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Initiation of synchronized neuronal bursting in neocortex

Initiation of synchronized neuronal bursting in neocortex Epilepsy is characterized by highly synchronized paroxysmal bursts of activity within a large population of cortical neurones1,2. Because such spontaneous, synchronized discharges can occur even in isolated blocks of neocortex3, mechanisms for initiating and coordinating this activity must reside within the cortex itself. However, the specific cellular properties and local neural circuitry responsible for such behaviour are unknown. In a previous study of neocortex in vitro, we found that treatment with the convulsants penicillin and bicuculline led to synchronized bursts which were driven by unusually large and long-lasting excitatory synaptic conductances4. I now report evidence that synchronized bursts are initiated by a small, spacially discrete subpopulation of cells located in the area comprising layer IV and upper layer V. Neural elements in these layers appear to project paroxysmal synaptic excitation radially, onto the neurones of other layers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Initiation of synchronized neuronal bursting in neocortex

Connors, Barry W.
Nature , Volume 310 (5979) – Aug 23, 1984
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References (17)

Publisher
Springer Journals
Copyright
Copyright © 1984 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/310685a0
Publisher site
See Article on Publisher Site

Abstract

Epilepsy is characterized by highly synchronized paroxysmal bursts of activity within a large population of cortical neurones1,2. Because such spontaneous, synchronized discharges can occur even in isolated blocks of neocortex3, mechanisms for initiating and coordinating this activity must reside within the cortex itself. However, the specific cellular properties and local neural circuitry responsible for such behaviour are unknown. In a previous study of neocortex in vitro, we found that treatment with the convulsants penicillin and bicuculline led to synchronized bursts which were driven by unusually large and long-lasting excitatory synaptic conductances4. I now report evidence that synchronized bursts are initiated by a small, spacially discrete subpopulation of cells located in the area comprising layer IV and upper layer V. Neural elements in these layers appear to project paroxysmal synaptic excitation radially, onto the neurones of other layers.

Journal

Nature – Springer Journals

Published: Aug 23, 1984

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