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Prospective, Randomized, Controlled Trial of Tissue Adhesive (2‐Octylcyanoacrylate) vs Standard Wound Closure Techniques for Laceration Repair

Prospective, Randomized, Controlled Trial of Tissue Adhesive (2‐Octylcyanoacrylate) vs Standard... ABSTRACT Objective: To compare a new tissue adhesive, 2‐octylcyanoacrylate, with standard wound closure techniques for the repair of traumatic lacerations. Methods: A prospective, randomized, controlled clinical trial enrolled consecutive patients >1 year of age with non‐bite, non‐crush‐induced lacerations who presented <6 hours after injury. Structured closed‐question data sheets were completed at the time of laceration repair and suture removal. Patients were randomly assigned to treatment with either 2‐octylcyanoacrylate or standard wound closure. Infection was determined at the time of suture removal. Long‐term cosmetic appearance (>3 months) was assessed by physicians using a previously validated categorical cosmetic scale and by patients using a 100‐mm visual analog scale. Results: There were 63 patients randomized to the octylcyanoacrylate group and 61 patients treated with standard wound closure techniques. The 2 treatment groups were similar with respect to age, gender, race, medical history, and wound characteristics. At the 5‐to‐10‐day follow‐up, only 1 wound was infected and only 2 wounds required reclosure due to dehiscence. These 3 patients received treatment with octylcyanoacrylate. At long‐term follow‐up, the cosmetic appearances were similar according to the patients (octylcyanoacrylate, 83.8 ± 19.4 mm vs standard techniques, 82.5 ± 17.6 mm; p = 0.72) and the physicians (optimal cosmetic appearance, 77% vs 80%; p = 0.67). Conclusions: Wounds treated with octylcyanoacrylate and standard wound closure techniques have similar cosmetic appearances 3 months later. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Academic Emergency Medicine Wiley

Prospective, Randomized, Controlled Trial of Tissue Adhesive (2‐Octylcyanoacrylate) vs Standard Wound Closure Techniques for Laceration Repair

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References (43)

Publisher
Wiley
Copyright
Copyright © 1998 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1069-6563
eISSN
1553-2712
DOI
10.1111/j.1553-2712.1998.tb02590.x
Publisher site
See Article on Publisher Site

Abstract

ABSTRACT Objective: To compare a new tissue adhesive, 2‐octylcyanoacrylate, with standard wound closure techniques for the repair of traumatic lacerations. Methods: A prospective, randomized, controlled clinical trial enrolled consecutive patients >1 year of age with non‐bite, non‐crush‐induced lacerations who presented <6 hours after injury. Structured closed‐question data sheets were completed at the time of laceration repair and suture removal. Patients were randomly assigned to treatment with either 2‐octylcyanoacrylate or standard wound closure. Infection was determined at the time of suture removal. Long‐term cosmetic appearance (>3 months) was assessed by physicians using a previously validated categorical cosmetic scale and by patients using a 100‐mm visual analog scale. Results: There were 63 patients randomized to the octylcyanoacrylate group and 61 patients treated with standard wound closure techniques. The 2 treatment groups were similar with respect to age, gender, race, medical history, and wound characteristics. At the 5‐to‐10‐day follow‐up, only 1 wound was infected and only 2 wounds required reclosure due to dehiscence. These 3 patients received treatment with octylcyanoacrylate. At long‐term follow‐up, the cosmetic appearances were similar according to the patients (octylcyanoacrylate, 83.8 ± 19.4 mm vs standard techniques, 82.5 ± 17.6 mm; p = 0.72) and the physicians (optimal cosmetic appearance, 77% vs 80%; p = 0.67). Conclusions: Wounds treated with octylcyanoacrylate and standard wound closure techniques have similar cosmetic appearances 3 months later.

Journal

Academic Emergency Medicine – Wiley

Published: Feb 1, 1998

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