Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/antiplatelet-drugs-em05aNJhss
References (188)
-
J.K. Mickelson, P.J. Simpson, M.T. Gallas (1987)
Thromboxane synthetase inhibition with CGS 13080 improves coronary blood flow after streptokinase induced thrombolysisAm Heart J, 113
-
C.R. Jones, R.J. Ambros, H.J. Rapold (1993)
Ro 44-9883: a novel non-peptide GP IIb/IIIa antagonist in man [abstract]Thromb Haemost, 69
-
E.J. Topol, R.M. Califf, H.F. Weisman (1994)
Randomised trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six monthsLancet, 343
-
R. Clarke, G. Mayo, P. Price (1991)
Suppression of thromboxane A2 but not of systemic prostacyclin by controlled release aspirinN Engl J Med, 325
-
L. Janzon, D. Bergquist, J. Boberg (1990)
Prevention of myocardial infarction and stroke in patients with intermittent claudication: effects of ticlopidine. Results from the STIMS, the Swedish Ticlopidine Multicentre StudyJ Intern Med, 227
-
E. Glusa (1991)
Hirudin and plateletsSemin Thromb Hemost, 17
-
R.J. Shebuski, J.M. Smith, B.L. Storer (1988)
Influence of selective prostaglandin endoperoxide thromboxane A2 receptor antagonism with sulotroban on lysis time and reocclusion rate after tissue plasminogen activator-induced coronary thrombolysis in the dogJ Pharmacol Exp Ther, 246
-
H.S. Mueller, P.S. Rao, M.A. Greenberg (1985)
Systemic and transcardiac platelet activity in acute myocardial infarction in man: resistance to prostacyclinCirculation, 72
-
E. Glusa, F. Markwardt (1990)
Platelet functions in recombinant hirudin-anticoagulated bloodHaemostasis, 20
-
A.A. Bos, J.W. Deckers, G.R. Heyndrickx (1993)
Safety and efficacy of recombinant hirudin (CGP 39393) versus heparin in patients with stable angina undergoing coronary angioplastyCirculation, 88
-
H.K. Gold, B.S. Coller, T. Yasuda (1988)
Rapid and sustained coronary artery recanalization with combined bolus injection of recombinant tissue-type plasminogen activator and monoclonal antiplatelet GPIIb/IIIa antibody in a canine preparation [abstract]Circulation, 77
-
K. Schrör (1993)
The basic pharmacology of ticlopidine and clopidogrelPlatelets, 4
-
G.I. Fiddler, P. Lumley (1990)
Preliminary clinical studies with thromboxane synthase inhibitors and thromboxane receptor blockers: a reviewCirculation, 81
-
P. Zoldhelyi, J. Bichler, W.G. Owen (1994)
Persistent thrombin generation in humans during specific thrombin inhibition with hirudinCirculation, 90
-
B.S. Coller, L.E. Scudder, J. Beer (1991)
Monoclonal antibodies to platelet glycoprotein IIb/IIIa as antithrombotic agentsAnn N Y Acad Sci, 614
-
S. Heptinstall, D.C. Berridge, H. Judge (1990)
Effects of streptokinase and recombinant tissue plasminogen activator on platelet aggregation in whole blood [abstract]Platelets, 1
-
I.A. Reilly, G.A. FitzGerald (1987)
Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugsBlood, 69
-
D.G.B. Mills, R. Puri, C.-J. Hu (1992)
Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclaseArterioscler Thromb, 12
-
F. Lanza, A. Beretz, A. Stierle (1988)
Epinephrine potentiates human platelet activation but is not an aggregating agentAm J Physiol, 255
-
J.F. Tschopp, C. Mazur, K. Gould (1994)
Inhibition of thrombosis by a selective fibrinogen receptor antagonist without effect on bleeding timeThromb Haemost, 72
-
L.C. Bock, L.C. Griffin, J.A. Latham (1992)
Selection of single-stranded DNA molecules that bind and inhibit human thrombinNature, 355
-
M. Heras, J.H. Chesebro, W.J. Penny (1989)
Effects of thrombin inhibition on the developement of acute platelet-thrombus deposition during angioplasty in pigs: heparin versus recombinant hirudin, a specific thrombin inhibitorCirculation, 79
-
P.J. Koudstaal, G. Ciabattoni, J. Gijn (1993)
Increased thromboxane biosynthesis in patients with acute cerebral ischemiaStroke, 24
-
N.A. Scott, G.L. Nunes, S.B. King (1994)
Local delivery of an antithrombin inhibits platelet-dependent thrombosisCirculation, 90
-
S. Rajagopalan, L.V. McIntire, E.R. Hall (1988)
The stimulation of arachidonic acid metabolism in human platelets by hydrodynamic stressBiochim Biophys Acta, 958
-
A. Bellavance (1993)
Efficacy of ticlopidine and aspirin for prevention of reversible cerebrovascular ischemic events: the Ticlopidine Aspirin Stroke StudyStroke, 24
-
C.P. Ratnatunga, S.F. Edmondson, G.M. Rees (1992)
High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generationCirculation, 85
-
K.J. Palmer, K.L. Goa (1993)
Defibrotide: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in vascular disordersDrugs, 45
-
P. Théroux, S. Kouz, M.L. Knudtson (1994)
A randomized double-blind controlled trial with the non-peptide platelet GP IIb/IIIa antagonist RO 44-9883 in unstable angina [abstract]Circulation, 90
-
I.-K. Jang, H.K. Gold, A.A. Ziskind (1990)
Prevention of platelet-rich arterial thrombosis by selective thrombin inhibitionCirculation, 81
-
P. Gresele, D. Blockmans, H. Deckmyn (1988)
Adenylate cyclase activation determines the effect of thromboxane synthase inhibitors on platelet aggregation in vitro. Comparison of platelets from responders and nonrespondersJ Pharmacol Exp Ther, 246
-
P. Zoldhelyi, J. Bichler, W.G. Owen (1993)
Measurement of thrombin-hirudin complex documents persistent thrombin formation in patients with unstable angina during anticoagulation with recombinant hirudin [abstract]Circulation, 88
-
A.J. Nichols, R.R. Ruffolo, W.F. Huffman (1992)
Development of GPIIb/IIIa antagonists as antithrombotic drugsTrends Pharmacol Sci, 13
-
J.D. Folts, E.G. Cromwell, G.G. Rowe (1976)
Platelet aggregation in partially obstructed coronary vessels and its elimination with aspirinCirculation, 54
-
J. Lefkovitz, E.J. Topol (1994)
Direct thrombin inhibitors in cardiovascular medicineCirculation, 90
-
I.J. Sarembock, S.D. Gertz, L.W. Gimple (1991)
Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbitsCirculation, 84
-
R.M. Hardisty, M.J. Powling, T.J.C. Nokes (1990)
The action of ticlopidine on human platelets: Studies on aggregation, secretion, calcium mobilization and membrane glycoproteinsThromb Haemost, 64
-
J. Hauptmann, E. Brüggener, F. Markwardt (1987)
Effect of heparin, hirudin, and a synthetic thrombin inhibitor on antithrombin III in thrombin-induced disseminated intravascular coagulation in ratsHaemostasis, 17
-
(1988)
Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarctionLancet, 2
-
W.W. Nichols, F.A. Nicolini, S. Khan (1993)
Failure of prostacyclin analog iloprost to sustain coronary blood flow after recombinant tissue-type plasminogen-induced thrombolysis in dogsAm Heart J, 126
-
H.R. Knapp, C. Healy, J. Lawson (1988)
Effects of low-dose aspirin on endogenous eicosanoid formation in normal and atherosclerotic menThromb Res, 50
-
M.J. Mellott, T.M. Connolly, S.J. York (1990)
Prevention of reocclusion by MCI-9038, a thrombin inhibitor, following t-PA-induced thrombolysis in a canine model of femoral arterial thrombosisThromb Haemost, 64
-
S. Roux, J.P. Carteaux, P. Hess (1994)
Experimental carotid thrombosis in the guinea pigThromb Haemost, 71
-
L.A. Harker (1994)
New antithrombotic strategies for resistant thrombotic processesJ Clin Pharmacol, 34
-
J. Nowak, G.A. FitzGerald (1989)
Redirection of prostaglandin endoperoxide metabolism at the platelet-vascular interface in manJ Clin Invest, 83
-
T.J. Rydel, K.G. Ravichandran, A. Tulinsky (1990)
The structure of a complex of recombinant hirudin and human α-thrombinScience, 249
-
(1994)
Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplastyN Engl J Med, 330
-
Z. Xiao, P. Théroux, J. Lévesque (1994)
Platelet aggregation in response to the thrombin receptor agonist peptide in patients with coronary artery diseaseCirculation, 90
-
D.R. Cooper, G.P. Lewis, G.E. Liebertman (1979)
ADP metabolism in vascular tissue, a possible thromboregulatory mechanismThromb Res, 14
-
M.R. Foster, E.J. Hornby, S. Brown (1993)
Improved potency and specificity of Arg-Gly-Asp (RGD) containing peptides as fibrinogen receptor blocking drugsThromb Res, 72
-
P.W. Serruys, W. Rutsch, G.R. Heyndrickx (1991)
Prevention of restenosis after percutaneous transluminal coronary angioplasty with thromboxane A2 receptor blockade: a randomized, double-blind placebo-controlled trialCirculation, 84
-
H. Kessels, S. Beguin, H. Andree (1994)
Measurement of thrombin generation in whole blood: the effect of heparin and aspirinThromb Haemost, 72
-
W.X. Li, A.V. Kaplan, G.W. Grant (1994)
A novel nucleotide-based thrombin inhibitor inhibits clot-bound thrombin and reduces arterial platelet thrombus formationBlood, 83
-
R. Verheggen, K. Schrör (1986)
The modification of platelet-induced coronary vasoconstriction by a thromboxane receptor antagonistJ Cardiovasc Pharmacol, 8
-
C.P. Cannon, J.M. Maraganore, J. Loscalzo (1993)
Anticoagulant effects of hirulog, a novel thrombin inhibitor, in patients with coronary artery diseaseAm J Cardiol, 71
-
G. Escolar, E. Bastida, R. Castillo (1987)
Ticlopidine inhibits platelet thrombus formation studied in a flowing systemThromb Res, 45
-
M. Verstraete, M. Nurmohamed, J. Kienast (1993)
Biologic effects of recombinant hirudin (CGP 39393) in human volunteersJ Am Coll Cardiol, 22
-
E. Bucha, G. Nowak, F. Markwardt (1988)
Prevention of experimental coronary thrombosis by hirudinFolia Haematol, 115
-
D.F. Rigel, R.W. Olson, R.W. Lappe (1992)
Comparison of hirudin and heparin as adjuncts to streptokinase thrombolysis in a canine model of coronary thrombosisCirc Res, 72
-
R.J. Shebuski, I.J. Stabilito, G.R. Sitko (1990)
Acceleration of recombinant tissue-type plasminogen activator-induced thrombolysis and prevention of reocclusion by the combination of heparin and the Arg-Gly-Asp-containing peptide bitistatin in a canine model of coronary thrombosisCirculation, 82
-
K.J. Winters, S.A. Santoro, J.P. Miletich (1991)
Relative importance of thrombin compared with plasmin-mediated platelet activation in response to plasminogen activation with streptokinaseCirculation, 84
-
J.M. Hérbert, A. Tissinier, G. Defreyn (1993)
Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbitsArterioscler Thromb, 13
-
C. Bode, M. Hudelmayer, P. Mehwald (1994)
Fibrin-targeted recombinant hirudin inhibits fibrin deposition on experimental clots more efficiently than recombinant hirudinCirculation, 90
-
M.M. Bernardi, R.M. Califf, N. Kleiman (1992)
Prolonged bleeding times do not predict hemorrhagic events in patients receiving the 7E3 glycoprotein IIb/IIIa platelet antibody [abstract]Circulation, 86
-
B.B. Weksler, S.B. Pett, D. Alonso (1983)
Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patientsN Engl J Med, 308
-
M.G. Sirois, M. Simons, E.E. Edelman (1994)
Platelet release of platelet-derived growth factor is required for intimial hyperplasia in rat vascular model injuryCirculation, 90
-
W.E. Rote, D.X. Mu, R.A. Roncinske (1993)
Prevention of experimental carotid artery thrombosis by applagginJ Pharmacol ExpTher, 267
-
H. Darius, J. Michael-Hepp, J. Meyer (1993)
Platelet prostacyclin receptor desensitization by iloprost but not by the analog taprostene [abstract]Thromb Haemost, 69
-
B.B. Weksler, K. Tack-Goldman, V.A. Subramanian (1985)
Cumulative inhibitory effect of low-dose aspirin on vascular prostacyclin and platelet thromboxane production in patients with atherosclerosisCirculation, 71
-
A. Gast, T.B. Tschopp, H.R. Baumgartner (1994)
Thrombin plays a key role in late platelet thrombus growth and/or stability: effect of a specific thrombin inhibitor on thrombogenesis induced by aortic subendothelium exposed to flowing rabbit bloodArterioscler Thromb, 14
-
D.J. Fitzgerald, G.A. FitzGerald (1989)
Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activatorProc Natl Acad Sci USA, 86
-
G.W. Albers (1992)
Role of ticlopidine for prevention of strokeStroke, 23
-
H.J.M. Barnett, M. Eliasziw, H.E. Meldrum (1995)
Drugs and surgery in the prevention of ischemic strokeN Engl J Med, 332
-
K.M. Mullane, D. Farnabaio (1988)
Thromboxane synthetase inhibitors reduce infarct size by a platelet-dependent, aspirin sensitive pathwayCirc Res, 62
-
H. Tohgi, H. Takahashi, K. Chiba (1993)
Coagulation-fibrinolysis system in poststroke patients receiving antiplatelet medicationStroke, 24
-
C. Patrono (1994)
Aspirin as an antiplatelet drugN Engl J Med, 330
-
B. Kaiser, J. Hauptmann (1992)
Pharmacology of synthetic thrombin inhibitors of the tripeptide typeCardiovasc Drug Rev, 10
-
C.S. Rinder, L.A. Student, J.L. Bonan (1993)
Aspirin does not inhibit adenosine diphosphate-induced platelet alpha-granule releaseBlood, 82
-
T.K. Lee, Y.C. Chen, I.N. Lien (1988)
Inhibitory effect of acetylsalicylic acid on platelet function in patients with completed stroke or reversible ischemic neurologic deficitStroke, 19
-
B.P. White, A.T. Sullivan, P. Lumley (1994)
Prevention of intra-coronary thrombosis in the anaesthetised dog: the importance of thromboxane A2 and thrombinThromb Haemost, 71
-
A.H. Gershlick, D. Spriggins, S.W. Davies (1994)
Failure of epoprostenol (prostacyclin, PGI2) to inhibit platelet aggregation and to prevent restenosis after coronary angioplasty: results of a randomised placebo controlled trialBr Heart J, 71
-
R.B. Haynes, R.S. Sandier, E.B. Larson (1992)
A critical appraisal of ticlopidine, a new antiplatelet agentArch Intern Med, 152
-
P. Zoldhelyi, M.W.I. Webster, V. Fuster (1993)
Recombinant hirudin in patients with chronic, stable coronary artery diseaseCirculation, 88
-
S.-K. Yao, J.C. Ober, J. McNatt (1992)
ADP plays an important role in mediating platelet aggregation and cyclic flow variations in vivo in stenosed and endothelium-injured canine coronary arteriesCirc Res, 70
-
N.A.F. Chronos, D.J. Wilson, S.L. Janes (1994)
Aspirin does not affect the flow cytometric detection of fibrinogen binding to, or release of α-granules or lysosymes from, human plateletsClin Sci, 87
-
S.P. Roux, K.S. Sakariassen, V.T. Turitto (1991)
Effect of aspirin and epinephrine on experimentally induced thrombogenesis in dogsArterioscler Thromb, 11
-
S.J. McAuliffe, J.A. Moors, H.M. Snow (1993)
Redirection of arachidonic acid metabolism by ICI D1542: effects on thrombus formation in the coronary artery of the anaesthetized dogBr J Pharmacol, 108
-
J.D. Folts, R.L. Levine, P.L. Kaufman (1991)
Cyclic flow reductions in stenosed monkey carotid arteries due to acute platelet thrombus formation: inhibited with aspirin but renewed with epinephrine [abstract]Circulation, 84
-
F. Bracht, K. Schrör (1994)
Isolation and identification of aptamers from defibrotide that act as thrombin antagonists in vitroBiochem Biophys Res Commun, 200
-
C.H.M. Samama, P. Bonnin, M. Bonneau (1992)
Comparative arterial antithrombotic activity of clopidogrel and acetyl salicylic acid in the pigThromb Haemost, 68
-
T. Hohlfeld, F. Scharnowski, M. Braun (1994)
Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemiaThromb Haemost, 71
-
M. Cattaneo, B. Akkawat, R.L. Kinlough-Rathbone (1994)
Ticlopidine facilitates the deaggregation of human platelets aggregated by thrombinThromb Haemost, 71
-
G.J. Roth, D.C. Calverley (1994)
Aspirin, platelets and thrombosis: theory and practiceBlood, 83
-
C. Ranke, H. Hecker, A. Creutzig (1993)
Dose-dependent effect of aspirin on carotid atherosclerosisCirculation, 87
-
P.R. Mayeux, H.E. Morton, J. Gillard (1988)
The affinities of prostaglandins H2 and thromboxane A2 for their receptors are similar in washed human plateletsBiochem Biophys Res Commun, 157
-
Y. Cadroy, S.R. Hanson, A.B. Kelly (1994)
Relative antithrombotic effects of monoclonal antibodies targeting different platelet glycoprotein-adhesive molecule interactions in nonhuman primatesJ Clin Invest, 83
-
K. Jaschonek, K.R. Karsch, H. Weisenberger (1986)
Platelet prostacyclin binding in coronary artery diseaseJ Am Coll Cardiol, 8
-
J.E. Tcheng, S.G. Ellis, B.S. George (1994)
Pharmacodynamics of chimeric glycoprotein IIb/IIIa integrin antiplatelet antibody Fab 7E3 in high-risk coronary angioplastyCirculation, 90
-
T. Sills, S. Heptinstall (1986)
Effects of a thromboxane synthetase inhibitor and a cAMP phosphodiesterase inhibitor, singly and in combination, on platelet behaviourThromb Haemost, 55
-
D. McTavish, D. Faulds, K.L. Goa (1990)
Ticlopidine: an updated review of its pharmacology and therapeutic use in platelet-dependent disordersDrugs, 40
-
H. Tabata, K. Mizuno, H. Etsuda (1994)
The efficacy of argatroban in the prevention of reocclusion and restenosis after reperfusion therapy in patients with acute myocardial infarction [abstract]Circulation, 90
-
N.A. Chronos, D.J. Patel, U. Sigwart (1994)
Intracoronary activitation of human platelets following balloon angioplasty despite aspirin and heparin in a flow cytometric study [abstract]Circulation, 90
-
N.M. Bornstein, V.G. Karepov, B.D. Aronovich (1994)
Failure of aspirin treatment after strokeStroke, 25
-
(1994)
Collaborative overview of randomised trials of antiplatelet therapy: I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patientsBMJ, 308
-
P.T. Larsson, N.H. Wallen, P. Hjemdahl (1994)
Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirinCirculation, 89
-
G. Oster, D.M. Huse, M.J. Lacey (1994)
Cost-effectiveness of ticlopidine in preventing stroke in high-risk patientsStroke, 25
-
J. Römisch, E. Paques (1991)
Thrombin-hirudin stability: a comparison with the thrombin-antithrombin III complexBlood Coagul Fibrinolysis, 2
-
(1994)
Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromesCirculation, 90
-
K.L. Neuhaus, R. Essen, U. Tebbe (1994)
Safety observations from the pilot phase of the randomized r-hirudin for improvement of thrombolysis (HIT-III) studyCirculation, 90
-
H. Sinzinger, K. Silberbauer, A.K. Horsch (1989)
Decreased sensitivity of human platelets to PGI2 during long-term intraarterial prostacyclin infusion in patients with peripheral vascular disease — a rebound phenomenonProstaglandins, 21
-
Y. Uchida, S. Murao (1979)
Effect of prostaglandin I2 on cyclical reductions of coronary blood flowJpn Circ J, 43
-
E.J. Topol, V. Fuster, R.A. Harrington (1994)
Recombinant hirudin for unstable angina pectorisCirculation, 89
-
B.J. Meyer, J.J. Badimon, A. Mailhac (1994)
Inhibition of growth of thrombus on fresh mural thrombus. Targeting optimal therapyCirculation, 90
-
(1994)
Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarctionCirculation, 89
-
G. Defreyn, A. Bernat, D. Delebassee (1989)
Pharmacology of ticlopidine: a reviewSemin Thromb Hemost, 15
-
T. Force, R. Milani, P. Hibberd (1991)
Aspirin-induced decline in prostacyclin production in patients with coronary artery disease is due to decreased endoperoxide shiftCirculation, 84
-
S.R. Hanson, L.A. Harker (1988)
Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-arginyl chloromethyl ketoneProc Natl Acad Sci USA, 85
-
S.-K. Kun, J.C. Ober, J.J. Ferguson (1994)
Clopidogrel is more effective than aspirin as adjuvant treatment to prevent reocclusion after thrombolysisAm J Physiol, 267
-
M. Cattaneo, R. Lombardi, D. Bettega (1993)
Shear-induced platelet aggregation is potentiated by desmopressin and inhibited by ticlopidineArterioscler Thromb, 13
-
W.K. Hass, J.D. Easton, H.P. Adams (1989)
A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patientsN Engl J Med, 321
-
S.A. Mousa, J.M. Bozarth, M.S. Forsythe (1994)
Antiplatelet and antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa receptor antagonistCirculation, 89
-
D.H. Carney, R. Mann, W.R. Redin (1992)
Enhancement of incisional wound healing and neovascularization in normal rats by thrombin and synthetic thrombin receptor activating peptidesJ Clin Invest, 89
-
M. Braun, J. Kramann, H. Strobach (1994)
Incomplete inhibition of platelet secretion by low-dose aspirinPlatelets, 5
-
C. DiMinno, A.M. Cerbone, P.L. Mattioli (1985)
Functionally thrombasthenic state in normal platelets following the administration of ticlopidineJ. Clin Invest, 75
-
P. Golino, G. Ambrosio, P. Gresele (1993)
The in vivo antiplatelet effects of thromboxane A2 synthase inhibitors are potentiated by simultaneous thromboxane A2/prostaglandin H2 receptor blockadeJ Pharmacol Exp Ther, 266
-
X. Carne, J.M. Arnau, J.R. Laporte (1989)
Aspirin, ticlopidine, and strokeLancet, 2
-
B. Kaiser, F. Markwardt (1986)
Experimental studies on the antithrombotic action of a highly effective synthetic thrombin inhibitorThromb Haemost, 55
-
J. Kienast, S.G. Thrompson, C. Raskino (1993)
Prothrombin activation fragment 1+2 and thrombin antithrombin III complexes in patients with angina pectors: relation to the presence and severity of coronary atherosclerosisThromb Haemost, 70
-
D.J. Fitzgerald, J. Fragetta, G.A. FitzGerald (1988)
Prostaglandin endoperoxides modulate the response to thromboxane synthase inhibition during coronary thrombolysisJ Clin Invest, 82
-
H. Tohgi, M. Murakami (1987)
The effect of ticlopidine on TIA compared with aspirin: a double-blind, twelve-month and open 24-month follow-up studyJpn J Med, 26
-
C.M. Helgason, K.M. Bolin, J.A. Hoff (1994)
Development of aspirin resistance in persons with previous ischemic strokeStroke, 25
-
R.-M. Lidón, P. Théroux, M. Juneau (1993)
Initial experience with a direct antithrombin, hirulog, in unstable angina: anticoagulant, antithrombotic and clinical effectsCirculation, 88
-
A.J. Marcus, L.B. Safier, K.A. Hajjar (1991)
Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase: thromboregulation by endothelial cellsJ Clin Invest, 88
-
V. Pengo, M. Boschello, A. Marzari (1986)
Adenosine diphosphate (ADP) induces α-granules release from platelets of native whole blood is reduced by ticlopidine but not by aspirin or dipyridamoleThromb Haemost, 56
-
G.R. May, W. Paul, P. Crook (1992)
The pharmacological modulation of thrombin-induced cerebral thromboembolism in the rabbitBr J Pharmacol, 106
-
B. Kaiser, A. Simon, F. Markwardt (1990)
Antithrombotic effects of recombinant hirudin in experimental angioplasty and intravascular thrombolysisThromb Haemost, 63
-
M.L. Simoons, M.J. Boer, M.J.B.M. Brand (1994)
Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable anginaCirculation, 89
-
D. Cox, T. Aoki, J. Seki (1994)
The pharmacology of the integrinsMed Res Rev, 14
-
N.S. Cook, G. Kottirsch, H.-G. Zerwes (1994)
Platelet glycoprotein IIb/IIIa antagonistsDrugs Future, 19
-
H.V. Anderson, R.L. Kirkheeide, A. Krishnaswami (1994)
Cyclic flow variations after coronary angioplasty in humans: clinical and angiographic characteristics and elimination with 7E3 monoclonal antiplatelet antibodyJ Am Coll Cardiol, 23
-
GVRK Sharma, D. Lapsley, J.A. Vita (1993)
Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectorisAm J Cardiol, 72
-
G.A. FitzGerald, B. Smith, A.K. Pedersen (1984)
Prostacyclin biosynthesis is increased in patients with severe atherosclerosis and platelet activationN Engl J Med, 310
-
H. Tohgi, S. Konno, K. Tamura (1992)
Effects of low to high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclinStroke, 23
-
A.H. Reece, P.L. Walton (1979)
Inhibition of intimal proliferation of rabbit aorta by ticlopidineThromb Haemost, 42
-
H.K. Gold, L.W. Gimple, T. Yasuda (1990)
Pharmacodynmic study of F (ab’)2 fragments of murine monoclonal antibody 7E3 directed against human platelet glycoprotein IIb/IIIa in patients with unstable angina pectorisJ Clin Invest, 86
-
W.E. Rote, D.X. Mu, B.R. Lucchesi (1993)
Thromboxane antagonism in experimental canine carotid artery thrombosisStroke, 24
-
S. Uchiyama, M. Yamazaki, S. Maruyama (1994)
Shear-induced platelet aggregation in cerebral ischemiaStroke, 25
-
I. Carlsson, G. Benthin, A.S. Petersson (1990)
Differential inhibition of thromboxane-A2 and prostacyclin synthesis by low dose acetylsalicylic acid in atherosclerotic patientsThromb Res, 57
-
W.A. Schumacher, C.L. Heran, T.E. Steinbacher (1993)
Superior activity of a thromboxane receptor antagonist as compared with aspirin in rat models of arterial and venous thrombosisJ Cardiovasc Pharmacol, 22
-
R.G. Kiss, H.R. Lu, T. Roskams (1994)
Time course of the effects of a single bolus injection of F (ab’)2 fragments of the anti-platelet GPIIb/IIIa antibody 7E3 on arterial eversion graft occlusion, platelet aggregation, and bleeding time in dogsArterioscler Thromb, 14
-
N. Kleiman, M. Ohmann, R. Califf (1993)
Profound inhibition of platelet aggregation with monoclonal antibody 7E 3 Fab after thrombolytic therapyJ Am Coll Cardiol, 22
-
S. Rotondo, E. Tascione, C. Cerletti (1993)
Ticlopidine does not reduce in vivo platelet thromboxane biosynthesis and metabolism in diabetic patientsPlatelets, 4
-
E.M. Antman (1994)
Hirudin in acute myocardial infarction: safety report from the thrombolysis and thrombin inhibition in myocardial infarction (TIMI) 9A trialCirculation, 90
-
T. Yasuda, H.K. Gold, J.T. Fallon (1988)
Monoclonal antibody against the platelet glycoprotein (GP) IIb/IIIa receptor prevents coronary artery reocclusion after reperfusion with recombinant tissue-type plasminogen activator in dogsJ Clin Invest, 81
-
I. Fox, A. Dawson, P. Loynds (1993)
Anticoagulant activity of hirulog, a direct thrombin inhibitor, in humansThromb Haemost, 69
-
J.L. Moake, N.A. Turner, N.A. Stathopoulos (1988)
Shear-induced platelet aggregation can be mediated by VWF released from platelets, as well as by exogenous large or unusually large VWF multimers, requires adenosine-diphosphate, and is resistant to aspirinBlood, 71
-
V. Fuster (1994)
Mechanisms leading to myocardial infarction: insights from studies of vascular biologyCiculation, 90
-
H. Berscheid, H. Grötsch, H. Neubauer (1992)
Determination of r-hirudin and α-human thrombin-hirudin complex in plasma samples: enzyme linked immunosorbent assays for hirudin and complex versus chromogenic thrombin substrate assayThromb Res, 66
-
J.B. Knudsen, E. Kjoller, K. Skagen (1985)
The effect of ticlopidine on platelet functions in acute myocardial infarction: a double blind controlled trialThromb Haemost, 53
-
R.M. Norris, H.D. White, D.B. Cross (1993)
Aspirin does not improve early arterial patency after streptokinase treatment for acute myocardial infarctionBr Heart J, 69
-
P. Golino, M. Rosolowsky, S.K. Yao (1990)
Endogenous prostaglandin endoperoxides and prostacyclin modulate the thrombolytic activity of tissue plasminogen activatorJ Clin Invest, 86
-
H.E. Roald, R.M. Barstad, P. Kierulf (1994)
Clopidogrel: a platelet inhibitor which inhibits thrombogenesis in non-anti-coagulated human blood independently of the blood flow conditionsThromb Haemost, 71
-
J.I. Weitz, M. Hudoba, D. Massel (1990)
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III independent inhibitorsJ Clin Invest, 86
-
F. Markwardt (1994)
The development of hirudin as an antithrombotic drugThromb Res, 74
-
K. Peerlinck, I. Lepeleire, M. Goldberg (1993)
MK-383 (L-700,462), a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist, is active in manCirculation, 88
-
D.B. Matchar, McCrory, J.M. Barnett, Feussner (1994)
Medical treatment for stroke preventionAnn Intern Med, 121
-
M.L. Dyken, H.J.M. Barnett, J.D. Easton (1992)
Low-dose aspirin and stroke: ‘It aint necessarily so’Stroke, 23
-
J. Valles, M.T. Sanos, J. Aznar (1991)
Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release and recruitmentBlood, 78
-
J.W. Homeister, J.K. Mickelson, P.T. Hoff (1991)
Recombinant hirudin reduces the incidence of thrombotic occlusion in a canine model of coronary vascular injuryCoron Artery Dis, 2
-
T. Yasu, S. Oshima, M. Imanishi (1993)
Effects of aspirin DL-lysine on thrombin generation in unstable angina pectorisAm JCardiol, 71
-
C. Tapparelli, R. Metternich, C. Ehrhardt (1993)
Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profileTrends Pharmacol Sci, 14
-
B. Tesfamariam (1994)
Distinct receptors and signaling pathways in α-thrombin-and thrombin receptor peptide-induced vascular contractionsCirc Res, 74
-
C. Escudero, L. Alvarez, J. Haro (1994)
Prevention of arterial thrombosis by a monoclonal antibody against the 100-109 amino acid sequence stretch of the beta-subunit of the human platelet fibrinogen receptor: a comparative study with low dose aspirinJ Am Coll Cardiol, 23
-
H.F. Kotze, S. Lamprecht, P.N. Badenhorst (1993)
In vivo inhibition of acute platelet-dependent thrombosis in a baboon model by Bay U3405, a thromboxane A2 -receptor antagonistThromb Haemost, 70
-
M. Gent, J.A. Blakely, J.D. Easton (1989)
The Canadian American Ticlopidine Study (CATS) in thromboembolic strokeLancet, 1
-
D. Tschöpe, H.P. Schultheiss, P. Kolarov (1983)
Platelet membrane activation markers are predictive for increase risk of acute ischemic events after PTCACirculation, 88
-
S.K. Yao, J. McNatt, K. Cui (1993)
Combined ADP and thromboxane A2 antagonism prevents cyclic flow variations in stenosed and endothelium-injured arteries in nonhuman primatesCirculation, 88
-
G. Melandri, F. Sempriki, V. Cervi (1994)
Platelet-vessel wall interaction under flow conditions is inhibited by the dual thromboxane inhibitor/thromboxane A2 receptor antagonist picotamide in humans [abstract]Circulation, 90
-
G. Defreyn, C. Gachet, P. Savi (1991)
Ticlopidine and clopidogrel (SR 25990C) selectively neutralize ADP inhibition of PGE1 -activated platelet adenylate cyclase in rats and rabbitsThromb Haemost, 65
-
W.E. Rote, D.G. Walsh, E.R. Bates (1992)
Comparison of 7E3 F (ab)2 antibody with hirudin after rt-PA induced thrombolysis in a chronic canine model of coronary thrombosis [abstract]FASEB J, 6
-
P. Golino, J. Ashton, P. Glas-Greenwalt (1988)
Mediation of reocclusion by thromboxane A2 and serotonin after thrombolysis with tissue plasminogen activator in a canine preparation of coronary thrombosisCirculation, 77
-
C. Patrono (1989)
Aspirin and human platelets: from clinical trials to acetylation of cyclooxygenase and backTrends Pharmacol Sci, 10
-
W.A. Schumacher, T.E. Steinbacher, C.L. Heran (1993)
Effects of antithrombotic drugs in a rat model of aspirin-insensitive arterial thrombosisThromb Haemost, 69
-
G. Vandeplassche, C. Hermans, Y. Somers (1993)
Combined thromboxane A2 synthase inhibition and prostaglandin endoperoxide receptor antagonism limits myocardial infarct size after mechanical coronary occlusion and reperfusion at doses enhancing coronary thrombolysis by streptokinaseJ Am Coll Cardiol, 21
-
J. Fingerle, R. Johnson, A.W. Clowes (1990)
Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid arteryProc Natl Acad Sci USA, 86
-
G. Prino, M. Mantovani, R. Niada (1978)
Advances in coagulation, fibrinolysis platelet aggregation and atherosclerosis -
H. Darius, S. Sellig, G.G. Belz (1994)
Aspirin 500 mg is superior to 100 and 40 mg/d for prevention of restenosis following PTCA [abstract]Circulation, 90
-
E. Deutsch, A.K. Rao, R.W. Colman (1993)
Selective thrombin inhibitors: the next generation of anticoagulantsJ Am Coll Cardiol, 22
- Publisher
- Springer Journals
- Copyright
- Copyright
- Subject
- Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
- ISSN
- 0012-6667
- eISSN
- 1179-1950
- DOI
- 10.2165/00003495-199550010-00002
- Publisher site
- See Article on Publisher Site
Abstract
Antiplatelet therapy has become a useful means of preventing acute thromboembolic artery occlusions in cardiovascular diseases. The rationale for this is an enhanced activity of circulating platelets and release of platelet-derived vasoactive mediators, probably due to endothelial dysfunction. This review discusses the current status of 4 major classes of antiplatelet compounds: (i) aspirin and related drugs active via cyclo-oxygenase product formation; (ii) thienopyridines (ticlopidine and clopidogrel); (iii) direct thrombin inhibitors (e.g. hirudin); and (iv) GPIIb/IIIa receptor antagonists [e.g. abciximab (c7E3 Fab)].
Journal
Drugs – Springer Journals
Published: Nov 3, 2012