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Tetrodotoxin-resistant relaxation to transmural nerve stimulation in isolated saphenous vein

Tetrodotoxin-resistant relaxation to transmural nerve stimulation in isolated saphenous vein Department of Medicine, Surgical Medical Research Institute, Edmonton, Alberta T6G 2G3, Canada SENARATNE, MANOHARA, AND TISSA KAPPAGODA. Tetrodotoxin-resistant relaxation to transmural nerve stimulation in isolated saphenous . Am. J. Physiol. 247 (Heart Circ. Physiol. 16): H952-H959, 1984.-The to transmural nerve stimulation () was characterized in rings of canine Saphenous s following sympathetic (guanethidine lo-* mol/l; phenoxybenzamine 2 x 10v5 mol/l; propranolol 2 X lo+ mol/ 1) and muscarinic blockade (atropine 5 x low6 mol/l). In prep- such a in the canine saphenous in vitro, following blockade of the contractile to transmural nerve stimulation. METHODS arations which were contracted with prostaglandin FZa, was applied as intermittent trains of stimuli of 30 s duration at frequencies of l-32 Hz. This stimulus elicited a frequencydependent relaxation [maximum relaxation 3.4 $- 0.21 (SE) g]. This relaxation was present in rings denuded of endothelium and was not altered significantly by cimetidine (lo-* mol/l), indomethacin (10m5 mol/l), aminophylline (low5 mol/l), or cyproheptadine (low6 mol/l). It was abolished by the Na’-K’ATPase inhibitor ouabain (2 X' lo-* mol/l) and in zero-K+ Krebs solution. When the experiment was repeated following storage of the isolated saphenous s for 9 days at 4°C failed to induce any relaxation. However, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Tetrodotoxin-resistant relaxation to transmural nerve stimulation in isolated saphenous vein

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Publisher
The American Physiological Society
Copyright
Copyright © 1984 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
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Abstract

Department of Medicine, Surgical Medical Research Institute, Edmonton, Alberta T6G 2G3, Canada SENARATNE, MANOHARA, AND TISSA KAPPAGODA. Tetrodotoxin-resistant relaxation to transmural nerve stimulation in isolated saphenous . Am. J. Physiol. 247 (Heart Circ. Physiol. 16): H952-H959, 1984.-The to transmural nerve stimulation () was characterized in rings of canine Saphenous s following sympathetic (guanethidine lo-* mol/l; phenoxybenzamine 2 x 10v5 mol/l; propranolol 2 X lo+ mol/ 1) and muscarinic blockade (atropine 5 x low6 mol/l). In prep- such a in the canine saphenous in vitro, following blockade of the contractile to transmural nerve stimulation. METHODS arations which were contracted with prostaglandin FZa, was applied as intermittent trains of stimuli of 30 s duration at frequencies of l-32 Hz. This stimulus elicited a frequencydependent relaxation [maximum relaxation 3.4 $- 0.21 (SE) g]. This relaxation was present in rings denuded of endothelium and was not altered significantly by cimetidine (lo-* mol/l), indomethacin (10m5 mol/l), aminophylline (low5 mol/l), or cyproheptadine (low6 mol/l). It was abolished by the Na’-K’ATPase inhibitor ouabain (2 X' lo-* mol/l) and in zero-K+ Krebs solution. When the experiment was repeated following storage of the isolated saphenous s for 9 days at 4°C failed to induce any relaxation. However,

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AJP - Heart and Circulatory Physiology – The American Physiological Society

Published: Dec 1, 1984

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