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Recombinant human leptin in women with hypothalamic amenorrhea.The New England journal of medicine, 351 10
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M. Rosenbaum, E. Murphy, S. Heymsfield, D. Matthews, R. Leibel (2002)
Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones.The Journal of clinical endocrinology and metabolism, 87 5
- Publisher
- Springer Journals
- Copyright
- Copyright © 2005 by Birkhäuser Verlag, Basel
- Subject
- Life Sciences; Cell Biology; Biomedicine general; Life Sciences, general; Biochemistry, general
- ISSN
- 1420-682X
- eISSN
- 1420-9071
- DOI
- 10.1007/s00018-004-4432-1
- pmid
- 15770417
- Publisher site
- See Article on Publisher Site
Abstract
The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo. Furthermore, we discuss potential mechanisms of leptin resistance, specifically focusing on data regarding the neuroanatomical locus of leptin resistance and potential mechanisms by which expression of the suppressor of cytokine signaling-3 may impair leptin action.
Journal
Cellular and Molecular Life Sciences – Springer Journals
Published: Jan 1, 2004