Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Scaffold proteins in MAP kinase signaling: more than simple passive activating platforms

Scaffold proteins in MAP kinase signaling: more than simple passive activating platforms Due to the central position of scaffold proteins in numerous signaling networks, especially in MAPK pathways, considerable efforts have been made to identify new scaffolds and to characterize their function and regulation. Most of our knowledge stems from studies of yeast MAPK scaffolds, but the identification of such scaffolds in higher eukaryotes provided a new dimension to this field and led to exciting and promising new insights into the regulation of MAPK signaling. In this review, we shortly summarize the well‐established basic functions of scaffolds in yeast and highlight concepts emerging from recent studies in yeast and higher eukaryotes. In particular, we discuss how scaffolds may actively influence MAPK signaling by inducing conformational changes of bound kinases or substrates, by controlling the localization of activated MAPK and the extent and output of MAPK activation, and by modulating MAPK kinetics through the recruitment of phosphatases or ubiquitin‐ligases. Finally, we summarize the current knowledge of scaffold regulation, and how these events may be functionally important for MAPK signaling. BioEssays 28: 146–156, 2006. © 2006 Wiley periodicals, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioEssays Wiley

Scaffold proteins in MAP kinase signaling: more than simple passive activating platforms

Dard, Nicolas; Peter, Matthias
BioEssays , Volume 28 (2) – Feb 1, 2006
Download PDF
11 pages

Loading next page...
 
/lp/wiley/scaffold-proteins-in-map-kinase-signaling-more-than-simple-passive-ZU0NG2dxoc

References (99)

Publisher
Wiley
Copyright
Copyright © 2006 Wiley Periodicals, Inc.
ISSN
0265-9247
eISSN
1521-1878
DOI
10.1002/bies.20351
pmid
16435292
Publisher site
See Article on Publisher Site

Abstract

Due to the central position of scaffold proteins in numerous signaling networks, especially in MAPK pathways, considerable efforts have been made to identify new scaffolds and to characterize their function and regulation. Most of our knowledge stems from studies of yeast MAPK scaffolds, but the identification of such scaffolds in higher eukaryotes provided a new dimension to this field and led to exciting and promising new insights into the regulation of MAPK signaling. In this review, we shortly summarize the well‐established basic functions of scaffolds in yeast and highlight concepts emerging from recent studies in yeast and higher eukaryotes. In particular, we discuss how scaffolds may actively influence MAPK signaling by inducing conformational changes of bound kinases or substrates, by controlling the localization of activated MAPK and the extent and output of MAPK activation, and by modulating MAPK kinetics through the recruitment of phosphatases or ubiquitin‐ligases. Finally, we summarize the current knowledge of scaffold regulation, and how these events may be functionally important for MAPK signaling. BioEssays 28: 146–156, 2006. © 2006 Wiley periodicals, Inc.

Journal

BioEssays – Wiley

Published: Feb 1, 2006

There are no references for this article.