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References (14)
-
In Kil, Sung Kim, Sun Lee, Jeen-Woo Park (2007)
Small interfering RNA-mediated silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and anticancer drugs.Free radical biology & medicine, 43 8
-
In Kil, T. Huh, Young Lee, Y. Lee, Jeen-Woo Park (2006)
Regulation of replicative senescence by NADP+ -dependent isocitrate dehydrogenase.Free radical biology & medicine, 40 1
-
G. Gasparre, A. Porcelli, E. Bonora, Lucia Pennisi, M. Toller, L. Iommarini, A. Ghelli, M. Moretti, Christine Betts, G. Martinelli, A. Ceroni, F. Curcio, V. Carelli, M. Rugolo, G. Tallini, G. Romeo (2007)
Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumorsProceedings of the National Academy of Sciences, 104
-
D. Hartong, M. Dange, T. McGee, E. Berson, T. Dryja, R. Colman (2008)
Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycleNature Genetics, 40
-
Hai Yan, D. Parsons, Geng-lin Jin, R. McLendon, B. Rasheed, Weishi Yuan, I. Kos, I. Batinic-Haberle, Siân Jones, G. Riggins, H. Friedman, A. Friedman, D. Reardon, J. Herndon, Kenneth Kinzler, V. Velculescu, B. Vogelstein, D. Bigner (2009)
IDH1 and IDH2 mutations in gliomas.The New England journal of medicine, 360 8
-
J. Uhm (2009)
An Integrated Genomic Analysis of Human Glioblastoma MultiformeYearbook of Neurology and Neurosurgery, 2009
-
Xiang Xu, Jingyue Zhao, Zhen Xu, B. Peng, Qiuhua Huang, E. Arnold, Jianping Ding (2004)
Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity*Journal of Biological Chemistry, 279
-
D. Parsons, Siân Jones, Xiaosong Zhang, Jimmy Lin, R. Leary, P. Angenendt, P. Mankoo, H. Carter, I. Siu, G. Gallia, A. Olivi, R. McLendon, B. Rasheed, S. Keir, T. Nikolskaya, Y. Nikolsky, D. Busam, H. Tekleab, L. Diaz, James Hartigan, Douglas Smith, R. Strausberg, S. Marie, S. Shinjo, Hai Yan, G. Riggins, D. Bigner, R. Karchin, N. Papadopoulos, G. Parmigiani, B. Vogelstein, V. Velculescu, K. Kinzler (2008)
An Integrated Genomic Analysis of Human Glioblastoma MultiformeScience, 321
-
Elaine MacKenzie, M. Selak, D. Tennant, L. Payne, S. Crosby, C. Frederiksen, D. Watson, E. Gottlieb (2007)
Cell-Permeating α-Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient CellsMolecular and Cellular Biology, 27
-
R. Deberardinis, J. Lum, G. Hatzivassiliou, C. Thompson (2008)
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.Cell metabolism, 7 1
-
F. Sacks (2009)
IDH 1 and IDH 2 Mutations in Gliomas -
Jörg Balss, Jochen Meyer, W. Mueller, A. Korshunov, C. Hartmann, A. Deimling (2008)
Analysis of the IDH1 codon 132 mutation in brain tumorsActa Neuropathologica, 116
-
J. Lee, M. Edderkaoui, P. Truong, I. Ohno, K. Jang, A. Berti, S. Pandol, A. Gukovskaya (2007)
NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases.Gastroenterology, 133 5
-
A. King, M. Selak, E. Gottlieb (2006)
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancerOncogene, 25
- Publisher
- The New England Journal of Medicine
- Copyright
- Copyright © 2009 Massachusetts Medical Society. All rights reserved.
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- DOI
- 10.1056/NEJMe0810213
- pmid
- 19228626
- Publisher site
- See Article on Publisher Site
Abstract
Whether mutations in metabolic pathways contribute to the pathogenesis of cancer is controversial.1,2 Cancer cells have long been noted to preferentially metabolize glucose through glycolysis, a discovery that has been translated to the clinic through positron-emission-tomography imaging of 18F-deoxyglucose uptake in tumors. Moreover, recent studies have uncovered recurrent somatic mutations in four genes involved in the metabolism of mitochondrial citrate that either cause or predispose cells to become malignant. In this issue of the Journal, Yan and colleagues3 report that 70% or more of low-grade gliomas bear mutations in one of two NADP+-dependent isocitrate dehydrogenase enzymes (IDH1 and . . .
Journal
The New England Journal of Medicine – The New England Journal of Medicine
Published: Feb 19, 2009