimes, M. Bochud, B. Boehm, E. Boerwinkle, E. Bottinger, C. Bouchard, S. Cauchi, J. Chambers, S. Chanock, R. Cooper, P. Bakker, G. Dedoussis, L. Ferrucci, P. Franks, P. Froguel, L. Groop, C. Haiman, A. Hamsten, M. Hayes, J. Hui, D. Hunter, K. Hveem, J. Jukema, R. Kaplan, M. Kivimaki, D. Kuh, M. Laakso, Yongmei Liu, N. Martin, W. März, M. Melbye, S. Moebus, P. Munroe, I. Njølstad, B. Oostra, C. Palmer, N. Pedersen, M. Perola, L. Pérusse, U. Peters, J. Powell, C. Power, T. Quertermous, R. Rauramaa, E. Reinmaa, P. Ridker, F. Rivadeneira, J. Rotter, T. Saaristo, D. Saleheen, D. Schlessinger, P. Slagboom, H. Snieder, T. Spector, K. Strauch, M. Stumvoll, J. Tuomilehto, M. Uusitupa, P. Harst, H. Völzke, M. Walker, N. Wareham, H. Watkins, H. Wichmann, James Wilson, P. Zanen, P. Deloukas, I. Heid, C. Lindgren, K. Mohlke, Elizabeth Speliotes, U. Thorsteinsdóttir, I. Barroso, C. Fox, K. North, D. Strachan, J. Beckmann, S. Berndt, M. Boehnke, I. Borecki, M. McCarthy, A. Metspalu, K. Stefánsson, A. Uitterlinden, C. Duijn, L. Franke, C. Willer, A. Price, G. Lettre, R. Loos, M. Weedon, E. Ingelsson, J. O’Connell, G. Abecasis, D. Chasman, M. Goddard, P. Visscher, J. Hirschhorn, T. Frayling (2014)

    Defining the role of common variation in the genomic and biological architecture of adult human height

    Nature genetics, 46

  • I. Heid, A. Jackson, J. Randall, T. Winkler, L. Qi, V. Steinthorsdottir, G. Thorleifsson, M. Zillikens, Elizabeth Speliotes, R. Mägi, T. Workalemahu, Charles White, N. Bouatia-Naji, T. Harris, S. Berndt, E. Ingelsson, C. Willer, M. Weedon, J. Luan, S. Vedantam, T. Esko, T. Kilpeläinen, Z. Kutalik, Shengxu Li, K. Monda, A. Dixon, C. Holmes, L. Kaplan, L. Liang, J. Min, M. Moffatt, C. Molony, G. Nicholson, E. Schadt, K. Zondervan, M. Feitosa, T. Ferreira, H. Allen, R. Weyant, E. Wheeler, A. Wood, K. Estrada, M. Goddard, G. Lettre, M. Mangino, D. Nyholt, S. Purcell, A. Smith, P. Visscher, Jian Yang, S. Mccarroll, J. Nemesh, B. Voight, D. Absher, N. Amin, T. Aspelund, L. Coin, N. Glazer, C. Hayward, N. Heard-Costa, J. Hottenga, Å. Johansson, T. Johnson, M. Kaakinen, K. Kapur, Shamika Ketkar, J. Knowles, P. Kraft, A. Kraja, C. Lamina, M. Leitzmann, B. McKnight, A. Morris, K. Ong, J. Perry, M. Peters, O. Polašek, I. Prokopenko, N. Rayner, S. Ripatti, F. Rivadeneira, N. Robertson, S. Sanna, U. Sovio, I. Surakka, A. Teumer, S. Wingerden, V. Vitart, J. Zhao, Christine Cavalcanti-Proença, P. Chines, E. Fisher, Jennifer Kulzer, C. Lecoeur, Narisu Narisu, C. Sandholt, L. Scott, K. Silander, K. Stark, Mari-Liis Tammesoo, Tanya Teslovich, N. Timpson, R. Watanabe, Ryan Welch, D. Chasman, M. Cooper, J. Jansson, J. Kettunen, R. Lawrence, Niina Pellikka, M. Perola, L. Vandenput, Helene Alavere, P. Almgren, L. Atwood, A. Bennett, R. Biffar, L. Bonnycastle, S. Bornstein, T. Buchanan, H. Campbell, I. Day, Mariano Dei, M. Dörr, P. Elliott, M. Erdos, J. Eriksson, N. Freimer, Mao Fu, Stefan Gaget, E. Geus, A. Gjesing, H. Grallert, J. Grässler, C. Groves, C. Guiducci, A. Hartikainen, N. Hassanali, A. Havulinna, K. Herzig, A. Hicks, J. Hui, W. Igl, P. Jousilahti, A. Jula, E. Kajantie, L. Kinnunen, I. Kolčić, S. Koskinen, P. Kovacs, H. Kroemer, V. Krželj, J. Kuusisto, K. Kvaløy, J. Laitinen, O. Lantieri, G. Lathrop, M. Lokki, R. Luben, B. Ludwig, W. McArdle, Anne McCarthy, M. Morken, M. Nelis, M. Neville, G. Paré, A. Parker, J. Peden, I. Pichler, K. Pietiläinen, Carl Platou, A. Pouta, M. Ridderstråle, N. Samani, J. Saramies, J. Sinisalo, J. Smit, R. Strawbridge, H. Stringham, A. Swift, M. Teder-Laving, Brian Thomson, G. Usala, J. Meurs, G. Ommen, V. Vatin, C. Volpato, H. Wallaschofski, G. Walters, E. Widén, S. Wild, G. Willemsen, D. Witte, L. Zgaga, P. Zitting, J. Beilby, A. James, M. Kähönen, T. Lehtimäki, M. Nieminen, C. Ohlsson, L. Palmer, O. Raitakari, P. Ridker, M. Stumvoll, A. Tönjes, J. Viikari, B. Balkau, Y. Ben-Shlomo, R. Bergman, H. Boeing, G. Smith, S. Ebrahim, P. Froguel, T. Hansen, C. Hengstenberg, K. Hveem, B. Isomaa, T. Jørgensen, F. Karpe, K. Khaw, M. Laakso, D. Lawlor, M. Marre, T. Meitinger, A. Metspalu, K. Midthjell, O. Pedersen, V. Salomaa, P. Schwarz, T. Tuomi, J. Tuomilehto, T. Valle, N. Wareham, A. Arnold, J. Beckmann, S. Bergmann, E. Boerwinkle, D. Boomsma, M. Caulfield, F. Collins, G. Eiriksdottir, V. Gudnason, U. Gyllensten, A. Hamsten, A. Hattersley, A. Hofman, F. Hu, T. Illig, C. Iribarren, M. Jarvelin, W. Kao, J. Kaprio, L. Launer, P. Munroe, B. Oostra, B. Penninx, P. Pramstaller, B. Psaty, T. Quertermous, A. Rissanen, I. Rudan, A. Shuldiner, N. Soranzo, T. Spector, A. Syvanen, M. Uda, A. Uitterlinden, H. Völzke, P. Vollenweider, James Wilson, J. Witteman, A. Wright, G. Abecasis, M. Boehnke, I. Borecki, P. Deloukas, T. Frayling, L. Groop, T. Haritunians, D. Hunter, R. Kaplan, K. North, J. O’Connell, L. Peltonen, D. Schlessinger, D. Strachan, J. Hirschhorn, T. Assimes, H. Wichmann, U. Thorsteinsdóttir, C. Duijn, K. Stefánsson, L. Cupples, R. Loos, I. Barroso, M. McCarthy, C. Fox, K. Mohlke, C. Lindgren (2010)

    Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

    Nature Genetics, 42

  • A. Sahu (2016)

    An Integrated Encyclopedia of DNA Elements in the Human Genome

  • Gil Abec, Gil McVean, David Be, David (Co-Chair), Richard (Co-Chair), G. Abecasis, D. Bentley, A. Chakravarti, A. Clark, P. Donnelly, Evan Eichler, Paul Flicek, S. Gabriel, Richard Gibbs, E. Green, M. Hurles, B. Knoppers, J. Korbel, E. Lander, Charles Lee, H. Lehrach, E. Mardis, Gabor Marth, Gil McVean, D. Nickerson, Jeanette Schmidt, S. Sherry, Jun Wang, R. Wilson, Richard Lewi, Richard Lewi, Richard Investigator), H. Dinh, C. Kovar, Sandy Lee, L. Lewis, D. Muzny, Jeff Reid, Min Wang, Jun Jiang, Jun Investigator), X. Fang, Xiaosen Guo, Min Jian, Hui Jiang, Xin Jin, Guoqing Li, Jingxiang Li, Yingrui Li, Zhuo Li, Xiao Liu, Yao Lu, Xuedi Ma, Zheng Su, S. Tai, M. Tang, Bo Wang, Guangbiao Wang, Honglong Wu, Renhua Wu, Ye Yin, Wenwei Zhang, Jiao Zhao, Meiru Zhao, Xiaole Zheng, Yan Zhou, Eric Gabriel, Eric Investigator), D. Altshuler, Stacey (Co-Chair), N. Gupta, Paul Sm, Paul Investigator), Laura Clarke, R. Leinonen, Richard Smith, Xiangqun Zheng-Bradley, David Humphray, David Investigator), R. Grocock, S. Humphray, Terena James, Z. Kingsbury, Hans (Project, Hans Investigator), Ralf Leader), Marcus Albrecht, V. Amstislavskiy, T. Borodina, M. Lienhard, F. Mertes, M. Sultan, B. Timmermann, M. Yaspo, Stephen Investigator), Gil Investigator), Elaine Wils, Elaine (Co-Chair), Richard Investigator), L. Fulton, R. Fulton, G. Weinstock, Richard Bu, Richard Investigator), Senduran Balasubramaniam, J. Burton, P. Danecek, Thomas Keane, Anja Kolb-Kokocinski, Shane McCarthy, J. Stalker, Michael Quail, Jeanette Web, Jeanette Web, Jeanette Investigator), C. Davies, J. Gollub, Teresa Webster, Brant Wong, Yiping Zhan, Adam Investigator), Richard Leader), Fuli Leader), M. Bainbridge, Danny Challis, U. Evani, James Lu, U. Nagaswamy, A. Sabo, Yi Wang, Jin Yu, Jun Li, L. Coin, L. Fang, Qibin Li, Zhenyu Li, Haoxiang Lin, Binghang Liu, Ruibang Luo, Nan Qin, Haojing Shao, Bingqiang Wang, Yinlong Xie, C. Ye, Chang Yu, Fan Zhang, Hancheng Zheng, Hongmei Zhu, Gabor Lee, Gabor Investigator), Erik Garrison, Deniz Kural, Wan-Ping Lee, Wen Leong, Alistair Ward, Jiantao Wu, Mengyao Zhang, Charles S, Charles Investigator), Lauren Griffin, Chih-heng Hsieh, Ryan Mills, Xinghua Shi, Marcin Grotthuss, Chengsheng Zhang, Mark Le, Mark Investigator), Mark Leader), E. Banks, G. Bhatia, Mauricio Carneiro, G. Angel, G. Genovese, R. Handsaker, C. Hartl, S. Mccarroll, J. Nemesh, R. Poplin, S. Schaffner, Khalid Shakir, Seungtai Makarov, Seungtai Investigator), J. Lihm, Vladimir Makarov, Hanjun Kim, Hanjun Investigator), Wook Kim, Ki Kim, Jan Rausch, Jan Investigator), T. Rausch, Paul Cunnin, Kathryn Beal, Fiona Cunningham, Javier Herrero, W. McLaren, G. Ritchie, Andrew Ro, Andrew Investigator), S. Gottipati, A. Keinan, Juan Rodriguez-Flores, Pardis T, Pardis Investigator), S. Grossman, S. Tabrizi, Ridhi Tariyal, David Stenson, David Investigator), E. Ball, P. Stenson, David Keir, B. Barnes, Markus Bauer, R. Cheetham, Tony Cox, M. Eberle, Scott Kahn, L. Murray, J. Peden, Richard Shaw, Kai Investigator), Mark Walker, Mark Investigator), Miriam Konkel, Jerilyn Walker, Daniel Lek, Daniel Investigator), M. Lek, Vyacheslav Herwig, Sudbrak Leader), R. Herwig, Mark Investigator), Carlos V, Carlos Investigator), Jake Byrnes, Francisco Vega, S. Gravel, E. Kenny, J. Kidd, P. Lacroute, B. Maples, A. Moreno-Estrada, Fouad Zakharia, Eran Baran, Eran Investigator), Yael Baran, David Home, David Investigator), Alexis Christoforides, Nils Homer, Tyler Izatt, Ahmet Kurdoglu, Shripad Sinari, Kevin Squire, Stephen Xiao, Chunlin Xiao, Jonathan Ye, Jonathan Investigator), V. Bafna, Kenny Ye, Esteban (Princ, Esteban Investigator), Ryan Investigator), Christopher Gignoux, David Ke, David Investigator), Sol Katzman, W. Kent, Bryan Howie, Andres Investigator), Emmanouil Lappalainen, Emmanouil Investigator), T. Lappalainen, Scott Tallon, Scott Investigator), Xinyue Liu, A. Maroo, L. Tallon, Jeffrey Michelson, Jeffrey Investigator), L. Michelson, Gonçalo K, Gonçalo (Co-Chair), Hyun Leader), Paul Anderson, A. Angius, A. Bigham, T. Blackwell, F. Busonero, F. Cucca, C. Fuchsberger, Chris Jones, G. Jun, Yun Li, R. Lyons, A. Maschio, E. Porcu, F. Reinier, S. Sanna, D. Schlessinger, C. Sidore, Adrian Tan, Mary Trost, Philip Hodgkinson, Philip Investigator), A. Hodgkinson, Gerton (Principal, Gerton Investigator), Gil (Co-Chair), Jonathan Investigator), Simon Investigator), C. Churchhouse, Olivier Delaneau, Anjali Gupta-Hinch, Z. Iqbal, I. Mathieson, A. Rimmer, Dionysia Xifara, Taras Investigator), Yunxin Xiong, Yunxin Investigator), Xiaoming Liu, Momiao Xiong, Lynn Xing, Lynn Investigator), D. Witherspoon, Jinchuan Xing, Evan (Princip, Evan Investigator), Brian Investigator), C. Alkan, Iman Hajirasouliha, F. Hormozdiari, Arthur Ko, Peter Sudmant, Elaine Chinwalla, Elaine Investigator), Ken Chen, A. Chinwalla, L. Ding, D. Dooling, D. Koboldt, M. McLellan, J. Wallis, M. Wendl, Qunyuan Zhang, Richard (Principal, Matthew Investigator), Chris Investigator), C. Albers, Q. Ayub, Yuan Chen, A. Coffey, V. Colonna, N. Huang, L. Jostins, Heng Li, A. Scally, Klaudia Walter, Yali Xue, Yujun Zhang, Mark Balasubra, Mark Investigator), A. Abyzov, S. Balasubramanian, Jieming Chen, Declan Clarke, Yao Fu, L. Habegger, A. Harmanci, Mike Jin, Ekta Khurana, Xinmeng Mu, Cristina Sisu, Yingrui (Co-Chair), Yingrui Zhu, Charles Hs, Charles (Co-Chair), Gabor Lee, Steven Ang, Steven Leader), Jeremiah Degenhardt, Paul Zheng, Jan Rausch, Jan (Co-Chair), A. Stütz, David Chee, David Homer, Deanna Xiao, D. Church, Jonathan Ye, J. Michaelson, Gerton (Principal, David Xing, Evan Alkan, Evan (Co-Chair), Ken Wallis, Matthew Blackbu, Matthew (Co-Chair), Benjamin Blackburne, S. Lindsay, Z. Ning, Mark Clar, Mark Investigator), Richard (Proj, Richard (Proj, Richard (Co-Chair), Xiaosen Wu, Gabor Garrison, Gabor (Co-Chair), Guillermo Poplin, M. DePristo, Andrew Rodriguez-Flores, Carlos Gravel, David Home, Gonçalo Kang, Gonçalo Investigator), Hyun Kang, Elaine Ful, Elaine Investigator), Richard Ke, Mark Balasubramanian, Erik Bainbridge, Richard Yu, F. Yu, Guillermo Handsaker, Paul Cunnin, Carlos Vega, David Kurdoglu, Chris Ch, Chris (Co-Chair), A. Frankish, J. Harrow, Mark Abyzo, Mark (Co-Chair), Richard K, Richard K, G. Fowler, Walker Hale, D. Kalra, Jun Zheng, Paul Clarke, Paul (Co-Chair), Laura Leader), Jonathan Barker, G. Kelman, Eugene Kulesha, Rajesh Radhakrishnan, Asier Roa, Dmitriy Smirnov, Ian Streeter, I. Toneva, Brendan Vaughan, David Kahn, Ralf Lienhard, David Kurdoglu, Stephen Ananiev, Stephen (Co-Chair), Victor Ananiev, Zinaida Belaia, Dimitriy Beloslyudtsev, Nathan Bouk, Chao Chen, Robert Cohen, Charles Cook, John Garner, T. Hefferon, M. Kimelman, Chunlei Liu, John Lopez, Peter Meric, Christa O'Sullivan, Yu. Ostapchuk, Lon Phan, Sergiy Ponomarov, Valerie Schneider, Eugene Shekhtman, K. Sirotkin, D. Slotta, Hua Zhang, Can Ko, Aravinda Abecasi, Aravinda (Co-Chair), Bartha (Co-Chair), G. Abecasis, K. Barnes, C. Beiswanger, E. Burchard, C. Bustamante, Hongyu Cai, H. Cao, R. Durbin, N. Gharani, Richard Gibbs, B. Henn, Danielle Jones, L. Jorde, J. Kaye, A. Kent (2012)

    An integrated map of genetic variation from 1,092 human genomes

    Nature, 491

  • J. Higgins, S. Thompson (2002)

    Quantifying heterogeneity in a meta‐analysis

    Statistics in Medicine, 21

  • M. Kanehisa, S. Goto (2000)

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    Nucleic acids research, 28 1

  • I. Shimizu, Y. Yoshida, J. Moriya, Aika Nojima, Akiyoshi Uemura, Yoshio Kobayashi, T. Minamino (2013)

    Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity.

    Cell metabolism, 18 4

  • T. Winkler, F. Day, Damien Croteau-Chonka, A. Wood, A. Locke, R. Mägi, T. Ferreira, T. Fall, M. Graff, A. Justice, J. Luan, S. Gustafsson, J. Randall, S. Vedantam, T. Workalemahu, T. Kilpeläinen, A. Scherag, T. Esko, Z. Kutalik, I. Heid, R. Loos (2014)

    Quality control and conduct of genome-wide association meta-analyses

    Nature Protocols, 9

  • S. Sawcer, G. Hellenthal, M. Pirinen, C. Spencer, N. Patsopoulos, L. Moutsianas, A. Dilthey, Z. Su, C. Freeman, S. Hunt, S. Edkins, Emma Gray, D. Booth, Simon Potter, A. Goris, G. Band, A. Oturai, A. Strange, J. Saarela, C. Bellenguez, B. Fontaine, M. Gillman, B. Hemmer, R. Gwilliam, F. Zipp, Alagurevathi Jayakumar, Roland Martin, S. Leslie, S. Hawkins, E. Giannoulatou, S. D'alfonso, H. Blackburn, F. Boneschi, J. Liddle, H. Harbo, M. Pérez, A. Spurkland, M. Waller, M. Mycko, M. Ricketts, M. Comabella, Naomi Hammond, I. Kockum, O. McCann, M. Ban, P. Whittaker, A. Kemppinen, P. Weston, C. Hawkins, S. Widaa, J. Zajicek, S. Dronov, N. Robertson, S. Bumpstead, L. Barcellos, R. Ravindrarajah, R. Abraham, L. Alfredsson, K. Ardlie, C. Aubin, A. Baker, K. Baker, S. Baranzini, L. Bergamaschi, R. Bergamaschi, A. Bernstein, A. Berthele, M. Boggild, J. Bradfield, D. Brassat, S. Broadley, D. Buck, H. Butzkueven, R. Capra, W. Carroll, P. Cavalla, E. Celius, S. Cepok, R. Chiavacci, F. Clerget-Darpoux, Katleen Clysters, G. Comi, M. Cossburn, I. Cournu-Rebeix, Mathew Cox, W. Cozen, B. Cree, A. Cross, D. Cusi, M. Daly, Emma Davis, P. Bakker, M. Debouverie, M. D'hooghe, K. Dixon, R. Dobosi, B. Dubois, D. Ellinghaus, I. Elovaara, F. Esposito, Claire Fontenille, S. Foote, A. Franke, D. Galimberti, A. Ghezzi, J. Glessner, R. Gomez, O. Gout, C. Graham, S. Grant, F. Guerini, H. Hakonarson, P. Hall, A. Hamsten, H. Hartung, R. Heard, S. Heath, J. Hobart, M. Hoshi, C. Infante-Duarte, G. Ingram, Wendy Ingram, T. Islam, M. Jagodic, M. Kabesch, A. Kermode, T. Kilpatrick, Cecilia Kim, N. Klopp, K. Koivisto, M. Larsson, M. Lathrop, J. Lechner-Scott, M. Leone, V. Leppä, U. Liljedahl, I. Bomfim, R. Lincoln, J. Link, Jianjun Liu, Å. Lorentzen, Sara Lupoli, F. Macciardi, T. Mack, M. Marriott, V. Martinelli, D. Mason, J. McCauley, F. Mentch, Inger‐Lise Mero, T. Mihalova, X. Montalban, J. Mottershead, K. Myhr, P. Naldi, W. Ollier, Alison Page, A. Palotie, J. Pelletier, L. Piccio, T. Pickersgill, F. Piehl, Susan Pobywajlo, H. Quach, P. Ramsay, M. Reunanen, R. Reynolds, J. Rioux, M. Rodegher, S. Roesner, J. Rubio, I. Rückert, M. Salvetti, E. Salvi, A. Santaniello, C. Schaefer, S. Schreiber, C. Schulze, R. Scott, F. Sellebjerg, K. Selmaj, D. Sexton, L. Shen, Brigid Simms-Acuna, S. Skidmore, P. Sleiman, C. Smestad, P. Sørensen, H. Søndergaard, J. Stankovich, R. Strange, A. Sulonen, E. Sundqvist, A. Syvänen, F. Taddeo, B. Taylor, J. Blackwell, P. Tienari, E. Bramon, A. Tourbah, M. Brown, E. Tronczyńska, J. Casas, N. Tubridy, A. Corvin, J. Vickery, Janusz Jankowski, P. Villoslada, H. Markus, Kai Wang, C. Mathew, J. Wason, C. Palmer, H. Wichmann, R. Plomin, E. Willoughby, A. Rautanen, J. Winkelmann, M. Wittig, R. Trembath, J. Yaouanq, A. Viswanathan, Haitao Zhang, N. Wood, R. Zuvich, P. Deloukas, C. Langford, A. Duncanson, J. Oksenberg, M. Pericak-Vance, J. Haines, T. Olsson, J. Hillert, A. Ivinson, P. Jager, L. Peltonen, G. Stewart, D. Hafler, S. Hauser, G. McVean, P. Donnelly, Alastair Compston (2011)

    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

    Nature, 476

  • M. Ashburner, C. Ball, J. Blake, D. Botstein, Heather Butler, J. Cherry, A. Davis, K. Dolinski, S. Dwight, J. Eppig, M. Harris, D. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. Matese, J. Richardson, M. Ringwald, G. Rubin (2000)

    Gene Ontology: tool for the unification of biology

    Nature Genetics, 25

  • Y. Okada, Y. Kamatani, A. Takahashi, K. Matsuda, N. Hosono, Hiroko Ohmiya, Y. Daigo, Kazuhiko Yamamoto, M. Kubo, Yusuke Nakamura, N. Kamatani (2010)

    A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.

    Human molecular genetics, 19 11

  • Mouse Genome Database Group

  • Xinqiang Huang, Chaofeng Yang, Yongde Luo, C. Jin, Fen Wang, W. Mckeehan (2007)

    FGFR4 Prevents Hyperlipidemia and Insulin Resistance but Underlies High-Fat Diet–Induced Fatty Liver

    Diabetes, 56

  • M Ashburner (2000)

    Gene ontology: tool for the unification of biology. The Gene Ontology Consortium

    Nature Genet., 25

  • Toshihiro Tanaka (2003)

    The International HapMap Project

    Nature, 426

  • A. Locke, Bratati Kahali, S. Berndt, A. Justice, T. Pers, F. Day, Corey Powell, S. Vedantam, Martin Buchkovich, Jian Yang, Damien Croteau-Chonka, T. Esko, T. Fall, T. Ferreira, S. Gustafsson, Z. Kutalik, J. Luan, R. Mägi, J. Randall, T. Winkler, A. Wood, T. Workalemahu, J. Faul, Jennifer Smith, J. Zhao, Wei Zhao, Jin Chen, R. Fehrmann, Å. Hedman, J. Karjalainen, Ellen Schmidt, D. Absher, N. Amin, Denise Anderson, M. Beekman, J. Bolton, J. Bragg-Gresham, S. Buyske, A. Demirkan, Guohong Deng, G. Ehret, B. Feenstra, M. Feitosa, K. Fischer, A. Goel, Jian Gong, A. Jackson, S. Kanoni, M. Kleber, K. Kristiansson, U. Lim, Vaneet Lotay, M. Mangino, I. Leach, C. Medina-Gomez, S. Medland, M. Nalls, Cameron Palmer, D. Pasko, S. Pechlivanis, M. Peters, I. Prokopenko, D. Shungin, A. Stančáková, R. Strawbridge, Y. Sung, Toshiko Tanaka, A. Teumer, S. Trompet, S. Laan, J. Setten, J. Vliet-Ostaptchouk, Zhaoming Wang, L. Yengo, Weihua Zhang, A. Isaacs, E. Albrecht, J. Ärnlöv, Gillian Arscott, A. Attwood, S. Bandinelli, Amy Barrett, Isabelita Bas, C. Bellis, A. Bennett, C. Berne, R. Blagieva, M. Blüher, S. Böhringer, L. Bonnycastle, Y. Böttcher, H. Boyd, M. Bruinenberg, I. Caspersen, Y. Chen, R. Clarke, E. Daw, A. Craen, G. Delgado, M. Dimitriou, A. Doney, N. Eklund, K. Estrada, Elodie Eury, L. Folkersen, Ross Fraser, M. Garcia, F. Geller, V. Giedraitis, B. Gigante, A. Go, A. Golay, A. Goodall, S. Gordon, Mathias Gorski, H. Grabe, H. Grallert, T. Grammer, J. Grässler, H. Grönberg, C. Groves, G. Gusto, J. Haessler, P. Hall, T. Haller, G. Hallmans, C. Hartman, M. Hassinen, C. Hayward, N. Heard-Costa, Q. Helmer, C. Hengstenberg, O. Holmen, J. Hottenga, A. James, J. Jeff, Å. Johansson, J. Jolley, Thorhildur Juliusdottir, L. Kinnunen, W. Koenig, M. Koskenvuo, W. Kratzer, J. Laitinen, C. Lamina, K. Leander, N. Lee, P. Lichtner, L. Lind, J. Lindström, K. Lo, S. Lobbens, R. Lorbeer, Yingchang Lu, F. Mach, P. Magnusson, A. Mahajan, W. McArdle, S. McLachlan, C. Menni, S. Merger, E. Mihailov, L. Milani, A. Moayyeri, K. Monda, M. Morken, A. Mulas, G. Müller, M. Müller-Nurasyid, A. Musk, R. Nagaraja, M. Nöthen, I. Nolte, S. Pilz, N. Rayner, Frida Renstrom, R. Rettig, J. Ried, S. Ripke, N. Robertson, L. Rose, S. Sanna, H. Scharnagl, S. Scholtens, F. Schumacher, W. Scott, T. Seufferlein, Jianxin Shi, A. Smith, Joanna Smolonska, A. Stanton, V. Steinthorsdottir, K. Stirrups, H. Stringham, J. Sundström, M. Swertz, A. Swift, A. Syvänen, S. Tan, B. Tayo, B. Thorand, G. Thorleifsson, J. Tyrer, H. Uh, L. Vandenput, F. Verhulst, S. Vermeulen, N. Verweij, J. Vonk, L. Waite, H. Warren, D. Waterworth, M. Weedon, L. Wilkens, C. Willenborg, T. Wilsgaard, M. Wojczynski, A. Wong, A. Wright, Qunyuan Zhang, E. Brennan, Murim Choi, Z. Dastani, A. Drong, P. Eriksson, A. Franco-Cereceda, J. Gådin, A. Gharavi, M. Goddard, R. Handsaker, Jinyan Huang, F. Karpe, S. Kathiresan, S. Keildson, K. Kiryluk, M. Kubo, Jong-Young Lee, L. Liang, R. Lifton, Baoshan Ma, S. Mccarroll, A. McKnight, J. Min, M. Moffatt, G. Montgomery, J. Murabito, G. Nicholson, D. Nyholt, Y. Okada, J. Perry, R. Dorajoo, E. Reinmaa, R. Salem, N. Sandholm, R. Scott, L. Stolk, A. Takahashi, Toshihiro Tanaka, F. Hooft, Anna Vinkhuyzen, H. Westra, W. Zheng, K. Zondervan, A. Heath, D. Arveiler, S. Bakker, J. Beilby, R. Bergman, J. Blangero, P. Bovet, H. Campbell, M. Caulfield, G. Cesana, A. Chakravarti, D. Chasman, P. Chines, F. Collins, D. Crawford, L. Cupples, D. Cusi, J. Danesh, U. Faire, H. Ruijter, A. Dominiczak, R. Erbel, J. Erdmann, J. Eriksson, M. Farrall, S. Felix, E. Ferrannini, J. Ferrières, I. Ford, N. Forouhi, T. Forrester, O. Franco, R. Gansevoort, P. Gejman, C. Gieger, O. Gottesman, V. Gudnason, U. Gyllensten, A. Hall, T. Harris, A. Hattersley, A. Hicks, L. Hindorff, A. Hingorani, A. Hofman, G. Homuth, G. Hovingh, S. Humphries, S. Hunt, E. Hyppönen, T. Illig, K. Jacobs, M. Jarvelin, K. Jöckel, B. Johansen, P. Jousilahti, J. Jukema, A. Jula, J. Kaprio, J. Kastelein, S. Keinanen-Kiukaanniemi, L. Kiemeney, P. Knekt, J. Kooner, C. Kooperberg, P. Kovacs, A. Kraja, M. Kumari, J. Kuusisto, T. Lakka, C. Langenberg, L. Marchand, T. Lehtimäki, V. Lyssenko, S. Männistö, A. Marette, T. Matise, C. McKenzie, B. McKnight, F. Moll, A. Morris, A. Morris, J. Murray, M. Nelis, C. Ohlsson, A. Oldehinkel, K. Ong, P. Madden, G. Pasterkamp, J. Peden, A. Peters, D. Postma, P. Pramstaller, J. Price, L. Qi, O. Raitakari, T. Rankinen, D. Rao, T. Rice, P. Ridker, J. Rioux, M. Ritchie, I. Rudan, V. Salomaa, N. Samani, J. Saramies, M. Sarzynski, H. Schunkert, P. Schwarz, P. Sever, A. Shuldiner, J. Sinisalo, R. Stolk, K. Strauch, A. Tönjes, D. Trégouët, A. Tremblay, E. Tremoli, J. Virtamo, M. Vohl, U. Völker, G. Waeber, G. Willemsen, J. Witteman, M. Zillikens, L. Adair, P. Amouyel, F. Asselbergs, T. Assimes, M. Bochud, B. Boehm, E. Boerwinkle, S. Bornstein, E. Bottinger, C. Bouchard, S. Cauchi, J. Chambers, S. Chanock, R. Cooper, P. Bakker, G. Dedoussis, L. Ferrucci, P. Franks, P. Froguel, L. Groop, C. Haiman, A. Hamsten, J. Hui, D. Hunter, K. Hveem, R. Kaplan, M. Kivimaki, D. Kuh, M. Laakso, Yongmei Liu, N. Martin, W. März, M. Melbye, A. Metspalu, S. Moebus, P. Munroe, I. Njølstad, B. Oostra, C. Palmer, N. Pedersen, M. Perola, L. Pérusse, U. Peters, C. Power, T. Quertermous, R. Rauramaa, F. Rivadeneira, T. Saaristo, D. Saleheen, N. Sattar, E. Schadt, D. Schlessinger, P. Slagboom, H. Snieder, T. Spector, U. Thorsteinsdóttir, M. Stumvoll, J. Tuomilehto, A. Uitterlinden, M. Uusitupa, P. Harst, M. Walker, H. Wallaschofski, N. Wareham, H. Watkins, D. Weir, H. Wichmann, James Wilson, P. Zanen, I. Borecki, P. Deloukas, C. Fox, I. Heid, J. O’Connell, D. Strachan, K. Stefánsson, C. Duijn, G. Abecasis, L. Franke, T. Frayling, M. McCarthy, P. Visscher, A. Scherag, C. Willer, M. Boehnke, K. Mohlke, C. Lindgren, J. Beckmann, I. Barroso, K. North, E. Ingelsson, J. Hirschhorn, R. Loos, Elizabeth Speliotes (2015)

    Genetic studies of body mass index yield new insights for obesity biology

    Nature, 518

  • S. Yusuf, S. Hawken, S. Ôunpuu, L. Bautista, M. Franzosi, P. Commerford, C. Lang, Z. Rumboldt, C. Onen, Li-sheng Liu, S. Tanomsup, P. Wangai, F. Razak, Arya Sharma, S. Anand (2005)

    Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case-control study

    The Lancet, 366

  • L. Hindorff, P. Sethupathy, Heather Junkins, E. Ramos, Jayashri Mehta, F. Collins, T. Manolio (2009)

    Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

    Proceedings of the National Academy of Sciences, 106

  • T. Pischon, H. Boeing, K. Hoffmann, M. Bergmann, M. Schulze, K. Overvad, Y. Schouw, E. Spencer, K. Moons, A. Tjønneland, J. Halkjær, M. Jensen, J. Stegger, F. Clavel-Chapelon, M. Boutron‐Ruault, V. Chajès, J. Linseisen, R. Kaaks, A. Trichopoulou, D. Trichopoulos, C. Bamia, S. Sieri, D. Palli, R. Tumino, P. Vineis, S. Panico, P. Peeters, A. May, H. Bueno-de-Mesquita, F. Duijnhoven, G. Hallmans, L. Weinehall, J. Manjer, B. Hedblad, E. Lund, A. Agudo, L. Arrióla, A. Barricarte, C. Navarro, Carlos Martinez, J. Quirós, T. Key, S. Bingham, K. Khaw, P. Boffetta, M. Jenab, P. Ferrari, E. Riboli (2008)

    General and abdominal adiposity and risk of death in Europe.

    The New England journal of medicine, 359 20

  • G. Goossens, E. Blaak, R. Theunissen, A. Duijvestijn, K. Clément, J. Tervaert, M. Thewissen (2012)

    Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans.

    Molecular immunology, 50 3

  • G. Abecasis, D. Altshuler, A. Auton, L. Brooks, R. Durbin, R. Gibbs, M. Hurles, G. McVean (2010)

    A map of human genome variation from population-scale sequencing

    Nature, 467

  • J. Wakefield (2007)

    A Bayesian measure of the probability of false discovery in genetic epidemiology studies.

    American journal of human genetics, 81 2

  • J. Maller, G. McVean, Jake Byrnes, Damjan Vukcevic, Kimmo Palin, Z. Su, J. Howson, A. Auton, S. Myers, A. Morris, M. Pirinen, M. Brown, P. Burton, M. Caulfield, Alastair Compston, M. Farrall, A. Hall, A. Hattersley, A. Hill, C. Mathew, M. Pembrey, J. Satsangi, M. Stratton, Jane Worthington, N. Craddock, M. Hurles, W. Ouwehand, M. Parkes, N. Rahman, A. Duncanson, J. Todd, D. Kwiatkowski, N. Samani, S. Gough, M. McCarthy, P. Deloukas, P. Donnelly (2012)

    Bayesian refinement of association signals for 14 loci in 3 common diseases

    Nature Genetics, 44

  • C. Mason, C. Craig, P. Katzmarzyk (2008)

    Influence of Central and Extremity Circumferences on All‐cause Mortality in Men and Women

    Obesity, 16

  • J. Wells (2007)

    Sexual dimorphism of body composition.

    Best practice & research. Clinical endocrinology & metabolism, 21 3

  • P. Deloukas, S. Kanoni, C. Willenborg, M. Farrall, T. Assimes, J. Thompson, E. Ingelsson, D. Saleheen, D. Saleheen, J. Erdmann, B. Goldstein, K. Stirrups, I. König, J. Cazier, Å. Johansson, A. Hall, Jong-Young Lee, C. Willer, J. Chambers, T. Esko, L. Folkersen, A. Goel, E. Grundberg, A. Havulinna, W. Ho, J. Hopewell, N. Eriksson, M. Kleber, K. Kristiansson, P. Lundmark, L. Lyytikäinen, S. Rafelt, D. Shungin, D. Shungin, R. Strawbridge, G. Thorleifsson, E. Tikkanen, E. Tikkanen, N. Zuydam, B. Voight, L. Waite, Weihua Zhang, A. Ziegler, D. Absher, D. Altshuler, D. Altshuler, A. Balmforth, I. Barroso, I. Barroso, P. Braund, P. Braund, C. Burgdorf, S. Claudi‐boehm, David Cox, M. Dimitriou, R. Do, R. Do, A. Doney, N. Mokhtari, P. Eriksson, K. Fischer, P. Fontanillas, A. Franco-Cereceda, B. Gigante, L. Groop, S. Gustafsson, J. Hager, G. Hallmans, B. Han, S. Hunt, H. Kang, T. Illig, T. Kessler, J. Knowles, G. Kolovou, J. Kuusisto, C. Langenberg, C. Langford, K. Leander, M. Lokki, Anders Lundmark, M. McCarthy, C. Meisinger, O. Melander, E. Mihailov, Seraya Maouche, A. Morris, M. Müller-Nurasyid, K. Nikus, J. Peden, N. Rayner, A. Rasheed, S. Rosinger, Diana Rubin, M. Rumpf, Arne Schäfer, M. Sivananthan, Ci Song, A. Stewart, S. Tan, G. Thorgeirsson, C. Schoot, Peter Wagner, Peter Wagner, G. Wells, P. Wild, Tsun-Po Yang, P. Amouyel, D. Arveiler, H. Basart, M. Boehnke, E. Boerwinkle, P. Brambilla, F. Cambien, A. Cupples, A. Cupples, U. Faire, A. Dehghan, P. Diemert, S. Epstein, A. Evans, M. Ferrario, J. Ferrières, D. Gauguier, D. Gauguier, A. Go, A. Goodall, A. Goodall, V. Gudnason, S. Hazen, H. Hólm, C. Iribarren, Y. Jang, M. Kähönen, F. Kee, Hyo‐Soo Kim, N. Klopp, W. Koenig, W. Kratzer, K. Kuulasmaa, M. Laakso, R. Laaksonen, Jiyoung Lee, L. Lind, W. Ouwehand, W. Ouwehand, W. Ouwehand, S. Parish, J-E Park, N. Pedersen, A. Peters, T. Quertermous, D. Rader, V. Salomaa, E. Schadt, Svati Shah, J. Sinisalo, K. Stark, K. Stefánsson, K. Stefánsson, D. Trégouët, J. Virtamo, L. Wallentin, N. Wareham, M. Zimmermann, M. Nieminen, C. Hengstenberg, M. Sandhu, M. Sandhu, T. Pastinen, A. Syvänen, G. Hovingh, G. Dedoussis, P. Franks, P. Franks, P. Franks, T. Lehtimäki, A. Metspalu, P. Zalloua, A. Siegbahn, S. Schreiber, S. Ripatti, S. Ripatti, S. Blankenberg, M. Perola, R. Clarke, B. Boehm, C. O’Donnell, M. Reilly, Winfried März, Winfried März, R. Collins, S. Kathiresan, S. Kathiresan, A. Hamsten, J. Kooner, U. Thorsteinsdóttir, U. Thorsteinsdóttir, J. Danesh, C. Palmer, R. Roberts, H. Watkins, H. Schunkert, N. Samani, N. Samani (2012)

    Large-scale association analysis identifies new risk loci for coronary artery disease

    Nature Genetics, 45

  • Samantha Hoopes, H. Willcockson, K. Caron (2012)

    Characteristics of Multi-Organ Lymphangiectasia Resulting from Temporal Deletion of Calcitonin Receptor-Like Receptor in Adult Mice

    PLoS ONE, 7

  • K. Jääger, T. Neuman (2011)

    Human dermal fibroblasts exhibit delayed adipogenic differentiation compared with mesenchymal stem cells.

    Stem cells and development, 20 8

  • Jian Yang, Beben Benyamin, Brian McEvoy, S. Gordon, A. Henders, D. Nyholt, P. Madden, A. Heath, N. Martin, G. Montgomery, M. Goddard, P. Visscher (2010)

    Common SNPs explain a large proportion of the heritability for human height

    Nature Genetics, 42

Publisher
Springer Journals
Copyright
Copyright © 2015 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/nature14132
Publisher site
See Article on Publisher Site

Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Journal

Nature – Springer Journals

Published: Feb 11, 2015

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