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Defective trophoblast function in mice with a targeted mutation of Ets2

Defective trophoblast function in mice with a targeted mutation of Ets2 Downloaded from genesdev.cshlp.org on October 26, 2021 - Published by Cold Spring Harbor Laboratory Press Defective trophoblast function in mice with a targeted mutation of Ets2 1 2 1 3 Hideyuki Yamamoto, Margaret L. Flannery, Sergey Kupriyanov, Jonathan Pearce, 1 1 1 2 Scott R. McKercher, Gregory W. Henkel, Richard A. Maki, Zena Werb, 1,4 and Robert G. Oshima 1 2 The Burnham Institute, La Jolla, California 92037 USA; Department of Anatomy, University of California, San Francisco, San Francisco, California 94143 USA; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada Members of the Ets family of transcription factors mediate transcriptional responses of multiple signaling pathways in diverse cell types and organisms. Targeted deletion of the conserved DNA binding domain of the Ets2 transcription factor results in the retardation and death of homozygous mouse embryos before 8.5 days of embryonic development. Defects in extraembryonic tissue gene expression and function include deficient expression of matrix metalloproteinase-9 (MMP-9, gelatinase B), persistent extracellular matrix, and failure of ectoplacental cone proliferation. Mutant embryos were rescued by aggregation with tetraploid mouse embryos, which complement the developmental defects by providing functional extraembryonic tissues. Rescued Ets2-deficient mice are viable and fertile but have wavy hair, curly http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Defective trophoblast function in mice with a targeted mutation of Ets2

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.12.9.1315
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Abstract

Downloaded from genesdev.cshlp.org on October 26, 2021 - Published by Cold Spring Harbor Laboratory Press Defective trophoblast function in mice with a targeted mutation of Ets2 1 2 1 3 Hideyuki Yamamoto, Margaret L. Flannery, Sergey Kupriyanov, Jonathan Pearce, 1 1 1 2 Scott R. McKercher, Gregory W. Henkel, Richard A. Maki, Zena Werb, 1,4 and Robert G. Oshima 1 2 The Burnham Institute, La Jolla, California 92037 USA; Department of Anatomy, University of California, San Francisco, San Francisco, California 94143 USA; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada Members of the Ets family of transcription factors mediate transcriptional responses of multiple signaling pathways in diverse cell types and organisms. Targeted deletion of the conserved DNA binding domain of the Ets2 transcription factor results in the retardation and death of homozygous mouse embryos before 8.5 days of embryonic development. Defects in extraembryonic tissue gene expression and function include deficient expression of matrix metalloproteinase-9 (MMP-9, gelatinase B), persistent extracellular matrix, and failure of ectoplacental cone proliferation. Mutant embryos were rescued by aggregation with tetraploid mouse embryos, which complement the developmental defects by providing functional extraembryonic tissues. Rescued Ets2-deficient mice are viable and fertile but have wavy hair, curly

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Genes & Development – Unpaywall

Published: May 1, 1998

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