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The action of insulin on the penetration of sugars into the perfused heart*

The action of insulin on the penetration of sugars into the perfused heart* J. Physiol. (1956), I3I, 526-54I THE ACTION OF INSULIN ON THE PENETRATION OF SUGARS INTO THE PERFUSED HEART* BY R. B. FISHER AND D. B. LINDSAYt Department of Biochemistry, University of Oxford (Received May 1955) Levine and his colleagues (Levine, Goldstein, & Huddlestun Klein, 1950; Goldstein, Henry, Huddlestun & have shown that insulin can Levine, 1953) increase the volume of distribution of galactose and of configurationally in fluids related sugars the body of eviscerated dogs and rats. Their work suggests that about half the body water is inaccessible to these in sugars the absence of circulating insulin, whereas the whole of the body water becomes accessible to them when insulin is administered. Since the sugars which exhibit this response to insulin have the same of configuration substituents on carbon atoms 1 to 3 as has glucose, there is ground for that the supposing behaviour of the sugars studied bear on may the physiological role of insulin. The effect of insuilin on the volume of distribution of glucose has been studied by Drury & Wick 14C-labelled Insulin (1951) using glucose. has no detectable effect but, as these authors point out, this is not inconsistent with the con- ception that insulin http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

The action of insulin on the penetration of sugars into the perfused heart*

Fisher, R. B.; Lindsay, D. B.
The Journal of Physiology , Volume 131 (3) – Jan 28, 1956
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References (31)

Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.1956.sp005480
Publisher site
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Abstract

J. Physiol. (1956), I3I, 526-54I THE ACTION OF INSULIN ON THE PENETRATION OF SUGARS INTO THE PERFUSED HEART* BY R. B. FISHER AND D. B. LINDSAYt Department of Biochemistry, University of Oxford (Received May 1955) Levine and his colleagues (Levine, Goldstein, & Huddlestun Klein, 1950; Goldstein, Henry, Huddlestun & have shown that insulin can Levine, 1953) increase the volume of distribution of galactose and of configurationally in fluids related sugars the body of eviscerated dogs and rats. Their work suggests that about half the body water is inaccessible to these in sugars the absence of circulating insulin, whereas the whole of the body water becomes accessible to them when insulin is administered. Since the sugars which exhibit this response to insulin have the same of configuration substituents on carbon atoms 1 to 3 as has glucose, there is ground for that the supposing behaviour of the sugars studied bear on may the physiological role of insulin. The effect of insuilin on the volume of distribution of glucose has been studied by Drury & Wick 14C-labelled Insulin (1951) using glucose. has no detectable effect but, as these authors point out, this is not inconsistent with the con- ception that insulin

Journal

The Journal of Physiology – Wiley

Published: Jan 28, 1956

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