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Divergent Effects of Zinc on Different Bacterial Pathogenic Agents

Divergent Effects of Zinc on Different Bacterial Pathogenic Agents Zinc is essential for immunologic function; therefore, it has been postulated that elevated serum levels of zinc might lead to improved immune responses. However, it is not known whether or how serum zinc levels contribute to a clinically relevant mechanism of immunologic activation. In our studies with human peripheral blood mononuclear cells and whole blood, the zinc level selectively enhanced the biologic activity of endotoxin. The combination of nonstimulatory doses of lipopolysaccharide (LPS) and nonstimulatory concentrations of zinc led to the secretion oflarge amounts ofinterleukin (IL)-1β. In contrast, zinc levels specifically down-regulated monocyte activation caused by some superantigens, staphylococcal enterotoxin A and E and Mycoplasma arthritidis-derived superantigen, but not toxic shock syndrome toxin-to This demonstrates that zinc levels control IL-t{:J secretion after both LPS and superantigen challenge within a clinically relevant range of concentrations. Our data suggest that the indications and contraindications for clinical zinc supplementation should be reconsidered. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Infectious Diseases Oxford University Press

Divergent Effects of Zinc on Different Bacterial Pathogenic Agents

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References (13)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0022-1899
eISSN
1537-6613
DOI
10.1093/infdis/171.2.486
Publisher site
See Article on Publisher Site

Abstract

Zinc is essential for immunologic function; therefore, it has been postulated that elevated serum levels of zinc might lead to improved immune responses. However, it is not known whether or how serum zinc levels contribute to a clinically relevant mechanism of immunologic activation. In our studies with human peripheral blood mononuclear cells and whole blood, the zinc level selectively enhanced the biologic activity of endotoxin. The combination of nonstimulatory doses of lipopolysaccharide (LPS) and nonstimulatory concentrations of zinc led to the secretion oflarge amounts ofinterleukin (IL)-1β. In contrast, zinc levels specifically down-regulated monocyte activation caused by some superantigens, staphylococcal enterotoxin A and E and Mycoplasma arthritidis-derived superantigen, but not toxic shock syndrome toxin-to This demonstrates that zinc levels control IL-t{:J secretion after both LPS and superantigen challenge within a clinically relevant range of concentrations. Our data suggest that the indications and contraindications for clinical zinc supplementation should be reconsidered.

Journal

The Journal of Infectious Diseases – Oxford University Press

Published: Feb 1, 1995

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