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Assessment of Thyroid Function by the Combined Use of the Serum Protein-Bound Iodine and Resin Uptake of 131I-Triiodothyronine

Assessment of Thyroid Function by the Combined Use of the Serum Protein-Bound Iodine and Resin... A comparison has been made between the diagnostic accuracy of the PBI, the resin uptake of 131I-T3 and their mathematical product (PBI × resin uptake), the “free thyroxine” index, an arbitrary figure, assumed to be proportional to the concentration of free thyroxine in the blood. The 3 parameters have been determined in a total of 154 patients (108 clinically euthyroid, of whom 23 were pregnant and 4 had the nephrotic syndrome; 30 thyrotoxic and 16 hypothyroid). PBI values outside the normal range were found in 17.4 %of the pregnant women and in 93.3 % of thyrotoxic and 100 % of hypothyroid patients. Resin uptake values outside the normal range were found in 91.3 % of the pregnant women, and in 96.7 % of thyrotoxic and 87.5 % of hypothyroid patients. All thyrotoxic and hypothyroid patients fell outside the normal range for the “free thyroxine” index, whereas all the pregnant women gave values inside the normal range. Although the PBI and resin uptake test are highly satisfactory in the diagnosis of thyroid dysfunction, they may both be invalid as indicators of thyroid status, when variations in the thyroxine-binding proteins of plasma or interference with their action occurs. If taken in conjunction with each other, however, these 2 indices may disclose such instances because of the characteristic deviations produced therein. In these individuals the use of the “free thyroxine” index may indicate the true thyroid status, and may also be a more accurate diagnostic aid than the PBI or resin uptake test alone in the assessment of thyrotoxicosis or hypothyroidism. This content is only available as a PDF. Author notes 1 Senior Luccock Fellow in Medicine, University of Newcastle upon Tyne. Present address: Department of Internal Medicine, University of Virginia Hospital, Charlottesville, Virginia. Copyright © 1965 by The Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

Assessment of Thyroid Function by the Combined Use of the Serum Protein-Bound Iodine and Resin Uptake of 131I-Triiodothyronine

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Publisher
Oxford University Press
Copyright
Copyright © 1965 by The Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
DOI
10.1210/jcem-25-1-39
Publisher site
See Article on Publisher Site

Abstract

A comparison has been made between the diagnostic accuracy of the PBI, the resin uptake of 131I-T3 and their mathematical product (PBI × resin uptake), the “free thyroxine” index, an arbitrary figure, assumed to be proportional to the concentration of free thyroxine in the blood. The 3 parameters have been determined in a total of 154 patients (108 clinically euthyroid, of whom 23 were pregnant and 4 had the nephrotic syndrome; 30 thyrotoxic and 16 hypothyroid). PBI values outside the normal range were found in 17.4 %of the pregnant women and in 93.3 % of thyrotoxic and 100 % of hypothyroid patients. Resin uptake values outside the normal range were found in 91.3 % of the pregnant women, and in 96.7 % of thyrotoxic and 87.5 % of hypothyroid patients. All thyrotoxic and hypothyroid patients fell outside the normal range for the “free thyroxine” index, whereas all the pregnant women gave values inside the normal range. Although the PBI and resin uptake test are highly satisfactory in the diagnosis of thyroid dysfunction, they may both be invalid as indicators of thyroid status, when variations in the thyroxine-binding proteins of plasma or interference with their action occurs. If taken in conjunction with each other, however, these 2 indices may disclose such instances because of the characteristic deviations produced therein. In these individuals the use of the “free thyroxine” index may indicate the true thyroid status, and may also be a more accurate diagnostic aid than the PBI or resin uptake test alone in the assessment of thyrotoxicosis or hypothyroidism. This content is only available as a PDF. Author notes 1 Senior Luccock Fellow in Medicine, University of Newcastle upon Tyne. Present address: Department of Internal Medicine, University of Virginia Hospital, Charlottesville, Virginia. Copyright © 1965 by The Endocrine Society

Journal

Journal of Clinical Endocrinology and Metabolism – Oxford University Press

Published: Jan 1, 1965

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