Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/genetics-of-metabolic-syndrome-ZnNM8omj0n
References (86)
-
Hengjiang Dong, B. Maddux, J. Altomonte, M. Meseck, D. Accili, R. Terkeltaub, Kristen Johnson, J. Youngren, I. Goldfine (2005)
Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.Diabetes, 54 2
-
Dr. DeRijk, M. Schaaf, Gordon Turner, N. Datson, E. Vreugdenhil, J. Cidlowski, E. Kloet, P. Emery, E. Sternberg, SEVILLA DETERA-WADLEIGH (2001)
A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis.The Journal of rheumatology, 28 11
-
L. Pennacchio, M. Olivier, J. Hubacek, Jonathan Cohen, D. Cox, J. Fruchart, R. Krauss, E. Rubin (2001)
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative SequencingScience, 294
-
Yoshiji Yamada, Kimihiko Kato, T. Hibino, K. Yokoi, H. Matsuo, Tomonori Segawa, Sachiro Watanabe, S. Ichihara, H. Yoshida, K. Satoh, Y. Nozawa (2007)
Prediction of genetic risk for metabolic syndrome.Atherosclerosis, 191 2
-
J. Robitaille, C. Brouillette, A. Houde, J. Despres, A. Tchernof, M. Vohl (2004)
Molecular screening of the 11beta-HSD1 gene in men characterized by the metabolic syndrome.Obesity research, 12 10
-
J. Seckl, Nik Morton, K. Chapman, B. Walker (2004)
Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue.Recent progress in hormone research, 59
-
S. Das, S. Hasstedt, Zhengxian Zhang, S. Elbein (2004)
Linkage and association mapping of a chromosome 1q21-q24 type 2 diabetes susceptibility locus in northern European Caucasians.Diabetes, 53 2
-
M. Ng, W. So, N. Cox, V. Lam, C. Cockram, J. Critchley, G. Bell, J. Chan (2004)
Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25.Diabetes, 53 6
-
H. Lyon, H. Lyon, H. Lyon, V. Emilsson, A. Hinney, I. Heid, J. Lasky-Su, J. Lasky-Su, Xiaofeng Zhu, G. Thorleifsson, Steinunn Gunnarsdottir, G. Walters, U. Thorsteinsdóttir, A. Kong, J. Gulcher, T. Nguyen, A. Scherag, A. Pfeufer, T. Meitinger, G. Brönner, W. Rief, M. Soto-Quiros, L. Avila, B. Klanderman, B. Raby, E. Silverman, S. Weiss, N. Laird, Xiao Ding, L. Groop, L. Groop, L. Groop, T. Tuomi, T. Tuomi, B. Isomaa, Kristina Bengtsson, Kristina Bengtsson, J. Butler, J. Butler, R. Cooper, C. Fox, C. O’Donnell, C. Vollmert, J. Celedón, H. Wichmann, J. Hebebrand, K. Stefánsson, C. Lange, J. Hirschhorn, J. Hirschhorn, J. Hirschhorn (2007)
The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All CohortsPLoS Genetics, 3
-
K. Alberti, P. Zimmet, J. Shaw (2005)
The metabolic syndrome—a new worldwide definitionThe Lancet, 366
-
S. Starr, K. Jameson, Annu Hogquist, Rev, J Roose, M. Mollenauer, V. Gupta, J. Stone, A. Weiss, L Berg, L. Finkelstein, J. Lucas, P. Schwartzberg, M Fukuda, T. Kojima, H. Kabayama, K. Mikoshiba, J. Biol, K Ching, Y. Kawakami, T. Kawakami, C. Tsoukas, A Guse, E. Greiner, F. Emmrich, K. Brand, Alberola-Ila, A. Altman, N. Gascoigne, G. Koretzky, L. Min, K. Mowen, R. Reisfeld, C. Schmedt, T. Frayling, N. Timpson, M. Weedon, E. Zeggini, R. Freathy, C. Lindgren, J. Perry, K. Elliott, H. Lango, N. Rayner, B. Shields, L. Harries, J. Barrett, S. Ebrahim, D. Lawlor, S. Ring, Y. Ben-Shlomo, L. Ferrucci, R. Loos, C. Palmer
References and Notes Supporting Online Material Materials and Methods Som Text Figs. S1 to S7 References a Common Variant in the Fto Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity -
Y. Yamada, S. Ichihara, K. Kato, T. Yoshida, K. Yokoi, H. Matsuo, S. Watanabe, N. Metoki, H. Yoshida, K. Satoh, Y. Aoyagi, A. Yasunaga, H. Park, M. Tanaka, W. Lee, Y. Nozawa (2007)
Genetic risk for metabolic syndrome: examination of candidate gene polymorphisms related to lipid metabolism in Japanese peopleJournal of Medical Genetics, 45
-
J. Stephens, S. Hurel, G. Lowe, A. Rumley, S. Humphries (2007)
Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus.Molecular genetics and metabolism, 90 4
-
Eva-Maria Sedlmeier, H. Grallert, C. Huth, H. Löwel, C. Herder, K. Strassburger, G. Giani, H. Wichmann, H. Hauner, T. Illig, W. Rathmann (2007)
Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg.European journal of endocrinology, 156 3
-
S. Shackleton, D. Lloyd, S. Jackson, R. Evans, M. Niermeijer, Baldev Singh, H. Schmidt, G. Brabant, Sudesh Kumar, P. Durrington, S. Gregory, S. O’Rahilly, R. Trembath (2000)
LMNA, encoding lamin A/C, is mutated in partial lipodystrophyNature Genetics, 24
-
N. Vionnet, E. Hani, S. Dupont, S. Gallina, S. Francke, Sébastien Dotte, Frédérique Matos, E. Durand, F. Leprêtre, C. Lecoeur, Philippe Gallina, Lirije Zekiri, C. Dina, P. Froguel (2000)
Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.American journal of human genetics, 67 6
-
S. Grundy, D. Bilheimer, A. Chait, L. Clark, M. Denke, R. Havel, W. Hazzard, S. Hulley, D. Hunninghake, R. Kreisberg, P. Kris-Etherton, J. Mckenney, Michael Newman, E. Schaefer, B. Sobel, C. Somelofski, M. Weinstein, H. Brewer, J. Cleeman, K. Donato, N. Ernst, J. Hoeg, B. Rifkind, J. Rossouw, C. Sempos, J. Gallivan, M. Harris, L. Quint-Adler (1993)
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)JAMA, 269 23
-
E. Komurcu-Bayrak, A. Onat, M. Poda, S. Humphries, J. Acharya, G. Hergenç, N. Coban, G. Can, N. Erginel-Unaltuna (2007)
The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks.Clinica chimica acta; international journal of clinical chemistry, 383 1-2
-
L. Emorine, S. Marullo, M. Briend-Sutren, G. Patey, K. Tate, C. Delavier-Klutchko, A. Strosberg (1989)
Molecular characterization of the human beta 3-adrenergic receptor.Science, 245 4922
-
Hayden. Huang, R. Kamm, Richard Lee (2004)
Cell mechanics and mechanotransduction: pathways, probes, and physiology.American journal of physiology. Cell physiology, 287 1
-
A. Syed, J. Irving, C. Redfern, A. Hall, N. Unwin, M. White, R. Bhopal, J. Weaver (2006)
Association of Glucocorticoid Receptor Polymorphism A3669G in Exon 9β with Reduced Central Adiposity in WomenObesity, 14
-
D. Bowden, M. Rudock, J. Ziegler, A. Lehtinen, Jianzhao Xu, L. Wagenknecht, D. Herrington, S. Rich, B. Freedman, J. Carr, C. Langefeld (2006)
Coincident Linkage of Type 2 Diabetes, Metabolic Syndrome, and Measures of Cardiovascular Disease in a Genome Scan of the Diabetes Heart StudyDiabetes, 55
-
H. Grallert, Eva-Maria Sedlmeier, C. Huth, M. Kolz, I. Heid, C. Meisinger, C. Herder, K. Strassburger, Anke Gehringer, Markus Haak, G. Giani, F. Kronenberg, H. Wichmann, J. Adamski, B. Paulweber, T. Illig, W. Rathmann (2007)
APOA5 variants and metabolic syndrome in Caucasianss⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of three tables, one figure. Published, JLR Papers in Press, September 3, 2007.Journal of Lipid Research, 48
-
Katrin Hoffmann, M. Mattheisen, S. Dahm, P. Nürnberg, Cheryl Roe, Julie Johnson, N. Cox, H. Wichmann, T. Wienker, Jan Schulze, Peter Schwarz, Tom Lindner (2007)
A German genome-wide linkage scan for type 2 diabetes supports the existence of a metabolic syndrome locus on chromosome 1p36.13 and a type 2 diabetes locus on chromosome 16p12.2Diabetologia, 50
-
R. Oakley, C. Jewell, M. Yudt, Daphne Bofetiado, J. Cidlowski (1999)
The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action.The Journal of biological chemistry, 274 39
-
E. Carballo, W. Lai, P. Blackshear (1998)
Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by TristetraprolinScience, 281
-
Biao Wang, F. Chehab (2006)
Deletion of the serotonin 2c receptor from transgenic mice overexpressing leptin does not affect their lipodystrophy but exacerbates their diet-induced obesity.Biochemical and biophysical research communications, 351 2
-
P. Russo, F. Lauria, M. Loguercio, G. Barba, J. Arnout, F. Cappuccio, M. Lorgeril, M. Donati, L. Iacoviello, V. Krogh, M. Dongen, A. Siani (2007)
-344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men.American journal of hypertension, 20 2
-
Masashi Tanaka, N. Fuku, Y. Nishigaki, H. Matsuo, Tomonori Segawa, Sachiro Watanabe, Kimihiko Kato, Kiyoshi Yoko, Masafumi Ito, Y. Nozawa, Yoshiji Yamada (2007)
Women With Mitochondrial Haplogroup N9a Are Protected Against Metabolic SyndromeDiabetes, 56
-
Hsiu-Fen Lin, Hsiu-Fen Lin, B. Boden-Albala, S. Juo, N. Park, T. Rundek, R. Sacco (2005)
Heritabilities of the metabolic syndrome and its components in the Northern Manhattan Family StudyDiabetologia, 48
-
Y. Bossé, J. Despres, Y. Chagnon, T. Rice, D. Rao, C. Bouchard, L. Pérusse, M. Vohl (2007)
Quantitative Trait Locus on 15q for a Metabolic Syndrome Variable Derived from Factor AnalysisObesity, 15
-
S. Tamaki, Yasuyuki Nakamura, Y. Tabara, T. Okamura, Y. Kita, T. Kadowaki, Y. Tsujita, M. Horie, T. Miki, H. Ueshima (2006)
Relationship between Metabolic Syndrome and Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene in a General Sample: The Shigaraki StudyHypertension Research, 29
-
F. Mousavinasab, T. Tähtinen, J. Jokelainen, P. Koskela, M. Vanhala, J. Oikarinen, M. Laakso, S. Keinänen-Kiukaanniemi (2006)
The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young finnish menEndocrine, 30
-
Y. Higaki, M. Hirshman, N. Fujii, L. Goodyear (2001)
Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle.Diabetes, 50 2
-
L. Shapiro, P. Scherer (1998)
The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factorCurrent Biology, 8
-
D. Carmelli, L. Cardon, R. Fabsitz (1994)
Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments?American journal of human genetics, 55 3
-
J. Gónzalez-Sánchez, M. Martínez-Larrad, M. Sáez, C. Zabena, M. Martínez-Calatrava, M. Serrano-Ríos (2007)
Endothelial nitric oxide synthase haplotypes are associated with features of metabolic syndrome.Clinical chemistry, 53 1
-
E. Ford, W. Giles, W. Dietz (2002)
Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.JAMA, 287 3
-
E. Rhee, K. Oh, Won-Young Lee, Se Kim, E. Oh, K. Baek, M. Kang, Sun Kim (2006)
Effects of two common polymorphisms of peroxisome proliferator-activated receptor-gamma gene on metabolic syndrome.Archives of medical research, 37 1
-
I. Tasic, M. Milojkovic, R. Sunder-Plassmann, G. Lazarević, N. Tasić, V. Stefanović (2007)
The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease.Clinica chimica acta; international journal of clinical chemistry, 377 1-2
-
S. Krief, F. Lönnqvist, S. Raimbault, B. Baude, A. Spronsen, Peter Arner, A. Strosberg, D. Ricquier, L. Emorine (1993)
Tissue distribution of beta 3-adrenergic receptor mRNA in man.The Journal of clinical investigation, 91 1
-
J.L. Mesa, R.J. Loos, P.W. Franks (2007)
Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studiesDiabetes, 56
-
G. Norata, M. Ongari, K. Garlaschelli, G. Tibolla, L. Grigore, S. Raselli, S. Vettoretti, I. Baragetti, D. Noto, A. Cefalù, G. Buccianti, M. Averna, A. Catapano (2007)
Effect of the −420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunctionJournal of Internal Medicine, 262
-
A. Tonjes, M. Scholz, M. Loeffler, M. Stumvoll (2006)
Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individualsDiabetes Care, 29
-
S. Grundy, J. Cleeman, S. Daniels, K. Donato, R. Eckel, B. Franklin, D. Gordon, R. Krauss, P. Savage, Sidney Smith, J. Spertus, F. Costa (2005)
Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement.Circulation, 112 17
-
A. Meirhaeghe, D. Cottel, P. Amouyel, J. Dallongeville (2005)
Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women.Diabetes, 54 10
-
D. Einhorn, G. Reaven, R. Cobin, E. Ford, O. Ganda, Y. Handelsman, Richard Hellman, P. Jellinger, D. Kendall, R. Krauss, Naomi Neufeld, S. Petak, H. Rodbard, J. Seibel, Donald Smith, P. Wilson (2003)
American College of Endocrinology position statement on the insulin resistance syndrome.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 9 3
-
R. Arya, J. Blangero, K. Williams, L. Almasy, T. Dyer, R. Leach, P. O'Connell, M. Stern, R. Duggirala (2002)
Factors of insulin resistance syndrome--related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic mexican-americans.Diabetes, 51 3
-
J. Mesa, R. Loos, P. Franks, K. Ong, J. Luan, S. O’Rahilly, N. Wareham, I. Barroso (2007)
Lamin A/C Polymorphisms, Type 2 Diabetes, and the Metabolic SyndromeDiabetes, 56
-
A. Tönjes, M. Scholz, M. Loeffler, M. Stumvoll (2006)
Association of Pro12Ala Polymorphism in Peroxisome Proliferator–Activated Receptor γ With Pre-Diabetic PhenotypesDiabetes Care, 29
-
C. Fleury, M. Neverova, S. Collins, S. Raimbault, O. Champigny, C. Lévi-Meyrueis, F. Bouillaud, M. Seldin, R. Surwit, D. Ricquier, C. Warden (1997)
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemiaNature Genetics, 15
-
R. Pollex, A. Hanley, B. Zinman, S. Harris, Hafiz Khan, R. Hegele (2006)
Metabolic syndrome in aboriginal Canadians: prevalence and genetic associations.Atherosclerosis, 184 1
-
J. Himms‐Hagen, M. Harper (2001)
Physiological Role of UCP3 May Be Export of Fatty Acids from Mitochondria When Fatty Acid Oxidation Predominates: An HypothesisExperimental Biology and Medicine, 226
-
M. Ng, W. So, V. Lam, C. Cockram, G. Bell, N. Cox, J. Chan (2004)
Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25.Diabetes, 53 10
-
J. McCarthy, Joanne Meyer, D. Moliterno, L. Newby, W. Rogers, E. Topol (2003)
Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patientsHuman Genetics, 114
-
T.M. Frayling, N.J. Timpson, M.N. Weedon (2007)
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesityScience, 316
-
Hua Wang, W. Chu, T. Lu, S. Hasstedt, P. Kern, S. Elbein (2004)
Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.American journal of physiology. Endocrinology and metabolism, 286 1
-
P. Lahiry, R. Pollex, R. Hegele (2008)
Uncloaking the Genetic Determinants of Metabolic SyndromeLifestyle Genomics, 1
-
C. Dina, D. Meyre, S. Gallina, E. Durand, A. Körner, P. Jacobson, L. Carlsson, W. Kiess, V. Vatin, C. Lecoeur, J. Delplanque, Emmanuel Vaillant, F. Pattou, J. Ruiz, J. Weill, C. Lévy‐Marchal, F. Horber, N. Potoczna, S. Hercberg, C. Stunff, P. Bougnères, P. Kovacs, M. Marre, B. Balkau, S. Cauchi, J. Chévre, P. Froguel (2007)
Variation in FTO contributes to childhood obesity and severe adult obesityNature Genetics, 39
-
C. Gallagher, C. Langefeld, C. Gordon, Joel Campbell, Josyf Mychalecky, M. Bryer‐Ash, S. Rich, D. Bowden, M. Sale (2007)
Association of the Estrogen Receptor-α Gene With the Metabolic Syndrome and Its Component Traits in African-American FamiliesDiabetes, 56
-
Catherine Chan, M. Saleh, V. Koshkin, M. Wheeler (2004)
Uncoupling protein 2 and islet function.Diabetes, 53 Suppl 1
-
W. Taylor, N. Unwin (2009)
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Detection, Evaluation, and Treatment of High Blood Cholesterol Education Program (NCEP) Expert Panel on Executive Summary of the Third Report of the National -
Wei-Shiung Yang, Yi-Ching Yang, Chi-Ling Chen, I. Wu, Jin-Ying Lu, F. Lu, T. Tai, Chih-Jen Chang (2007)
Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly.The American journal of clinical nutrition, 86 2
-
Y. Lee, S. Nair, E. Rousseau, D. Allison, G. Page, P. Tataranni, C. Bogardus, P. Permana (2005)
Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genesDiabetologia, 48
-
J. Robitaille, C. Brouillette, A. Houde, S. Lemieux, L. Pérusse, A. Tchernof, D. Gaudet, M. Vohl (2004)
Association between the PPARα-L162V polymorphism and components of the metabolic syndromeJournal of Human Genetics, 49
-
B. Balkau, M.A. Charles (1999)
Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR)Diabet Med, 16
-
L. Bouchard, A. Tchernof, Y. Deshaies, S. Marceau, O. Lescelleur, S. Biron, M. Vohl (2007)
ZFP36: a Promising Candidate Gene for Obesity-Related Metabolic Complications Identified by Converging GenomicsObesity Surgery, 17
-
W. Hsueh, P. Jean, B. Mitchell, T. Pollin, W. Knowler, M. Ehm, C. Bell, H. Sakul, M. Wagner, D. Burns, A. Shuldiner (2003)
Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24.Diabetes, 52 2
-
R. Loos, P. Katzmarzyk, D. Rao, T. Rice, A. Leon, J. Skinner, J. Wilmore, T. Rankinen, C. Bouchard (2003)
Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study.The Journal of clinical endocrinology and metabolism, 88 12
-
G. Pieper (1999)
Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease durationDiabetologia, 42
-
F. Thameem, V. Farook, C. Bogardus, M. Procházka (2006)
Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians.Diabetes, 55 3
-
Haiqing Shen, L. Qi, E. Tai, S. Chew, C. Tan, J. Ordovás (2006)
Uncoupling Protein 2 Promoter Polymorphism −866G/A, Central Adiposity, and Metabolic Syndrome in AsiansObesity, 14
-
Michael Miller, J. Rhyne, Hegang Chen, Valerie Beach, Richard Ericson, K. Luthra, M. Dwivedi, Anoop Misra (2007)
APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome.Archives of medical research, 38 4
-
R. Hegele, C. Anderson, Jian Wang, Doreen Jones, H. Cao (2000)
Association between nuclear lamin A/C R482Q mutation and partial lipodystrophy with hyperinsulinemia, dyslipidemia, hypertension, and diabetes.Genome research, 10 5
-
J. Robitaille, D. Gaudet, L. Pérusse, M. Vohl (2007)
Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta −87T>C polymorphism and dietary fat in French-CanadiansInternational Journal of Obesity, 31
-
H. Mulder, B. Franke, Annemarie der, J. Arends, F. Wilmink, H. Scheffer, A. Egberts (2007)
The Association Between HTR2C Gene Polymorphisms and the Metabolic Syndrome in Patients With SchizophreniaJournal of Clinical Psychopharmacology, 27
-
K. Edwards, B. Newman, E. Mayer, Joeseph Selby, R. Krauss, M. Austin (1997)
Heritability of factors of the insulin resistance syndrome in women twinsGenetic Epidemiology, 14
-
H. Cao, R. Hegele (2000)
Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy.Human molecular genetics, 9 1
-
S. Sookoian, Claudio González, C. Pirola (2005)
Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome.Obesity research, 13 12
-
Y. Hamid, C. Rose, S. Urhammer, C. Glümer, R. Nolsøe, O. Kristiansen, T. Mandrup-Poulsen, T. Mandrup-Poulsen, K. Borch-Johnsen, K. Borch-Johnsen, T. Jørgensen, T. Hansen, O. Pedersen, O. Pedersen (2005)
Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian DanesDiabetologia, 48
-
Yong-Xiao Wang, Yun‐Min Zheng, Q. Mei, Qinqping Wang, M. Collier, S. Fleischer, H. Xin, M. Kotlikoff (2004)
FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.American journal of physiology. Cell physiology, 286 3
-
C.J. Gallagher, C.D. Langefeld, C.J. Gordon (2007)
Association of the estrogen receptor-alpha gene with the metabolic syndrome and its component traits in African-American families: the Insulin Resistance Atherosclerosis Family StudyDiabetes, 56
-
B. Balkau, M. Charles (1999)
Comment on the provisional report from the WHO consultationDiabetic Medicine, 16
-
C. Langefeld, L. Wagenknecht, J. Rotter, A. Williams, J. Hokanson, M. Saad, D. Bowden, S. Haffner, J. Norris, S. Rich, B. Mitchell (2004)
Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study.Diabetes, 53 4
-
H. Grallert, E.M. Sedlmeier, C. Huth (2007)
APOA5 variants and metabolic syndrome in CaucasiansJ Lipid Res, 48
-
A. Kissebah, G. Sonnenberg, Joel Myklebust, Michael Goldstein, K. Broman, Roland James, Jacqueline Marks, G. Krakower, H. Jacob, J. Weber, L. Martin, J. Blangero, A. Comuzzie (2000)
Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.Proceedings of the National Academy of Sciences of the United States of America, 97 26
- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Current Medicine Group LLC
- Subject
- Medicine & Public Health; Diabetes
- ISSN
- 1534-4827
- eISSN
- 1539-0829
- DOI
- 10.1007/s11892-008-0025-y
- Publisher site
- See Article on Publisher Site
Abstract
Metabolic syndrome (MetS) is a common phenotype, affecting about 24% of the US population. It is associated with an increased risk for type 2 diabetes and cardiovascular disease. Although there is no universally accepted definition for MetS, affected individuals commonly have a cluster of features, including abdominal obesity, hypertension, dyslipidemia, and dysglycemia. Recently, there has been extensive interest in potential genetic contributions to MetS. At present, no single gene or cluster of genes has been consistently replicated for MetS among different populations, likely due to the complex interplay between gene and environment necessary for expression of this phenotype. We review recent studies regarding the genetic contributions to MetS.
Journal
Current Diabetes Reports – Springer Journals
Published: May 4, 2008