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Morbilliform Eruption in a Liver Transplantation Patient

Morbilliform Eruption in a Liver Transplantation Patient Abstract One of the most challenging situations in dermatology is the evaluation of a critically ill patient with a morbilliform eruption. Herein, we report on a 50-year-old white woman who underwent an orthotopic liver transplantation for autoimmune hepatitis and end-stage liver dis REPORT OF A CASE A 50-year-old white woman underwent an orthotopic liver transplantation for autoimmune hepatitis and end-stage liver disease. Her donor was an ABO identical man. Her initial postoperative course was unremarkable except for a short episode of organ rejection that was successfully treated with increased doses of systemic corticosteroids. On postoperative day 19, the patient was unexpectedly found to be leukopenic with a leukocyte count of 0.2×109/L. Subsequently, she became thrombocytopenic and anemic and developed group D enterococcal and Klebsiella pneumoniae sepsis. Apart from her hepatic disease, the patient's medical history was unremarkable. However, she reportedly had had an urticarial reaction to penicillin 30 years References 1. Burdick JF, Vogelsang GB, Smith WJ, et al. Severe graft versus host disease in a liver-transplant recipient . N Engl J Med. 1988;318:689-691.Crossref 2. Bhaduri BR, Tan KC, Humphreys S, et al. Graft-versus-host disease after orthotopic liver transplant in a child . Transplant Proc. 1990;22:2378-2380. 3. Marubayashi S, Matsuzaka C, Takeda A, et al. Fatal generalized acute graft-versus-host disease in a liver transplant recipient . Transplantation. 1990;50: 709-711.Crossref 4. Jamieson NV, Joysey V, Friend PJ, et al. Graft-versus-host disease in solid organ transplantation . Transpl Int. 1991;4:67-71.Crossref 5. Roberts JP, Ascher NL, Lake J, et al. Graft-versus-host disease after liver transplantation in humans: a report of four cases . Hepatology. 1991;14:274-281.Crossref 6. Collins RH, Cooper B, Nikaein A, et al. Graft-versus-host disease in a liver transplant recipient . Ann Intern Med. 1992;116:391-392.Crossref 7. Collins RH, Anastasi J, Terstappen LW, et al. Brief report: donor-derived longterm multilineage hematopoiesis in a liver transplant recipient . N Engl J Med. 1993;328:762-765.Crossref 8. Pageaux GP, Perrigault PF, Fabre JM, et al. Lethal acute graft-versus-host disease in a liver transplant recipient: relations with cell migration and chimerism . Clin Transplant. 1995;9:65-69. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Morbilliform Eruption in a Liver Transplantation Patient

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1996.03890340021003
Publisher site
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Abstract

Abstract One of the most challenging situations in dermatology is the evaluation of a critically ill patient with a morbilliform eruption. Herein, we report on a 50-year-old white woman who underwent an orthotopic liver transplantation for autoimmune hepatitis and end-stage liver dis REPORT OF A CASE A 50-year-old white woman underwent an orthotopic liver transplantation for autoimmune hepatitis and end-stage liver disease. Her donor was an ABO identical man. Her initial postoperative course was unremarkable except for a short episode of organ rejection that was successfully treated with increased doses of systemic corticosteroids. On postoperative day 19, the patient was unexpectedly found to be leukopenic with a leukocyte count of 0.2×109/L. Subsequently, she became thrombocytopenic and anemic and developed group D enterococcal and Klebsiella pneumoniae sepsis. Apart from her hepatic disease, the patient's medical history was unremarkable. However, she reportedly had had an urticarial reaction to penicillin 30 years References 1. Burdick JF, Vogelsang GB, Smith WJ, et al. Severe graft versus host disease in a liver-transplant recipient . N Engl J Med. 1988;318:689-691.Crossref 2. Bhaduri BR, Tan KC, Humphreys S, et al. Graft-versus-host disease after orthotopic liver transplant in a child . Transplant Proc. 1990;22:2378-2380. 3. Marubayashi S, Matsuzaka C, Takeda A, et al. Fatal generalized acute graft-versus-host disease in a liver transplant recipient . Transplantation. 1990;50: 709-711.Crossref 4. Jamieson NV, Joysey V, Friend PJ, et al. Graft-versus-host disease in solid organ transplantation . Transpl Int. 1991;4:67-71.Crossref 5. Roberts JP, Ascher NL, Lake J, et al. Graft-versus-host disease after liver transplantation in humans: a report of four cases . Hepatology. 1991;14:274-281.Crossref 6. Collins RH, Cooper B, Nikaein A, et al. Graft-versus-host disease in a liver transplant recipient . Ann Intern Med. 1992;116:391-392.Crossref 7. Collins RH, Anastasi J, Terstappen LW, et al. Brief report: donor-derived longterm multilineage hematopoiesis in a liver transplant recipient . N Engl J Med. 1993;328:762-765.Crossref 8. Pageaux GP, Perrigault PF, Fabre JM, et al. Lethal acute graft-versus-host disease in a liver transplant recipient: relations with cell migration and chimerism . Clin Transplant. 1995;9:65-69.

Journal

Archives of Dermatology – American Medical Association

Published: Oct 1, 1996

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