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Insulin-like Growth Factor-I is Inversely Related to Adiposity in Overweight Latino Children

Insulin-like Growth Factor-I is Inversely Related to Adiposity in Overweight Latino Children INTRODUCTION The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 1.7 yr; body mass index: 28.2 5.4 kg/m 2 ). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, ρ <0.001 and r = -0.25, ρ <0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, ρ <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, ρ = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children. KEY W O R D S IGF, IGFBP-1, IGFBP-3, visceral fat, obesity, children Reprint address: Michael I. Goran, Ph.D. Departments of Preventive M e d i c i n e and Physiology & Biophysics University of Southern C a l i f o r n i a 2 2 5 0 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Endocrinology and Metabolism de Gruyter

Insulin-like Growth Factor-I is Inversely Related to Adiposity in Overweight Latino Children

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References (31)

Publisher
de Gruyter
Copyright
Copyright © 2008 by the
ISSN
0334-018X
eISSN
2191-0251
DOI
10.1515/JPEM.2008.21.9.855
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTION The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 1.7 yr; body mass index: 28.2 5.4 kg/m 2 ). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, ρ <0.001 and r = -0.25, ρ <0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, ρ <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, ρ = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children. KEY W O R D S IGF, IGFBP-1, IGFBP-3, visceral fat, obesity, children Reprint address: Michael I. Goran, Ph.D. Departments of Preventive M e d i c i n e and Physiology & Biophysics University of Southern C a l i f o r n i a 2 2 5 0

Journal

Journal of Pediatric Endocrinology and Metabolism – de Gruyter

Published: Sep 1, 2008

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