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New Hypothesis of Insulin Secretion

New Hypothesis of Insulin Secretion RELEASE of insulin from beta cells of the islets of Langer-hans occurs as a result of the movement of secretory granules to the surface of the cells. Here the membranous sacs encasing the granules fuse with the plasma membrane, rupture and liberate the granules into the extracellular space1. This process is called emiocytosis. Although glucose represents the most important physiologic stimulus for the release of insulin from the beta cells, it has been shown recently that the rates of secretion of insulin are also altered in the presence of a wide variety of other agents2. So far, little information is available concerning the relationship between the biochemical effects of these agents and the process of emiocytosis. We suggest here a working hypothesis for the events which occur between biochemical stimulation and the liberation of secretory granules into the extracellular space. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

New Hypothesis of Insulin Secretion

LACY, PAUL E.; HOWELL, SIMON L.; YOUNG, DONALD A.; FINK, C. JOAN
Nature , Volume 219 (5159) – Sep 14, 1968
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References (11)

Publisher
Springer Journals
Copyright
Copyright © 1968 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/2191177a0
Publisher site
See Article on Publisher Site

Abstract

RELEASE of insulin from beta cells of the islets of Langer-hans occurs as a result of the movement of secretory granules to the surface of the cells. Here the membranous sacs encasing the granules fuse with the plasma membrane, rupture and liberate the granules into the extracellular space1. This process is called emiocytosis. Although glucose represents the most important physiologic stimulus for the release of insulin from the beta cells, it has been shown recently that the rates of secretion of insulin are also altered in the presence of a wide variety of other agents2. So far, little information is available concerning the relationship between the biochemical effects of these agents and the process of emiocytosis. We suggest here a working hypothesis for the events which occur between biochemical stimulation and the liberation of secretory granules into the extracellular space.

Journal

Nature – Springer Journals

Published: Sep 14, 1968

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