Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/oxford-university-press/the-roles-of-tlrs-rlrs-and-nlrs-in-pathogen-recognition-YG4J84ui2R
References (261)
-
A. Beelen, Z. Zelinkova, Esther Taanman-Kueter, F. Muller, D. Hommes, S. Zaat, M. Kapsenberg, E. Jong (2007)
Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.Immunity, 27 4
-
P. Pisitkun, J. Deane, M. Difilippantonio, Tatyana Tarasenko, A. Satterthwaite, S. Bolland (2006)
Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene DuplicationScience, 312
-
Huazhang An, J. Hou, Jun Zhou, Wei Zhao, Hongmei Xu, Yuejuan Zheng, Yizhi Yu, Shuxun Liu, Xuetao Cao (2008)
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1Nature Immunology, 9
-
Daniel Stetson, R. Medzhitov (2006)
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.Immunity, 24 1
-
A. Amer, L. Franchi, T. Kanneganti, M. Body-Malapel, Nesrin Özören, Graham Brady, Sasha Meshinchi, R. Jagirdar, A. Gewirtz, S. Akira, G. Núñez (2006)
Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf*Journal of Biological Chemistry, 281
-
K. Ishii, C. Coban, H. Kato, Ken Takahashi, Yuichi Torii, F. Takeshita, H. Ludwig, G. Sutter, Koichi Suzuki, H. Hemmi, Shintaro Sato, Masahiro Yamamoto, S. Uematsu, T. Kawai, O. Takeuchi, S. Akira (2006)
A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNANature Immunology, 7
-
H. Yoshida, Y. Okabe, Kohki Kawane, H. Fukuyama, S. Nagata (2005)
Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNANature Immunology, 6
-
Masahiro Yamamoto, T. Okamoto, K. Takeda, Shintaro Sato, H. Sanjo, S. Uematsu, T. Saitoh, N. Yamamoto, H. Sakurai, K. Ishii, S. Yamaoka, T. Kawai, Y. Matsuura, O. Takeuchi, S. Akira (2006)
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signalingNature Immunology, 7
-
Ari Molofsky, B. Byrne, Natalie Whitfield, Cressida Madigan, E. Fuse, K. Tateda, M. Swanson (2006)
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infectionThe Journal of Experimental Medicine, 203
-
Y. Crow, B. Hayward, R. Parmar, P. Robins, A. Leitch, Manir Ali, D. Black, H. Bokhoven, H. Brunner, B. Hamel, P. Corry, Frances Cowan, S. Frints, J. Klepper, J. Livingston, S. Lynch, R. Massey, J. Meritet, J. Michaud, G. Ponsot, T. Voit, P. Lebon, D. Bonthron, A. Jackson, D. Barnes, T. Lindahl (2006)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locusNature Genetics, 38
-
Daniel Stetson, J. Ko, T. Heidmann, R. Medzhitov (2008)
Trex1 Prevents Cell-Intrinsic Initiation of AutoimmunityCell, 134
-
Jae-hyuck Shim, Changchun Xiao, Amber Paschal, S. Bailey, P. Rao, M. Hayden, Ki-Young Lee, C. Bussey, M. Steckel, N. Tanaka, G. Yamada, S. Akira, Kunihiro Matsumoto, S. Ghosh (2005)
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Genes & development, 19 22
-
R. Goffic, V. Balloy, M. Lagranderie, L. Alexopoulou, N. Escriou, R. Flavell, M. Chignard, M. Si-Tahar (2006)
Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute PneumoniaPLoS Pathogens, 2
-
L. Franchi, T. Kanneganti, G. Dubyak, G. Núñez (2007)
Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria*Journal of Biological Chemistry, 282
-
K. Hoshino, O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, S. Akira (1999)
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.Journal of immunology, 162 7
-
H. Kong, D. Anderson, C. Lee, M. Jang, T. Tamura, Prafullakumar Tailor, Hyun Cho, J. Cheong, H. Xiong, H. Morse, K. Ozato (2007)
Cutting Edge: Autoantigen Ro52 Is an Interferon Inducible E3 Ligase That Ubiquitinates IRF-8 and Enhances Cytokine Expression in Macrophages1The Journal of Immunology, 179
-
K. Arimoto, Hitoshi Takahashi, Takayuki Hishiki, H. Konishi, T. Fujita, K. Shimotohno (2007)
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125Proceedings of the National Academy of Sciences, 104
-
R. Lande, Josh Gregorio, V. Facchinetti, Bithi Chatterjee, Yi-hong Wang, B. Homey, W. Cao, Yu Wang, Bing Su, F. Nestle, T. Zal, I. Mellman, J. Schröder, Yong‐jun Liu, M. Gilliet (2007)
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptideNature, 449
-
Hoshino (1999)
3749The Journal of Immunology, 162
-
Shen-Ying Zhang, E. Jouanguy, S. Ugolini, A. Smahi, G. Elain, P. Romero, David Segal, V. Sancho-Shimizu, Lazaro Lorenzo, A. Puel, C. Picard, A. Chapgier, S. Plancoulaine, M. Titeux, C. Cognet, H. Bernuth, Cheng-Lung Ku, A. Casrouge, Xin-Xin Zhang, L. Barreiro, J. Leonard, C. Hamilton, P. Lebon, B. Héron, L. Vallée, L. Quintana-Murci, A. Hovnanian, F. Rozenberg, É. Vivier, F. Geissmann, M. Tardieu, L. Abel, J. Casanova (2007)
TLR3 Deficiency in Patients with Herpes Simplex EncephalitisScience, 317
-
Melanie Brinkmann, E. Spooner, K. Hoebe, B. Beutler, H. Ploegh, You-Me Kim (2007)
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signalingThe Journal of Cell Biology, 177
-
F. Martinon, Laetitia Agostini, E. Meylan, J. Tschopp (2004)
Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin InflammasomeCurrent Biology, 14
-
J. Satsangi (2008)
Faculty Opinions recommendation of Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. -
S. Girardin, I. Boneca, L. Carneiro, A. Antignac, M. Jéhanno, J. Viala, K. Tedin, M. Taha, A. Labigne, Ulrich Zäthringer, A. Coyle, P. Distefano, J. Bertin, P. Sansonetti, D. Philpott (2003)
Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial PeptidoglycanScience, 300
-
K. Ishii, T. Kawagoe, S. Koyama, Kosuke Matsui, H. Kumar, T. Kawai, S. Uematsu, O. Takeuchi, F. Takeshita, C. Coban, S. Akira (2008)
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccinesNature, 451
-
M. Kleinman, Kiyoshi Yamada, A. Takeda, V. Chandrasekaran, M. Nozaki, J. Baffi, R. Albuquerque, S. Yamasaki, M. Itaya, Yuzhen Pan, B. Appukuttan, D. Gibbs, Zhenglin Yang, K. Karikó, B. Ambati, Traci Wilgus, L. DiPietro, E. Sakurai, Kang Zhang, Justine Smith, E. Taylor, J. Ambati (2008)
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3Nature, 452
-
Annick Mayor, F. Martinon, T. Smedt, V. Petrilli, J. Tschopp (2007)
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responsesNature Immunology, 8
-
L. Franchi, A. Amer, M. Body-Malapel, T. Kanneganti, Nesrin Özören, R. Jagirdar, N. Inohara, P. Vandenabeele, J. Bertin, A. Coyle, E. Grant, G. Núñez (2006)
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophagesNature Immunology, 7
-
A. Krug, G. Luker, W. Barchet, D. Leib, S. Akira, M. Colonna (2004)
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.Blood, 103 4
-
J. Hoffmann (2003)
The immune response of DrosophilaNature, 426
-
T. Haas, J. Metzger, F. Schmitz, A. Heit, T. Müller, E. Latz, H. Wagner (2008)
The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation.Immunity, 28 3
-
P. Taylor, S. Tsoni, J. Willment, K. Dennehy, Marcela Rosas, Helen Findon, K. Haynes, C. Steele, M. Botto, S. Gordon, Gordon Brown (2007)
Dectin-1 is required for beta-glucan recognition and control of fungal infection.Nature immunology, 8 1
-
F. Schmitz, A. Heit, S. Guggemoos, A. Krug, J. Mages, M. Schiemann, H. Adler, I. Drexler, T. Haas, R. Lang, H. Wagner (2007)
Interferon‐regulatory‐factor 1 controls Toll‐like receptor 9‐mediated IFN‐β production in myeloid dendritic cellsEuropean Journal of Immunology, 37
-
Masahiro Yamamoto, S. Yamazaki, S. Uematsu, Shintaro Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Kuwata, O. Takeuchi, K. Takeshige, T. Saitoh, S. Yamaoka, N. Yamamoto, Shunsuke Yamamoto, T. Muta, K. Takeda, S. Akira (2004)
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.Nature, 430 6996
-
K. Hoshino, T. Sugiyama, M. Matsumoto, Takashi Tanaka, M. Saito, H. Hemmi, O. Ohara, S. Akira, T. Kaisho (2006)
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9.Nature, 440 7086
-
S. Koyama, K. Ishii, H. Kumar, T. Tanimoto, C. Coban, S. Uematsu, T. Kawai, S. Akira (2007)
Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and VaccinationThe Journal of Immunology, 179
-
Siddharth Balachandran, E. Thomas, G. Barber (2004)
A FADD-dependent innate immune mechanism in mammalian cellsNature, 432
-
S. Girardin, I. Boneca, J. Viala, M. Chamaillard, A. Labigne, G. Thomas, D. Philpott, P. Sansonetti (2003)
Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection*The Journal of Biological Chemistry, 278
-
D. Muruve, V. Petrilli, Anne-Kathrin Zaiss, Lindsay White, Sharon Clark, P. Ross, R. Parks, J. Tschopp (2008)
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune responseNature, 452
-
K. Hoebe, P. Georgel, S. Rutschmann, Xin Du, S. Mudd, K. Crozat, S. Sovath, L. Shamel, T. Hartung, U. Zähringer, B. Beutler (2005)
CD36 is a sensor of diacylglyceridesNature, 433
-
H. Hara, Chitose Ishihara, A. Takeuchi, Takayuki Imanishi, L. Xue, S. Morris, M. Inui, T. Takai, A. Shibuya, S. Saijo, Y. Iwakura, N. Ohno, H. Koseki, H. Yoshida, J. Penninger, T. Saito (2007)
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptorsNature Immunology, 8
-
G. Oganesyan, Supriya Saha, Beichu Guo, Jeannie He, A. Shahangian, B. Zarnegar, Andrea Perry, G. Cheng (2006)
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral responseNature, 439
-
D. Underhill, Eddie Rossnagle, C. Lowell, Randi Simmons (2005)
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.Blood, 106 7
-
N. Rogers, E. Slack, A. Edwards, M. Nolte, O. Schulz, E. Schweighoffer, David Williams, S. Gordon, V. Tybulewicz, Gordon Brown, C. Sousa (2005)
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.Immunity, 22 4
-
H. Tsujimura, T. Tamura, H. Kong, A. Nishiyama, K. Ishii, D. Klinman, K. Ozato (2004)
Toll-Like Receptor 9 Signaling Activates NF-κB through IFN Regulatory Factor-8/IFN Consensus Sequence Binding Protein in Dendritic Cells1The Journal of Immunology, 172
-
T. Akazawa, T. Ebihara, M. Okuno, Yutaka Okuda, M. Shingai, K. Tsujimura, Toshitada Takahashi, M. Ikawa, M. Okabe, N. Inoue, Miki Okamoto-Tanaka, Hiroyoshi Ishizaki, J. Miyoshi, M. Matsumoto, T. Seya (2007)
Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cellsProceedings of the National Academy of Sciences, 104
-
D. Monack (2008)
Faculty Opinions recommendation of Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. -
Yelena Pobezinskaya, You-Sun Kim, S. Choksi, M. Morgan, Tao Li, Chengyu Liu, Zheng-Gang Liu (2008)
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptorsNature Immunology, 9
-
D. Soulat, T. Bürckstümmer, Sandra Westermayer, Adriana Goncalves, A. Bauch, Adrijana Stefanovic, O. Hantschel, K. Bennett, T. Decker, G. Superti-Furga (2008)
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune responseThe EMBO Journal, 27
-
Jonathan Kagan, R. Medzhitov (2006)
Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor SignalingCell, 125
-
F. Yarovinsky, Dekai Zhang, J. Andersen, G. Bannenberg, C. Serhan, M. Hayden, S. Hieny, F. Sutterwala, R. Flavell, S. Ghosh, A. Sher (2005)
TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like ProteinScience, 308
-
L. Feldmeyer, M. Keller, G. Niklaus, D. Hohl, S. Werner, H. Beer (2007)
The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by KeratinocytesCurrent Biology, 17
-
J. Ting, D. Kastner, H. Hoffman (2006)
CATERPILLERs, pyrin and hereditary immunological disordersNature Reviews Immunology, 6
-
J. Bruey, N. Bruey-Sédano, F. Luciano, D. Zhai, Ruchi Balpai, Chunyan Xu, C. Kress, B. Bailly-maitre, Xiaoqing Li, A. Osterman, S. Matsuzawa, A. Terskikh, B. Faustin, John Reed (2007)
Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1Cell, 129
-
(1996)
The dorsoventral regulatory gene cassette -
H. Lee, Jennifer Lund, B. Ramanathan, N. Mizushima, A. Iwasaki (2007)
Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic CellsScience, 315
-
Ken Takahashi, T. Kawai, H. Kumar, Shintaro Sato, S. Yonehara, S. Akira (2006)
Cutting Edge: Roles of Caspase-8 and Caspase-10 in Innate Immune Responses to Double-Stranded RNAThe Journal of Immunology, 176
-
K. Edelmann, S. Richardson-Burns, L. Alexopoulou, K. Tyler, R. Flavell, M. Oldstone (2004)
Does Toll-like receptor 3 play a biological role in virus infections?Virology, 322 2
-
Michael Shaw, T. Reimer, Yun-Gi Kim, G. Núñez (2008)
NOD-like receptors (NLRs): bona fide intracellular microbial sensors.Current opinion in immunology, 20 4
-
M. Yoneyama, T. Fujita (2008)
Structural mechanism of RNA recognition by the RIG-I-like receptors.Immunity, 29 2
-
Y. Kumagai, O. Takeuchi, H. Kato, H. Kumar, Kosuke Matsui, E. Morii, K. Aozasa, T. Kawai, S. Akira (2007)
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.Immunity, 27 2
-
H. Hisaeda, K. Tetsutani, T. Imai, C. Moriya, Liping Tu, S. Hamano, Xuefeng Duan, B. Chou, H. Ishida, Akiko Aramaki, Jianying Shen, K. Ishii, C. Coban, S. Akira, K. Takeda, K. Yasutomo, M. Torii, K. Himeno (2008)
Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells1The Journal of Immunology, 180
-
Fumi Matsumoto, S. Saitoh, Ryutaro Fukui, Toshihiko Kobayashi, N. Tanimura, Kazunori Konno, Y. Kusumoto, Sachiko Akashi-Takamura, K. Miyake (2008)
Cathepsins are required for Toll-like receptor 9 responses.Biochemical and biophysical research communications, 367 3
-
P. Parroche, F. Lauw, N. Goutagny, E. Latz, B. Monks, A. Visintin, Kristen Halmen, M. Lamphier, M. Olivier, D. Bartholomeu, R. Gazzinelli, D. Golenbock (2007)
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9Proceedings of the National Academy of Sciences, 104
-
K. Honda, Y. Ohba, H. Yanai, Hideo Negishi, T. Mizutani, A. Takaoka, C. Taya, T. Taniguchi (2005)
Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon inductionNature, 434
-
Boyoun Park, Melanie Brinkmann, E. Spooner, Clarissa Lee, You-Me Kim, H. Ploegh (2008)
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9Nature Immunology, 9
-
A. Takaoka, Zhichao Wang, M. Choi, H. Yanai, Hideo Negishi, T. Ban, Yan Lu, M. Miyagishi, T. Kodama, K. Honda, Y. Ohba, T. Taniguchi (2007)
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune responseNature, 448
-
Masahiro Yamamoto, S. Yamazaki, S. Uematsu, Shintaro Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Kuwata, O. Takeuchi, K. Takeshige, T. Saitoh, S. Yamaoka, N. Yamamoto, Shunsuke Yamamoto, T. Muta, K. Takeda, S. Akira (2004)
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζNature, 430
-
Eric Boyden, W. Dietrich (2006)
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxinNature Genetics, 38
-
F. Chen, D. Bhatia, Q. Chang, V. Castranova (2006)
Finding NEMO by K63-linked polyubiquitin chainCell Death and Differentiation, 13
-
A. McGettrick, E. Brint, E. Palsson-McDermott, D. Rowe, D. Golenbock, N. Gay, K. Fitzgerald, L. O’Neill (2006)
Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.Proceedings of the National Academy of Sciences of the United States of America, 103 24
-
A. Pichlmair, O. Schulz, C. Tan, T. Näslund, P. Liljeström, F. Weber, C. Sousa (2006)
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-PhosphatesScience, 314
-
Li Zheng, Huifang Dai, Mian Zhou, Mei Li, Purnima Singh, J. Qiu, W. Tsark, Qin Huang, K. Kernstine, Xuemei Zhang, D. Lin, B. Shen (2007)
Fen1 mutations result in autoimmunity, chronic inflammation and cancersNature Medicine, 13
-
D. Zamboni, Koichi Kobayashi, Koichi Kobayashi, T. Kohlsdorf, Y. Ogura, E. Long, R. Vance, K. Kuida, S. Mariathasan, V. Dixit, R. Flavell, W. Dietrich, C. Roy (2006)
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infectionNature Immunology, 7
-
N. Tanimura, S. Saitoh, Fumi Matsumoto, Sachiko Akashi-Takamura, K. Miyake (2008)
Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.Biochemical and biophysical research communications, 368 1
-
C. Janeway, R. Medzhitov (2002)
Innate immune recognition.Annual review of immunology, 20
-
K. Ishii, S. Akira (2006)
Innate immune recognition of, and regulation by, DNA.Trends in immunology, 27 11
-
M. Jin, Sung Kim, J. Heo, Mi Lee, Ho Kim, S. Paik, Hayyoung Lee, Jie-Oh Lee (2007)
Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated LipopeptideCell, 130
-
Jörg Fritz, R. Ferrero, D. Philpott, S. Girardin (2006)
Nod-like proteins in immunity, inflammation and diseaseNature Immunology, 7
-
Yen-Michael Hsu, Yongliang Zhang, Y. You, Donghai Wang, Hongxiu Li, Omar Duramad, X. Qin, C. Dong, Xin Lin (2007)
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogensNature Immunology, 8
-
J. Bustamante, S. Boisson-Dupuis, E. Jouanguy, C. Picard, A. Puel, L. Abel, J. Casanova (2008)
Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases.Current opinion in immunology, 20 1
-
Y. Okabe, Kohki Kawane, S. Akira, T. Taniguchi, S. Nagata (2005)
Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradationThe Journal of Experimental Medicine, 202
-
T. Ren, D. Zamboni, C. Roy, W. Dietrich, R. Vance (2006)
Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage ImmunityPLoS Pathogens, 2
-
K. Miyake (2007)
Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors.Seminars in immunology, 19 1
-
J. Deane, P. Pisitkun, Rebecca Barrett, L. Feigenbaum, T. Town, J. Ward, R. Flavell, S. Bolland (2007)
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation.Immunity, 27 5
-
R. Higgs, J. Gabhann, N. Larbi, E. Breen, K. Fitzgerald, C. Jefferies (2008)
The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-β Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF31The Journal of Immunology, 181
-
A. Goto, Kazufumi Matsushita, Viola Gesellchen, L. Chamy, David Kuttenkeuler, O. Takeuchi, J. Hoffmann, S. Akira, M. Boutros, J. Reichhart (2008)
Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and miceNature Immunology, 9
-
O. Gross, A. Gewies, Katrin Finger, M. Schäfer, T. Sparwasser, C. Peschel, I. Förster, J. Ruland (2006)
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunityNature, 442
-
Jonathan Jones, Jeffery Dangl (2006)
The plant immune systemNature, 444
-
P. Pelegrín, A. Surprenant (2007)
Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1β Release through a Dye Uptake-independent Pathway*Journal of Biological Chemistry, 282
-
K. Fitzgerald, S. McWhirter, K. Faia, D. Rowe, E. Latz, D. Golenbock, A. Coyle, S. Liao, T. Maniatis (2003)
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.Nature immunology, 4 5
-
S. Mariathasan, D. Weiss, K. Newton, J. McBride, K. O’Rourke, M. Roose-Girma, Wyne Lee, Y. Weinrauch, D. Monack, V. Dixit (2006)
Cryopyrin activates the inflammasome in response to toxins and ATPNature, 440
-
C. Guiducci, C. Ghirelli, Marie-Annick Marloie-Provost, T. Matray, R. Coffman, Yong‐jun Liu, F. Barrat, V. Soumelis (2008)
PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activationThe Journal of Experimental Medicine, 205
-
Rashu Seth, Lijun Sun, Chee-Kwee Ea, Zhijian Chen (2005)
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3Cell, 122
-
A. Takaoka, H. Yanai, S. Kondo, G. Duncan, Hideo Negishi, T. Mizutani, S. Kano, K. Honda, Y. Ohba, T. Mak, T. Taniguchi (2005)
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptorsNature, 434
-
M. Shlomchik (2005)
Faculty Opinions recommendation of Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. -
Jörg Fritz, L. Bourhis, G. Sellge, J. Magalhaes, H. Fsihi, T. Kufer, C. Collins, J. Viala, R. Ferrero, S. Girardin, D. Philpott (2007)
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.Immunity, 26 4
-
T. Kawai, Shintaro Sato, K. Ishii, C. Coban, H. Hemmi, Masahiro Yamamoto, Kenta Terai, M. Matsuda, J. Inoue, S. Uematsu, O. Takeuchi, S. Akira (2004)
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6Nature Immunology, 5
-
M. Jin, Jie-Oh Lee (2008)
Structures of the toll-like receptor family and its ligand complexes.Immunity, 29 2
-
S. Uematsu, M. Jang, Nicolas Chevrier, Zijin Guo, Y. Kumagai, Masahiro Yamamoto, H. Kato, Nagako Sougawa, H. Matsui, H. Kuwata, H. Hemmi, C. Coban, T. Kawai, K. Ishii, O. Takeuchi, M. Miyasaka, K. Takeda, S. Akira (2006)
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cellsNature Immunology, 7
-
Halle (2008)
857Nature immunology, 9
-
I. Tattoli, L. Carneiro, M. Jéhanno, J. Magalhaes, Youmin Shu, D. Philpott, D. Arnoult, S. Girardin (2008)
NLRX1 is a mitochondrial NOD‐like receptor that amplifies NF‐κB and JNK pathways by inducing reactive oxygen species productionEMBO reports, 9
-
2543
Blood, 206
-
Liang-Guo Xu, Y. Wang, Ke-jun Han, Lianyun Li, Z. Zhai, H. Shu (2005)
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β SignalingMolecular Cell, 19
-
Ishikawa (2008)
674Nature; Physical Science (London), 455
-
Kiyohiro Takahasi, M. Yoneyama, Tatsuya Nishihori, R. Hirai, H. Kumeta, R. Narita, M. Gale, F. Inagaki, T. Fujita (2008)
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses.Molecular cell, 29 4
-
T. Kanneganti, Nesrin Özören, M. Body-Malapel, A. Amer, Jong-Hwan Park, L. Franchi, J. Whitfield, W. Barchet, M. Colonna, P. Vandenabeele, J. Bertin, A. Coyle, E. Grant, S. Akira, G. Núñez (2006)
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3Nature, 440
-
You-Me Kim, Melanie Brinkmann, M. Paquet, H. Ploegh (2008)
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomesNature, 452
-
Jong-Hwan Park, Yun-Gi Kim, C. McDonald, T. Kanneganti, M. Hasegawa, M. Body-Malapel, N. Inohara, G. Núñez (2007)
RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs1The Journal of Immunology, 178
-
L. Alexopoulou, Agnieszka Holt, R. Medzhitov, R. Flavell (2001)
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3Nature, 413
-
V. Petrilli, S. Papin, Catherine Dostert, Annick Mayor, F. Martinon, F. Martinon, J. Tschopp (2007)
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentrationCell Death and Differentiation, 14
-
Sonia Sharma, B. tenOever, N. Grandvaux, Guo-Ping Zhou, R. Lin, J. Hiscott (2003)
Triggering the Interferon Antiviral Response Through an IKK-Related PathwayScience, 300
-
S. Leibundgut-Landmann, O. Gross, M. Robinson, F. Osorio, Emma Slack, Emma Slack, S. Tsoni, E. Schweighoffer, V. Tybulewicz, Gordon Brown, J. Ruland, C. Sousa (2007)
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17Nature Immunology, 8
-
N. Jounai, F. Takeshita, K. Kobiyama, A. Sawano, A. Miyawaki, K. Xin, K. Ishii, T. Kawai, S. Akira, Koichi Suzuki, K. Okuda (2007)
The Atg5–Atg12 conjugate associates with innate antiviral immune responsesProceedings of the National Academy of Sciences, 104
-
Fabienne Plattner, F. Yarovinsky, Stéphane Romero, D. Didry, M. Carlier, A. Sher, Dominique Soldati-Favre (2008)
Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response.Cell host & microbe, 3 2
-
P. Pelegrín, A. Surprenant (2006)
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptorThe EMBO Journal, 25
-
C. Rothlin, Sourav Ghosh, E. Zúñiga, M. Oldstone, G. Lemke (2007)
TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune ResponseCell, 131
-
M. Goldman (2008)
Faculty Opinions recommendation of The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. -
Koichi Kobayashi, M. Chamaillard, Y. Ogura, O. Henegariu, N. Inohara, G. Núñez, R. Flavell (2005)
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal TractScience, 307
-
A. Piccini, S. Carta, S. Tassi, D. Lasiglié, G. Fossati, A. Rubartelli (2008)
ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine wayProceedings of the National Academy of Sciences, 105
-
E. Latz, A. Schoenemeyer, A. Visintin, K. Fitzgerald, B. Monks, C. Knetter, E. Lien, N. Nilsen, T. Espevik, D. Golenbock (2004)
TLR9 signals after translocating from the ER to CpG DNA in the lysosomeNature Immunology, 5
-
O. Hitotsumatsu, Regina‐Celeste Ahmad, Rita Tavares, Min Wang, D. Philpott, Emre Turer, Bettina Lee, Nataliya Shiffin, Rommel Advincula, B. Malynn, C. Werts, A. Ma (2008)
The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.Immunity, 28 3
-
H. Kumar, S. Koyama, K. Ishii, T. Kawai, S. Akira (2008)
Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell ResponsesThe Journal of Immunology, 180
-
H. Kato, O. Takeuchi, Shintaro Sato, M. Yoneyama, Masahiro Yamamoto, Kosuke Matsui, S. Uematsu, A. Jung, T. Kawai, K. Ishii, O. Yamaguchi, K. Otsu, T. Tsujimura, C. Koh, C. Sousa, Y. Matsuura, T. Fujita, S. Akira (2006)
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA virusesNature, 441
-
Jennifer Lund, L. Alexopoulou, A. Sato, M. Karow, N. Adams, N. Gale, A. Iwasaki, R. Flavell (2004)
Recognition of single-stranded RNA viruses by Toll-like receptor 7.Proceedings of the National Academy of Sciences of the United States of America, 101 15
-
K. Hoshino, T. Sugiyama, M. Matsumoto, Takashi Tanaka, M. Saito, H. Hemmi, O. Ohara, S. Akira, T. Kaisho (2006)
IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9Nature, 440
-
R. Baccala, K. Hoebe, D. Kono, B. Beutler, A. Theofilopoulos (2007)
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunityNature Medicine, 13
-
C. Janeway (1989)
Approaching the asymptote? Evolution and revolution in immunology.Cold Spring Harbor symposia on quantitative biology, 54 Pt 1
-
Sarah Ewald, Bettina Lee, Laura Lau, K. Wickliffe, G. Shi, H. Chapman, G. Barton (2008)
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptorNature, 456
-
M. Schröder, Marcin Baran, A. Bowie (2008)
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKε‐mediated IRF activationThe EMBO Journal, 27
-
Supriya Saha, E. Pietras, Jeannie He, Jason Kang, Su-yang Liu, G. Oganesyan, A. Shahangian, B. Zarnegar, Travis Shiba, Yao Wang, G. Cheng (2006)
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and CardifThe EMBO Journal, 25
-
E. Meylan, J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager, J. Tschopp (2005)
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusNature, 437
-
O. Ananieva, J. Darragh, C. Johansen, Julia Carr, J. Mcilrath, Jin Park, A. Wingate, Claire Monk, R. Toth, Susana Santos, L. Iversen, J. Arthur (2008)
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signalingNature Immunology, 9
-
Hiroki Ishikawa, Glen Barber (2008)
STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingNature, 456
-
M. Michallet, E. Meylan, M. Ermolaeva, J. Vazquez, Manuele Rebsamen, J. Curran, Hendrik Poeck, Michael Bscheider, G. Hartmann, M. König, U. Kalinke, M. Pasparakis, J. Tschopp (2008)
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.Immunity, 28 5
-
A. Goto, Kazufumi Matsushita, Viola Gesellchen, L. Chamy, David Kuttenkeuler, O. Takeuchi, J. Hoffmann, S. Akira, M. Boutros, J. Reichhart (2007)
Akirins, highly conserved nuclear proteins, required for NF-κB dependent gene expression in Drosophila and miceNature immunology, 9
-
J. Cedarbaum (2004)
SurvivalAmyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 5
-
T. Kawai, Ken Takahashi, Shintaro Sato, C. Coban, H. Kumar, H. Kato, K. Ishii, O. Takeuchi, S. Akira (2005)
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionNature Immunology, 6
-
H. Warren (2005)
Toll-like receptors.Critical care medicine, 33 12 Suppl
-
K. Malathi, B. Dong, M. Gale, R. Silverman (2007)
Small self-RNA generated by RNase L amplifies antiviral innate immunityNature, 448
-
H. Bernuth, C. Picard, Z. Jin, Rungnapa Pankla, Hui Xiao, Cheng-Lung Ku, M. Chrabieh, I. Mustapha, P. Ghandil, Y. Camcıoğlu, Júlia Vasconcelos, N. Sirvent, M. Guedes, A. Vitor, M. Herrero-Mata, J. Aróstegui, C. Rodrigo, L. Alsina, E. Ruíz-Ortiz, M. Juan, C. Fortuny, J. Yagüe, J. Antón, M. Pascal, Huey-Hsuan Chang, L. Jannière, Yoann Rose, B. Garty, H. Chapel, A. Issekutz, L. Maródi, C. Rodríguez-Gallego, J. Banchereau, L. Abel, Xiaoxia Li, D. Chaussabel, A. Puel, J. Casanova (2003)
Pyogenic Bacterial Infections in Humans with MyD88 DeficiencyScience, 321
-
S. Uematsu, K. Fujimoto, M. Jang, Bo-Gie Yang, Y. Jung, Mika Nishiyama, Shintaro Sato, T. Tsujimura, Masafumi Yamamoto, Y. Yokota, H. Kiyono, M. Miyasaka, K. Ishii, S. Akira (2008)
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5Nature Immunology, 9
-
Saitoh (2008)
264Nature; Physical Science (London), 456
-
S. Eisenbarth, O. Colegio, William O'Connor, F. Sutterwala, R. Flavell (2008)
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvantsNature, 453
-
Gilliet (2008)
594Nature reviews. Immunology, 8
-
J. Hampe, A. Franke, P. Rosenstiel, A. Till, M. Teuber, K. Huse, M. Albrecht, Gabriele Mayr, F. Vega, Jason Briggs, Simone Günther, N. Prescott, Clive Onnie, R. Häsler, B. Sipos, U. Fölsch, Thomas Lengauer, M. Platzer, C. Mathew, M. Krawczak, S. Schreiber (2007)
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1Nature Genetics, 39
-
T. Means, E. Latz, F. Hayashi, M. Murali, D. Golenbock, A. Luster (2005)
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.The Journal of clinical investigation, 115 2
-
N. Kayagaki, Q. Phung, Salina Chan, Ruchir Chaudhari, C. Quan, K. O’Rourke, M. Eby, E. Pietras, G. Cheng, J. Bazan, Zemin Zhang, D. Arnott, V. Dixit (2007)
A Deubiquitinase That Regulates Type I Interferon ProductionScience, 318
-
K. Cadwell, John Liu, Sarah Brown, H. Miyoshi, Joy Loh, J. Lennerz, C. Kishi, Wumesh Kc, Javier Carrero, S. Hunt, C. Stone, E. Brunt, R. Xavier, B. Sleckman, Ellen Li, N. Mizushima, T. Stappenbeck, H. Iv (2008)
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cellsNature, 456
-
M. McDermott, J. Tschopp (2007)
From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases.Trends in molecular medicine, 13 9
-
H. Yu, B. Finlay (2008)
The caspase-1 inflammasome: a pilot of innate immune responses.Cell host & microbe, 4 3
-
M. Clare-Salzler, C. Xia (2009)
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases -
S. Saijo, N. Fujikado, T. Furuta, S. Chung, Hayato Kotaki, Keisuke Seki, K. Sudo, S. Akira, Y. Adachi, N. Ohno, T. Kinjo, Kiwamu Nakamura, K. Kawakami, Y. Iwakura (2007)
Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicansNature Immunology, 8
-
Zhengfan Jiang, P. Georgel, Xin Du, L. Shamel, S. Sovath, S. Mudd, M. Huber, C. Kalis, S. Keck, C. Galanos, M. Freudenberg, B. Beutler (2005)
CD14 is required for MyD88-independent LPS signalingNature Immunology, 6
-
S. Uematsu, Shintaro Sato, Masahiro Yamamoto, Tomonori Hirotani, H. Kato, F. Takeshita, M. Matsuda, C. Coban, K. Ishii, T. Kawai, O. Takeuchi, S. Akira (2005)
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α inductionThe Journal of Experimental Medicine, 201
-
Feici Diao, Shu Li, Yang Tian, Min Zhang, Liang-Guo Xu, Y. Zhang, Ruipeng Wang, Danying Chen, Z. Zhai, Bo Zhong, P. Tien, H. Shu (2007)
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinaseProceedings of the National Academy of Sciences, 104
-
S. Cassel, S. Eisenbarth, S. Iyer, J. Sadler, O. Colegio, L. Tephly, A. Carter, P. Rothman, R. Flavell, F. Sutterwala, F. Sutterwala (2008)
The Nalp3 inflammasome is essential for the development of silicosisProceedings of the National Academy of Sciences, 105
-
T. Kanneganti, M. Lamkanfi, G. Núñez (2007)
Intracellular NOD-like receptors in host defense and disease.Immunity, 27 4
-
Shintaro Sato, H. Sanjo, K. Takeda, J. Ninomiya-Tsuji, Masahiro Yamamoto, T. Kawai, Kunihiro Matsumoto, O. Takeuchi, S. Akira (2005)
Essential function for the kinase TAK1 in innate and adaptive immune responsesNature Immunology, 6
-
D. Smyth, J. Cooper, Rebecca Bailey, S. Field, O. Burren, L. Smink, C. Guja, C. Ionescu-Tîrgoviste, B. Widmer, D. Dunger, D. Savage, N. Walker, D. Clayton, J. Todd (2006)
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) regionNature Genetics, 38
-
U. Ohto, K. Fukase, K. Miyake, Y. Satow (2007)
Crystal Structures of Human MD-2 and Its Complex with Antiendotoxic Lipid IVaScience, 316
-
Kohki Kawane, M. Ohtani, K. Miwa, Takuji Kizawa, Y. Kanbara, Y. Yoshioka, H. Yoshikawa, S. Nagata (2006)
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophagesNature, 443
-
A. DeFranco (2008)
Faculty Opinions recommendation of TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. -
C. Coban, K. Ishii, T. Kawai, H. Hemmi, Shintaro Sato, S. Uematsu, Masahiro Yamamoto, O. Takeuchi, S. Itagaki, Nirbhay Kumar, T. Horii, S. Akira (2005)
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoinThe Journal of Experimental Medicine, 201
-
Lemaitre (1996)
973Cell, 86
-
Hanfen Li, S. Willingham, J. Ting, F. Re (2008)
Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP31The Journal of Immunology, 181
-
J. Ting, R. Lovering, E. Alnemri, J. Bertin, J. Boss, B. Davis, R. Flavell, S. Girardin, A. Godzik, J. Harton, H. Hoffman, J. Hugot, N. Inohara, A. MacKenzie, L. Maltais, G. Núñez, Y. Ogura, L. Otten, D. Philpott, John Reed, W. Reith, S. Schreiber, V. Steimle, P. Ward (2008)
The NLR gene family: a standard nomenclature.Immunity, 28 3
-
Fitzgerald (2003)
491Nature immunology, 4
-
F. Martinon, V. Petrilli, Annick Mayor, A. Tardivel, J. Tschopp (2006)
Gout-associated uric acid crystals activate the NALP3 inflammasomeNature, 440
-
N. Inohara, Y. Ogura, A. Fontalba, O. Gutiérrez, F. Pons, J. Crespo, K. Fukase, S. Inamura, S. Kusumoto, M. Hashimoto, S. Foster, A. Moran, J. Fernández-Luna, G. Núñez (2003)
Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2The Journal of Biological Chemistry, 278
-
C. Prewitt (2010)
THE CRYSTAL STRUCTURE -
V. Hornung, Jana Ellegast, Sarah Kim, K. Brzózka, A. Jung, H. Kato, Hendrik Poeck, S. Akira, K. Conzelmann, M. Schlee, S. Endres, G. Hartmann (2006)
5'-Triphosphate RNA Is the Ligand for RIG-IScience, 314
-
Catherine Dostert, V. Petrilli, R. Bruggen, C. Steele, B. Mossman, J. Tschopp (2008)
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and SilicaScience, 320
-
F. Heil, H. Hemmi, H. Hochrein, Franziska Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner, S. Bauer (2004)
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8Science, 303
-
R. Medzhitov, P. Preston-Hurlburt, C. Janeway (1997)
A human homologue of the Drosophila Toll protein signals activation of adaptive immunityNature, 388
-
K. Tabeta, P. Georgel, E. Janssen, Xin Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, Jason Goode, L. Alexopoulou, R. Flavell, B. Beutler (2004)
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.Proceedings of the National Academy of Sciences of the United States of America, 101 10
-
Breen, K. Fitzgerald, C. Jefferies, R. Higgs, J. Gabhann, N. Larbi (2008)
The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN- Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3 -
F. Hayashi, Kelly Smith, A. Ozinsky, T. Hawn, E. Yi, D. Goodlett, J. Eng, S. Akira, D. Underhill, A. Aderem (2001)
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Nature, 410
-
J. Vollmer, Sibylle Tluk, C. Schmitz, S. Hamm, M. Jurk, A. Forsbach, S. Akira, Kindra Kelly, W. Reeves, S. Bauer, A. Krieg (2005)
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8The Journal of Experimental Medicine, 202
-
T. Kawai, S. Akira (2006)
Innate immune recognition of viral infectionNature Immunology, 7
-
Christina Lau, C. Broughton, Abigail Tabor, S. Akira, R. Flavell, M. Mamula, S. Christensen, M. Shlomchik, G. Viglianti, I. Rifkin, A. Marshak‐Rothstein (2005)
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagementThe Journal of Experimental Medicine, 202
-
M. Shinohara, Linrong Lu, Jing Bu, M. Werneck, Koichi Kobayashi, L. Glimcher, H. Cantor (2006)
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.Nature immunology, 7 5
-
M. Shinohara, Linrong Lu, Jing Bu, M. Werneck, Koichi Kobayashi, L. Glimcher, H. Cantor (2006)
Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cellsNature Immunology, 7
-
V. Hornung, F. Bauernfeind, A. Halle, Eivind Samstad, H. Kono, K. Rock, K. Fitzgerald, E. Latz (2008)
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationNature Immunology, 9
-
Prafullakumar Tailor, T. Tamura, H. Kong, T. Kubota, Mayumi Kubota, P. Borghi, L. Gabriele, K. Ozato (2007)
The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.Immunity, 27 2
-
C. Moore, D. Bergstralh, J. Duncan, Y. Lei, T. Morrison, A. Zimmermann, M. Accavitti-Loper, V. Madden, Lijun Sun, Z. Ye, J. Lich, M. Heise, Zhijian Chen, J. Ting (2008)
NLRX1 is a regulator of mitochondrial antiviral immunityNature, 451
-
Ho Kim, B. Park, Jung-In Kim, Sung Kim, Judong Lee, Se Oh, P. Enkhbayar, N. Matsushima, Hayyoung Lee, O. Yoo, Jie-Oh Lee (2007)
Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist EritoranCell, 130
-
Michaela Gack, Y. Shin, C. Joo, T. Urano, Chengyu Liang, Lijun Sun, O. Takeuchi, S. Akira, Zhijian Chen, S. Inoue, Jae Jung (2007)
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activityNature, 446
-
Huazhang An, Wei Zhao, J. Hou, Yan Zhang, Yun Xie, Yuejuan Zheng, Hongmei Xu, C. Qian, Jun Zhou, Yizhi Yu, Shuxun Liu, G. Feng, Xuetao Cao (2006)
SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.Immunity, 25 6
-
E. Meylan, J. Tschopp, M. Karin (2006)
Intracellular pattern recognition receptors in the host responseNature, 442
-
L. Franchi, G. Núñez (2008)
The Nlrp3 inflammasome is critical for aluminium hydroxide‐mediated IL‐1β secretion but dispensable for adjuvant activityEuropean Journal of Immunology, 38
-
H. Kato, Shintaro Sato, M. Yoneyama, Masahiro Yamamoto, S. Uematsu, Kosuke Matsui, T. Tsujimura, K. Takeda, T. Fujita, O. Takeuchi, S. Akira (2005)
Cell type-specific involvement of RIG-I in antiviral response.Immunity, 23 1
-
S. Akira, S. Uematsu, O. Takeuchi (2006)
Pathogen Recognition and Innate ImmunityCell, 124
-
O. Schulz, S. Diebold, M. Chen, T. Näslund, M. Nolte, L. Alexopoulou, Y. Azuma, R. Flavell, P. Liljeström, C. Sousa (2005)
Toll-like receptor 3 promotes cross-priming to virus-infected cellsNature, 433
-
E. Leadbetter, I. Rifkin, A. Hohlbaum, Britte Beaudette, M. Shlomchik, A. Marshak‐Rothstein (2002)
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptorsNature, 416
-
H. Häcker, V. Redecke, B. Blagoev, I. Kratchmarova, L. Hsu, Gang Wang, M. Kamps, E. Raz, H. Wagner, G. Häcker, M. Mann, M. Karin (2006)
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6Nature, 439
-
M. Sanjuán, C. Dillon, S. Tait, S. Moshiach, F. Dorsey, Samuel Connell, M. Komatsu, Keiji Tanaka, J. Cleveland, S. Withoff, D. Green (2007)
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosisNature, 450
-
F. Sutterwala, Y. Ogura, M. Szczepanik, M. Szczepanik, M. Lara-Tejero, G. Lichtenberger, E. Grant, J. Bertin, A. Coyle, J. Galán, P. Askenase, R. Flavell (2006)
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.Immunity, 24 3
-
M. Takagi (2011)
Toll-like ReceptorJournal of Clinical and Experimental Hematopathology, 51
-
Thiagarajan Venkataraman, M. Valdes, R. Elsby, S. Kakuta, G. Caceres, S. Saijo, Y. Iwakura, G. Barber (2007)
Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral ResponsesThe Journal of Immunology, 178
-
J. Viala, Catherine Chaput, I. Boneca, A. Cardona, S. Girardin, A. Moran, R. Athman, S. Mémet, M. Huerre, A. Coyle, P. Distefano, P. Sansonetti, A. Labigne, J. Bertin, D. Philpott, R. Ferrero (2004)
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity islandNature Immunology, 5
-
Edward Miao, C. Alpuche-Aranda, Monica Dors, April Clark, M. Bader, Samuel Miller, A. Aderem (2006)
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via IpafNature Immunology, 7
-
Katoh Hiroki, Akira Shizuo (2006)
Differential Roles of MDA5 and RIG-I in the Recognition of RNA Viruses. -
Benjamin Gantner, Randi Simmons, Scott Canavera, S. Akira, D. Underhill (2003)
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2The Journal of Experimental Medicine, 197
-
Taylor (2007)
31Nature immunology, 8
-
V. Bhoj, Qinmiao Sun, E. Bhoj, C. Somers, Xiang Chen, J. Torres, A. Mejias, A. Gómez, H. Jafri, O. Ramilo, Zhijian Chen (2008)
MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virusProceedings of the National Academy of Sciences, 105
-
N. Inohara, M. Chamaillard, C. McDonald, G. Núñez (2005)
NOD-LRR proteins: role in host-microbial interactions and inflammatory disease.Annual review of biochemistry, 74
-
K. Honda, H. Yanai, T. Mizutani, Hideo Negishi, Naoya Shimada, N. Suzuki, Y. Ohba, A. Takaoka, W. Yeh, T. Taniguchi (2004)
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.Proceedings of the National Academy of Sciences of the United States of America, 101 43
-
M. Kool, V. Petrilli, T. Smedt, Aline Rolaz, H. Hammad, M. Nimwegen, I. Bergen, Rosa Castillo, B. Lambrecht, J. Tschopp (2008)
Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 InflammasomeThe Journal of Immunology, 181
-
Jane Tian, A. Avalos, S. Mao, Bo Chen, K. Senthil, Herren Wu, P. Parroche, Stacey Drabic, D. Golenbock, C. Sirois, J. Hua, L. An, L. Audoly, Greg Rosa, A. Bierhaus, P. Naworth, A. Marshak‐Rothstein, M. Crow, K. Fitzgerald, E. Latz, P. Kiener, A. Coyle (2007)
Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGENature Immunology, 8
-
M. Napirei, H. Karsunky, B. Zevnik, H. Stephan, H. Mannherz, T. Möröy (2000)
Features of systemic lupus erythematosus in Dnase1-deficient miceNature Genetics, 25
-
K. Atarashi, J. Nishimura, T. Shima, Y. Umesaki, Masahiro Yamamoto, M. Onoue, H. Yagita, N. Ishii, R. Evans, K. Honda, K. Takeda (2008)
ATP drives lamina propria TH17 cell differentiationNature, 455
-
Hideo Negishi, Yasuyuki Fujita, H. Yanai, S. Sakaguchi, Xinshou Ouyang, M. Shinohara, H. Takayanagi, Y. Ohba, T. Taniguchi, K. Honda (2006)
Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction programProceedings of the National Academy of Sciences, 103
-
1835
Cell death and differentiation, 13
-
Takeshi Saito, D. Owen, F. Jiang, J. Marcotrigiano, M. Gale (2008)
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNANature, 454
-
L. Gurcel, L. Abrami, S. Girardin, Jürg Tschopp, F. Goot, F. Goot (2006)
Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell SurvivalCell, 126
-
H. Hemmi, T. Kaisho, O. Takeuchi, Shintaro Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, S. Akira (2002)
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathwayNature Immunology, 3
-
J. Marques, Thalie Devosse, Die Wang, M. Zamanian-Daryoush, Paul Serbinowski, R. Hartmann, T. Fujita, M. Behlke, B. Williams (2006)
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cellsNature Biotechnology, 24
-
Karla Lightfield, J. Persson, Sky Brubaker, Chelsea Witte, J. Moltke, Eric Dunipace, T. Henry, Yao-Hui Sun, D. Cado, W. Dietrich, D. Monack, R. Tsolis, R. Vance (2008)
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellinNature Immunology, 9
-
R. Medzhitov (2007)
Recognition of microorganisms and activation of the immune responseNature, 449
-
K. Tabeta, K. Hoebe, E. Janssen, Xin Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, Jason Goode, L. Shamel, A. Herskovits, D. Portnoy, M. Cooke, L. Tarantino, T. Wiltshire, B. Steinberg, S. Grinstein, B. Beutler (2006)
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9Nature Immunology, 7
-
Kagan (2008)
361Nature immunology, 9
-
R. Graham, R. Graham, S. Kozyrev, Emily Baechler, M. Reddy, R. Plenge, R. Plenge, J. Bauer, W. Ortmann, T. Koeuth, M. Escribano, B. Pons-Estel, M. Petri, M. Daly, M. Daly, P. Gregersen, Javier Martín, D. Altshuler, D. Altshuler, T. Behrens, M. Alarcón-Riquelme (2006)
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosusNature Genetics, 38
-
M. Asagiri, T. Hirai, T. Kunigami, Shunya Kamano, H. Gober, Kazuo Okamoto, K. Nishikawa, E. Latz, D. Golenbock, K. Aoki, K. Ohya, Yuuki Imai, Y. Morishita, K. Miyazono, S. Kato, P. Saftig, H. Takayanagi (2008)
Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental ArthritisScience, 319
-
A. Jung, H. Kato, Y. Kumagai, H. Kumar, T. Kawai, O. Takeuchi, S. Akira (2007)
Lymphocytoid Choriomeningitis Virus Activates Plasmacytoid Dendritic Cells and Induces a Cytotoxic T-Cell Response via MyD88Journal of Virology, 82
-
L. O’Neill (2008)
When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction.Immunity, 29 1
-
Takashi Tanaka, M. Grusby, T. Kaisho (2007)
PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunitNature Immunology, 8
-
S. Diebold, T. Kaisho, H. Hemmi, S. Akira, C. Sousa (2004)
Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNAScience, 303
-
M. Hasegawa, Y. Fujimoto, P. Lucas, H. Nakano, K. Fukase, G. Núñez, N. Inohara (2008)
A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activationThe EMBO Journal, 27
-
S. Cui, Katharina Eisenächer, A. Kirchhofer, K. Brzózka, A. Lammens, K. Lammens, T. Fujita, K. Conzelmann, A. Krug, K. Hopfner (2008)
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.Molecular cell, 29 2
-
G. Barton, Jonathan Kagan, R. Medzhitov (2006)
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNANature Immunology, 7
-
M. Chamaillard, M. Hashimoto, Y. Horie, J. Masumoto, S. Qiu, Lisa Saab, Y. Ogura, A. Kawasaki, K. Fukase, S. Kusumoto, M. Valvano, S. Foster, T. Mak, G. Núñez, N. Inohara (2003)
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acidNature Immunology, 4
-
B. Beutler, Celine Eidenschenk, K. Crozat, J. Imler, O. Takeuchi, J. Hoffmann, S. Akira (2007)
Genetic analysis of resistance to viral infectionNature Reviews Immunology, 7
-
H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, Shintaro Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, S. Akira (2000)
A Toll-like receptor recognizes bacterial DNANature, 408
-
J. Correia, Y. Miranda, N. Leonard, R. Ulevitch (2007)
SGT1 is essential for Nod1 activationProceedings of the National Academy of Sciences, 104
-
T. Kanneganti, M. Body-Malapel, A. Amer, Jong-Hwan Park, J. Whitfield, L. Franchi, Z. Taraporewala, David Miller, J. Patton, N. Inohara, G. Núñez (2006)
Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA*>Journal of Biological Chemistry, 281
-
H. Kato, O. Takeuchi, Eriko Mikamo-Satoh, R. Hirai, T. Kawai, Kazufumi Matsushita, Akane Hiiragi, T. Dermody, T. Fujita, S. Akira (2008)
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5The Journal of Experimental Medicine, 205
-
T. Nishiya, E. Kajita, S. Miwa, A. DeFranco (2005)
TLR3 and TLR7 Are Targeted to the Same Intracellular Compartments by Distinct Regulatory Elements*♦Journal of Biological Chemistry, 280
-
Jennifer Lund, A. Sato, S. Akira, R. Medzhitov, A. Iwasaki (2003)
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic CellsThe Journal of Experimental Medicine, 198
-
K. Honda, H. Yanai, Hideo Negishi, M. Asagiri, Mitsuharu Sato, T. Mizutani, Naoya Shimada, Y. Ohba, A. Takaoka, N. Yoshida, T. Taniguchi (2005)
IRF-7 is the master regulator of type-I interferon-dependent immune responsesNature, 434
-
Bo Zhong, Yan Yang, Shu Li, Yan-Yi Wang, Y. Li, Feici Diao, Cao-Qi Lei, Xiao He, Lu Zhang, P. Tien, H. Shu (2008)
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.Immunity, 29 4
-
Liang-Guo Xu, Yan-Yi Wang, Ke-jun Han, Lianyun Li, Z. Zhai, H. Shu (2005)
VISA is an adapter protein required for virus-triggered IFN-beta signaling.Molecular cell, 19 6
-
L. Hsu, S. Ali, S. McGillivray, Ping-Hui Tseng, S. Mariathasan, E. Humke, L. Eckmann, J. Powell, V. Nizet, V. Dixit, M. Karin (2008)
A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptideProceedings of the National Academy of Sciences, 105
-
A. Krug, A. French, W. Barchet, Jens Fischer, A. Dzionek, J. Pingel, M. Orihuela, S. Akira, W. Yokoyama, M. Colonna (2004)
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.Immunity, 21 1
-
Daniel Stetson, R. Medzhitov (2006)
Type I interferons in host defense.Immunity, 25 3
-
W. Barchet, A. Blasius, M. Cella, M. Colonna (2005)
Plasmacytoid dendritic cellsImmunologic Research, 32
-
T. Kawagoe, Shintaro Sato, Kazufumi Matsushita, H. Kato, Kosuke Matsui, Y. Kumagai, T. Saitoh, T. Kawai, O. Takeuchi, S. Akira (2008)
Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2Nature Immunology, 9
-
RLRs and NLRs in pathogen recognition 337 -
岡部 泰賢 (2006)
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation -
Tian Wang, T. Town, L. Alexopoulou, John Anderson, E. Fikrig, R. Flavell (2004)
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitisNature Medicine, 10
-
K. Yasutomo, T. Horiuchi, S. Kagami, H. Tsukamoto, C. Hashimura, M. Urushihara, Y. Kuroda (2001)
Mutation of DNASE1 in people with systemic lupus erythematosusNature Genetics, 28
-
407
Journal of Clinical Investigation, 115
-
M. Ermolaeva, M. Michallet, N. Papadopoulou, O. Utermöhlen, K. Kranidioti, G. Kollias, J. Tschopp, M. Pasparakis (2008)
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responsesNature Immunology, 9
-
T. Kanneganti, M. Lamkanfi, Yun-Gi Kim, Grace Chen, Jong-Hwan Park, L. Franchi, P. Vandenabeele, G. Núñez (2007)
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.Immunity, 26 4
-
M. Hasegawa, Y. Fujimoto, P. Lucas, H. Nakano, K. Fukase, G. Núñez, N. Inohara (2008)
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.The EMBO journal, 27 2
-
S. Pichyangkul, K. Yongvanitchit, U. Kum-arb, H. Hemmi, S. Akira, A. Krieg, D. Heppner, V. Stewart, H. Hasegawa, S. Looareesuwan, G. Shanks, R. Miller (2004)
Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway1The Journal of Immunology, 172
-
M. Lee-Kirsch, Maolian Gong, Dipanjan Chowdhury, L. Senenko, K. Engel, Young-Ae Lee, U. Silva, S. Bailey, T. Witte, T. Vyse, J. Kere, C. Pfeiffer, S. Harvey, Andrew Wong, S. Koskenmies, O. Hummel, K. Rohde, R. Schmidt, A. Dominiczak, M. Gahr, T. Hollis, F. Perrino, J. Lieberman, N. Hübner (2007)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosusNature Genetics, 39
-
Dekai Zhang, Guolong Zhang, M. Hayden, M. Greenblatt, C. Bussey, R. Flavell, S. Ghosh (2004)
A Toll-like Receptor That Prevents Infection by Uropathogenic BacteriaScience, 303
-
A. Poltorak, Xiaolong He, I. Smirnova, Mu-ya Liu, C. Huffel, Xin Du, D. Birdwell, Erica Alejos, Maria Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, Betsy Layton, B. Beutler (1998)
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.Science, 282 5396
-
J. Choe, M. Kelker, I. Wilson (2005)
Crystal Structure of Human Toll-Like Receptor 3 (TLR3) EctodomainScience, 309
-
T. Kawai, S. Akira (2006)
TLR signaling.Current topics in microbiology and immunology, 311
- Publisher
- Oxford University Press
- Copyright
- The Japanese Society for Immunology. 2009. All rights reserved. For permissions, please e-mail: [email protected]
- ISSN
- 0953-8178
- eISSN
- 1460-2377
- DOI
- 10.1093/intimm/dxp017
- pmid
- 19246554
- Publisher site
- See Article on Publisher Site
Abstract
The mammalian innate immune system detects the presence of microbial infection through germ line-encoded pattern recognition receptors (PRRs). Toll-like receptors, retinoic acid-inducible gene-I-like receptors and nucleotide-binding oligomerization domain-like receptors serve as PRRs that recognize different but overlapping microbial components. They are expressed in different cellular compartments such as the cell surface, endosome, lysosome or cytoplasm and activate specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes. This review summarizes recent insights into pathogen sensing by these PRRs and their signaling pathways.
Journal
International Immunology – Oxford University Press
Published: Feb 26, 2009
Keywords: innate immunity NOD-like receptor RIG-I-like receptor signal transduction Toll-like receptor