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- Publisher
- Springer Journals
- Copyright
- Copyright © 2013 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
- Subject
- Life Sciences; Life Sciences, general; Biochemistry, general; Protein Structure; Membrane Biology; Biological Microscopy
- ISSN
- 1545-9993
- eISSN
- 1545-9985
- DOI
- 10.1038/nsmb.2520
- Publisher site
- See Article on Publisher Site
Abstract
Friedreich's ataxia is one of several hereditary neurodegenerative disorders caused expansion of trinucleotide repeats, but the mechanism of their genomic propagation is unknown. A new plasmid-based system to probe human replicative intermediates reveals that GAA/TTC repeats interfere with replication, thus suggesting that repeat expansion occurs by postreplicative mechanisms.
Journal
Nature Structural & Molecular Biology – Springer Journals
Published: Mar 3, 2013