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- Publisher
- The New England Journal of Medicine
- Copyright
- Copyright © 1993 Massachusetts Medical Society. All rights reserved.
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- DOI
- 10.1056/NEJM199305203282012
- pmid
- 8117345
- Publisher site
- See Article on Publisher Site
Abstract
This issue of the Journal contains two important reports of large-scale prospective studies, one in men1 and one in women,2 showing that the use of large doses of vitamin E supplements is associated with a significantly decreased risk of coronary heart disease. The study populations were enormous -- almost 40,000 men and more than 80,000 women -- and the participants were followed for four and eight years, respectively. The studies were very carefully conducted: there was more than 95 percent follow-up, independent validation of the dietary questionnaires, and careful documentation of end points. In both studies the benefit of vitamin . . .
Journal
The New England Journal of Medicine – The New England Journal of Medicine
Published: May 20, 1993