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The Role of Functional Neuroimaging in the Neuropsychology of Depression

The Role of Functional Neuroimaging in the Neuropsychology of Depression Depressed individuals show impaired performance in tests of attention and concentration. They also exhibit PET resting state abnormalities in dorsal prefrontal cortex and anterior cingulate, regions known to be substrates of attentional processing in healthy individuals. This chapter outlines a strategy to study neuropsychological mechanisms in emotional disorders using functional imaging methods. It reviews evidence strongly implicating the dorsolateral prefrontal cortex, particularly in the right hemisphere, as a key brain structure in emotion/cognition interactions in negative mood states. It will be argued that this neocortical region is a crucial convergence zone, being the substrate of sustained attention to the external environment, and the main target of limbic-cortical influences during changes in mood state across health and disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical and Experimental Neuropsychology Taylor & Francis

The Role of Functional Neuroimaging in the Neuropsychology of Depression

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References (58)

Publisher
Taylor & Francis
Copyright
Copyright Taylor & Francis Group, LLC
ISSN
1744-411x
eISSN
1380-3395
DOI
10.1076/jcen.23.1.121.1223
pmid
11320448
Publisher site
See Article on Publisher Site

Abstract

Depressed individuals show impaired performance in tests of attention and concentration. They also exhibit PET resting state abnormalities in dorsal prefrontal cortex and anterior cingulate, regions known to be substrates of attentional processing in healthy individuals. This chapter outlines a strategy to study neuropsychological mechanisms in emotional disorders using functional imaging methods. It reviews evidence strongly implicating the dorsolateral prefrontal cortex, particularly in the right hemisphere, as a key brain structure in emotion/cognition interactions in negative mood states. It will be argued that this neocortical region is a crucial convergence zone, being the substrate of sustained attention to the external environment, and the main target of limbic-cortical influences during changes in mood state across health and disease.

Journal

Journal of Clinical and Experimental NeuropsychologyTaylor & Francis

Published: Feb 1, 2001

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