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Prediction of coronary atherosclerotic disease with liver transaminase level

Prediction of coronary atherosclerotic disease with liver transaminase level Background/Aims: Recent studies have shown that liver transaminases are associated with components of the metabolic syndrome including central obesity, type 2 diabetes, dyslipidaemia and high blood pressure, but their direct influence on coronary atherosclerosis has not been investigated before. We conducted this study to evaluate the predictive value of liver transaminases for angiography‐documented coronary atherosclerosis in patients with coronary heart disease. Methods: Six hundred and thirty consecutive patients with suspicious coronary artery disease (CAD) who were candidates for coronary angiography were enrolled. In addition to coronary angiography, measurements of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations, C‐reactive protein (CRP) level and assessment of the traits of the metabolic syndrome were performed in all patients. Results: ALT and ALT/AST ratios were significantly correlated with angiographic atherosclerosis score in women (r=0.17 and 0.24 respectively). Logistic regression analysis showed that the ALT/AST ratio in women could predict severe CAD (odds ratio (OR) 3.93, 95% confidence interval (CI) 1.76–8.76). After adjustment for components of the metabolic syndrome and CRP concentration, the OR remained significant (4.00 (1.76–9.14)). Although significant in univariate analysis, neither ALT (OR 0.98, 95% CI 0.77–1.15) nor AST (OR 0.99, 95% CI 0.72–1.22) could predict severe CAD in men. Conclusion: An elevated ALT/AST ratio in women predicts coronary atherosclerosis independently of the metabolic syndrome and serum CRP concentration, and should warrant further diagnostic and therapeutic interventions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Liver International Wiley

Prediction of coronary atherosclerotic disease with liver transaminase level

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References (41)

Publisher
Wiley
Copyright
Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1478-3223
eISSN
1478-3231
DOI
10.1111/j.1478-3231.2007.01545.x
pmid
17696927
Publisher site
See Article on Publisher Site

Abstract

Background/Aims: Recent studies have shown that liver transaminases are associated with components of the metabolic syndrome including central obesity, type 2 diabetes, dyslipidaemia and high blood pressure, but their direct influence on coronary atherosclerosis has not been investigated before. We conducted this study to evaluate the predictive value of liver transaminases for angiography‐documented coronary atherosclerosis in patients with coronary heart disease. Methods: Six hundred and thirty consecutive patients with suspicious coronary artery disease (CAD) who were candidates for coronary angiography were enrolled. In addition to coronary angiography, measurements of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations, C‐reactive protein (CRP) level and assessment of the traits of the metabolic syndrome were performed in all patients. Results: ALT and ALT/AST ratios were significantly correlated with angiographic atherosclerosis score in women (r=0.17 and 0.24 respectively). Logistic regression analysis showed that the ALT/AST ratio in women could predict severe CAD (odds ratio (OR) 3.93, 95% confidence interval (CI) 1.76–8.76). After adjustment for components of the metabolic syndrome and CRP concentration, the OR remained significant (4.00 (1.76–9.14)). Although significant in univariate analysis, neither ALT (OR 0.98, 95% CI 0.77–1.15) nor AST (OR 0.99, 95% CI 0.72–1.22) could predict severe CAD in men. Conclusion: An elevated ALT/AST ratio in women predicts coronary atherosclerosis independently of the metabolic syndrome and serum CRP concentration, and should warrant further diagnostic and therapeutic interventions.

Journal

Liver International – Wiley

Published: Sep 1, 2007

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