Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The Physiological Basis of Memory

The Physiological Basis of Memory By J. A. DEUTSCH University of California, San Diego, California The present review confines itself to recent developments in the physi­ ological bases of memory. The review deals mainly with advances produced by the application of techniques which cause amnesia. There is also a sec­ tion on experiments using spreading depression as a too!. An attempt has been made to evaluate these topics critically and in depth. PROTEIN SYNTHESIS INHIBITION AND MEMORY The original impetus to the work with protein synthesis inhibitors was the idea that memory storage was in some way connected with the synthesis of protein molecules. If this was the case, it should be possible to prevent the formation or maintenance of memory after a learning experience by the administration of substances preventing the synthesis of protein. Flexner, one of the earliest and most thorough investigators using this technique, has recently published a valuable review of his work (31). Flexner and his collaborators teach mice what is essentially an escape task in a Y -maze. After the mice are trained, puromycin is injected intra­ cerebrally 1 to 60 days after training. The mice are typically retested 3 to 4 days after treatment. Memory loss is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Psychology Annual Reviews

The Physiological Basis of Memory

Deutsch, J A
Annual Review of Psychology , Volume 20 (1) – Feb 1, 1969
Download PDF
20 pages

Loading next page...
 
/lp/annual-reviews/the-physiological-basis-of-memory-epbVA0TJxk

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Annual Reviews
Copyright
Copyright 1969 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4308
eISSN
1545-2085
DOI
10.1146/annurev.ps.20.020169.000505
pmid
4888624
Publisher site
See Article on Publisher Site

Abstract

By J. A. DEUTSCH University of California, San Diego, California The present review confines itself to recent developments in the physi­ ological bases of memory. The review deals mainly with advances produced by the application of techniques which cause amnesia. There is also a sec­ tion on experiments using spreading depression as a too!. An attempt has been made to evaluate these topics critically and in depth. PROTEIN SYNTHESIS INHIBITION AND MEMORY The original impetus to the work with protein synthesis inhibitors was the idea that memory storage was in some way connected with the synthesis of protein molecules. If this was the case, it should be possible to prevent the formation or maintenance of memory after a learning experience by the administration of substances preventing the synthesis of protein. Flexner, one of the earliest and most thorough investigators using this technique, has recently published a valuable review of his work (31). Flexner and his collaborators teach mice what is essentially an escape task in a Y -maze. After the mice are trained, puromycin is injected intra­ cerebrally 1 to 60 days after training. The mice are typically retested 3 to 4 days after treatment. Memory loss is

Journal

Annual Review of Psychology – Annual Reviews

Published: Feb 1, 1969

There are no references for this article.