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Gastrointestinal stromal tumors

Gastrointestinal stromal tumors tumors are a completely separate group from leiomyoma, Background: We reviewed radiologic features of gastro- leiomyosarcoma, or schwannoma. At present, GISTs are intestinal stromal tumors (GISTs) and correlated them defined as cellular spindle cell, epithelioid, or, occasion- with clinical and pathologic findings. ally, pleomorphic mesenchymal tumors of the GI tract Methods: We investigated a series of 39 c-Kit–positive that express the Kit (CD117, stem cell factor receptor) GISTs. Clinical and radiologic findings and management protein [1]. Most GISTs harbor mutations in the c-Kit of these patients were recorded. protooncogene that resulted in a gain of function of the Results: Twenty women and 19 men (mean age 64 years) enzymatic activity of the Kit tyrosine kinase [2]. had histologically proved GIST. Tumor locations were GISTs can appear in any segment of the GI tract or in the small bowel (n = 20), stomach (n = 14), rectum the mesentery or omentum nearby. They can present as (n = 4), and omentum (n = l). Symptoms at presenta- small, incidentally found nodules or as larger aggressive tion were most frequently gastrointestinal bleeding sarcomas. However, GISTs detected in the stomach and (n = 14) and abdominal pain (n = l1). Tumors were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Abdominal Radiology Springer Journals

Gastrointestinal stromal tumors

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References (28)

Publisher
Springer Journals
Copyright
Copyright © 2006 by Springer Science+Business Media, Inc.
Subject
Medicine & Public Health; Imaging / Radiology; Gastroenterology; Hepatology
ISSN
2366-004X
eISSN
1432-0509
DOI
10.1007/s00261-004-0092-8
pmid
16465584
Publisher site
See Article on Publisher Site

Abstract

tumors are a completely separate group from leiomyoma, Background: We reviewed radiologic features of gastro- leiomyosarcoma, or schwannoma. At present, GISTs are intestinal stromal tumors (GISTs) and correlated them defined as cellular spindle cell, epithelioid, or, occasion- with clinical and pathologic findings. ally, pleomorphic mesenchymal tumors of the GI tract Methods: We investigated a series of 39 c-Kit–positive that express the Kit (CD117, stem cell factor receptor) GISTs. Clinical and radiologic findings and management protein [1]. Most GISTs harbor mutations in the c-Kit of these patients were recorded. protooncogene that resulted in a gain of function of the Results: Twenty women and 19 men (mean age 64 years) enzymatic activity of the Kit tyrosine kinase [2]. had histologically proved GIST. Tumor locations were GISTs can appear in any segment of the GI tract or in the small bowel (n = 20), stomach (n = 14), rectum the mesentery or omentum nearby. They can present as (n = 4), and omentum (n = l). Symptoms at presenta- small, incidentally found nodules or as larger aggressive tion were most frequently gastrointestinal bleeding sarcomas. However, GISTs detected in the stomach and (n = 14) and abdominal pain (n = l1). Tumors were

Journal

Abdominal Radiology – Springer Journals

Published: Feb 7, 2006

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