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Bovine Lactoferrin Can Be Taken Up by the Human Intestinal Lactoferrin Receptor and Exert Bioactivities

Bovine Lactoferrin Can Be Taken Up by the Human Intestinal Lactoferrin Receptor and Exert... ORIGINAL ARTICLE:HEPATOLOGY AND NUTRITION Bovine Lactoferrin Can Be Taken Up by the Human Intestinal Lactoferrin Receptor and Exert Bioactivities Bo Lo¨nnerdal, Rulan Jiang, and Xiaou Du function, and bone growth to enhancement of cellular proliferation and differentiation (1–3). It is found in extracellular secretions such See ‘‘Bovine Lactoferrin, Human Lactoferrin, and Bio- as milk, pancreatic fluid, bile, saliva, and mucosal excretions, but it activity’’ by Bhatia on page 589. also is present in neutrophils, where it participates in phagocytotic killing. It is particularly abundant in human colostrum and milk, ABSTRACT with concentrations ranging from 1 to 6 g/L (3). It is also present in cow’s milk, albeit at considerably lower concentrations (0.03– Objective: Human lactoferrin (hLF), a major protein in human milk, has 0.1 g/L in mature bovine milk). Because of its many biological been shown to exert multiple biological activities. To achieve some of the activities, purified bovine LF (bLF) is commercially available benefits of breast-fed infants, we investigated the feasibility of adding (CbLF) in large quantities for various applications. commercially available bovine LF (CbLF) to infant formula. Human LF (hLF) has been shown to bind to a specific LF Subjects and Methods: An intestinal enterocyte model (Caco-2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Gastroenterology & Nutrition Wolters Kluwer Health

Bovine Lactoferrin Can Be Taken Up by the Human Intestinal Lactoferrin Receptor and Exert Bioactivities

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Copyright
Copyright 2011 by ESPGHAN and NASPGHAN. Unauthorized reproduction of this article is prohibited.
ISSN
0277-2116
eISSN
1536-4801
DOI
10.1097/MPG.0b013e318230a419
pmid
21832946
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE:HEPATOLOGY AND NUTRITION Bovine Lactoferrin Can Be Taken Up by the Human Intestinal Lactoferrin Receptor and Exert Bioactivities Bo Lo¨nnerdal, Rulan Jiang, and Xiaou Du function, and bone growth to enhancement of cellular proliferation and differentiation (1–3). It is found in extracellular secretions such See ‘‘Bovine Lactoferrin, Human Lactoferrin, and Bio- as milk, pancreatic fluid, bile, saliva, and mucosal excretions, but it activity’’ by Bhatia on page 589. also is present in neutrophils, where it participates in phagocytotic killing. It is particularly abundant in human colostrum and milk, ABSTRACT with concentrations ranging from 1 to 6 g/L (3). It is also present in cow’s milk, albeit at considerably lower concentrations (0.03– Objective: Human lactoferrin (hLF), a major protein in human milk, has 0.1 g/L in mature bovine milk). Because of its many biological been shown to exert multiple biological activities. To achieve some of the activities, purified bovine LF (bLF) is commercially available benefits of breast-fed infants, we investigated the feasibility of adding (CbLF) in large quantities for various applications. commercially available bovine LF (CbLF) to infant formula. Human LF (hLF) has been shown to bind to a specific LF Subjects and Methods: An intestinal enterocyte model (Caco-2

Journal

Journal of Pediatric Gastroenterology & Nutrition – Wolters Kluwer Health

Published: Dec 1, 2011

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