Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/refining-the-impact-of-tcf7l2-gene-variants-on-type-2-diabetes-and-Y968jeZMzG
References (34)
-
A. Kong, D. Gudbjartsson, J. Sainz, G. Jónsdóttir, S. Gudjonsson, Bjorgvin Richardsson, Sigrun Sigurdardóttir, J. Barnard, B. Hallbeck, G. Másson, A. Shlien, S. Palsson, M. Frigge, T. Thorgeirsson, J. Gulcher, K. Stefánsson (2002)
A high-resolution recombination map of the human genomeNature Genetics, 31
-
Yang Wei-we (2008)
A Review on -
Kosuke Teshima, G. Coop, M. Przeworski (2006)
How reliable are empirical genomic scans for selective sweeps?Genome research, 16 6
-
A. Dempster, N. Laird, D. Rubin (1977)
Maximum likelihood from incomplete data via the EM - algorithm plus discussions on the paper -
C. Rotimi, G. Dunston, K. Berg, Omobosola Akinsete, A. Amoah, S. Owusu, J. Acheampong, Kofi Boateng, Oli Jm, G. Okafor, B. Onyenekwe, B. Onyenekwe, B. Osotimehin, B. Osotimehin, F. Abbiyesuku, Thomas Johnson, O. Fasanmade, P. Furbert-Harris, R. Kittles, Mirjana Vekich, O. Adegoke, G. Bonney, F. Collins (2001)
In search of susceptibility genes for type 2 diabetes in West Africa: the design and results of the first phase of the AADM study.Annals of epidemiology, 11 1
-
M. Olivier (2003)
A haplotype map of the human genome.Nature, 437 7063
-
B. Voight, S. Kudaravalli, X. Wen, J. Pritchard (2006)
A Map of Recent Positive Selection in the Human GenomePLoS Biology, 4
-
J. Erdmann, F. Lippl, S. Wagenpfeil, V. Schusdziarra (2005)
Differential association of basal and postprandial plasma ghrelin with leptin, insulin, and type 2 diabetes.Diabetes, 54 5
-
S. Gretarsdottir, G. Thorleifsson, S. Reynisdottir, A. Manolescu, S. Jónsdóttir, T. Jonsdottir, T. Gudmundsdóttir, S. Bjarnadottir, O. Einarsson, H. Gudjonsdottir, M. Hawkins, G. Gudmundsson, H. Gudmundsdóttir, H. Andrason, A. Gudmundsdottir, M. Sigurdardottir, T. Chou, J. Nahmias, S. Goss, S. Sveinbjörnsdóttir, E. Valdimarsson, F. Jakobsson, U. Agnarsson, V. Gudnason, G. Thorgeirsson, J. Fingerle, M. Gurney, D. Gudbjartsson, M. Frigge, A. Kong, K. Stefánsson, J. Gulcher (2003)
The gene encoding phosphodiesterase 4D confers risk of ischemic strokeNature Genetics, 35
-
A. Adeyemo, Guanjie Chen, Yuanxiu Chen, C. Rotimi (2005)
Genetic structure in four West African population groupsBMC Genetics, 6
-
J. Neel (1962)
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?American journal of human genetics, 14
-
J. Florez, K. Jablonski, N. Bayley, T. Pollin, P. Bakker, A. Shuldiner, W. Knowler, D. Nathan, D. Altshuler (2006)
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.The New England journal of medicine, 355 3
-
S. Arora, Anubhuti (2006)
Role of neuropeptides in appetite regulation and obesity – A reviewNeuropeptides, 40
-
E. Cerasi, P. Dieterle, H. Ege, A. Englhardt, H. Frerichs, W. Gepts, A. Hasselblatt, H. Henrichs, L. Herberg, J. Hoet, H. Hungerland, K. Jahnke, R. Jarrett, G. Jörgensen, K. Jørgensen, H. Kasemir, H. Keen, L. Kerp, V. Leclercq-Meyer, H. Liebermeister, G. Löffler, R. Luft, Willy Malaisse, J. Markussen, M. Möllering, H. Schadewaldt, J. Schlichtkrull, K. Schöffling, U. Schwedes, Peter Scriba, F. Sundby, Klaus-Henning Usadel, L. Weiss, H. Zimmermann, K. Oberdisse (1924)
DIABETES MELLITUSMedical Journal of Australia, 1
-
M. Slatkin, Giorgio Bertorelle (2001)
The use of intraallelic variability for testing neutrality and estimating population growth rate.Genetics, 158 2
-
G. Andersen, J. Overgaard, A. Albrechtsen, C. Glümer, K. Borch-Johnsen, T. Jørgensen, T. Hansen, O. Pedersen (2005)
Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white DanesDiabetologia, 49
-
C. Groves, E. Zeggini, J. Minton, T. Frayling, M. Weedon, N. Rayner, G. Hitman, M. Walker, S. Wiltshire, A. Hattersley, M. McCarthy (2006)
Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual RiskDiabetes, 55
-
G. Laval, L. Excoffier (2004)
SIMCOAL 2.0: a program to simulate genomic diversity over large recombining regions in a subdivided population with a complex historyBioinformatics, 20 15
-
D. Roberts, L. Cavalli-Sforza (1996)
The History and Geography of Human GenesJournal of the Royal Anthropological Institute, 2
-
L. Excoffier, P. Smouse, J. Quattro (1992)
Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.Genetics, 131 2
-
L. Jónsdóttir, N. Sigfússon, V. Gudnason, H. Sigvaldason, G. Thorgeirsson (2001)
Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study.Journal of cardiovascular risk, 9 2
-
C. Falk, P. Rubinstein (1987)
Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculationsAnnals of Human Genetics, 51
-
S. Schaffner, C. Foo, S. Gabriel, D. Reich, M. Daly, D. Altshuler (2005)
Calibrating a coalescent simulation of human genome sequence variation.Genome research, 15 11
-
L. Amundadottir, P. Sulem, J. Gudmundsson, Agnar Helgason, A. Baker, B. Agnarsson, A. Sigurdsson, K. Benediktsdottir, J. Cazier, J. Sainz, Margret Jakobsdottir, J. Kostic, Droplaug Magnúsdóttir, Shyamali Ghosh, Kari Agnarsson, B. Birgisdottir, L. Roux, A. Ólafsdóttir, T. Blondal, M. Andrésdóttir, Ó. Grétarsdóttir, J. Bergthórsson, D. Gudbjartsson, Arnaldur Gylfason, G. Thorleifsson, A. Manolescu, K. Kristjánsson, G. Geirsson, H. Isaksson, J. Douglas, J. Johansson, K. Bälter, F. Wiklund, J. Montie, Xiaoying Yu, B. Suarez, C. Ober, K. Cooney, H. Gronberg, W. Catalona, G. Einarsson, R. Barkardottir, J. Gulcher, A. Kong, U. Thorsteinsdóttir, K. Stefánsson (2006)
A common variant associated with prostate cancer in European and African populationsNature Genetics, 38
-
G. McVean, P. Awadalla, P. Fearnhead (2002)
A coalescent-based method for detecting and estimating recombination from gene sequences.Genetics, 160 3
-
S. O’Rahilly, I. Barroso, N. Wareham (2005)
Genetic Factors in Type 2 Diabetes: The End of the Beginning?Science, 307
-
L. Jónsdóttir, N. Sigfússon, Vilmundur Gunason, H. Sigvaldason, G. Thorgeirsson (2002)
Do Lipids, Blood Pressure, Diabetes, and Smoking Confer Equal Risk of Myocardial Infarction in Women as in Men? the Reykjavik StudyEuropean Journal of Cardiovascular Prevention & Rehabilitation, 9
-
AP Dempster, NM Laird, DB Rubin (1977)
Maximum likelihood from incomplete data via EM algorithmJ. R. Stat. Soc. Ser. B Methodol., 39
-
M. Beaumont, R. Nichols (1996)
Evaluating loci for use in the genetic analysis of population structureProceedings of the Royal Society of London. Series B: Biological Sciences, 263
-
H. Bandelt, P. Forster, A. Röhl (1999)
Median-joining networks for inferring intraspecific phylogenies.Molecular biology and evolution, 16 1
-
N. Mantel, W. Haenszel (1959)
Statistical aspects of the analysis of data from retrospective studies of disease.Journal of the National Cancer Institute, 22 4
-
Pardis Sabeti, D. Reich, J. Higgins, Haninah Levine, D. Richter, S. Schaffner, S. Gabriel, J. Platko, N. Patterson, G. McDonald, H. Ackerman, S. Campbell, D. Altshuler, R. Cooper, D. Kwiatkowski, R. Ward, E. Lander (2002)
Detecting recent positive selection in the human genome from haplotype structureNature, 419
-
A. Hinney, S. Hohmann, F. Geller, Constanze Vogel, C. Hess, Anne-Kathrin Wermter, Britta Brokamp, H. Goldschmidt, W. Siegfried, H. Remschmidt, H. Schäfer, T. Gudermann, J. Hebebrand (2003)
Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.The Journal of clinical endocrinology and metabolism, 88 9
-
S. Grant, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, A. Manolescu, J. Sainz, Agnar Helgason, H. Stefánsson, V. Emilsson, A. Helgadóttir, U. Styrkársdóttir, K. Magnússon, G. Walters, E. Pálsdóttir, T. Jonsdottir, T. Gudmundsdóttir, Arnaldur Gylfason, Jona Saemundsdottir, R. Wilensky, M. Reilly, D. Rader, Y. Bagger, C. Christiansen, V. Gudnason, Gunnar Sigurdsson, U. Thorsteinsdóttir, J. Gulcher, A. Kong, K. Stefánsson (2006)
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesNature Genetics, 38
- Publisher
- Springer Journals
- Copyright
- Copyright © 2007 by Nature Publishing Group
- Subject
- Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- DOI
- 10.1038/ng1960
- Publisher site
- See Article on Publisher Site
Abstract
We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (PAR) of 17%–28% in three populations of European ancestry 1 . Here, we refine the definition of the TCF7L2 type 2diabetes risk variant, HapBT2D, to the ancestral T allele of a SNP, rs7903146, through replication in West African and Danish type 2 diabetes case-control studies and an expanded Icelandic study. We also identify another variant of the same gene, HapA, that shows evidence of positive selection in East Asian, European and West African populations. Notably, HapA shows a suggestive association with body mass index and altered concentrations of the hunger-satiety hormones ghrelin and leptin in males, indicating that the selective advantage of HapA may have been mediated through effects on energy metabolism.
Journal
Nature Genetics – Springer Journals
Published: Jan 7, 2007