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- Publisher
- Wiley
- Copyright
- Copyright © 1995 Cambridge University Press
- ISSN
- 0265-9247
- eISSN
- 1521-1878
- DOI
- 10.1002/bies.950170203
- pmid
- 7748170
- Publisher site
- See Article on Publisher Site
Abstract
Diffuse‐type gastric carcinomas show diminished cell‐cell adhesion. A recent paper(1) reports that 50% of these carcinomas contain mutations in the E‐cadherin gene, resulting in the destruction of the calcium‐binding sites of E‐cadherin, and providing strong in vivo evidence that alterations in E‐cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.
Journal
BioEssays – Wiley
Published: Feb 1, 1995