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Turning off the tap

Turning off the tap RE SEARCH HIGHLIGHT S ME TA S TASI S IN THE NEWS Stress is good for you? Women who experience A plausible candidate increased levels of stress are less likely to develop breast cancer, according Cancer mortality is most often the suppressor gene Brms1. However, GTPase activating protein (GAP) to a study by Danish result of metastasis rather than this gene has no obvious polymor- that negatively regulates RAP1 and scientists (Nielsen, N. R. et al., Br. Med. J. 9 September the primary tumour. Previous phisms that influence metastasis RAP2 GTPases. Human SIPA1 has 2005 (doi: 10.1136/ studies from Kent Hunter’s group and so was discounted from this recently been found to interact bmj.38547.638183.06)). demonstrated that the genetic study. with the water channel aquaporin 2 Stress can reduce background of the host can influ- To identify other potential can- (AQP2), by its PDZ domain, so the oestrogen production and ence metastatic efficiency. Now, didates the authors used a multiple authors used AQP2 to see if the oestrogen is a known risk Hunter and colleagues have identi- cross-mapping strategy that uses alanine to threonine substitution factor in breast cancer. Therefore, the authors fied a candidate gene, Sipa1, with the shared http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Cancer Springer Journals

Turning off the tap

Novak, Kristine
Nature Reviews Cancer , Volume 5 (10) – Oct 1, 2005
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References (1)

Publisher
Springer Journals
Copyright
Copyright © Springer Nature Limited 2005
Subject
Biomedicine; Biomedicine, general; Cancer Research
ISSN
1474-175X
eISSN
1474-1768
DOI
10.1038/nrc1722
Publisher site
See Article on Publisher Site

Abstract

RE SEARCH HIGHLIGHT S ME TA S TASI S IN THE NEWS Stress is good for you? Women who experience A plausible candidate increased levels of stress are less likely to develop breast cancer, according Cancer mortality is most often the suppressor gene Brms1. However, GTPase activating protein (GAP) to a study by Danish result of metastasis rather than this gene has no obvious polymor- that negatively regulates RAP1 and scientists (Nielsen, N. R. et al., Br. Med. J. 9 September the primary tumour. Previous phisms that influence metastasis RAP2 GTPases. Human SIPA1 has 2005 (doi: 10.1136/ studies from Kent Hunter’s group and so was discounted from this recently been found to interact bmj.38547.638183.06)). demonstrated that the genetic study. with the water channel aquaporin 2 Stress can reduce background of the host can influ- To identify other potential can- (AQP2), by its PDZ domain, so the oestrogen production and ence metastatic efficiency. Now, didates the authors used a multiple authors used AQP2 to see if the oestrogen is a known risk Hunter and colleagues have identi- cross-mapping strategy that uses alanine to threonine substitution factor in breast cancer. Therefore, the authors fied a candidate gene, Sipa1, with the shared

Journal

Nature Reviews Cancer – Springer Journals

Published: Oct 1, 2005

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