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References (123)
-
Jon Chambers, M. Davies, A. Gaulton, A. Hersey, S. Velankar, R. Petryszak, Janna Hastings, L. Bellis, S. McGlinchey, John Overington (2013)
UniChem: a unified chemical structure cross-referencing and identifier tracking systemJournal of Cheminformatics, 5
-
BK Bulik-Sullivan (2015)
LD Score regression distinguishes confounding from polygenicity in genome-wide association studiesNat. Genet., 47
-
Lin-Quan Sun, David Lee, Quangeng Zhang, W. Xiao, Eric Raabe, A. Meeker, D. Miao, D. Huso, R. Arceci (2004)
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.Genes & development, 18 9
-
Human genome region MHC (Genome Reference Consortium -
Clare Bycroft, C. Freeman, D. Petkova, G. Band, L. Elliott, K. Sharp, A. Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O'Connell, A. Cortes, S. Welsh, A. Young, Mark Effingham, G. McVean, S. Leslie, N. Allen, P. Donnelly, J. Marchini (2018)
The UK Biobank resource with deep phenotyping and genomic dataNature, 562
-
Sunghwan Kim, Jie Chen, Tiejun Cheng, A. Gindulyte, Jia He, Siqian He, Qingliang Li, Benjamin Shoemaker, P. Thiessen, Bo Yu, L. Zaslavsky, Jian Zhang, Evan Bolton (2018)
PubChem 2019 update: improved access to chemical dataNucleic Acids Research, 47
-
D. Lang (2020)
General Network (HTTP/FTP/...) Client Interface for R [R package RCurl version 1.98-1.2] -
Gábor Csárdi, T. Nepusz (2006)
The igraph software package for complex network research, 1695
-
Maria Fernandes, Cen Wan, Robi Tacutu, Diogo Barardo, A. Rajput, Jingwei Wang, Harikrishnan Thoppil, Daniel Thornton, Chenhao Yang, A. Freitas, J. Magalhães (2016)
Systematic analysis of the gerontome reveals links between aging and age-related diseasesHuman Molecular Genetics, 25
-
Barret Schloerke, Jason Crowley, Di Cook, F. Briatte, M. Marbach, Edwin Thoen, Amos Elberg (2016)
Extension to ggplot2 -
L. Kaufman, P. Rousseeuw (1991)
Finding Groups in Data: An Introduction to Cluster Analysis -
Kelsy Cotto, A. Wagner, Yang-Yang Feng, Susanna Kiwala, Adam Coffman, Gregory Spies, Alexander Wollam, N. Spies, O. Griffith, M. Griffith (2017)
DGIdb 3.0: a redesign and expansion of the drug–gene interaction databaseNucleic Acids Research, 46
-
E. Gamazon, A. Segrè, M. Bunt, X. Wen, H. Xi, F. Hormozdiari, H. Ongen, A. Konkashbaev, E. Derks, F. Aguet, J. Quan, D. Nicolae, E. Eskin, Manolis Kellis, G. Getz, M. McCarthy, E. Dermitzakis, N. Cox, K. Ardlie (2018)
Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variationNature genetics, 50
-
L. Mason, R. Bentall, W. el-Deredy (2012)
Funding: LM received interdisciplinary funding from the Medical Research Council and Economic and Social Research Council. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. -
Z. Mungan, Binnur Şimşek (2017)
Which drugs are risk factors for the development of gastroesophageal reflux disease?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 28 Suppl 1
-
(2020)
Changing genomic coordinate systems with rtracklayer::liftOver. Version 1.12.0 (Bioconductor Package Maintainer -
K. Ardlie, David DeLuca, A. Segrè, Timothy Sullivan, Taylor Young, Ellen Gelfand, Casandra Trowbridge, Julian Maller, T. Tukiainen, M. Lek, Lucas Ward, P. Kheradpour, Benjamin Iriarte, Yan Meng, Cameron Palmer, T. Esko, W. Winckler, J. Hirschhorn, M. Kellis, Daniel MacArthur, Gad Getz, Andrey Shabalin, Gen Li, Yi-Hui Zhou, A. Nobel, Ivan Rusyn, Fred Wright, Tuuli Lappalainen, Pedro Ferreira, H. Ongen, Manuel Rivas, Alexis Battle, Sara Mostafavi, Jean Monlong, M. Sammeth, Marta Melé, F. Reverter, Jakob Goldmann, Daphne Koller, R. Guigó, Mark McCarthy, E. Dermitzakis, Eric Gamazon, Hae Im, A. Konkashbaev, D. Nicolae, Nancy Cox, T. Flutre, Xiaoquan Wen, Matthew Stephens, Jonathan Pritchard, Zhidong Tu, Bin Zhang, Tao Huang, Quan Long, Luan Lin, Jialiang Yang, Jun Zhu, Jun Liu, A. Brown, Bernadette Mestichelli, D. Tidwell, E. Lo, Mike Salvatore, Saboor Shad, Jeffrey Thomas, John Lonsdale, M. Moser, Bryan Gillard, E. Karasik, Kimberly Ramsey, Christopher Choi, Barbara Foster, John Syron, Johnelle Fleming, Harold Magazine, Rick Hasz, Gary Walters, J. Bridge, Mark Miklos, Susan Sullivan, Laura Barker, H. Traino, M. Mosavel, L. Siminoff, Dana Valley, D. Rohrer, Scott Jewell, P. Branton, L. Sobin, M. Barcus, L. Qi, J. McLean, P. Hariharan, K. Um, Shenpei Wu, David Tabor, C. Shive, Anna Smith, Stephen Buia, Anita Undale, Karna Robinson, Nancy Roche, Kimberly Valentino, Angela Britton, R. Burges, Debra Bradbury, Kenneth Hambright, John Seleski, G. Korzeniewski, Kenyon Erickson, Yvonne Marcus, Jorge Tejada, Mehran Taherian, Chunrong Lu, Margaret Basile, Deborah Mash, Simona Volpi, Jeffery Struewing, Gary Temple, Joy Boyer, Deborah Colantuoni, Roger Little, S. Koester, Latarsha Carithers, Helen Moore, P. Guan, Carolyn Compton, Sherilyn Sawyer, J. Demchok, Jimmie Vaught, C. Rabiner, Lockhart (2015)
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humansScience, 348
-
A. Gaulton, A. Hersey, M. Nowotka, A. Bento, Jon Chambers, David Mendez, Prudence Mutowo-Meullenet, Francis Atkinson, L. Bellis, Elena Cibrián-Uhalte, M. Davies, Nathan Dedman, Anneli Karlsson, María Magariños, John Overington, G. Papadatos, Ines Smit, A. Leach (2016)
The ChEMBL database in 2017Nucleic Acids Research, 45
-
MHC region of the human genome -
(2020)
RCurl: General Network (HTTP/FTP/.. -
K. Lage, N. Hansen, E. Karlberg, A. Eklund, Francisco Roque, P. Donahoe, Z. Szallasi, T. Jensen, S. Brunak (2008)
A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexesProceedings of the National Academy of Sciences, 105
-
Robi Tacutu, Daniel Thornton, Emily Johnson, A. Budovsky, Diogo Barardo, Thomas Craig, E. Diana, Gilad Lehmann, Dmitri Toren, Jingwei Wang, V. Fraifeld, J. Magalhães (2017)
Human Ageing Genomic Resources: new and updated databasesNucleic Acids Research, 46
-
S Durinck, PT Spellman, E Birney, W Huber (2009)
Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRtNat. Protoc., 4
-
A. Poduri, G. Evrony, Xuyu Cai, C. Walsh (2013)
Somatic Mutation, Genomic Variation, and Neurological DiseaseScience, 341
-
R. Tibshirani, G. Walther, T. Hastie (2000)
Estimating the number of clusters in a data set via the gap statisticJournal of the Royal Statistical Society: Series B (Statistical Methodology), 63
-
T. Consortium (2018)
The Gene Ontology Resource: 20 years and still GOing strongNucleic Acids Research, 47
-
Aging Human Hematopoietic Stem Cells Manifest Profound 1171 -
(2018)
towards 1095 personalized comorbidity profiles -
C. López-Otín, M. Blasco, L. Partridge, M. Serrano, G. Kroemer (2013)
The Hallmarks of AgingCell, 153
-
R. Avelar, Javier Ortega, Robi Tacutu, E. Tyler, Dominic Bennett, P. Binetti, A. Budovsky, Kasit Chatsirisupachai, Emily Johnson, Alex Murray, Samuel Shields, Daniela Tejada-Martinez, Daniel Thornton, V. Fraifeld, C. Bishop, J. Magalhães (2020)
A multidimensional systems biology analysis of cellular senescence in aging and diseaseGenome Biology, 21
-
T. Finkel, M. Serrano, M. Blasco (2007)
The common biology of cancer and ageingNature, 448
-
S. Durinck, P. Spellman, E. Birney, W. Huber (2009)
Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRtNature Protocols, 4
-
(2019)
pheatmap: pretty heatmaps -
B. Bulik-Sullivan, H. Finucane, V. Anttila, A. Gusev, F. Day, Po-ru Loh, L. Duncan, J. Perry, N. Patterson, E. Robinson, M. Daly, A. Price, B. Neale (2015)
An Atlas of Genetic Correlations across Human Diseases and TraitsNature genetics, 47
-
(2020)
ggforce: Accelerating “ggplot2. -
M Lawrence, R Gentleman, V Carey (2009)
rtracklayer: an R package for interfacing with genome browsersBioinformatics, 25
-
T Berisa (2016)
10.1093/bioinformatics/btv546Bioinformatics, 32
-
W. Zhou, J. Nielsen, L. Fritsche, Rounak Dey, M. Gabrielsen, B. Wolford, J. Lefaive, Peter Vandehaar, Sarah Gagliano, A. Gifford, L. Bastarache, Wei-Qi Wei, J. Denny, Maoxuan Lin, K. Hveem, H. Kang, G. Abecasis, C. Willer, Seunggeun Lee (2017)
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studiesNature genetics, 50
-
Simon Johnson, Xiao Dong, J. Vijg, Y. Suh (2015)
Genetic evidence for common pathways in human age-related diseasesAging Cell, 14
-
A. Cortes, Patrick Albers, C. Dendrou, L. Fugger, G. McVean (2019)
Identifying cross-disease components of genetic risk across hospital data in the UK BiobankNature genetics, 52
-
Jeffrey Arnold (2016)
Extra Themes, Scales and Geoms for 'ggplot2' -
(1953)
AN UNSOLVED PROBLEM OF BIOLOGYMedical Journal of Australia, 1
-
Taras Oleksyk, Adam C, A. Auton, G. Abecasis, D. Altshuler, R. Durbin, D. Bentley, A. Chakravarti, A. Clark, P. Donnelly, E. Eichler, Paul Flicek, S. Gabriel, R. Gibbs, E. Green, M. Hurles, B. Knoppers, J. Korbel, E. Lander, Charles Lee, H. Lehrach, E. Mardis, Gabor Marth, G. McVean, D. Nickerson, Jeanette Schmidt, S. Sherry, Jun Wang, R. Wilson, K. Barnes, C. Beiswanger, E. Burchard, C. Bustamante, Hongyu Cai, H. Cao, N. Gerry, N. Gharani, Christopher Gignoux, S. Gravel, B. Henn, Danielle Jones, L. Jorde, J. Kaye, A. Keinan, A. Kent, A. Kerasidou, Yingrui Li, R. Mathias, A. Moreno-Estrada, P. Ossorio, M. Parker, Alissa Resch, C. Rotimi, C. Royal, Karla Sandoval, Yeyang Su, R. Sudbrak, Zhongming Tian, S. Tishkoff, L. Toji, C. Tyler-Smith, M. Via, Yuhong Wang, Huanming Yang, Ling Yang, Jia Zhu, L. Brooks, A. Felsenfeld, J. Mcewen, Yekaterina Vaydylevich, A. Duncanson, Michael Dunn, J. Schloss, Erik Garrison, Hyun Kang, J. Marchini, Shane McCarthy (2015)
A global reference for human genetic variationNature, 526
-
(2015)
UCSC.hg19.knownGene: annotation package for TxDb object(s). R package version 3.2.2 (Bioconductor Package Maintainer -
Allison Shultz, Timothy Sackton (2018)
Immune genes are hotspots of shared positive selection across birds and mammalseLife, 8
-
Ekta Khurana, Yao Fu, D. Chakravarty, F. Demichelis, M. Rubin, M. Gerstein (2016)
Role of non-coding sequence variants in cancerNature Reviews Genetics, 17
-
E. Crimmins (2015)
Lifespan and Healthspan: Past, Present, and Promise.The Gerontologist, 55 6
-
J. Sánchez-Valle, Héctor Tejero, J. Fernández, D. Juan, S. Capella-Gutiérrez, F. Al-Shahrour, R. Tabarés-Seisdedos, V. Pancaldi, A. Valencia (2018)
Unveiling the molecular basis of disease co-occurrence: towards personalized comorbidity profilesbioRxiv
-
(2020)
preprocessCore: A collection of pre-processing functions -
G. Williams (1957)
PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCEEvolution, 11
-
Christopher Chang, C. Chow, L. Tellier, Shashaank Vattikuti, S. Purcell, James Lee (2014)
Second-generation PLINK: rising to the challenge of larger and richer datasetsGigaScience, 4
-
M. Parkes, A. Cortes, D. Heel, M. Brown (2013)
Genetic insights into common pathways and complex relationships among immune-mediated diseasesNature Reviews Genetics, 14
-
A. Chouakria, P. Nagabhushan (2007)
Adaptive dissimilarity index for measuring time series proximityAdvances in Data Analysis and Classification, 1
-
S. Seiler (2016)
Finding Groups In Data -
Tomaz Berisa, Joseph Pickrell (2015)
Approximately independent linkage disequilibrium blocks in human populationsbioRxiv
-
Stefanie Piegholdt, G. Rimbach, A. Wagner (2016)
The phytoestrogen prunetin affects body composition and improves fitness and lifespan in male Drosophila melanogasterThe FASEB Journal, 30
-
R. Team (2014)
R: A language and environment for statistical computing.MSOR connections, 1
-
(2020)
ggnetwork: Geometries to Plot Networks with “ggplot2. -
J. Sánchez-Valle, Héctor Tejero, J. Fernández, D. Juan, B. Urda-García, S. Capella-Gutiérrez, F. Al-Shahrour, R. Tabarés-Seisdedos, A. Baudot, V. Pancaldi, A. Valencia (2020)
Interpreting molecular similarity between patients as a determinant of disease comorbidity relationshipsNature Communications, 11
-
D. Ellinghaus, L. Jostins, S. Spain, A. Cortes, J. Bethune, B. Han, Yu Park, S. Raychaudhuri, J. Pouget, M. Hübenthal, T. Folseraas, Yunpeng Wang, T. Esko, A. Metspalu, H. Westra, L. Franke, T. Pers, R. Weersma, V. Collij, M. D’Amato, J. Halfvarson, A. Jensen, W. Lieb, F. Degenhardt, A. Forstner, A. Hofmann, S. Schreiber, U. Mrowietz, B. Juran, K. Lazaridis, S. Brunak, A. Dale, R. Trembath, S. Weidinger, M. Weichenthal, E. Ellinghaus, James Elder, J. Barker, O. Andreassen, D. McGovern, T. Karlsen, J. Barrett, M. Parkes, M. Brown, A. Franke (2016)
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared lociNature genetics, 48
-
Stephanie Bien, U. Peters (2019)
Moving from one to many: insights from the growing list of pleiotropic cancer risk genesBritish Journal of Cancer, 120
-
A. Gutiérrez-Sacristán, À. Bravo, Alexia Giannoula, M. Mayer, F. Sanz, L. Furlong (2018)
comoRbidity: an R package for the systematic analysis of disease comorbiditiesBioinformatics, 34
-
Valerie Obenchain, Michael Lawrence, V. Carey, S. Gogarten, P. Shannon, Martin Morgan (2014)
VariantAnnotation: a Bioconductor package for exploration and annotation of genetic variantsBioinformatics, 30 14
-
Po-ru Loh, George Tucker, B. Bulik-Sullivan, B. Vilhjálmsson, H. Finucane, R. Salem, D. Chasman, P. Ridker, B. Neale, B. Berger, N. Patterson, A. Price (2014)
Efficient Bayesian mixed model analysis increases association power in large cohortsNature genetics, 47
-
H. Wickham, Mara Averick, Jennifer Bryan, Winston Chang, Lucy McGowan, Romain François, Garrett Grolemund, Alex Hayes, Lionel Henry, J. Hester, M. Kuhn, Thomas Pedersen, Evan Miller, S. Bache, K. Müller, Jeroen Ooms, David Robinson, D. Seidel, Vitalie Spinu, Kohske Takahashi, Davis Vaughan, Claus Wilke, Kara Woo, Hiroaki Yutani (2019)
Welcome to the TidyverseJ. Open Source Softw., 4
-
B. Bitarello, Cesare Filippo, J. Teixeira, J. Schmidt, Philip Kleinert, D. Meyer, A. Andrés (2017)
Signatures of Long-Term Balancing Selection in Human GenomesGenome Biology and Evolution, 10
-
JK Pickrell (2016)
10.1038/ng.3570Nat. Genet., 48
-
T. Flatt, L. Partridge (2018)
Horizons in the evolution of agingBMC Biology, 16
-
O. Panagiotou, J. Ioannidis (2012)
What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations.International journal of epidemiology, 41 1
-
Extended Data Fig. 2 | Distribution of median age-of-onset across disease categories. Points show diseases grouped by categories -
M. Wolfson, A. Budovsky, Robi Tacutu, V. Fraifeld (2009)
The signaling hubs at the crossroad of longevity and age-related disease networks.The international journal of biochemistry & cell biology, 41 3
-
Kristen Fortney, M. Kotlyar, I. Jurisica (2010)
Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans agingGenome Biology, 11
-
MD Young (2010)
10.1186/gb-2010-11-2-r14Genome Biol., 11
-
Lei Zhang, J. Vijg (2018)
Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging.Annual review of genetics, 52
-
R. Nielsen, C. Bustamante, A. Clark, S. Glanowski, Timothy Sackton, M. Hubisz, A. Fledel-Alon, D. Tanenbaum, D. Civello, T. White, John Sninsky, M. Adams, M. Cargill (2005)
A Scan for Positively Selected Genes in the Genomes of Humans and ChimpanzeesPLoS Biology, 3
-
Jeroen Ooms (2014)
The jsonlite Package: A Practical and Consistent Mapping Between JSON Data and R ObjectsArXiv, abs/1403.2805
-
Zheng Ning, Y. Pawitan, Xia Shen (2020)
High-definition likelihood inference of genetic correlations across human complex traitsNature Genetics, 52
-
A. Buniello, J. MacArthur, M. Cerezo, Laura Harris, J. Hayhurst, Cinzia Malangone, A. McMahon, Joannella Morales, Edward Mountjoy, E. Sollis, D. Suveges, Olga Vrousgou, P. Whetzel, R. Amode, Jose Guillen, H. Riat, S. Trevanion, Peggy Hall, Heather Junkins, P. Flicek, Tony Burdett, L. Hindorff, Fiona Cunningham, H. Parkinson (2018)
The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019Nucleic Acids Research, 47
-
P. Medawar (1953)
UNSOLVED problem of biology.The Medical journal of Australia, 1 24
-
Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia. Cancer 1172 -
BOLT - LMM v 2 . 3 . 1 User Manual -
Y. Benjamini, D. Yekutieli (2001)
THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCYAnnals of Statistics, 29
-
10.5962/bhl.title.27468
-
(2019)
cluster: cluster analysis basics and extensions -
GC Williams (1957)
10.2307/2406060Evolution, 11
-
S. Marttila, L. Kananen, S. Häyrynen, J. Jylhävä, T. Nevalainen, A. Hervonen, M. Jylhä, M. Nykter, M. Hurme (2015)
Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expressionBMC Genomics, 16
-
(2020)
ggplot2" Based Publication Ready Plots -
C. Kosiol, T. Vinař, R. Fonseca, M. Hubisz, C. Bustamante, R. Nielsen, A. Siepel (2008)
Patterns of Positive Selection in Six Mammalian GenomesPLoS Genetics, 4
-
Charles Darwin (1930)
The Genetical Theory of Natural SelectionNature, 126
-
Emmalee Adelman, Emmalee Adelman, Hsuan-Ting Huang, Alejandro Roisman, Andre Olsson, A. Colaprico, Tingting Qin, R. Lindsley, R. Bejar, N. Salomonis, H. Grimes, M. Figueroa (2019)
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.Cancer discovery
-
K. Kanchi, Kimberly Johnson, Charles Lu, M. McLellan, Mark Leiserson, M. Wendl, Qunyuan Zhang, D. Koboldt, Mingchao Xie, C. Kandoth, Joshua McMichael, Matthew Wyczalkowski, D. Larson, Heather Schmidt, Christopher Miller, R. Fulton, P. Spellman, E. Mardis, T. Druley, T. Graubert, P. Goodfellow, Benjamin Raphael, R. Wilson, L. Ding (2014)
Integrated Analysis of Germline and Somatic Variants in Ovarian CancerNature communications, 5
-
L. Partridge, J. Deelen, P. Slagboom (2018)
Facing up to the global challenges of ageingNature, 561
-
Joseph Pickrell, Tomaz Berisa, J. Liu, Laure Ségurel, J. Tung, D. Hinds (2015)
Detection and interpretation of shared genetic influences on 42 human traitsNature genetics, 48
-
N. Solovieff, C. Cotsapas, Phil Lee, S. Purcell, J. Smoller (2013)
Pleiotropy in complex traits: challenges and strategiesNature Reviews Genetics, 14
-
Z. Medvedev (1990)
AN ATTEMPT AT A RATIONAL CLASSIFICATION OF THEORIES OF AGEINGBiological Reviews, 65
-
(2020)
ggpubr: “ggplot2 -
(2014)
RColorBrewer: ColorBrewer Palettes -
liftOver: Changing genomic coordinate systems with rtracklayer -
K. Slowikowski (2020)
Automatically Position Non-Overlapping Text Labels with 'ggplot2' [R package ggrepel version 0.8.2] -
(2010)
Gene ontology analysis for 1159 RNA - seq : accounting for selection bias -
J. Rodríguez, U. Marigorta, D. Hughes, N. Spataro, E. Bosch, A. Navarro (2017)
Antagonistic pleiotropy and mutation accumulation influence human senescence and diseaseNature Ecology &Evolution, 1
-
G. Kempermann (2015)
Faculty Opinions recommendation of Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. -
J. Stephenson, R. Laskowski, Andrew Nightingale, M. Hurles, J. Thornton (2019)
VarMap: a web tool for mapping genomic coordinates to protein sequence and structure and retrieving protein structural annotationsBioinformatics, 35
-
(2001)
Series B (Statistical 1111 Methodology) vol -
Jiguang Wang, Shihua Zhang, Yong Wang, Luonan Chen, Xiang-Sun Zhang (2009)
Disease-Aging Network Reveals Significant Roles of Aging Genes in Connecting Genetic DiseasesPLoS Computational Biology, 5
-
M. Ashburner, C. Ball, J. Blake, D. Botstein, Heather Butler, J. Cherry, A. Davis, K. Dolinski, S. Dwight, J. Eppig, M. Harris, D. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. Matese, J. Richardson, M. Ringwald, G. Rubin, G. Sherlock (2000)
Gene Ontology: tool for the unification of biologyNature Genetics, 25
-
I. Pe’er, R. Yelensky, D. Altshuler, M. Daly (2007)
Estimation of the Multiple Testing Burden for Genomewide Association Studies of Common VariantsNature Precedings, 2
-
C. Anderson, F. Pettersson, G. Clarke, L. Cardon, A. Morris, K. Zondervan (2010)
Data quality control in genetic case-control association studiesNature Protocols, 5
-
Michael Lawrence, W. Huber, Hervé Pagès, Patrick Aboyoun, Marc Carlson, R. Gentleman, Martin Morgan, V. Carey (2013)
Software for Computing and Annotating Genomic RangesPLoS Computational Biology, 9
-
D. Berndt, J. Clifford (1994)
Using Dynamic Time Warping to Find Patterns in Time Series -
R. Avelar, Javier Ortega, Robi Tacutu, E. Tyler, Dominic Bennett, P. Binetti, A. Budovsky, Kasit Chatsirisupachai, Emily Johnson, Alex Murray, Samuel Shields, Daniela Tejada-Martinez, Daniel Thornton, V. Fraifeld, C. Bishop, J. Magalhães (2019)
A Multidimensional Systems Biology Analysis of Cellular Senescence in Ageing and DiseasebioRxiv
-
(2020)
data.table: Extension of ‘data.frame -
M Lawrence (2009)
10.1093/bioinformatics/btp328Bioinformatics, 25
-
Xin Chen, Ming Li, B. Ma, J. Tromp (2002)
DNACompress: fast and effective DNA sequence compressionBioinformatics, 18 12
-
Pablo Montero, J. Vilar (2014)
TSclust: An R Package for Time Series ClusteringJournal of Statistical Software, 62
-
Diogo Barardo, Daniel Thornton, Harikrishnan Thoppil, Michael Walsh, Samim Sharifi, Susana Ferreira, Andreja Anžič, Maria Fernandes, Patrick Monteiro, T. Grum, Rui Cordeiro, Evandro De-Souza, A. Budovsky, N. Araujo, Jan Gruber, M. Petrascheck, V. Fraifeld, A. Zhavoronkov, A. Moskalev, J. Magalhães (2017)
The DrugAge database of aging‐related drugsAging Cell, 16
-
All remaining analyses were performed using R 81 -
Teresa Niccoli, L. Partridge (2012)
Ageing as a Risk Factor for DiseaseCurrent Biology, 22
-
(2020)
scales: Scale Functions for Visualization -
B. Bulik-Sullivan, Po-ru Loh, H. Finucane, S. Ripke, Jian Yang, N. Patterson, M. Daly, A. Price, B. Neale (2014)
LD Score regression distinguishes confounding from polygenicity in genome-wide association studiesNature Genetics, 47
-
L. O'Connor, A. Price (2017)
Distinguishing genetic correlation from causation across 52 diseases and complex traitsNature Genetics, 50
-
S. Lee, S. Ripke, B. Neale, S. Faraone, S. Purcell, R. Perlis, B. Mowry, A. Thapar, M. Goddard, J. Witte, D. Absher, I. Agartz, H. Akil, F. Amin, O. Andreassen, A. Anjorin, R. Anney, V. Anttila, D. Arking, P. Asherson, M. Azevedo, L. Backlund, J. Badner, A. Bailey, T. Banaschewski, J. Barchas, M. Barnes, T. Barrett, N. Bass, A. Battaglia, M. Bauer, M. Bayés, F. Bellivier, Sarah Bergen, W. Berrettini, C. Betancur, T. Bettecken, J. Biederman, E. Binder, D. Black, D. Blackwood, C. Bloss, M. Boehnke, D. Boomsma, G. Breen, R. Breuer, R. Bruggeman, P. Cormican, N. Buccola, J. Buitelaar, W. Bunney, J. Buxbaum, W. Byerley, Enda Byrne, S. Caesar, W. Cahn, R. Cantor, M. Casas, A. Chakravarti, K. Chambert, K. Choudhury, S. Cichon, C. Cloninger, D. Collier, E. Cook, H. Coon, B. Cormand, A. Corvin, W. Coryell, D. Craig, I. Craig, J. Crosbie, M. Cuccaro, D. Curtis, D. Czamara, S. Datta, G. Dawson, R. Day, E. Geus, F. Degenhardt, S. Djurovic, G. Donohoe, A. Doyle, J. Duan, F. Dudbridge, E. Duketis, R. Ebstein, H. Edenberg, J. Elia, S. Ennis, B. Étain, A. Fanous, A. Farmer, I. Ferrier, M. Flickinger, E. Fombonne, T. Foroud, J. Frank, B. Franke, C. Fraser, R. Freedman, N. Freimer, C. Freitag, M. Friedl, L. Frisén, L. Gallagher, P. Gejman, L. Georgieva, E. Gershon, D. Geschwind, I. Giegling, M. Gill, S. Gordon, K. Gordon-Smith, E. Green, T. Greenwood, D. Grice, M. Gross, D. Grozeva, W. Guan, H. Gurling, L. Haan, J. Haines, H. Hakonarson, Joachim Hallmayer, S. Hamilton, M. Hamshere, T. Hansen, A. Hartmann, M. Hautzinger, A. Heath, A. Henders, S. Herms, I. Hickie, M. Hipolito, S. Hoefels, P. Holmans, F. Holsboer, W. Hoogendijk, J. Hottenga, C. Hultman, Vanessa Hus, A. Ingason, M. Ising, S. Jamain, E. Jones, I. Jones, L. Jones, Jung‐Ying Tzeng, A. Kähler, R. Kahn, R. Kandaswamy, M. Keller, J. Kennedy, E. Kenny, L. Kent, Yunjung Kim, G. Kirov, S. Klauck, L. Klei, J. Knowles, M. Kohli, Daniel Koller, B. Konte, A. Korszun, L. Krabbendam, R. Krasucki, J. Kuntsi, P. Kwan, M. Landén, Niklas Långström, M. Lathrop, J. Lawrence, W. Lawson, M. Leboyer, D. Ledbetter, Phil Lee, T. Lencz, K. Lesch, D. Levinson, C. Lewis, Jun Li, P. Lichtenstein, J. Lieberman, D. Lin, D. Linszen, Chunyu Liu, F. Lohoff, S. Loo, C. Lord, J. Lowe, S. Lucae, D. Macintyre, P. Madden, E. Maestrini, P. Magnusson, Pamela Mahon, W. Maier, A. Malhotra, S. Mane, C. Martin, N. Martin, M. Mattheisen, K. Matthews, M. Mattingsdal, S. Mccarroll, K. McGhee, J. McGough, P. McGrath, P. McGuffin, M. McInnis, A. McIntosh, R. Mckinney, A. McLean, F. McMahon, W. McMahon, A. McQuillin, H. Medeiros, S. Medland, S. Meier, I. Melle, F. Meng, Jobst Meyer, C. Middeldorp, L. Middleton, V. Milanova, A. Miranda, A. Monaco, G. Montgomery, J. Moran, D. Moreno-De-Luca, G. Morken, D. Morris, E. Morrow, V. Moskvina, P. Muglia, Thomas Mühleisen, W. Muir, B. Müller-Myhsok, M. Murtha, R. Myers, I. Myin‐Germeys, M. Neale, S. Nelson, C. Nievergelt, I. Nikolov, V. Nimgaonkar, W. Nolen, M. Nöthen, J. Nurnberger, E. Nwulia, D. Nyholt, C. O’Dushlaine, R. Oades, A. Olincy, G. Oliveira, L. Olsen, R. Ophoff, U. Osby, M. Owen, A. Palotie, J. Parr, A. Paterson, C. Pato, M. Pato, B. Penninx, M. Pergadia, M. Pericak-Vance, B. Pickard, J. Pimm, J. Piven, D. Posthuma, J. Potash, F. Poustka, P. Propping, V. Puri, D. Quested, E. Quinn, J. Ramos-Quiroga, H. Rasmussen, S. Raychaudhuri, K. Rehnström, A. Reif, M. Ribasés, J. Rice, M. Rietschel, K. Roeder, H. Roeyers, L. Rossin, A. Rothenberger, G. Rouleau, D. Ruderfer, D. Rujescu, A. Sanders, Stephan Sanders, S. Santangelo, J. Sergeant, R. Schachar, M. Schalling, A. Schatzberg, W. Scheftner, G. Schellenberg, S. Scherer, N. Schork, T. Schulze, J. Schumacher, M. Schwarz, E. Scolnick, L. Scott, Jianxin Shi, P. Shilling, Stanley Shyn, J. Silverman, S. Slager, S. Smalley, J. Smit, Erin Smith, E. Sonuga-Barke, D. Clair, M. State, M. Steffens, H. Steinhausen, J. Strauss, J. Strohmaier, T. Stroup, J. Sutcliffe, P. Szatmari, S. Szelinger, S. Thirumalai, Robert Thompson, A. Todorov, F. Tozzi, J. Treutlein, M. Uhr, E. Oord, G. Grootheest, J. os, A. Vicente, V. Vieland, J. Vincent, P. Visscher, C. Walsh, T. Wassink, S. Watson, M. Weissman, T. Werge, T. Wienker, E. Wijsman, G. Willemsen, N. Williams, A. Willsey, S. Witt, W. Xu, A. Young, T. Yu, S. Zammit, P. Zandi, Peng Zhang, F. Zitman, S. Zöllner, B. Devlin, J. Kelsoe, P. Sklar, M. Daly, M. O’Donovan, N. Craddock, P. Sullivan, J. Smoller, K. Kendler, N. Wray (2013)
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPsNature Genetics, 45
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(2015)
TxDb.Hsapiens.UCSC.hg19.knownGene: Annotation package for TxDb object(s)
- Publisher
- Springer Journals
- Copyright
- Copyright © The Author(s), under exclusive licence to Springer Nature America, Inc. 2021
- ISSN
- 2662-8465
- eISSN
- 2662-8465
- DOI
- 10.1038/s43587-021-00051-5
- Publisher site
- See Article on Publisher Site
Abstract
Age is a common risk factor in many diseases, but the molecular basis for this relationship is elusive. In this study we identified four disease clusters from 116 diseases in UK Biobank data, defined by their age-of-onset profiles, and found that diseases with the same onset profile are genetically more similar, suggesting a common etiology. This similarity was not explained by disease categories, co-occurrences or disease cause–effect relationships. Two of the four disease clusters had an increased risk of occurrence from ages 20 and 40 years, respectively. They both showed an association with known aging-related genes, yet differed in functional enrichment and evolutionary profiles. Moreover, they both had age-related expression and methylation changes. We also tested mutation accumulation and antagonistic pleiotropy theories of aging and found support for both.
Journal
Nature Aging – Springer Journals
Published: Apr 1, 2021