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pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16<i><sup>INK4a</sup></i> tumor suppressor gene

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes... Downloaded from genesdev.cshlp.org on November 1, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION INK4b INK4c INK4d p15 , p18 , and p19 ) retains pRB family pRB family proteins are proteins in their hypophosphorylated, growth-suppres- sive states and prevents G1-to-S progression. Disruption required for H3K27 of the INK4–RB pathway, consisting of INK4–cyclinDs– trimethylation and Polycomb CDK4/6–RB–E2Fs, deregulates G1-to-S control and rep- resents a common event in the development of most, if repression complexes binding not all, types of cancer (Sherr 1996). INK4a to and silencing p16 Among the major challenges toward a better under- standing of G1 control by the INK4–pRB pathway is how tumor suppressor gene different INK4 genes are regulated, thereby linking G1 control to different cellular pathways. INK4 proteins are 1 1,2 3 Yojiro Kotake, Ru Cao, Patrick Viatour, relatively stable, and the primary regulation of INK4 is 3 1,2 1,4 Julien Sage, Yi Zhang, and Yue Xiong through transcriptional control. The expression of each of the INK4 genes is distinctly different during develop- Department of Biochemistry and Biophysics, Lineberger ment, in different adult tissues, and in response to dif- Comprehensive Cancer Center, Program in Molecular Biology ferent cellular conditions (Roussel 1999). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16<i><sup>INK4a</sup></i> tumor suppressor gene

Kotake, Yojiro; Cao, Ru; Viatour, Patrick; Sage, Julien; Zhang, Yi; Xiong, Yue
Genes & Development – Jan 1, 2007
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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1499407
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Abstract

Downloaded from genesdev.cshlp.org on November 1, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION INK4b INK4c INK4d p15 , p18 , and p19 ) retains pRB family pRB family proteins are proteins in their hypophosphorylated, growth-suppres- sive states and prevents G1-to-S progression. Disruption required for H3K27 of the INK4–RB pathway, consisting of INK4–cyclinDs– trimethylation and Polycomb CDK4/6–RB–E2Fs, deregulates G1-to-S control and rep- resents a common event in the development of most, if repression complexes binding not all, types of cancer (Sherr 1996). INK4a to and silencing p16 Among the major challenges toward a better under- standing of G1 control by the INK4–pRB pathway is how tumor suppressor gene different INK4 genes are regulated, thereby linking G1 control to different cellular pathways. INK4 proteins are 1 1,2 3 Yojiro Kotake, Ru Cao, Patrick Viatour, relatively stable, and the primary regulation of INK4 is 3 1,2 1,4 Julien Sage, Yi Zhang, and Yue Xiong through transcriptional control. The expression of each of the INK4 genes is distinctly different during develop- Department of Biochemistry and Biophysics, Lineberger ment, in different adult tissues, and in response to dif- Comprehensive Cancer Center, Program in Molecular Biology ferent cellular conditions (Roussel 1999).

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Genes & Development – Unpaywall

Published: Jan 1, 2007

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