Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

CIGARETTE SMOKING AND THE RISK OF CERVICAL NEOPLASIA

CIGARETTE SMOKING AND THE RISK OF CERVICAL NEOPLASIA The relationship between cigarette smoking and risk of cervical neoplasia was evaluated in a case-control study of 183 women with cervical intraepithelial neoplasia compared with 183 age-matched outpatient controls, and of 230 cases of invasive cervical cancer compared with 230 controls in hospital for acute conditions unrelated to any of the identified or suspected risk factors for cervical cancer. Current cigarette smoking was associated with an elevated risk of cervical lntraepithelial neoplasla (relative risk = 1.76, 95 per cent confidence interval = 1.14–2.27) and of invasive cancer (relative risk = 1.69, 95 per cent confidence interval = 1.08–2.65). ThIs association was only partially accounted for by a large number of identified potential confounding factors, including indicators of socioeconomic status and sexual habits. The risk increased with the number of cigarettes smoked and was apparently greater for women who started smoking at younger ages. The relative risk of intraepithellal neoplasia was elevated within 20 years after the start of smoking and showed little tendency to increase with increasing duration. On the other hand, the risk of invasive cervical cancer was apparently unaffected by smoking less than 20 years and increased steadily thereafter, reaching a point estimate of 3.63 after 40 years or more. If one assumes that Intraeplthelial neoplasla is an early stage of cervical cancer, this pattern of risk is consistent with the predictions from the multistage theory of carcinogenesia, If the effect of smoking is on one of the eariler stages. No obvious distorting factors, apart from the play of chance, is likely to produce such a risk pattern. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Epidemiology Oxford University Press

CIGARETTE SMOKING AND THE RISK OF CERVICAL NEOPLASIA

Download PDF
8 pages

Loading next page...
 
/lp/oxford-university-press/cigarette-smoking-and-the-risk-of-cervical-neoplasia-ddMw1P5DVe

References (0)

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0002-9262
eISSN
1476-6256
DOI
10.1093/oxfordjournals.aje.a114220
Publisher site
See Article on Publisher Site

Abstract

The relationship between cigarette smoking and risk of cervical neoplasia was evaluated in a case-control study of 183 women with cervical intraepithelial neoplasia compared with 183 age-matched outpatient controls, and of 230 cases of invasive cervical cancer compared with 230 controls in hospital for acute conditions unrelated to any of the identified or suspected risk factors for cervical cancer. Current cigarette smoking was associated with an elevated risk of cervical lntraepithelial neoplasla (relative risk = 1.76, 95 per cent confidence interval = 1.14–2.27) and of invasive cancer (relative risk = 1.69, 95 per cent confidence interval = 1.08–2.65). ThIs association was only partially accounted for by a large number of identified potential confounding factors, including indicators of socioeconomic status and sexual habits. The risk increased with the number of cigarettes smoked and was apparently greater for women who started smoking at younger ages. The relative risk of intraepithellal neoplasia was elevated within 20 years after the start of smoking and showed little tendency to increase with increasing duration. On the other hand, the risk of invasive cervical cancer was apparently unaffected by smoking less than 20 years and increased steadily thereafter, reaching a point estimate of 3.63 after 40 years or more. If one assumes that Intraeplthelial neoplasla is an early stage of cervical cancer, this pattern of risk is consistent with the predictions from the multistage theory of carcinogenesia, If the effect of smoking is on one of the eariler stages. No obvious distorting factors, apart from the play of chance, is likely to produce such a risk pattern.

Journal

American Journal of Epidemiology – Oxford University Press

Published: Jan 1, 1986

There are no references for this article.