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- Publisher
- Wiley
- Copyright
- © 2015 Federation of European Biochemical Societies
- eISSN
- 1873-3468
- DOI
- 10.1016/0014-5793(87)80373-3
- Publisher site
- See Article on Publisher Site
Abstract
A new β‐lactam‐inducible penicillin‐binding protein (PBP) that has extremely low affinity to penicillin and most other β‐lactam antibiotics has been widely found in highly, β‐lactam(methicillin)‐resistant Staphylococcus aureus (MRSA). The gene for this protein was sequenced and the nucleotide sequence in its promoter and close upstream area was found to show close similarity with that of staphylococcal penicillinase, while the amino acid sequence over a wide range of the molecule was found to be similar to those of two PBPs of Escherichia coli, the shape‐determining protein (PBP 2) and septum‐forming one (PBP 3). Probably the MRSA PBP (M r 76462) evolved by recombination of two genes: an inducible type I penicillinase gene and a PBP gene of a bacterium, causing the formation of a β‐lactam‐inducible MRSA PBP.
Journal
Febs Letters – Wiley
Published: Aug 31, 1987
Keywords: ; ; ; ; ;