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In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent

In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic... In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent René M. Botnar, PhD; Alexandra S. Perez, BS; Sonia Witte, PhD; Andrea J. Wiethoff, PhD; James Laredo, MD, PhD; James Hamilton, PhD; William Quist, MD†; Edward C. Parsons, Jr, PhD; Anand Vaidya, BS; Andrew Kolodziej, PhD; John A. Barrett, PhD; Philip B. Graham, PhD; Robert M. Weisskoff, PhD; Warren J. Manning, MD; Michael T. Johnstone, MD Background—Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus visualization may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of direct imaging of acute and subacute thrombosis using MRI together with a novel fibrin-binding gadolinium-labeled peptide, EP-1873, in an experimental animal model of plaque rupture and thrombosis. Methods and Results—Fifteen male New Zealand White rabbits (weight, 3.5 kg) were made atherosclerotic by feeding a high-cholesterol diet after endothelial aortic injury. Plaque rupture was then induced with the use of Russell’s viper venom (RVV) and histamine. Subsequently, MRI of the subrenal aorta was performed before RVV, after RVV, and after EP-1873. Histology was performed on regions suggested by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation Wolters Kluwer Health

In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent

Johnstone, Michael T.
Circulation , Volume 109 (16) – Apr 1, 2004
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ISSN
0009-7322
eISSN
1524-4539
DOI
10.1161/01.CIR.0000127034.50006.C0
pmid
15066940
Publisher site
See Article on Publisher Site

Abstract

In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent René M. Botnar, PhD; Alexandra S. Perez, BS; Sonia Witte, PhD; Andrea J. Wiethoff, PhD; James Laredo, MD, PhD; James Hamilton, PhD; William Quist, MD†; Edward C. Parsons, Jr, PhD; Anand Vaidya, BS; Andrew Kolodziej, PhD; John A. Barrett, PhD; Philip B. Graham, PhD; Robert M. Weisskoff, PhD; Warren J. Manning, MD; Michael T. Johnstone, MD Background—Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus visualization may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of direct imaging of acute and subacute thrombosis using MRI together with a novel fibrin-binding gadolinium-labeled peptide, EP-1873, in an experimental animal model of plaque rupture and thrombosis. Methods and Results—Fifteen male New Zealand White rabbits (weight, 3.5 kg) were made atherosclerotic by feeding a high-cholesterol diet after endothelial aortic injury. Plaque rupture was then induced with the use of Russell’s viper venom (RVV) and histamine. Subsequently, MRI of the subrenal aorta was performed before RVV, after RVV, and after EP-1873. Histology was performed on regions suggested by

Journal

Circulation – Wolters Kluwer Health

Published: Apr 1, 2004

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