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Long-term Outcomes of CLIPPERS (Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids) in a Consecutive Series of 12 Patients

Long-term Outcomes of CLIPPERS (Chronic Lymphocytic Inflammation With Pontine Perivascular... ORIGINAL CONTRIBUTION Long-term Outcomes of CLIPPERS (Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids) in a Consecutive Series of 12 Patients Guillaume Taieb, MD; Claire Duflos, MD; Dimitri Renard, MD; Bertrand Audoin, MD, PhD; Elsa Kaphan, MD; Jean Pelletier, MD, PhD; Nadège Limousin, MD; Christine Tranchant, MD, PhD; Stephane Kremer, MD; Je´rome de Sèze, MD, PhD; Romain Lefaucheur, MD; David Malteˆte, MD, PhD; David Brassat, MD, PhD; Michel Clanet, MD, PhD; Patrice Desbordes, MD; Eric Thouvenot, MD, PhD; Laurent Magy, MD, PhD; Thierry Vincent, MD, PhD; Jean-Luc Faillie, MD; Nicolas de Champfleur, MD; Giovanni Castelnovo, MD; Sandrine Eimer, MD; Dominique Figarella Branger, MD, PhD; Emmanuelle Uro-Coste, MD, PhD; Pierre Labauge, MD, PhD Background: Chronic lymphocytic inflammation with stant oligoclonal bands were found on cerebrospinal fluid pontine perivascular enhancement responsive to ste- investigation in 4 patients, with an increased T-cell ra- roids (CLIPPERS) is a central nervous system inflamma- tio of CD4 to CD8. Among 7 available brain biopsy speci- tory disease. mens, staining was positive for perivascular CD4 T lym- phocytes in 5 samples. Thirty-eight of 42 relapses were Objective: To describe the disease course of CLIPPERS. treated with pulse corticosteroid therapy, which led to improvement, with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Long-term Outcomes of CLIPPERS (Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids) in a Consecutive Series of 12 Patients

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References (15)

Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2012.122
pmid
22777259
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Long-term Outcomes of CLIPPERS (Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids) in a Consecutive Series of 12 Patients Guillaume Taieb, MD; Claire Duflos, MD; Dimitri Renard, MD; Bertrand Audoin, MD, PhD; Elsa Kaphan, MD; Jean Pelletier, MD, PhD; Nadège Limousin, MD; Christine Tranchant, MD, PhD; Stephane Kremer, MD; Je´rome de Sèze, MD, PhD; Romain Lefaucheur, MD; David Malteˆte, MD, PhD; David Brassat, MD, PhD; Michel Clanet, MD, PhD; Patrice Desbordes, MD; Eric Thouvenot, MD, PhD; Laurent Magy, MD, PhD; Thierry Vincent, MD, PhD; Jean-Luc Faillie, MD; Nicolas de Champfleur, MD; Giovanni Castelnovo, MD; Sandrine Eimer, MD; Dominique Figarella Branger, MD, PhD; Emmanuelle Uro-Coste, MD, PhD; Pierre Labauge, MD, PhD Background: Chronic lymphocytic inflammation with stant oligoclonal bands were found on cerebrospinal fluid pontine perivascular enhancement responsive to ste- investigation in 4 patients, with an increased T-cell ra- roids (CLIPPERS) is a central nervous system inflamma- tio of CD4 to CD8. Among 7 available brain biopsy speci- tory disease. mens, staining was positive for perivascular CD4 T lym- phocytes in 5 samples. Thirty-eight of 42 relapses were Objective: To describe the disease course of CLIPPERS. treated with pulse corticosteroid therapy, which led to improvement, with

Journal

JAMA Neurology – American Medical Association

Published: Jul 1, 2012

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