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HuR recruits let-7/RISC to repress c-Myc expression

HuR recruits let-7/RISC to repress c-Myc expression Downloaded from genesdev.cshlp.org on October 10, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION target mRNAs, HuR has been implicated in various bi- HuR recruits let-7/RISC ological processes, including cell division, immune and stress responses, differentiation, and carcinogenesis (Lo´pez to repress c-Myc expression de Silanes et al. 2005; Hinman and Lou 2008; Kim and Gorospe 2008). Hyeon Ho Kim, Yuki Kuwano, The mRNA encoding the proto-oncogene c-Myc was Subramanya Srikantan, Eun Kyung Lee, identified previously as a target of HuR (Lafon et al. 1998), Jennifer L. Martindale, and Myriam Gorospe but the influence of HuR on c-Myc expression was not analyzed in detail. Our studies to test the influence of HuR Laboratory of Cellular and Molecular Biology, National Institute on c-Myc expression revealed that HuR bound the c-Myc on Aging-Intramural Research Program, National Institutes of 39UTR at a site proximal to that bound by the miRNA let- Health, Baltimore, Maryland 21224, USA 7. miRNAs are ;22-nucleotide (nt) transcripts that asso- ciate with the 59UTR, coding region (CR), and 39UTR of RNA-binding proteins (RBPs) and microRNAs (miRNAs) target mRNAs forming imperfect hybrids, and can reduce are potent post-transcriptional regulators of gene expres- target mRNA stability and repress http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

HuR recruits let-7/RISC to repress c-Myc expression

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1812509
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Abstract

Downloaded from genesdev.cshlp.org on October 10, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION target mRNAs, HuR has been implicated in various bi- HuR recruits let-7/RISC ological processes, including cell division, immune and stress responses, differentiation, and carcinogenesis (Lo´pez to repress c-Myc expression de Silanes et al. 2005; Hinman and Lou 2008; Kim and Gorospe 2008). Hyeon Ho Kim, Yuki Kuwano, The mRNA encoding the proto-oncogene c-Myc was Subramanya Srikantan, Eun Kyung Lee, identified previously as a target of HuR (Lafon et al. 1998), Jennifer L. Martindale, and Myriam Gorospe but the influence of HuR on c-Myc expression was not analyzed in detail. Our studies to test the influence of HuR Laboratory of Cellular and Molecular Biology, National Institute on c-Myc expression revealed that HuR bound the c-Myc on Aging-Intramural Research Program, National Institutes of 39UTR at a site proximal to that bound by the miRNA let- Health, Baltimore, Maryland 21224, USA 7. miRNAs are ;22-nucleotide (nt) transcripts that asso- ciate with the 59UTR, coding region (CR), and 39UTR of RNA-binding proteins (RBPs) and microRNAs (miRNAs) target mRNAs forming imperfect hybrids, and can reduce are potent post-transcriptional regulators of gene expres- target mRNA stability and repress

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Genes & Development – Unpaywall

Published: Jul 2, 2009

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