Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Arterial Stiffness and Arterial Wave Reflections Are Associated With Systolic and Diastolic Function in Patients With Normal Ejection Fraction

Arterial Stiffness and Arterial Wave Reflections Are Associated With Systolic and Diastolic... BackgroundIncreased arterial stiffness and early wave reflections have been observed in patients with heart failure and normal ejection fraction (HFNEF). We investigated, whether impaired arterial function is associated with impaired systolic and diastolic function and symptomatic status.MethodsWe prospectively enrolled 336 patients (mean age 63.5 years) undergoing coronary angiography, and assessed pulse wave velocity (PWV) invasively, arterial wave reflections (augmentation index (AIx); pressure augmentation (AP)) noninvasively using radial applanation tonometry and a validated transfer function, and characteristic impedance (Zc) using echocardiography with tonometry. In addition, echocardiography including tissue Doppler of the mitral annulus was performed.ResultsPeak systolic velocity (S′) varied inversely with AIx (R = −0.38, P < 0.001), AP (R = −0.48, P < 0.0001), PWV (R = −0.39, P < 0.001), and Zc (R = −0.29, P < 0.01). Likewise, early diastolic velocity (E′) showed a strong, negative correlation with AP (R = −0.32, P < 0.01), PWV (R = −0.64, P < 0.0001), and Zc (R = −0.50, P < 0.0001). Higher filling pressures were associated with increased wave reflections (AIx, AP) and arterial stiffness (PWV, Zc). All associations were independent of age and gender. Patients suffering from exertional dyspnea had increased AIx, AP, and PWV.ConclusionsIn middle-aged and elderly patients, increased arterial stiffness and wave reflections are consistently and independently associated with impaired systolic and diastolic function and with functional limitations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Hypertension Oxford University Press

Arterial Stiffness and Arterial Wave Reflections Are Associated With Systolic and Diastolic Function in Patients With Normal Ejection Fraction

Download PDF
9 pages

Loading next page...
 
/lp/oxford-university-press/arterial-stiffness-and-arterial-wave-reflections-are-associated-with-Zf6ptJVpFa

References (34)

Publisher
Oxford University Press
Copyright
© 2008 by the American Journal of Hypertension, Ltd.
Subject
Articles
ISSN
0895-7061
eISSN
1941-7225
DOI
10.1038/ajh.2008.277
pmid
18787521
Publisher site
See Article on Publisher Site

Abstract

BackgroundIncreased arterial stiffness and early wave reflections have been observed in patients with heart failure and normal ejection fraction (HFNEF). We investigated, whether impaired arterial function is associated with impaired systolic and diastolic function and symptomatic status.MethodsWe prospectively enrolled 336 patients (mean age 63.5 years) undergoing coronary angiography, and assessed pulse wave velocity (PWV) invasively, arterial wave reflections (augmentation index (AIx); pressure augmentation (AP)) noninvasively using radial applanation tonometry and a validated transfer function, and characteristic impedance (Zc) using echocardiography with tonometry. In addition, echocardiography including tissue Doppler of the mitral annulus was performed.ResultsPeak systolic velocity (S′) varied inversely with AIx (R = −0.38, P < 0.001), AP (R = −0.48, P < 0.0001), PWV (R = −0.39, P < 0.001), and Zc (R = −0.29, P < 0.01). Likewise, early diastolic velocity (E′) showed a strong, negative correlation with AP (R = −0.32, P < 0.01), PWV (R = −0.64, P < 0.0001), and Zc (R = −0.50, P < 0.0001). Higher filling pressures were associated with increased wave reflections (AIx, AP) and arterial stiffness (PWV, Zc). All associations were independent of age and gender. Patients suffering from exertional dyspnea had increased AIx, AP, and PWV.ConclusionsIn middle-aged and elderly patients, increased arterial stiffness and wave reflections are consistently and independently associated with impaired systolic and diastolic function and with functional limitations.

Journal

American Journal of Hypertension – Oxford University Press

Published: Nov 1, 2008

There are no references for this article.