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Transfer of cupric sulfate across rat small intestine,in vitro and effect of chelating agents on it’s transfer

Transfer of cupric sulfate across rat small intestine,in vitro and effect of chelating agents on... The transfer of cupric sulfate across the rat small intestinein vitro was studied by perfusion method using the segments of everted rat small intestine. Copper transport was approximately propotional to the metal concentration in the mucosal solution and no difference was observed in the metal transport among rat duodenum, jejunum and ileum. It was suggested from these results that copper transport across the rat small intestine would occur by passive diffusion. The effect of various chelating agents on copper transport across the rat small intestinein vitro and its uptake by the intestine were also studied. Copper transport was greatly enhanced in the presence of EDTA and NTA. Copper uptake decreased to a greater extent in the presence of EPTA and NTA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Pharmacal Research Springer Journals

Transfer of cupric sulfate across rat small intestine,in vitro and effect of chelating agents on it’s transfer

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References (20)

Publisher
Springer Journals
Copyright
Copyright © The Pharmaceutical Society of Korea 1988
ISSN
0253-6269
eISSN
1976-3786
DOI
10.1007/bf02857709
Publisher site
See Article on Publisher Site

Abstract

The transfer of cupric sulfate across the rat small intestinein vitro was studied by perfusion method using the segments of everted rat small intestine. Copper transport was approximately propotional to the metal concentration in the mucosal solution and no difference was observed in the metal transport among rat duodenum, jejunum and ileum. It was suggested from these results that copper transport across the rat small intestine would occur by passive diffusion. The effect of various chelating agents on copper transport across the rat small intestinein vitro and its uptake by the intestine were also studied. Copper transport was greatly enhanced in the presence of EDTA and NTA. Copper uptake decreased to a greater extent in the presence of EPTA and NTA.

Journal

Archives of Pharmacal Research – Springer Journals

Published: Jun 1, 1988

Keywords: copper transport; rat small intestine; perfusion method; passive diffusion; copper uptake; chelating agent; copper-EDTA complex

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