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- Publisher
- Wiley
- Copyright
- Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
- ISSN
- 1433-7851
- eISSN
- 1521-3773
- DOI
- 10.1002/anie.200700256
- pmid
- 17397121
- Publisher site
- See Article on Publisher Site
Abstract
Sights set on a cure: Memoquin (1) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity. In animal models, 1 causes a remarkable decrease in the formation of AD neurodegenerative hallmarks and a significant reversal of behavioral deficits. hAChE, BACE‐1, and NQO1 are enzymes targeted by 1.
Journal
Angewandte Chemie International Edition – Wiley
Published: May 11, 2007